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Invited Review

Automatic analysis of corneal nerves imaged using in vivo confocal microscopy

, BSc PhD & , MOptom PhD GradCertOcTher FBCLA FAAO
Pages 147-161 | Received 13 Jun 2017, Accepted 12 Oct 2017, Published online: 21 Apr 2021

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Kofi Asiedu, Arun V Krishnan, Natalie Kwai, Ann Poynten & Maria Markoulli. (2023) Conjunctival microcirculation in ocular and systemic microvascular disease. Clinical and Experimental Optometry 106:7, pages 694-702.
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Kore Chan, Zachary Badanes & Eric C. Ledbetter. (2023) Decreased corneal subbasal nerve fiber length and density in diabetic dogs with cataracts using in vivo confocal microscopy. Veterinary Ophthalmology.
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Alessia Colonna & Fabio Scarpa. (2023) Clinically Based Automated Tracing and Tortuosity Estimation of Corneal Nerve Fibers From Confocal Microscopy Images. Cornea 42:1, pages 127-134.
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Itziar Fernández, Amanda Vázquez, Margarita Calonge, Miguel J. Maldonado, Ana de la Mata & Alberto López-Miguel. (2022) New Method for the Automated Assessment of Corneal Nerve Tortuosity Using Confocal Microscopy Imaging. Applied Sciences 12:20, pages 10450.
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Md Asif Khan Setu, Stefan Schmidt, Gwen Musial, Michael E. Stern & Philipp Steven. (2022) Segmentation and Evaluation of Corneal Nerves and Dendritic Cells From In Vivo Confocal Microscopy Images Using Deep Learning. Translational Vision Science & Technology 11:6, pages 24.
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Yuxiang Gu, Xin Liu, Xiaoning Yu, Qiyu Qin, Naiji Yu, Weishaer Ke, Kaijun Wang & Min Chen. (2022) Corneal in vivo Confocal Microscopy for Assessment of Non-Neurological Autoimmune Diseases: A Meta-Analysis. Frontiers in Medicine 9.
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Erdost Yildiz, Abdullah Taha Arslan, Ayse Yildiz Tas, Ali Faik Acer, Sertaç Demir, Afsun Sahin & Duygun Erol Barkana. (2021) Generative Adversarial Network Based Automatic Segmentation of Corneal Subbasal Nerves on In Vivo Confocal Microscopy Images. Translational Vision Science & Technology 10:6, pages 33.
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Anna M. Roszkowska, Carmelo Licitra, Giuseppe Tumminello, Elisa I. Postorino, Michele R. Colonna & Pasquale Aragona. (2021) Corneal nerves in diabetes—The role of the in vivo corneal confocal microscopy of the subbasal nerve plexus in the assessment of peripheral small fiber neuropathy. Survey of Ophthalmology 66:3, pages 493-513.
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Anna M. Roszkowska, Adam Wylęgała, Romana Gargano, Rosaria Spinella, Leandro Inferrera, Bogusława Orzechowska-Wylęgała & Pasquale Aragona. (2021) Impact of corneal parameters, refractive error and age on density and morphology of the subbasal nerve plexus fibers in healthy adults. Scientific Reports 11:1.
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Lei Mou, Yitian Zhao, Huazhu Fu, Yonghuai Liu, Jun Cheng, Yalin Zheng, Pan Su, Jianlong Yang, Li Chen, Alejandro F. Frangi, Masahiro Akiba & Jiang Liu. (2021) CS -Net: Deep learning segmentation of curvilinear structures in medical imaging . Medical Image Analysis 67, pages 101874.
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Pan Su, Xuanhao Zhang, Hao Qiu, Jianyang Xie, Yitian Zhao, Jiang Liu & Tianhua Chen. 2021. Fuzzy Logic. Fuzzy Logic 131 143 .
Hassan Mansoor, Hong Chang Tan, Molly Tzu-Yu Lin, Jodhbir S. Mehta & Yu-Chi Liu. (2020) Diabetic Corneal Neuropathy. Journal of Clinical Medicine 9:12, pages 3956.
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Pan Su, Tianhua Chen, Jianyang Xie, Yalin Zheng, Hong Qi, Davide Borroni, Yitian Zhao & Jiang Liu. (2020) Corneal nerve tortuosity grading via ordered weighted averaging‐based feature extraction. Medical Physics 47:10, pages 4983-4996.
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Yitian Zhao, Jiong Zhang, Ella Pereira, Yalin Zheng, Pan Su, Jianyang Xie, Yifan Zhao, Yonggang Shi, Hong Qi, Jiang Liu & Yonghuai Liu. (2020) Automated Tortuosity Analysis of Nerve Fibers in Corneal Confocal Microscopy. IEEE Transactions on Medical Imaging 39:9, pages 2725-2737.
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Honghan Chen, Bang Chen, Dan Zhang, Jiong Zhang, Jiang Liu & Yitian Zhao. (2020) Automatic Tortuosity Estimation of Nerve Fibers and Retinal Vessels in Ophthalmic Images. Applied Sciences 10:14, pages 4788.
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Hsiao-Sang Chu, Sheng-Lung Huang & Wei-Li Chen. (2020) In-Depth Thinking About the Diagnostic Methods and Treatment Strategies for the Corneal Nerves in Ocular Surface Disorders. Current Ophthalmology Reports 8:1, pages 19-27.
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Bryan M. Williams, Davide Borroni, Rongjun Liu, Yitian Zhao, Jiong Zhang, Jonathan Lim, Baikai Ma, Vito Romano, Hong Qi, Maryam Ferdousi, Ioannis N. Petropoulos, Georgios Ponirakis, Stephen Kaye, Rayaz A. Malik, Uazman Alam & Yalin Zheng. (2019) An artificial intelligence-based deep learning algorithm for the diagnosis of diabetic neuropathy using corneal confocal microscopy: a development and validation study. Diabetologia 63:2, pages 419-430.
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Shyam Sunder Tummanapalli, Tushar Issar, Aimy Yan, Natalie Kwai, Ann M. Poynten, Arun V. Krishnan, Mark D.P. Willcox & Maria Markoulli. (2020) Corneal nerve fiber loss in diabetes with chronic kidney disease. The Ocular Surface 18:1, pages 178-185.
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Kun Zhao, Hui Zhang, Yitian Zhao, Jianyang Xie, Yalin Zheng, David Borroni, Hong Qi & Jiang Liu. 2020. Medical Image Understanding and Analysis. Medical Image Understanding and Analysis 459 469 .
Andreas Bartschat, Stephan Allgeier, Tim Scherr, Johannes Stegmaier, Sebastian Bohn, Klaus-Martin Reichert, Arjan Kuijper, Markus Reischl, Oliver Stachs, Bernd Köhler & Ralf Mikut. (2019) Fuzzy tissue detection for real-time focal control in corneal confocal microscopy. at - Automatisierungstechnik 67:10, pages 879-888.
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Domenico Schiano Lomoriello, Irene Abicca, Mariacristina Parravano, Daniela Giannini, Benedetta Russo, Simona Frontoni & Fabiana Picconi. (2019) Early Alterations of Corneal Subbasal Plexus in Uncomplicated Type 1 Diabetes Patients. Journal of Ophthalmology 2019, pages 1-8.
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Pan Su, Yitian Zhao, Tianhua Chen, Jianyang Xie, Yifan Zhao, Hong Qi, Yalin Zheng & Jiang Liu. 2019. Medical Image Computing and Computer Assisted Intervention – MICCAI 2019. Medical Image Computing and Computer Assisted Intervention – MICCAI 2019 12 20 .
Stephan Allgeier, Andreas Bartschat, Sebastian Bohn, Sabine Peschel, Klaus-Martin Reichert, Karsten Sperlich, Marcus Walckling, Veit Hagenmeyer, Ralf Mikut, Oliver Stachs & Bernd Köhler. (2018) 3D confocal laser-scanning microscopy for large-area imaging of the corneal subbasal nerve plexus. Scientific Reports 8:1.
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