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Molecular and Cellular Biology Volume 34, 2014 - Issue 9
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Article

Simultaneous Gene Editing by Injection of mRNAs Encoding Transcription Activator-Like Effector Nucleases into Mouse Zygotes

Chunliang Lia Howard Hughes Medical Institute, St. Jude Children's Research Hospital, Memphis, Tennessee, USA;b Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
,
Rong Qia Howard Hughes Medical Institute, St. Jude Children's Research Hospital, Memphis, Tennessee, USA;b Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
,
Rebecca Singleterrya Howard Hughes Medical Institute, St. Jude Children's Research Hospital, Memphis, Tennessee, USA;b Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
,
Judith Hylea Howard Hughes Medical Institute, St. Jude Children's Research Hospital, Memphis, Tennessee, USA;b Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
,
Amanda Balcha Howard Hughes Medical Institute, St. Jude Children's Research Hospital, Memphis, Tennessee, USA;b Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
,
Xiuling Lic Transgenic Gene Knockout Shared Resource, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
,
Jack Sublettc Transgenic Gene Knockout Shared Resource, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
,
Hartmut Bernsc Transgenic Gene Knockout Shared Resource, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
,
Marcus Valentined Cytogenetics Core, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
,
Virginia Valentined Cytogenetics Core, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
&
Charles J. Sherra Howard Hughes Medical Institute, St. Jude Children's Research Hospital, Memphis, Tennessee, USA;b Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USACorrespondence[email protected]
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Pages 1649-1658 | Received 08 Jan 2014, Accepted 14 Feb 2014, Published online: 20 Mar 2023

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Ying K. Tam, Thomas D. Madden & Michael J. Hope. (2016) Pieter Cullis’ quest for a lipid-based, fusogenic delivery system for nucleic acid therapeutics: success with siRNA so what about mRNA?. Journal of Drug Targeting 24:9, pages 774-779.
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Nur Diana Anuar, Sebastian Kurscheid, Matt Field, Lei Zhang, Edward Rebar, Philip Gregory, Thierry Buchou, Josephine Bowles, Peter Koopman, David J. Tremethick & Tatiana A. Soboleva. (2019) Gene editing of the multi-copy H2A.B gene and its importance for fertility. Genome Biology 20:1.
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Lien Van Hoecke & Kenny Roose. (2019) How mRNA therapeutics are entering the monoclonal antibody field. Journal of Translational Medicine 17:1.
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Masahito Watanabe, Kazuaki Nakano, Ayuko Uchikura, Hitomi Matsunari, Sayaka Yashima, Kazuhiro Umeyama, Shuko Takayanagi, Tetsushi Sakuma, Takashi Yamamoto, Sumiyo Morita, Takuro Horii, Izuho Hatada, Ryuichi Nishinakamura, Hiromitsu Nakauchi & Hiroshi Nagashima. (2019) Anephrogenic phenotype induced by SALL1 gene knockout in pigs. Scientific Reports 9:1.
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Shaina N. Porter, Rachel M. Levine & Shondra M. Pruett‐Miller. 2011. Comprehensive Physiology. Comprehensive Physiology 665 714 .
BaoHan T. Vo, Jin Ah Kwon, Chunliang Li, David Finkelstein, Beisi Xu, Brent A. Orr, Charles J. Sherr & Martine F. Roussel. (2018) Mouse medulloblastoma driven by CRISPR activation of cellular Myc. Scientific Reports 8:1.
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Vitezslav Kriz, Michaela Krausova, Petra Buresova, Jan Dobes, Dusan Hrckulak, Olga Babosova, Jiri Svec & Vladimir Korinek. (2017) Establishment of a tagged variant of Lgr4 receptor suitable for functional and expression studies in the mouse. Transgenic Research 26:5, pages 689-701.
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Jolieke G. van OosterwijkChunliang LiXue Yang, Joseph T. OpfermanCharles J. Sherr. (2017) Small mitochondrial Arf (smArf) protein corrects p53-independent developmental defects of Arf tumor suppressor-deficient mice . Proceedings of the National Academy of Sciences 114:28, pages 7420-7425.
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Chong FENG, Xi-rui LI, Hui-ting CUI, Chuan LONG, Xia LIU, Xing-hua TIAN, Deng-ke PAN & Yu-zhu LUO. (2016) Highly efficient generation of GGTA1 knockout pigs using a combination of TALEN mRNA and magnetic beads with somatic cell nuclear transfer. Journal of Integrative Agriculture 15:7, pages 1540-1549.
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Benjamin L. Oakes, Danny F. Xia, Elizabeth F. Rowland, Denise J. Xu, Irina Ankoudinova, Jennifer S. Borchardt, Lei Zhang, Patrick Li, Jeffrey C. Miller, Edward J. Rebar & Marcus B. Noyes. (2016) Multi-reporter selection for the design of active and more specific zinc-finger nucleases for genome editing. Nature Communications 7:1.
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Jaehoon Lee, Jae-il Rho, Sushil Devkota, Young Hoon Sung & Han-Woong Lee. (2016) Developing genetically engineered mouse models using engineered nucleases: Current status, challenges, and the way forward. Drug Discovery Today: Disease Models 20, pages 13-20.
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Benedikt Wefers, Christina Brandl, Oskar Ortiz, Wolfgang Wurst & Ralf Kühn. 2016. TALENs. TALENs 229 243 .
MAURÍCIO ROCHA-MARTINS, GABRIEL R. CAVALHEIRO, GABRIEL E. MATOS-RODRIGUES & RODRIGO A.P. MARTINS. (2015) From Gene Targeting to Genome Editing: Transgenic animals applications and beyond. Anais da Academia Brasileira de Ciências 87:2 suppl, pages 1323-1348.
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Qiwei Shan, Yi Zhang, Kunling Chen, Kang Zhang & Caixia Gao. (2015) Creation of fragrant rice by targeted knockout of the OsBADH2 gene using TALEN technology . Plant Biotechnology Journal 13:6, pages 791-800.
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Tetsuya Ishii. (2015) Germline genome-editing research and its socioethical implications. Trends in Molecular Medicine 21:8, pages 473-481.
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Chuxin Liu, Liping Xiao, Feida Li, Huanhuan Zhang, Qin Li, Huan Liu, Shujin Fu, Chao Li, Xingju Zhang, Jun Wang, Nicklas H. Staunstrup, Yong Li & Huanming Yang. (2014) Generation of outbred Ace2 knockout mice by RNA transfection of TALENs displaying colitis reminiscent pathophysiology and inflammation. Transgenic Research 24:3, pages 433-446.
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Jonathan D. Moore. (2015) The impact of CRISPR–Cas9 on target identification and validation. Drug Discovery Today 20:4, pages 450-457.
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Daniel Sommer, Annika E. Peters, Ann-Kathrin Baumgart & Marc Beyer. (2015) TALEN-mediated genome engineering to generate targeted mice. Chromosome Research 23:1, pages 43-55.
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Tomomi Aida. 2015. Targeted Genome Editing Using Site-Specific Nucleases. Targeted Genome Editing Using Site-Specific Nucleases 167 182 .
Petr Kasparek, Michaela Krausova, Radka Haneckova, Vitezslav Kriz, Olga Zbodakova, Vladimir Korinek & Radislav Sedlacek. (2014) Efficient gene targeting of the Rosa26 locus in mouse zygotes using TALE nucleases . FEBS Letters 588:21, pages 3982-3988.
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James N. F. Scott, Adam P. Kupinski & Joan Boyes. (2014) Targeted genome regulation and modification using transcription activator-like effectors. FEBS Journal 281:20, pages 4583-4597.
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Tobias Wijshake, Darren J. Baker & Bart van de Sluis. (2014) Endonucleases: new tools to edit the mouse genome. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1842:10, pages 1942-1950.
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X Wu, P R Blackburn, R C Tschumper, S C Ekker & D F Jelinek. (2014) TALEN-mediated genetic tailoring as a tool to analyze the function of acquired mutations in multiple myeloma cells. Blood Cancer Journal 4:5, pages e210-e210.
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