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Journal of Toxicology: Toxin Reviews Volume 22, 2003 - Issue 4
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Research Article

Pharmacology and Toxicology of Major Constituents of Marijuana—On the Metabolic Activation of Cannabinoids and Its Mechanism

Ikuo Yamamoto School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714‐1 Yoshino‐cho, Nobeoka, 882‐8508, Japan
,
Kazuhito Watanabe Faculty of Pharmaceutical Sciences, Hokuriku University, Ho‐3 Kanagawa‐machi, Kanazawa, 920‐1181, Japan
,
Tamihide Matsunaga Division of Pharmacy, Shinshu University Hospital, 3‐1‐1 Asahi, Matsumoto, 390‐8621, Japan
,
Toshiyuki Kimura Faculty of Pharmaceutical Sciences, Hokuriku University, Ho‐3 Kanagawa‐machi, Kanazawa, 920‐1181, Japan
,
Tatsuya Funahashi Faculty of Pharmaceutical Sciences, Hokuriku University, Ho‐3 Kanagawa‐machi, Kanazawa, 920‐1181, Japan
&
Hidetoshi Yoshimura Nakamura Gakuen University, 5‐7‐1 Befu, Johnan‐ku, Fukuoka, 814‐0104, Japan
Pages 577-589 | Published online: 12 Nov 2003

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Caitlin M. Brown, Brad Reisfeld & Arthur N. Mayeno. (2008) Cytochromes P450: A Structure-Based Summary of Biotransformations Using Representative Substrates. Drug Metabolism Reviews 40:1, pages 1-100.
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Articles from other publishers (17)

Carmen Adella Sirbu, Aida M. Manole, Titus M. Vasile, Gabriela S. Toma, Livia R. Dobrican, Dan G. Varvara & Octavian Vasiliu. (2022) Cannabinoids – a new therapeutic strategy in neurology. Romanian Journal of Military Medicine 125:3, pages 349-355.
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Toktam Alirezaei, Mohammad Kalateh Agha Mohammadi & Rana Irilouzadian. (2022) Marijuana-induced myocarditis in a 24-year-old man. Archive of Clinical Cases 9:2, pages 69-74.
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Shilpi Goenka. (2022) Comparative Study of Δ9-Tetrahydrocannabinol and Cannabidiol on Melanogenesis in Human Epidermal Melanocytes from Different Pigmentation Phototypes: A Pilot Study. Journal of Xenobiotics 12:2, pages 131-144.
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Han Peng & Fereidoon Shahidi. (2021) Cannabis and Cannabis Edibles: A Review. Journal of Agricultural and Food Chemistry 69:6, pages 1751-1774.
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Marta Vázquez, Carlos García-Carnelli, Cecilia Maldonado & Pietro Fagiolino. 2021. Cannabinoids and Sleep. Cannabinoids and Sleep 27 42 .
Han Li, Yuzhi Liu, Danni Tian, Lei Tian, Xingke Ju, Liang Qi, Yongbo Wang & Chengyuan Liang. (2020) Overview of cannabidiol (CBD) and its analogues: Structures, biological activities, and neuroprotective mechanisms in epilepsy and Alzheimer’s disease. European Journal of Medicinal Chemistry 192, pages 112163.
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宗博 韩. (2019) A Study Review of the Biological Effect and Preparation of Cannabidiol. Botanical Research 08:03, pages 190-195.
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William R. Arnold, Austin T. Weigle & Aditi Das. (2018) Cross-talk of cannabinoid and endocannabinoid metabolism is mediated via human cardiac CYP2J2. Journal of Inorganic Biochemistry 184, pages 88-99.
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Jane Sachs, Erin McGlade & Deborah Yurgelun-Todd. (2015) Safety and Toxicology of Cannabinoids. Neurotherapeutics 12:4, pages 735-746.
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. (2015) Scientific Opinion on the risks for human health related to the presence of tetrahydrocannabinol (THC) in milk and other food of animal origin. EFSA Journal 13:6.
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Kazuhito Watanabe, Misa Miyamoto, Satoshi Yamaori, Koutaro Hasegawa, Kanako Watanabe & Osamu Suzuki. (2013) Human brain microsomes: their abilities to metabolize tetrahydrocannabinols and cannabinol. Forensic Toxicology 31:2, pages 307-311.
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Rongrong Jiang, Satoshi Yamaori, Shuso Takeda, Ikuo Yamamoto & Kazuhito Watanabe. (2011) Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes. Life Sciences 89:5-6, pages 165-170.
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. (2011) Scientific Opinion on the safety of hemp (Cannabis genus) for use as animal feed. EFSA Journal 9:3.
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Kazuhito Watanabe, Mai Fujinami, Satoshi Yamaori & Ikuo Yamamoto. (2010) Possible involvement of Cyp3a enzymes in the metabolism of tetrahydrocannabinols by mouse brain microsomes. Forensic Toxicology 29:1, pages 56-60.
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Kazuhito Watanabe, Satoshi Yamaori, Tatsuya Funahashi, Toshiyuki Kimura & Ikuo Yamamoto. (2007) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes. Life Sciences 80:15, pages 1415-1419.
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Tatsuya Funahashi, Yuuki Tanaka, Satoshi Yamaori, Toshiyuki Kimura, Tamihide Matsunaga, Shigeru Ohmori, Takashi Kageyama, Ikuo Yamamoto & Kazuhito Watanabe. (2005) Stimulatory Effects of Testosterone and Progesterone on the NADH-and NADPH-dependent Oxidation of 7β-Hydroxy-Δ8-tetrahydrocannabinol to 7-Oxo-Δ8-tetrahydrocannabinol in Monkey Liver Microsomes. Drug Metabolism and Pharmacokinetics 20:5, pages 358-367.
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Ikuo YAMAMOTO. (2005) The Studies on the Structure-Activity Relationship of Allyl Substituted Oxopyrimidines Searching for the Novel Antagonist or Agonist of Barbiturates to the Sleep Mechanism Based on the Uridine Receptor Theory —Barbituric Acid to Uridine (Part I)<sup>1)</sup>—新睡眠薬及び睡眠薬拮抗物質の探索研究から睡眠機構研究に辿りつくまで —バルビツール酸からウリジンまで（その1)<sup>1)</sup>—. YAKUGAKU ZASSHI 125:1, pages 73-120.
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