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Focus Papers

Inhibition of Alzheimer amyloid β aggregation by polyvalent trehalose

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Article: 024407 | Received 31 Jan 2008, Accepted 30 Jun 2008, Published online: 24 Jul 2008

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Ali Maruf, Małgorzata Milewska, Máté Varga & Ilona Wandzik. (2023) Trehalose-Bearing Carriers to Target Impaired Autophagy and Protein Aggregation Diseases. Journal of Medicinal Chemistry.
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Daniele Vinciguerra, Madeline B. Gelb & Heather D. Maynard. (2022) Synthesis and Application of Trehalose Materials. JACS Au 2:7, pages 1561-1587.
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Małgorzata Milewska, Andrzej Milewski, Ilona Wandzik & Martina H. Stenzel. (2022) Structurally analogous trehalose and sucrose glycopolymers – comparative characterization and evaluation of their effects on insulin fibrillation. Polymer Chemistry 13:13, pages 1831-1843.
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Masoomeh Khalifeh, Morgayn I. Read, George E. Barreto & Amirhossein Sahebkar. (2020) Trehalose against Alzheimer's Disease: Insights into a Potential Therapy. BioEssays 42:8.
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G. Di Natale, S. Zimbone, F. Bellia, M.F. Tomasello, M.L. Giuffrida, G. Pappalardo & E. Rizzarelli. (2018) Potential therapeutics of Alzheimer's diseases: New insights into the neuroprotective role of trehalose‐conjugated beta sheet breaker peptides. Peptide Science 110:5.
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Kamil Piwowarek, Edyta Lipińska, Elżbieta Hać-Szymańczuk, Marek Kieliszek & Iwona Ścibisz. (2017) Propionibacterium spp.—source of propionic acid, vitamin B12, and other metabolites important for the industry. Applied Microbiology and Biotechnology 102:2, pages 515-538.
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Koushik Debnath, Nibedita Pradhan, Brijesh Kumar Singh, Nihar R. Jana & Nikhil R. Jana. (2017) Poly(trehalose) Nanoparticles Prevent Amyloid Aggregation and Suppress Polyglutamine Aggregation in a Huntington’s Disease Model Mouse. ACS Applied Materials & Interfaces 9:28, pages 24126-24139.
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Nibedita Pradhan, Shashi Shekhar, Nihar R. Jana & Nikhil R. Jana. (2017) Sugar-Terminated Nanoparticle Chaperones Are 10 2 –10 5 Times Better Than Molecular Sugars in Inhibiting Protein Aggregation and Reducing Amyloidogenic Cytotoxicity . ACS Applied Materials & Interfaces 9:12, pages 10554-10566.
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Shinya Yano, Naozumi Teramoto, Rikako Miyamoto, Eiichi Nakajima, Kazuaki Hashimoto & Mitsuhiro Shibata. (2014) Fibroblast cell proliferation on photo-cured trehalose cinnamoyl ester thin films. Journal of Bioactive and Compatible Polymers 30:1, pages 87-98.
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Jayaraman Jayamani & Ganesh Shanmugam. (2014) Gallic acid, one of the components in many plant tissues, is a potential inhibitor for insulin amyloid fibril formation. European Journal of Medicinal Chemistry 85, pages 352-358.
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Sharbari Palmal, Nihar R. Jana & Nikhil R. Jana. (2014) Inhibition of Amyloid Fibril Growth by Nanoparticle Coated with Histidine-Based Polymer. The Journal of Physical Chemistry C 118:37, pages 21630-21638.
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Hemalatha Rajaram, Manoj Kumar Palanivelu, Thiruma V. Arumugam, Venkatesan M. Rao, P. Nicholas Shaw, Ross P. McGeary & Benjamin P. Ross. (2014) ‘Click’ assembly of glycoclusters and discovery of a trehalose analogue that retards Aβ40 aggregation and inhibits Aβ40-induced neurotoxicity. Bioorganic & Medicinal Chemistry Letters 24:18, pages 4523-4528.
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Jayaraman Jayamani, Ganesh Shanmugam & Ettayapuram Ramaprasad Azhagiya Singam. (2014) Inhibition of insulin amyloid fibril formation by ferulic acid, a natural compound found in many vegetables and fruits. RSC Adv. 4:107, pages 62326-62336.
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Hirokazu SetoYutaro OgataTatsuya MurakamiYu HoshinoYoshiko Miura. (2011) Selective Protein Separation Using Siliceous Materials with a Trimethoxysilane-Containing Glycopolymer. ACS Applied Materials & Interfaces 4:1, pages 411-417.
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Masaya Wada, Yuta Miyazawa & Yoshiko Miura. (2011) A specific inhibitory effect of multivalent trehalose toward Aβ(1-40) aggregation. Polymer Chemistry 2:8, pages 1822.
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Aslin Izmitli, Carolina Schebor, Michael P. McGovern, Allam S. Reddy, Nicholas L. Abbott & Juan J. de Pablo. (2011) Effect of trehalose on the interaction of Alzheimer's Aβ-peptide and anionic lipid monolayers. Biochimica et Biophysica Acta (BBA) - Biomembranes 1808:1, pages 26-33.
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Min S. Wang, Shanta Boddapati & Michael R. Sierks. (2010) Antifibrillizing agents catalyze the formation of unstable intermediate aggregates of beta‐amyloid. Biotechnology Progress 26:4, pages 1172-1179.
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