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Review

Current status of corneal collagen cross‐linking for keratoconus: a review

, FRANZCO & , FRCS FRANZCO FRCOphth(UK)
Pages 155-164 | Received 01 Aug 2012, Accepted 03 Oct 2012, Published online: 15 Apr 2021

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Richard Lindsay & Stephen J Vincent. (2022) Temporal trends in Medicare item number 10924 for irregular astigmatism. Clinical and Experimental Optometry 105:5, pages 552-555.
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Deniz Ozarslan Ozcan & Sait Coskun Ozcan. (2021) Efficacy of two silicone-hydrogel bandage contact lenses after corneal crosslinking. Clinical and Experimental Optometry 104:4, pages 505-509.
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Daniel A Godefrooij, Mustapha El Kandoussi, Nienke Soeters & Robert PL Wisse. (2017) Higher order optical aberrations and visual acuity in a randomized controlled trial comparing transepithelial versus epithelium-off corneal crosslinking for progressive keratoconus. Clinical Ophthalmology 11, pages 1931-1936.
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Shufang Wei, Cuiying Zhang, Shaoru Zhang, Yanyun Xu & Guoying Mu. (2017) Treatment Results of Corneal Collagen Cross-Linking Combined with Riboflavin and 440 Nm Blue Light for Bacterial Corneal Ulcer in Rabbits. Current Eye Research 42:10, pages 1401-1406.
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Jorge L Alio, Ahmed A Abdelghany & Miguel J Maldonado. (2014) Cataract surgery in cases with previous corneal surgery. Expert Review of Ophthalmology 9:3, pages 247-257.
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Charles Nj Mcghee. (2013) Keratoconus: the arc of past, present and future. Clinical and Experimental Optometry 96:2, pages 137-139.
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Articles from other publishers (48)

Andrea Conde Penedo, Victoria Díaz Tomé, Anxo Fernández Ferreiro, Miguel González Barcia & Francisco J. Otero Espinar. (2021) Enhancement in corneal permeability of riboflavin using cyclodextrin derivates complexes as a previous step to transepithelial cross-linking. European Journal of Pharmaceutics and Biopharmaceutics 162, pages 12-22.
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Bonnie Nga Kwan Choy, Alex Lap Ki Ng, Ming Ming Zhu, Catherine Chunling Liu, Sheng Xu & Jimmy Shiu Ming Lai. (2020) Randomized Control Trial on the Effectiveness of Collagen Cross-linking on Bullous Keratopathy. Cornea 39:11, pages 1341-1347.
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Alexandra Z. CrawfordJie Zhang, Akilesh Gokul, Charles N.J. McGheeSue E. Ormonde. (2020) The Enigma of Environmental Factors in Keratoconus. Asia-Pacific Journal of Ophthalmology 9:6, pages 549-556.
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Cristina Ariadna Nicula, Dorin Nicula, Anca Maria Rednik & Adriana Elena Bulboacă. (2020) Comparative Results of “Epi-Off” Conventional versus “Epi-Off” Accelerated Cross-Linking Procedure at 5-year Follow-Up. Journal of Ophthalmology 2020, pages 1-13.
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Isabel Dapena, Jack S. Parker & Gerrit R.J. Melles. (2020) Potential benefits of modified corneal tissue grafts for keratoconus: Bowman layer ‘inlay’ and ‘onlay’ transplantation, and allogenic tissue ring segments. Current Opinion in Ophthalmology 31:4, pages 276-283.
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Yi Zhou, Sergey Alexandrov, Andrew Nolan, Nandan Das, Rajib Dey & Martin Leahy. (2020) Noninvasive detection of nanoscale structural changes in cornea associated with cross‐linking treatment. Journal of Biophotonics 13:6.
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Guillermo Rocha, Tarek Ibrahim, Eric Gulliver & Kylee Lewis. (2019) Combined Phototherapeutic Keratectomy, Intracorneal Ring Segment Implantation, and Corneal Collagen Cross-Linking in Keratoconus Management. Cornea 38:10, pages 1233-1238.
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Owen Burton, Abi Tenen & Christopher Hodge. (2019) First presentation of keratoconus in a geriatric patient: Diagnosis and treatment of late progression. JCRS Online Case Reports 7:4, pages 65-70.
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Anastasios John Kanellopoulos. (2019) Ten-Year Outcomes of Progressive Keratoconus Management With the Athens Protocol (Topography-Guided Partial-Refraction PRK Combined With CXL). Journal of Refractive Surgery 35:8, pages 478-483.
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Anastasios John Kanellopoulos, Filippos Vingopoulos & Anna Maria Sideri. (2019) Long-Term Stability With the Athens Protocol (Topography-Guided Partial PRK Combined With Cross-Linking) in Pediatric Patients With Keratoconus. Cornea 38:8, pages 1049-1057.
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Juliana Almodin, Edna M Almodin & Flávia Almodin. (2019) Association of Ferrara Intracorneal Ring Segments with Phakic Intraocular Lens for Improved Visual Acuity in Young Keratoconus Patients: A Case Series. International Journal of Keratoconus and Ectatic Corneal Diseases 8:1, pages 23-28.
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Gonzalo García de Oteyza, Laura A. González Dibildox, Kristian A. Vázquez-Romo, André Tapia Vázquez, Jesús H. Dávila Alquisiras, Blanca E. Martínez-Báez, Ana M. García-Albisua, Manuel Ramírez & Everardo Hernández-Quintela. (2019) Bowman layer transplantation using a femtosecond laser. Journal of Cataract and Refractive Surgery 45:3, pages 261-266.
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Marco Lombardo & Giuseppe Lombardo. (2019) Noninvasive real-time assessment of riboflavin consumption in standard and accelerated corneal crosslinking. Journal of Cataract and Refractive Surgery 45:1, pages 80-86.
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Grace Lytle & John Marshall. 2019. Controversies in the Management of Keratoconus. Controversies in the Management of Keratoconus 87 108 .
Ramez Barbara, A. M. J. Turnbull, A. Malem, D. F. Anderson, P. Hossain, A. Konstantopoulos & Adel Barbara. 2019. Controversies in the Management of Keratoconus. Controversies in the Management of Keratoconus 1 16 .
Rénuka S Birbal, Korine van Dijk, Jack S Parker, Henny Otten, Maha Belmoukadim, Lisanne Ham, Lamis Baydoun, Isabel Dapena & Gerrit R J Melles. (2018) Manual mid-stromal dissection as a low risk procedure to stabilize mild to moderate progressive keratoconus. Eye and Vision 5:1.
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Samuel J. Kuechler, Christoph Tappeiner, Dan Epstein & Beatrice E. Frueh. (2018) Keratoconus Progression After Corneal Cross-Linking in Eyes With Preoperative Maximum Keratometry Values of 58 Diopters and Steeper. Cornea 37:11, pages 1444-1448.
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Giuseppe Lombardo, Valentina Villari, Norberto L. Micali, Nancy Leone, Cristina Labate, Maria P. De Santo & Marco Lombardo. (2018) Non-invasive optical method for real-time assessment of intracorneal riboflavin concentration and efficacy of corneal cross-linking. Journal of Biophotonics 11:7, pages e201800028.
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Edna Motta Almodin, Paulo Ferrara, Flavia Motta Almodin Camin & Juliana Motta Almodin Colallilo. (2018) Femtosecond laser–assisted intrastromal corneal lenticule implantation for treatment of advanced keratoconus in a child’s eye. JCRS Online Case Reports 6:2, pages 25-29.
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Ricardo Alexandre Stock, Thaís Thumé & Elcio Luiz Bonamigo. (2017) Acute corneal hydrops during pregnancy with spontaneous resolution after corneal cross-linking for keratoconus: a case report. Journal of Medical Case Reports 11:1.
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Kun Wang, Wenhang Wang, Xiaomeng Wu, Jingdong Xiao, Yaowei Liu & Anjun Liu. (2017) Effect of photochemical UV/riboflavin-mediated cross-links on different properties of fish gelatin films. Journal of Food Process Engineering 40:5, pages e12536.
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Emine Kalkan Akçay, Aydan Kilicarslan, Betul Seher Uysal, Gozde Hondur, Pinar Kosekahya, Hasan Altinkaynak & Nurullah Cagil. (2017) Tear Function and Ocular Surface Alterations After Accelerated Corneal Collagen Cross-Linking in Progressive Keratoconus. Eye & Contact Lens: Science & Clinical Practice 43:5, pages 302-307.
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Xiaoyu Zhang, Ling Sun, Yang Shen, Mi Tian, Jing Zhao, Yu Zhao, Meiyan Li & Xingtao Zhou. (2017) Biomechanical and Histopathologic Effects of Pulsed-Light Accelerated Epithelium-On/-Off Corneal Collagen Cross-Linking. Cornea 36:7, pages 854-859.
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Marco Lombardo, Daniela Giannini, Giuseppe Lombardo & Sebastiano Serrao. (2017) Randomized Controlled Trial Comparing Transepithelial Corneal Cross-linking Using Iontophoresis with the Dresden Protocol in Progressive Keratoconus. Ophthalmology 124:6, pages 804-812.
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Friederike Schaub, Philip Enders, Björn O. Bachmann, Ludwig M. Heindl & Claus Cursiefen. (2017) Effect of corneal collagen crosslinking on subsequent deep anterior lamellar keratoplasty (DALK) in keratoconus. Graefe's Archive for Clinical and Experimental Ophthalmology 255:4, pages 811-816.
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Ramez Barbara, Andrew M. J. Turnbull, Parwez Hossain, David F. Anderson & Adel Barbara. 2017. Keratoconus. Keratoconus 13 23 .
Arthur B. Cummings, Mazen M. Sinjab, Kathryn M. Hatch, Jonathan Talamo, Bradley Randleman, Anastasios John Kanellopoulos, George Asimellis, Hani Sakla, Wassim Altroudi, Yaron S. Rabinowitz, Aylin Kılıç, Roy Scott Rubinfeld, Renato Ambrósio Junior, Mohamed El-Kateb, Dale P. DeVore, Michael A. Ross, Bruce H. De Woolfson, Olivia Dryjski & R. Doyle Stulting. 2017. Corneal Collagen Cross Linking. Corneal Collagen Cross Linking 87 165 .
Rebecca McQuaid, Michael Mrochen, Brian Vohnsen, Eberhard Spoerl, Sabine Kling & Cynthia J. Roberts. 2017. Corneal Collagen Cross Linking. Corneal Collagen Cross Linking 63 86 .
Salvatore Luceri, Jack Parker, Isabel Dapena, Lamis Baydoun, Silke Oellerich, Korine van Dijk & Gerrit R. J. Melles. (2016) Corneal Densitometry and Higher Order Aberrations After Bowman Layer Transplantation. Cornea 35:7, pages 959-966.
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Kimberly M. Metzler, Cynthia J. Roberts, Ashraf M. Mahmoud, Gunjan Agarwal & Jun Liu. (2016) Ex Vivo Transepithelial Collagen Cross-linking in Porcine and Human Corneas Using Human Decorin Core Protein. Journal of Refractive Surgery 32:6, pages 410-417.
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Justin T. Kwan, Kristine Dalton & Barry A. Weissman. (2016) Contact Lens Applications and the Corneal Dystrophies. Eye & Contact Lens: Science & Clinical Practice 42:3, pages 177-184.
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Shiji Ummar. (2016) Corneal Collagen Cross-linking in Infective Keratitis. International Journal of Keratoconus and Ectatic Corneal Diseases 5:1, pages 13-16.
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Virgilio GalvisAlejandro TelloNéstor I. CarreñoAlvaro I. OrtizRodrigo BarreraCarlos Julian RodriguezMiguel E. Ochoa. (2016) Corneal Cross-Linking (with a Partial Deepithelization) in Keratoconus with Five Years of Follow-Up. Ophthalmology and Eye Diseases 8, pages OED.S38364.
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Marco Lombardo, Sebastiano Serrao, Paolo Raffa, Marianna Rosati & Giuseppe Lombardo. (2016) Novel Technique of Transepithelial Corneal Cross-Linking Using Iontophoresis in Progressive Keratoconus. Journal of Ophthalmology 2016, pages 1-11.
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Johnny E. Moore, Davide Schiroli & C. B. Tara Moore. (2016) Potential Effects of Corneal Cross-Linking upon the Limbus. BioMed Research International 2016, pages 1-11.
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Ariela Gordon-Shaag, Michel Millodot, Igor Kaiserman, Tzahi Sela, Guy Barnett Itzhaki, Yaffa Zerbib, Efrat Matityahu, Shira Shkedi, Svetlana Miroshnichenko & Einat Shneor. (2015) Risk factors for keratoconus in Israel: a case-control study. Ophthalmic and Physiological Optics 35:6, pages 673-681.
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Jack S. Parker, Korine van Dijk & Gerrit R.J. Melles. (2015) Treatment options for advanced keratoconus: A review. Survey of Ophthalmology 60:5, pages 459-480.
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Korine van Dijk, Vasilios S. Liarakos, Jack Parker, Lisanne Ham, Jessica T. Lie, Esther A. Groeneveld-van Beek & Gerrit R.J. Melles. (2015) Bowman Layer Transplantation to Reduce and Stabilize Progressive, Advanced Keratoconus. Ophthalmology 122:5, pages 909-917.
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Ramin Saravani, Farzaneh Hasanian-Langroudi, Mohammad-Hosein Validad, Davood Yari, Gholamreza Bahari, Mahmood Faramarzi, Mehdi Khateri & Somayeh Bahadoram. (2015) Evaluation of Possible Relationship Between COL4A4 Gene Polymorphisms and Risk of Keratoconus. Cornea 34:3, pages 318-322.
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C. Nicula, D. Nicula, R. Popescu & A. Saplonţai-Pop. (2015) Corneal collagen cross-linking in keratoconus – long-term prospective study. Journal Français d'Ophtalmologie 38:3, pages 199-205.
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Uri Elbaz, Carl Shen, Alejandro Lichtinger, Noa Avni Zauberman, Yakov Goldich, Setareh Ziai & David S Rootman. (2015) Accelerated versus standard corneal collagen crosslinking combined with same day phototherapeutic keratectomy and single intrastromal ring segment implantation for keratoconus. British Journal of Ophthalmology 99:2, pages 155-159.
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Ariela Gordon-Shaag, Michel Millodot, Einat Shneor & Yutao Liu. (2015) The Genetic and Environmental Factors for Keratoconus. BioMed Research International 2015, pages 1-19.
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Suphi Taneri, Elias Jarade, John A. Kanellopoulos & David Muller. (2015) Current Concepts and Future Developments of Corneal Cross-Linking. Journal of Ophthalmology 2015, pages 1-2.
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Emine Esra Karaca, Mehmet Cüneyt Özmen, Feyzahan Ekici, Erdem Yüksel & Zülal Türkoğlu. (2014) Neutrophil-to-Lymphocyte Ratio May Predict Progression in Patients With Keratoconus. Cornea 33:11, pages 1168-1173.
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Grace Lytle. (2014) Advances in the Technology of Corneal Cross-Linking for Keratoconus. Eye & Contact Lens: Science & Clinical Practice 40:6, pages 358-364.
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Uri Elbaz, Carl Shen, Alejandro Lichtinger, Noa A. Zauberman, Yakov Goldich, Clara C. Chan, Allan R. Slomovic & David S. Rootman. (2014) Accelerated (9-mW/cm2) Corneal Collagen Crosslinking for Keratoconus—A 1-Year Follow-up. Cornea 33:8, pages 769-773.
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Joyce A. Craig, James Mahon, Ann Yellowlees, Teresa Barata, Julie Glanville, Mick Arber, Lakshmi Mandava, John Powell & Francisco Figueiredo. (2014) Epithelium-Off Photochemical Corneal Collagen Cross-Linkage Using Riboflavin and Ultraviolet A for Keratoconus and Keratectasia: A Systematic Review and Meta-Analysis. The Ocular Surface 12:3, pages 202-214.
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Anastasios John Kanellopoulos & George Asimellis. (2014) Keratoconus Management: Long-Term Stability of Topography-Guided Normalization Combined With High-Fluence CXL Stabilization (The Athens Protocol). Journal of Refractive Surgery 30:2, pages 88-93.
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