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Molecular and Cellular Biology Volume 35, 2015 - Issue 12

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Cleavage of BLOC1S1 mRNA by IRE1 Is Sequence Specific, Temporally Separate from XBP1 Splicing, and Dispensable for Cell Viability under Acute Endoplasmic Reticulum Stress

Michael D. BrightDivisions of Cancer Therapeutics and Molecular Pathology, The Institute of Cancer Research, London, United KingdomCorrespondence[email protected]

Daniel N. ItzhakDivisions of Cancer Therapeutics and Molecular Pathology, The Institute of Cancer Research, London, United Kingdom

Christopher P. WardellDivisions of Cancer Therapeutics and Molecular Pathology, The Institute of Cancer Research, London, United Kingdom

Gareth J. MorganDivisions of Cancer Therapeutics and Molecular Pathology, The Institute of Cancer Research, London, United Kingdom

Faith E. DaviesDivisions of Cancer Therapeutics and Molecular Pathology, The Institute of Cancer Research, London, United Kingdom

Pages 2186-2202 | Received 09 Jan 2015, Accepted 02 Apr 2015, Published online: 20 Mar 2023

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https://doi.org/10.1128/MCB.00013-15
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Anirban Roy, Meiricris Tomaz da Silva, Raksha Bhat, Kyle R Bohnert, Takao Iwawaki & Ashok Kumar. (2021) The IRE1/XBP1 signaling axis promotes skeletal muscle regeneration through a cell non-autonomous mechanism. eLife 10.
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Donghwi Bae, Kristin A. Moore, Jessica M. Mella, Samantha Y. Hayashi & Julie Hollien. (2019) Degradation of Blos1 mRNA by IRE1 repositions lysosomes and protects cells from stress . Journal of Cell Biology 218:4, pages 1118-1127.
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Ahmad Abdullah & Palaniyandi Ravanan. (2018) The unknown face of IRE1α – Beyond ER stress. European Journal of Cell Biology 97:5, pages 359-368.
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Michael D. Bright, Paul A. Clarke, Paul Workman & Faith E. Davies. (2018) Oncogenic RAC1 and NRAS drive resistance to endoplasmic reticulum stress through MEK/ERK signalling. Cellular Signalling 44, pages 127-137.
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Mari McMahon, Afshin Samali & Eric Chevet. (2017) Regulation of the unfolded protein response by noncoding RNA. American Journal of Physiology-Cell Physiology 313:3, pages C243-C254.
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Javier A Gomez & D Thomas Rutkowski. (2016) Experimental reconstitution of chronic ER stress in the liver reveals feedback suppression of BiP mRNA expression. eLife 5.
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Lindsey Devisscher, Margherita Vieri, Susan E. Logue, Jens Panse, Anja Geerts, Hans van Vlierberghe, Eric Chevet, Adrienne M. Gorman, Afshin Samali & Behzad Kharabi Masouleh. (2016) Targeting the angio-proteostasis network: Combining the forces against cancer. Pharmacology & Therapeutics 167, pages 1-12.
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Marcel Boß, Yvette Newbatt, Sahil Gupta, Ian Collins, Bernhard Brüne & Dmitry Namgaladze. (2016) AMPK-independent inhibition of human macrophage ER stress response by AICAR. Scientific Reports 6:1.
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Daniela Eletto, Davide Eletto, Sarah Boyle & Yair Argon. (2015) PDIA6 regulates insulin secretion by selectively inhibiting the RIDD activity of IRE1. The FASEB Journal 30:2, pages 653-665.
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Miao Wang & Randal J. Kaufman. (2016) Protein misfolding in the endoplasmic reticulum as a conduit to human disease. Nature 529:7586, pages 326-335.
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Justin R. Hassler, Donalyn L. Scheuner, Shiyu Wang, Jaeseok Han, Vamsi K. Kodali, Philip Li, Julie Nguyen, Jenny S. George, Cory Davis, Shengyang P. Wu, Yongsheng Bai, Maureen Sartor, James Cavalcoli, Harmeet Malhi, Gregory Baudouin, Yaoyang Zhang, John R. Yates III, Pamela Itkin-Ansari, Niels Volkmann & Randal J. Kaufman. (2015) The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells. PLOS Biology 13:10, pages e1002277.
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Kristin Moore & Julie Hollien. (2015) Ire1-mediated decay in mammalian cells relies on mRNA sequence, structure, and translational status. Molecular Biology of the Cell 26:16, pages 2873-2884.
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Cleavage of BLOC1S1 mRNA by IRE1 Is Sequence Specific, Temporally Separate from XBP1 Splicing, and Dispensable for Cell Viability under Acute Endoplasmic Reticulum Stress

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Cleavage of BLOC1S1 mRNA by IRE1 Is Sequence Specific, Temporally Separate from XBP1 Splicing, and Dispensable for Cell Viability under Acute Endoplasmic Reticulum Stress

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