Search in:

Molecular and Cellular Biology Volume 33, 2013 - Issue 11

Views

CrossRef citations to date

Altmetric

Article

Epithelial Tyrosine Phosphatase SHP-2 Protects against Intestinal Inflammation in Mice

Geneviève Coulombea Département d'Anatomie et de Biologie Cellulaire, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Québec, Canada

Caroline Leblanca Département d'Anatomie et de Biologie Cellulaire, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Québec, Canada

Sébastien Cagnola Département d'Anatomie et de Biologie Cellulaire, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Québec, Canada

Faiza Malouma Département d'Anatomie et de Biologie Cellulaire, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Québec, Canada

Étienne Lemieuxa Département d'Anatomie et de Biologie Cellulaire, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Québec, Canada

Nathalie Perreaulta Département d'Anatomie et de Biologie Cellulaire, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Québec, Canada

Gen-Sheng Fengb Department of Pathology and Division of Biological Sciences, University of California San Diego, La Jolla, California, USA

François Boudreaua Département d'Anatomie et de Biologie Cellulaire, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Québec, Canada

Nathalie Rivarda Département d'Anatomie et de Biologie Cellulaire, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Québec, CanadaCorrespondence[email protected]

show all

Pages 2275-2284 | Received 10 Jan 2013, Accepted 20 Mar 2013, Published online: 20 Mar 2023

Cite this article
https://doi.org/10.1128/MCB.00043-13

Full Article
Figures & data
References
Citations
Metrics
Reprints & Permissions

Citations (32)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Articles from other publishers (32)

Xiaolong Tang, Chumei Qi, Honghong Zhou & Yongshuo Liu. (2022) Critical roles of PTPN family members regulated by non-coding RNAs in tumorigenesis and immunotherapy. Frontiers in Oncology 12.
Crossref

Jie Pan, Lisha Zhou, Chenyang Zhang, Qiang Xu & Yang Sun. (2022) Targeting protein phosphatases for the treatment of inflammation-related diseases: From signaling to therapy. Signal Transduction and Targeted Therapy 7:1.
Crossref

Paul J. Wisniewski, Mitzi Nagarkatti & Prakash S. Nagarkatti. (2021) Regulation of Intestinal Stem Cell Stemness by the Aryl Hydrocarbon Receptor and Its Ligands. Frontiers in Immunology 12.
Crossref

Takashi Matozaki, Takenori Kotani, Yoji Murata & Yasuyuki Saito. (2020) Roles of Src family kinase, Ras, and mTOR signaling in intestinal epithelial homeostasis and tumorigenesis. Cancer Science 112:1, pages 16-21.
Crossref

Lijun Wang, Douglas C. Moore, Jiahui Huang, Yuhong Wang, Hu Zhao, Jerry D‐H Yue, Cynthia L. Jackson, Peter J. Quesenberry, Weibiao Cao & Wentian Yang. (2020) SHP2 regulates the development of intestinal epithelium by modifying OSTERIX + crypt stem cell self‐renewal and proliferation . The FASEB Journal 35:1.
Crossref

Chi Ben, Xiaojing Wu, Atsushi Takahashi-Kanemitsu, Christopher Takaya Knight, Takeru Hayashi & Masanori Hatakeyama. (2020) Alternative splicing reverses the cell-intrinsic and cell-extrinsic pro-oncogenic potentials of YAP1. Journal of Biological Chemistry 295:41, pages 13965-13980.
Crossref

Heng Zhou, Ning Li, Yuan Yuan, Ya-Ge Jin, Qingqing Wu, Ling Yan, Zhou-Yan Bian, Wei Deng, Di-Fei Shen, Hongliang Li & Qi-Zhu Tang. (2020) Leukocyte immunoglobulin-like receptor B4 protects against cardiac hypertrophy via SHP-2-dependent inhibition of the NF-κB pathway. Journal of Molecular Medicine 98:5, pages 691-705.
Crossref

Dadong Shen, Wenxia Chen, Jinlin Zhu, Guofeng Wu, Runpu Shen, Meiyang Xi & Haopeng Sun. (2020) Therapeutic potential of targeting SHP2 in human developmental disorders and cancers. European Journal of Medicinal Chemistry 190, pages 112117.
Crossref

Yvonn Heun, Joachim Pircher, Thomas Czermak, Philipp Bluem, Georg Hupel, Monica Bohmer, Bjoern F. Kraemer, Kristin Pogoda, Alexander Pfeifer, Markus Woernle, Andrea Ribeiro, Max Hübner, Simone Kreth, Ralf A. Claus, Sebastian Weis, Luisa Ungelenk, Florian Krötz, Ulrich Pohl & Hanna Mannell. (2019) Inactivation of the tyrosine phosphatase SHP-2 drives vascular dysfunction in Sepsis. EBioMedicine 42, pages 120-132.
Crossref

Zhengqi Wang, Tamisha Y. Vaughan, Wandi Zhu, Yuhong Chen, Guoping Fu, Magdalena Medrzycki, Hikaru Nishio, Silvia T. Bunting, Pamela A. Hankey-Giblin, Asma Nusrat, Charles A. Parkos, Demin Wang, Renren Wen & Kevin D. Bunting. (2019) Gab2 and Gab3 Redundantly Suppress Colitis by Modulating Macrophage and CD8+ T-Cell Activation. Frontiers in Immunology 10.
Crossref

Marie-Josée Langlois, Raphaëlle Servant, Vilcy Reyes Nicolás, Christine Jones, Sébastien A.B. Roy, Marilène Paquet, Julie C. Carrier, Nathalie Rivard, Francois Boudreau & Nathalie Perreault. (2019) Loss of PTEN Signaling in Foxl1+ Mesenchymal Telocytes Initiates Spontaneous Colonic Neoplasia in Mice. Cellular and Molecular Gastroenterology and Hepatology 8:3, pages 530-533.e5.
Crossref

Jessica Gagné-Sansfacon, Ariane Langlois, Marie-Josée Langlois, Geneviève Coulombe, Sarah Tremblay, Vanessa Vaillancourt-Lavigueur, Cheng-Kui Qu, Alfredo Menendez & Nathalie Rivard. (2019) The tyrosine phosphatase Shp-2 confers resistance to colonic inflammation by driving goblet cell function and crypt regeneration. The Journal of Pathology 247:1, pages 135-146.
Crossref

Xin Tun, Keiji Yasukawa & Ken-ichi Yamada. (2018) Nitric Oxide Is Involved in Activation of Toll-Like Receptor 4 Signaling through Tyrosine Nitration of Src Homology Protein Tyrosine Phosphatase 2 in Murine Dextran Sulfate-Induced Colitis. Biological and Pharmaceutical Bulletin 41:12, pages 1843-1852.
Crossref

Kelly A. Pike & Michel L. Tremblay. (2018) Protein Tyrosine Phosphatases: Regulators of CD4 T Cells in Inflammatory Bowel Disease. Frontiers in Immunology 9.
Crossref

Danny Kit-Sang Yip, Landon L Chan, Iris K Pang, Wei Jiang, Nelson L S Tang, Weichuan Yu & Kevin Y Yip. (2018) A network approach to exploring the functional basis of gene–gene epistatic interactions in disease susceptibility. Bioinformatics 34:10, pages 1741-1749.
Crossref

Yan Huang, Jie Wang, Fuao Cao, Hailong Jiang, An Li, Jianzhong Li, Lei Qiu, Hao Shen, Wenjun Chang, Chuanxiang Zhou, Yamin Pan & Yiming Lu. (2017) SHP2 associates with nuclear localization of STAT3: significance in progression and prognosis of colorectal cancer. Scientific Reports 7:1.
Crossref

Ming-Fo Hsu, Ahmed Bettaieb, Yoshihiro Ito, James Graham, Peter J. Havel & Fawaz G. Haj. (2017) Protein tyrosine phosphatase Shp2 deficiency in podocytes attenuates lipopolysaccharide-induced proteinuria. Scientific Reports 7:1.
Crossref

David Lepage, Élise Bélanger, Christine Jones, Sarah Tremblay, Joannie M. Allaire, Joannie Bruneau, Claude Asselin, Nathalie Perreault, Alfredo Menendez, Fernand-Pierre Gendron & Francois Boudreau. (2016) Gata4 is critical to maintain gut barrier function and mucosal integrity following epithelial injury. Scientific Reports 6:1.
Crossref

Geneviève Coulombe, Ariane Langlois, Giada De Palma, Marie‐Josée Langlois, Justin L. McCarville, Jessica Gagné‐Sanfaçon, Nathalie Perreault, Gen‐Sheng Feng, Premysl Bercik, François Boudreau, Elena F. Verdu & Nathalie Rivard. (2016) SHP‐2 Phosphatase Prevents Colonic Inflammation by Controlling Secretory Cell Differentiation and Maintaining Host‐Microbiota Homeostasis. Journal of Cellular Physiology 231:11, pages 2529-2540.
Crossref

Jessica Gagné-Sansfaçon, Geneviève Coulombe, Marie-Josée Langlois, Ariane Langlois, Marilene Paquet, Julie Carrier, Gen-Sheng Feng, Cheng-Kui Qu & Nathalie Rivard. (2016) SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development. Oncotarget 7:40, pages 65676-65695.
Crossref

Geneviève Coulombe & Nathalie Rivard. (2016) New and Unexpected Biological Functions for the Src-Homology 2 Domain-Containing Phosphatase SHP-2 in the Gastrointestinal Tract. Cellular and Molecular Gastroenterology and Hepatology 2:1, pages 11-21.
Crossref

Angelica Soares, Evandro José Beraldi, Paulo Emílio Botura Ferreira, Roberto Barbosa Bazotte & Nilza Cristina Buttow. (2015) Intestinal and neuronal myenteric adaptations in the small intestine induced by a high-fat diet in mice. BMC Gastroenterology 15:1.
Crossref

Mylène Tajan, Audrey de Rocca Serra, Philippe Valet, Thomas Edouard & Armelle Yart. (2015) SHP2 sails from physiology to pathology. European Journal of Medical Genetics 58:10, pages 509-525.
Crossref

M. Rizwan Siddiqui, Chandra S. Mayanil, Kwang Sik Kim & Tadanori Tomita. (2015) Angiopoietin-1 Regulates Brain Endothelial Permeability through PTPN-2 Mediated Tyrosine Dephosphorylation of Occludin. PLOS ONE 10:6, pages e0130857.
Crossref

Havovi Chichger, Julie Braza, Huetran Duong & Elizabeth O. Harrington. (2015) SH2 Domain-Containing Protein Tyrosine Phosphatase 2 and Focal Adhesion Kinase Protein Interactions Regulate Pulmonary Endothelium Barrier Function. American Journal of Respiratory Cell and Molecular Biology 52:6, pages 695-707.
Crossref

Jing-Fei Teng, Kai Wang, Yao Li, Fa-Jun Qu, Qing Yuan, Xin-Gang Cui, Quan-Xing Wang & Dan-Feng Xu. (2015) Conditional Knockout of Src Homology 2 Domain-containing Protein Tyrosine Phosphatase-2 in Myeloid Cells Attenuates Renal Fibrosis after Unilateral Ureter Obstruction. Chinese Medical Journal 128:9, pages 1196-1201.
Crossref

Marianne R. Spalinger, Declan F. McCole, Gerhard Rogler & Michael Scharl. (2015) Role of Protein Tyrosine Phosphatases in Regulating the Immune System. Inflammatory Bowel Diseases 21:3, pages 645-655.
Crossref

S Viaud, R Daillère, I G Boneca, P Lepage, P Langella, M Chamaillard, M J Pittet, F Ghiringhelli, G Trinchieri, R Goldszmid & L Zitvogel. (2014) Gut microbiome and anticancer immune response: really hot Sh*t!. Cell Death & Differentiation 22:2, pages 199-214.
Crossref

Sam Butterworth, Michael Overduin & Alastair J Barr. (2014) Targeting protein tyrosine phosphatase SHP2 for therapeutic intervention. Future Medicinal Chemistry 6:12, pages 1423-1437.
Crossref

Peifen Cai, Wenjie Guo, HuaQin Yuan, Qian Li, Weicheng Wang, Yang Sun, Xiaomin Li & Yanhong Gu. (2014) Expression and clinical significance of tyrosine phosphatase SHP-2 in colon cancer. Biomedicine & Pharmacotherapy 68:3, pages 285-290.
Crossref

Hironori Yamashita, Takenori Kotani, Jung-ha Park, Yoji Murata, Hideki Okazawa, Hiroshi Ohnishi, Yonson Ku & Takashi Matozaki. (2014) Role of the Protein Tyrosine Phosphatase Shp2 in Homeostasis of the Intestinal Epithelium. PLoS ONE 9:3, pages e92904.
Crossref

Tao Zhang, Wenjie Guo, Yang Yang, Wen Liu, Lele Guo, Yanhong Gu, Yongqian Shu, Lu Wang, Xuefeng Wu, Zichun Hua, Yuehai Ke, Yang Sun, Yan Shen & Qiang Xu. (2013) Loss of SHP-2 activity in CD4+ T cells promotes melanoma progression and metastasis. Scientific Reports 3:1.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.

People also read
Recommended articles
Cited by

To cite this article:

Reference style: APA Chicago Harvard

Citation copied to clipboard

Reference styles above use APA (6th edition), Chicago (16th edition) & Harvard (10th edition)

Download citation

Download a citation file in RIS format that can be imported by citation management software including EndNote, ProCite, RefWorks and Reference Manager.

Choose format: RIS BibTex RefWorks Direct Export

Choose options: Citation Citation & abstract Citation & references

Epithelial Tyrosine Phosphatase SHP-2 Protects against Intestinal Inflammation in Mice

Articles from other publishers (32)

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

Epithelial Tyrosine Phosphatase SHP-2 Protects against Intestinal Inflammation in Mice

Citations (32)

Articles from other publishers (32)

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date