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Molecular and Cellular Biology Volume 32, 2012 - Issue 10
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Article

The Saccharomyces cerevisiae Nrd1-Nab3 Transcription Termination Pathway Acts in Opposition to Ras Signaling and Mediates Response to Nutrient Depletion

Miranda M. Darbya Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
,
Leo Serebrenia Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
,
Xuewen Pana Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA;b High Throughput Biology Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
,
Jef D. Boekea Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA;b High Throughput Biology Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
&
Jeffry L. Cordena Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USACorrespondence[email protected]
Pages 1762-1775 | Received 11 Jan 2012, Accepted 07 Mar 2012, Published online: 20 Mar 2023

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Jonathan Merran & Jeffry L. Corden. (2017) Yeast RNA-Binding Protein Nab3 Regulates Genes Involved in Nitrogen Metabolism. Molecular and Cellular Biology 37:18.
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Thomas W O'Rourke, Travis J Loya, PamelaSara E Head, John R Horton & Daniel Reines. (2015) Amyloid-like assembly of the low complexity domain of yeast Nab3. Prion 9:1, pages 34-47.
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Articles from other publishers (28)

Tommaso Villa & Odil Porrua. (2022) Pervasive transcription: a controlled risk. The FEBS Journal 290:15, pages 3723-3736.
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Katherine M. Hutchinson, Jeremy C. Hunn & Daniel Reines. (2022) Nab3 nuclear granule accumulation is driven by respiratory capacity. Current Genetics 68:5-6, pages 581-591.
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Jeremy C. Hunn, Katherine M. Hutchinson, Joshua B. Kelley & Daniel Reines. (2022) Variable penetrance of Nab3 granule accumulation quantified by a new tool for high-throughput single-cell granule analysis. Current Genetics 68:3-4, pages 467-480.
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Nouhou Haidara, Marta Giannini & Odil Porrua. (2022) Modulated termination of non-coding transcription partakes in the regulation of gene expression. Nucleic Acids Research 50:3, pages 1430-1448.
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Chihiro Kadooka, Kosuke Izumitsu, Masahira Onoue, Kayu Okutsu, Yumiko Yoshizaki, Kazunori Takamine, Masatoshi Goto, Hisanori Tamaki & Taiki Futagami. (2019) Mitochondrial Citrate Transporters CtpA and YhmA Are Required for Extracellular Citric Acid Accumulation and Contribute to Cytosolic Acetyl Coenzyme A Generation in Aspergillus luchuensis mut. kawachii . Applied and Environmental Microbiology 85:8.
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Manfred Schmid & Torben Heick Jensen. 2019. The Biology of mRNA: Structure and Function. The Biology of mRNA: Structure and Function 113 132 .
Travis J. Loya, Thomas W. O’Rourke, William C. Simke, Joshua B. Kelley & Daniel Reines. (2018) Nab3’s localization to a nuclear granule in response to nutrient deprivation is determined by its essential prion-like domain. PLOS ONE 13:12, pages e0209195.
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Courtney Whalen, Christine Tuohy, Thomas Tallo, James W Kaufman, Claire Moore & Jason N Kuehner. (2018) RNA Polymerase II Transcription Attenuation at the Yeast DNA Repair Gene, DEF1 , Involves Sen1-Dependent and Polyadenylation Site-Dependent Termination . G3 Genes|Genomes|Genetics 8:6, pages 2043-2058.
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Kwan Yin Lee, Ziyan Chen, River Jiang & Marc D Meneghini. (2018) H3K4 Methylation Dependent and Independent Chromatin Regulation by JHD2 and SET1 in Budding Yeast . G3 Genes|Genomes|Genetics 8:5, pages 1829-1839.
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Hannah E. Mischo, Yujin Chun, Kevin M. Harlen, Brendan M. Smalec, Somdutta Dhir, L. Stirling Churchman & Stephen Buratowski. (2018) Cell-Cycle Modulation of Transcription Termination Factor Sen1. Molecular Cell 70:2, pages 312-326.e7.
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Derek Wilkinson, Libuše Váchová, Otakar Hlaváček, Jana Maršíková, Gregor D. Gilfillan & Zdena Palková. (2018) Long Noncoding RNAs in Yeast Cells and Differentiated Subpopulations of Yeast Colonies and Biofilms. Oxidative Medicine and Cellular Longevity 2018, pages 1-12.
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Travis J. Loya, Thomas W. O’Rourke & Daniel Reines. (2017) The hnRNP-like Nab3 termination factor can employ heterologous prion-like domains in place of its own essential low complexity domain. PLOS ONE 12:10, pages e0186187.
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Xin Chen, Kunal Poorey, Melissa N. Carver, Ulrika Müller, Stefan Bekiranov, David T. Auble & David A. Brow. (2017) Transcriptomes of six mutants in the Sen1 pathway reveal combinatorial control of transcription termination across the Saccharomyces cerevisiae genome. PLOS Genetics 13:6, pages e1006863.
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Rob van Nues, Gabriele Schweikert, Erica de Leau, Alina Selega, Andrew Langford, Ryan Franklin, Ira Iosub, Peter Wadsworth, Guido Sanguinetti & Sander Granneman. (2017) Kinetic CRAC uncovers a role for Nab3 in determining gene expression profiles during stress. Nature Communications 8:1.
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Agnieszka Tudek, Manfred Schmid & Torben Heick Jensen. (2017) Nuclear Decay Factors Crack Up mRNA. Molecular Cell 65:5, pages 775-776.
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Stefan Bresson, Alex Tuck, Desislava Staneva & David Tollervey. (2017) Nuclear RNA Decay Pathways Aid Rapid Remodeling of Gene Expression in Yeast. Molecular Cell 65:5, pages 787-800.e5.
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Indranil Malik, Chenxi Qiu, Thomas Snavely & Craig D. Kaplan. (2017) Wide-ranging and unexpected consequences of altered Pol II catalytic activity in vivo . Nucleic Acids Research, pages gkx037.
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Mia Jaffe, Gavin Sherlock & Sasha F Levy. (2017) iSeq: A New Double-Barcode Method for Detecting Dynamic Genetic Interactions in Yeast. G3 Genes|Genomes|Genetics 7:1, pages 143-153.
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Santhosh Kumar Sariki, Pushpendra Kumar Sahu, Upendarrao Golla, Vikash Singh, Gajendra Kumar Azad & Raghuvir S. Tomar. (2016) Sen1, the homolog of human Senataxin, is critical for cell survival through regulation of redox homeostasis, mitochondrial function, and the TOR pathway in Saccharomyces cerevisiae . The FEBS Journal 283:22, pages 4056-4083.
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Karen M. ArndtDaniel Reines. (2015) Termination of Transcription of Short Noncoding RNAs by RNA Polymerase II. Annual Review of Biochemistry 84:1, pages 381-404.
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Yupeng Chen, Lirong Zhang, Conchi Estarás, Seung H. Choi, Luis MorenoJr.Jr., Jonathan Karn, James J. Moresco, John R. YatesIIIIII & Katherine A. Jones. (2014) A gene-specific role for the Ssu72 RNAPII CTD phosphatase in HIV-1 Tat transactivation. Genes & Development 28:20, pages 2261-2275.
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Manuele Castelnuovo, Judith B. Zaugg, Elisa Guffanti, Andrea Maffioletti, Jurgi Camblong, Zhenyu Xu, Sandra Clauder-Münster, Lars M. Steinmetz, Nicholas M. Luscombe & Françoise Stutz. (2022) Role of histone modifications and early termination in pervasive transcription and antisense-mediated gene silencing in yeast. Nucleic Acids Research 42:7, pages 4348-4362.
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Shaun Webb, Ralph D Hector, Grzegorz Kudla & Sander Granneman. (2014) PAR-CLIP data indicate that Nrd1-Nab3-dependent transcription termination regulates expression of hundreds of protein coding genes in yeast. Genome Biology 15:1, pages R8.
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Manuele Castelnuovo, Samir Rahman, Elisa Guffanti, Valentina Infantino, Françoise Stutz & Daniel Zenklusen. (2013) Bimodal expression of PHO84 is modulated by early termination of antisense transcription. Nature Structural & Molecular Biology 20:7, pages 851-858.
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Minkyu Kim & Stephen Buratowski. 2013. Posttranscriptional Gene Regulation. Posttranscriptional Gene Regulation 19 40 .
Dane Z. Hazelbaker, Sebastian Marquardt, Wiebke Wlotzka & Stephen Buratowski. (2013) Kinetic Competition between RNA Polymerase II and Sen1-Dependent Transcription Termination. Molecular Cell 49:1, pages 55-66.
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Hannah E. Mischo & Nick J. Proudfoot. (2013) Disengaging polymerase: Terminating RNA polymerase II transcription in budding yeast. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1829:1, pages 174-185.
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Christie S Chang, Astrid Clarke & Lorraine Pillus. (2012) Suppression Analysis of esa1 Mutants in Saccharomyces cerevisiae Links NAB3 to Transcriptional Silencing and Nucleolar Functions . G3 Genes|Genomes|Genetics 2:10, pages 1223-1232.
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