Advanced search
Publication Cover
Clinical and Experimental Optometry Volume 96, 2013 - Issue 2
Submit an article Journal homepage
130
Views
74
CrossRef citations to date
0
Altmetric
Research Paper

Effects of eye rubbing on the levels of protease, protease activity and cytokines in tears: relevance in keratoconus

Sivaraman A BalasubramanianBrien Holden Vision Institute, , Kensington, New South Wales, Australia, ;School of Optometry and Vision Science, The University of New South Wales, Kensington, New South Wales, Australia, ;School of Medicine, Deakin University, Waurn Ponds, Victoria, Australia, View further author information
, MBBS DO PhD,
David C PyeSchool of Optometry and Vision Science, The University of New South Wales, Kensington, New South Wales, Australia, ;Centre for Eye Health, The University of New South Wales, Kensington, New South Wales, Australia, View further author information
, MOptom &
Mark Dp WillcoxSchool of Optometry and Vision Science, The University of New South Wales, Kensington, New South Wales, Australia, View further author information
, PhD
Pages 214-218 | Received 27 Jul 2012, Accepted 11 Jan 2013, Published online: 15 Apr 2021

Citations (74)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (12)

Tim Berger, Nóra Szentmáry, Ning Chai, Elias Flockerzi, Loay Daas, Tanja Stachon & Berthold Seitz. (2023) In Vitro Expression Analysis of Cytokines and ROS-Related Genes in Human Corneal Fibroblasts and Keratocytes of Healthy and Keratoconus Corneas. Ocular Immunology and Inflammation 0:0, pages 1-10.
Read now
Shahira Mahmoud, Ahmed El-Massry, Mohamed Bahgat Goweida & Islam Ahmed. (2022) Pediatric Keratoconus in A Tertiary Eye Center in Alexandria: A Cross-sectional Study. Ophthalmic Epidemiology 29:1, pages 49-56.
Read now
Thomas John, Sean Tighe & Hosam Sheha. (2021) Keyhole Anterior Lamellar Keratoplasty for Boston Keratoprosthesis Corneal Melt. Clinical Ophthalmology 15, pages 3993-3996.
Read now
Nathan Efron. (2021) Celebrating outstanding research articles published in Clinical and Experimental Optometry. Clinical and Experimental Optometry 104:7, pages 741-743.
Read now
Erdinc Bozkurt & Turgay Ucak. (2021) Serum Inflammation Biomarkers in Patients with Keratoconus. Ocular Immunology and Inflammation 29:6, pages 1164-1167.
Read now
Eray Atalay, Raymond P Najjar, Tin Aung Tun, Onur Özalp, Mustafa D Bilgeç & Nilgün Yıldırım. (2019) Corneal elevation changes after forced eyelid closure in healthy participants and in patients with keratoconus. Clinical and Experimental Optometry 102:6, pages 590-595.
Read now
Mohammad Naderan, Mohammad Taher Rajabi, Parviz Zarrinbakhsh & Anahita Bakhshi. (2017) Effect of Allergic Diseases on Keratoconus Severity. Ocular Immunology and Inflammation 25:3, pages 418-423.
Read now
Charles W Mcmonnies. (2016) Eye rubbing type and prevalence including contact lens ‘removal‐relief’ rubbing. Clinical and Experimental Optometry 99:4, pages 366-372.
Read now
Gökhan Pekel, Fatih Firinci, Semra Acer, Seher Kasikçi, Ramazan Yagci, Emin Mete & Ebru Nevin Çetin. (2016) Optical densitometric measurements of the cornea and lens in children with allergic rhinoconjunctivitis. Clinical and Experimental Optometry 99:1, pages 51-55.
Read now
Gonzalo Carracedo, Alberto Recchioni, Nicolás Alejandre-Alba, Alba Martin-Gil, Almudena Crooke, Ignacio Jimenez-Alfaro Morote & Jesús Pintor. (2015) Signs and Symptoms of Dry Eye in Keratoconus Patients: A Pilot Study. Current Eye Research 40:11, pages 1088-1094.
Read now
Marie-Claude Robert & Claes H. Dohlman. (2014) A Review of Corneal Melting after Boston Keratoprosthesis. Seminars in Ophthalmology 29:5-6, pages 349-357.
Read now
Charles Nj Mcghee. (2013) Keratoconus: the arc of past, present and future. Clinical and Experimental Optometry 96:2, pages 137-139.
Read now

Articles from other publishers (62)

Parisa Mirzapour, David J. McCanna & Lyndon Jones. (2021) In vitro analysis of the interaction of tear film inflammatory markers with contemporary contact lens materials. Contact Lens and Anterior Eye 44:5, pages 101430.
Crossref
Valentin Navel, Jean Malecaze, Bruno Pereira, Julien S. Baker, François Malecaze, Vincent Sapin, Frédéric Chiambaretta & Frédéric Dutheil. (2020) Oxidative and antioxidative stress markers in keratoconus: a systematic review and meta‐analysis. Acta Ophthalmologica 99:6.
Crossref
Srujana Sahebjada, Haitham H. Al-Mahrouqi, Sophia Moshegov, Sathiya M. Panchatcharam, Elsie Chan, Mark Daniell & Paul N. Baird. (2021) Eye rubbing in the aetiology of keratoconus: a systematic review and meta-analysis. Graefe's Archive for Clinical and Experimental Ophthalmology 259:8, pages 2057-2067.
Crossref
Srujana Sahebjada, Elsie Chan, Jing Xie, Grant R. Snibson, Mark Daniell & Paul N. Baird. (2020) Risk factors and association with severity of keratoconus: the Australian study of Keratoconus. International Ophthalmology 41:3, pages 891-899.
Crossref
Shih‐Feng Weng, Ren‐Long Jan, Jhi‐Joung Wang, Sung‐Huei Tseng & Yuh‐Shin Chang. (2020) Association between atopic keratoconjunctivitis and the risk of keratoconus. Acta Ophthalmologica 99:1.
Crossref
Debby Yeung, Paul J. Murphy & Luigina Sorbara. (2021) Comparative Analysis of Tear Proteins in Keratoconic Scleral Lens Wearers with Variation in Limbal Clearance. Optometry and Vision Science 98:2, pages 143-149.
Crossref
Praveen Subudhi, Sweta Patro & Nageswar Rao Subudhi. 2021. Eyesight and Medical Image Cognition - Recent Advances and New Perspectives [Working Title]. Eyesight and Medical Image Cognition - Recent Advances and New Perspectives [Working Title].
Sepehr Feizi, Mohammad Ali Javadi, Mohammadhasan Alemzadeh-Ansari, Amir Arabi, Toktam Shahraki & Ahmad Kheirkhah. (2021) Management of corneal complications in vernal keratoconjunctivitis: A review. The Ocular Surface 19, pages 282-289.
Crossref
Yaron S. Rabinowitz, Virgilio Galvis, Alejandro Tello, Daniela Rueda & Juan Daniel García. (2021) Genetics vs chronic corneal mechanical trauma in the etiology of keratoconus. Experimental Eye Research 202, pages 108328.
Crossref
Alexandra Z. CrawfordJie Zhang, Akilesh Gokul, Charles N.J. McGheeSue E. Ormonde. (2020) The Enigma of Environmental Factors in Keratoconus. Asia-Pacific Journal of Ophthalmology 9:6, pages 549-556.
Crossref
Rohit Shetty, Sharon D'Souza, Pooja Khamar, Arkasubhra Ghosh, Rudy M.M.A. NuijtsSwaminathan Sethu. (2020) Biochemical Markers and Alterations in Keratoconus. Asia-Pacific Journal of Ophthalmology 9:6, pages 533-540.
Crossref
Uxía Regueiro, María Pérez-Mato, Pablo Hervella, Francisco Campos, Tomás Sobrino & Isabel Lema. (2020) Toll-like receptors as diagnostic targets in pellucid marginal degeneration. Experimental Eye Research 200, pages 108211.
Crossref
Erdinç Bozkurt & Fatih Bagcier. (2020) Keratoconus: a potential risk factor for osteoarthritis. International Ophthalmology 40:10, pages 2545-2552.
Crossref
Wolfgang G.K. Müller-Lierheim. (2020) Why Chain Length of Hyaluronan in Eye Drops Matters. Diagnostics 10:8, pages 511.
Crossref
Toufik Bettahar, Chemseddine Rahmoune & Djamel Benazzouz. (2020) Keratoconus prognosis study for patients with corneal external mechanical stress mode. International Ophthalmology 40:7, pages 1673-1686.
Crossref
Sarah Moran, Ludovic Gomez, Kevin Zuber & Damien Gatinel. (2020) A Case-Control Study of Keratoconus Risk Factors. Cornea 39:6, pages 697-701.
Crossref
Thomas L. A. Volatier, Francisco C. Figueiredo & Che J. Connon. (2019) Keratoconus at a Molecular Level: A Review. The Anatomical Record 303:6, pages 1680-1688.
Crossref
Damien Gatinel, Virgilio Galvis, Alejandro Tello, Camilo A. Niño, Juán J. Rey, Paul A. Camacho & Sergio E. Serrano. (2019) Obstructive Sleep Apnea–Hypopnea Syndrome and Keratoconus: An Epiphenomenon Related to Sleep Position?. Cornea 39:4, pages e11-e12.
Crossref
Rashmi Mittal & Hitendra Ahooja. (2020) Thermo-cauterization and amniotic membrane grafting for extensive hydrops in a child with vernal keratoconjunctivitis. Indian Journal of Ophthalmology 68:4, pages 644.
Crossref
Prerna Ahuja, Zelda Dadachanji, Rohit Shetty, SowmyaArudi Nagarajan, Pooja Khamar, Swaminathan Sethu & Sharon D'Souza. (2020) Relevance of IgE, allergy and eye rubbing in the pathogenesis and management of Keratoconus. Indian Journal of Ophthalmology 68:10, pages 2067.
Crossref
Melek Mutlu, Ozge Sarac, Nurullah Cağıl & Gamze Avcıoğlu. (2019) Relationship between tear eotaxin-2 and MMP-9 with ocular allergy and corneal topography in keratoconus patients. International Ophthalmology 40:1, pages 51-57.
Crossref
Kenneth A. Beckman, Preeya K. Gupta, Marjan Farid, John P. Berdahl, Elizabeth Yeu, Brandon Ayres, Clara C. Chan, José A.P. Gomes, Edward J. Holland, Terry Kim, Christopher E. Starr & Francis S. Mah. (2019) Corneal crosslinking: Current protocols and clinical approach. Journal of Cataract and Refractive Surgery 45:11, pages 1670-1679.
Crossref
Hadas Ben-Eli, Nir Erdinest & Abraham Solomon. (2019) Pathogenesis and complications of chronic eye rubbing in ocular allergy. Current Opinion in Allergy & Clinical Immunology 19:5, pages 526-534.
Crossref
Antonio Di Zazzo, Alessandra Micera, Maria De Piano, Magdalena Cortes & Stefano Bonini. (2018) Tears and ocular surface disorders: Usefulness of biomarkers. Journal of Cellular Physiology 234:7, pages 9982-9993.
Crossref
Deepali Singhal, Pranita Sahay, Prafulla K. Maharana, Nimmy Raj, Namrata Sharma & Jeewan S. Titiyal. (2019) Vernal Keratoconjunctivitis. Survey of Ophthalmology 64:3, pages 289-311.
Crossref
Erica di Martino, Manir Ali & Chris F. Inglehearn. (2019) Matrix metalloproteinases in keratoconus – Too much of a good thing?. Experimental Eye Research 182, pages 137-143.
Crossref
Subhadeep Roy, Saumya Yadav, Tanushree Dasgupta, Shikha Chawla, Radhika Tandon & Sourabh Ghosh. (2019) Interplay between hereditary and environmental factors to establish an in vitro disease model of keratoconus. Drug Discovery Today 24:2, pages 403-416.
Crossref
. 2019. Contact Lenses. Contact Lenses e51 e97 .
Anjali PrasharAnjali Prashar. 2019. Shed Tears for Diagnostics. Shed Tears for Diagnostics 103 124 .
Anjali PrasharAnjali Prashar. 2019. Shed Tears for Diagnostics. Shed Tears for Diagnostics 85 102 .
Anjali PrasharAnjali Prashar. 2019. Shed Tears for Diagnostics. Shed Tears for Diagnostics 21 49 .
Yousef Shanti, Ithar Beshtawi, Sa’ed H. Zyoud, Ahlam Abu-Samra, Areen Abu-Qamar, Reem Barakat & Reham Shehada. (2018) Characteristics of keratoconic patients at two main eye centres in Palestine: a cross-sectional study. BMC Ophthalmology 18:1.
Crossref
Sophia Masterton & Mark Ahearne. (2018) Mechanobiology of the corneal epithelium. Experimental Eye Research 177, pages 122-129.
Crossref
Cosimo Mazzotta, Claudio Traversi, Pierfrancesco Mellace, Simone A. Bagaglia, Silvio Zuccarini, Rita Mencucci & Soosan Jacob. (2018) Keratoconus Progression in Patients With Allergy and Elevated Surface Matrix Metalloproteinase 9 Point-of-Care Test. Eye & Contact Lens: Science & Clinical Practice 44:2, pages S48-S53.
Crossref
Naoko Kato, Kenji Konomi, Megumi Shinzawa, Kozue Kasai, Takeshi Ide, Ikuko Toda, Chikako Sakai, Kazuno Negishi, Kazuo Tsubota & Jun Shimazaki. (2018) Corneal crosslinking for keratoconus in Japanese populations: one year outcomes and a comparison between conventional and accelerated procedures. Japanese Journal of Ophthalmology 62:5, pages 560-567.
Crossref
Rabab Sharif, Ben Fowler & Dimitrios Karamichos. (2018) Collagen cross-linking impact on keratoconus extracellular matrix. PLOS ONE 13:7, pages e0200704.
Crossref
Teresa Tsai, Sandra Kuehn, Nikolaos Tsiampalis, Minh-Khoa Vu, Vinodh Kakkassery, Gesa Stute, H. Burkhard Dick & Stephanie C. Joachim. (2018) Anti-inflammatory cytokine and angiogenic factors levels in vitreous samples of diabetic retinopathy patients. PLOS ONE 13:3, pages e0194603.
Crossref
Stephan Johannes Linke. (2018) Einseitiger Keratokonus durch chronisches Augenreiben? Eine detektivische Investigation. Karger Kompass Ophthalmologie, pages 140-142.
Crossref
Forouhe Zahir-Jouzdani, Fatemeh Atyabi & Nazanin Mojtabavi. (2017) Interleukin-6 participation in pathology of ocular diseases. Pathophysiology 24:3, pages 123-131.
Crossref
Gen-Lai Du, Wei-Yi Chen, Xiao-Na Li, Rui He & Peng-Fei Feng. (2017) Induction of MMP-1 and −3 by cyclical mechanical stretch is mediated by IL-6 in cultured fibroblasts of keratoconus. Molecular Medicine Reports 15:6, pages 3885-3892.
Crossref
Lisa McAnena, Frank Doyle & Michael O'Keefe. (2017) Cross-linking in children with keratoconus: a systematic review and meta-analysis. Acta Ophthalmologica 95:3, pages 229-239.
Crossref
Cosimo Mazzotta, Frederik Raiskup, Stefano Baiocchi, Giuliano Scarcelli, Marc D. Friedman & Claudio TraversiCosimo Mazzotta, Frederik Raiskup, Stefano Baiocchi, Giuliano Scarcelli, Marc D. Friedman & Claudio Traversi. 2017. Management of Early Progressive Corneal Ectasia. Management of Early Progressive Corneal Ectasia 33 62 .
Trevor Sherwin, Salim Ismail, I-Ping Loh & Jennifer Jane McGhee. 2017. Keratoconus. Keratoconus 25 41 .
Pierre Fournié, Stéphane D. Galiacy & François Malecaze. 2017. Keratoconus. Keratoconus 7 12 .
Krishnatej Nishtala, Natasha Pahuja, Rohit Shetty, Rudy M. M. A. Nuijts & Arkasubhra Ghosh. (2016) Tear biomarkers for keratoconus. Eye and Vision 3:1.
Crossref
Roberto Caputo, Francesco Versaci, Neri Pucci, Cinzia de Libero, Gioia Danti, Salvatore De Masi, Rita Mencucci, Elio Novembre & Bennie H. Jeng. (2016) Very Low Prevalence of Keratoconus in a Large Series of Vernal Keratoconjunctivitis Patients. American Journal of Ophthalmology 172, pages 64-71.
Crossref
Gonzalo Carracedo, José Manuel González-Méijome, Alba Martín-Gil, Jesús Carballo & Jesús Pintor. (2016) The influence of rigid gas permeable lens wear on the concentrations of dinucleotides in tears and the effect on dry eye signs and symptoms in keratoconus. Contact Lens and Anterior Eye 39:5, pages 375-379.
Crossref
Mohammad Mehdi Sadoughi, Danial Roshandel, Javad Rezaei, Neda Einollahi & Bahram Einollahi. (2016) Clinical Evidence of Decreased Iris Resistance in Patients With Keratoconus. Cornea 35:7, pages 967-971.
Crossref
. (2016) Eye Rubbing, a Sine Qua Non for Keratoconus?. International Journal of Keratoconus and Ectatic Corneal Diseases 5:1, pages 6-12.
Crossref
Catalina Ionescu, Catalina Gabriela Corbu, Cristiana Tanase, Christian Jonescu-Cuypers, Cristina Nicula, Dana Dascalescu, Miruna Cristea & Liliana-Mary Voinea. (2016) Inflammatory Biomarkers Profile as Microenvironmental Expression in Keratoconus. Disease Markers 2016, pages 1-8.
Crossref
Robert P.L. Wisse, Jonas J.W. Kuiper, Renze Gans, Saskia Imhof, Timothy R.D.J. Radstake & Allegonda Van der Lelij. (2015) Cytokine Expression in Keratoconus and its Corneal Microenvironment: A Systematic Review. The Ocular Surface 13:4, pages 272-283.
Crossref
Virgilio Galvis, Alejandro Tello, Rodrigo Barrera & Camilo A. Niño. (2015) Inflammation in Keratoconus. Cornea 34:8, pages e22-e23.
Crossref
Rana Sorkhabi, Amir Ghorbanihaghjo, Nazli Taheri & Mohammad Hosein Ahoor. (2014) Tear film inflammatory mediators in patients with keratoconus. International Ophthalmology 35:4, pages 467-472.
Crossref
Mohammad Naderan, Mohammad Taher Rajabi, Saeed Shoar, Mohammad Amin Kamaleddin, Morteza Naderan, Farzaneh Rezagholizadeh, Masoome Zolfaghari & Rozhin Pahlevani. (2015) Distribution of ABO and Rh Blood Groups in Patients With Keratoconus. Eye & Contact Lens: Science & Clinical Practice 41:4, pages 214-217.
Crossref
V Galvis, T Sherwin, A Tello, J Merayo, R Barrera & A Acera. (2015) Keratoconus: an inflammatory disorder?. Eye 29:7, pages 843-859.
Crossref
Mohammad Naderan, Saeed Shoar, Farzaneh Rezagholizadeh, Masoome Zolfaghari & Morteza Naderan. (2015) Characteristics and associations of keratoconus patients. Contact Lens and Anterior Eye 38:3, pages 199-205.
Crossref
Charles W. McMonnies. (2015) Inflammation and Keratoconus. Optometry and Vision Science 92:2, pages e35-e41.
Crossref
George D. Kymionis, Konstantinos I. Tsoulnaras, Stella V. Blazaki & Michael A. Grentzelos. (2015) Eye Rubbing as a Possible Cause of Clinical Progressive Keratoconus in a Forme Fruste Keratoconic Family. Open Journal of Ophthalmology 05:01, pages 19-22.
Crossref
Ariela Gordon-Shaag, Michel Millodot, Einat Shneor & Yutao Liu. (2015) The Genetic and Environmental Factors for Keratoconus. BioMed Research International 2015, pages 1-19.
Crossref
Elizabeth Hawkes & Mayank A Nanavaty. (2014) Eye Rubbing and Keratoconus: A Literature Review. International Journal of Keratoconus and Ectatic Corneal Diseases 3:3, pages 118-121.
Crossref
José Ignacio Recalde Yurrita, Juan San Cristóbal Espalza & Juan A. Durán de la Colina. 2014. Biomecánica y arquitectura corneal. Biomecánica y arquitectura corneal 389 392 .
Jingjing You, Li Wen, Athena Roufas, Michele C. Madigan & Gerard Sutton. (2013) Expression of SFRP Family Proteins in Human Keratoconus Corneas. PLoS ONE 8:6, pages e66770.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.