Advanced search
Publication Cover
Molecular and Cellular Biology Volume 30, 2010 - Issue 17
Submit an article Journal homepage
20
Views
45
CrossRef citations to date
0
Altmetric
Article

Phosphoinositide-Dependent Kinase 1 Provides Negative Feedback Inhibition to Toll-Like Receptor-Mediated NF-κB Activation in Macrophages

Bhagirath Chaurasia1 Department of Mouse Genetics and Metabolism, Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, D-50674 Cologne, Center of Molecular Medicine Cologne, 2nd Department for Internal Medicine, University Hospital of Cologne, D-50937 Cologne, and Max Planck Institute for the Biology of Ageing, D-50937Cologne, Germany
,
Jan Mauer1 Department of Mouse Genetics and Metabolism, Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, D-50674 Cologne, Center of Molecular Medicine Cologne, 2nd Department for Internal Medicine, University Hospital of Cologne, D-50937 Cologne, and Max Planck Institute for the Biology of Ageing, D-50937Cologne, Germany
,
Linda Koch1 Department of Mouse Genetics and Metabolism, Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, D-50674 Cologne, Center of Molecular Medicine Cologne, 2nd Department for Internal Medicine, University Hospital of Cologne, D-50937 Cologne, and Max Planck Institute for the Biology of Ageing, D-50937Cologne, Germany
,
Julia Goldau1 Department of Mouse Genetics and Metabolism, Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, D-50674 Cologne, Center of Molecular Medicine Cologne, 2nd Department for Internal Medicine, University Hospital of Cologne, D-50937 Cologne, and Max Planck Institute for the Biology of Ageing, D-50937Cologne, Germany
,
Anja-Sterner Kock2 Department of Experimental Medicine, University Hospital of Cologne, D-50937Cologne, Germany
&
Jens C. Brüning1 Department of Mouse Genetics and Metabolism, Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, D-50674 Cologne, Center of Molecular Medicine Cologne, 2nd Department for Internal Medicine, University Hospital of Cologne, D-50937 Cologne, and Max Planck Institute for the Biology of Ageing, D-50937Cologne, GermanyCorrespondence[email protected]
Pages 4354-4366 | Received 20 Jan 2010, Accepted 18 Jun 2010, Published online: 20 Mar 2023

Citations (45)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Ty Dale Troutman, J. Fernando Bazan & Chandrashekhar Pasare. (2012) Toll-like receptors, signaling adapters and regulation of the pro-inflammatory response by PI3K. Cell Cycle 11:19, pages 3559-3567.
Read now

Articles from other publishers (44)

Reza Salehi, Meshach Asare-Werehene, Brandon A. Wyse, Atefeh Abedini, Bo Pan, Alex Gutsol, Sahar Jahangiri, Peter Szaraz, Kevin D. Burns, Barbara Vanderhyden, Julang Li, Dylan Burger, Clifford L. Librach & Benjamin K. Tsang. (2023) Granulosa cell-derived miR-379-5p regulates macrophage polarization in polycystic ovarian syndrome. Frontiers in Immunology 14.
Crossref
Juewon Kim, Hyung-Su Kim, Dong-Hwa Choi, Jiwon Choi, Sung Yeon Cho, Seung-Hun Kim, Heung-Soo Baek, Kee Dong Yoon, Sang Wook Son, Eui Dong Son, Yong-Deog Hong, Jaeyoung Ko, Si-Young Cho & Won-Seok Park. (2022) Kaempferol tetrasaccharides restore skin atrophy via PDK1 inhibition in human skin cells and tissues: Bench and clinical studies. Biomedicine & Pharmacotherapy 156, pages 113864.
Crossref
Wei Lei, Changcheng Zhao, Jiasen Sun, Yanling Jin & Zhijun Duan. (2022) Activation of α7nAChR preserves intestinal barrier integrity by enhancing the HO-1 / STAT3 signaling to inhibit NF-κB activation in mice. Biomedicine & Pharmacotherapy 149, pages 112733.
Crossref
Wenqian Xu, Yuliang Cheng, Yahui Guo, Weirong Yao & He Qian. (2022) Targeting tumor associated macrophages in hepatocellular carcinoma. Biochemical Pharmacology 199, pages 114990.
Crossref
Ioanna Lapi, Maria G. Daskalaki, Konstantinos Axarlis, Eleni Paflioti, Philip N. Tsichlis, Eleni Vergadi & Christos Tsatsanis. 2022. PI3K and AKT Isoforms in Immunity. PI3K and AKT Isoforms in Immunity 165 196 .
Yongyuan Zheng, Shu Zhu, Xingrong Zheng, Wenxiong Xu, Xuejun Li, Jianguo Li, Zhiliang Gao, Chan Xie & Liang Peng. (2021) Serum from Acute-on-chronic Liver Failure Patients May Affect Mesenchymal Stem Cells Transplantation by Impairing the Immunosuppressive Function of Cells. Journal of Clinical and Translational Hepatology 000:000, pages 000-000.
Crossref
Yeo Song Lee, Su Jeong Song, Hye Kyung Hong, Bo Young Oh, Woo Yong Lee & Yong Beom Cho. (2020) The FBW7-MCL-1 axis is key in M1 and M2 macrophage-related colon cancer cell progression: validating the immunotherapeutic value of targeting PI3Kγ. Experimental & Molecular Medicine 52:5, pages 815-831.
Crossref
Henry Taylor, Arian D. J. Laurence & Holm H. Uhlig. (2019) The Role of PTEN in Innate and Adaptive Immunity. Cold Spring Harbor Perspectives in Medicine 9:12, pages a036996.
Crossref
Min Zhou, Haoshu Fang, Min Du, Changyong Li, Rui Tang, Haiyan Liu, Zhi Gao, Zongshu Ji, Bibo Ke & Xu-Lin Chen. (2019) The Modulation of Regulatory T Cells via HMGB1/PTEN/β-Catenin Axis in LPS Induced Acute Lung Injury. Frontiers in Immunology 10.
Crossref
Wei-Min Zhou, Gao-Liang Wu, Ji Huang, Jin-Gao Li, Chao Hao, Qiu-Ming He, Xiao-Dan Chen, Gong-Xian Wang & Xin-Hua Tu. (2019) Low expression of PDK1 inhibits renal cell carcinoma cell proliferation, migration, invasion and epithelial mesenchymal transition through inhibition of the PI3K-PDK1-Akt pathway. Cellular Signalling 56, pages 1-14.
Crossref
Sarah Kadelka, Brittany P. Boribong, Liwu Li & Stanca M. Ciupe. (2018) Modeling the Bistable Dynamics of the Innate Immune System. Bulletin of Mathematical Biology 81:1, pages 256-276.
Crossref
Soumojit Pal, Poulomi Nath, Debabrata Das, Sudip Hajra & Sudipta Maitra. (2018) Cross-talk between insulin signalling and LPS responses in mouse macrophages. Molecular and Cellular Endocrinology 476, pages 57-69.
Crossref
Susan Klaeger, Stephanie Heinzlmeir, Mathias Wilhelm, Harald PolzerBinje Vick, Paul-Albert Koenig, Maria ReineckeBenjamin RuprechtSvenja PetzoldtChen MengJana ZechaKatrin Reiter, Huichao QiaoDominic Helm, Heiner KochMelanie SchoofGiulia CanevariElena CasaleStefania Re DepaoliniAnnette FeuchtingerZhixiang Wu, Tobias Schmidt, Lars RueckertWilhelm Becker, Jan HuengesAnne-Kathrin GarzBjoern-Oliver Gohlke, Daniel Paul ZolgGian Kayser, Tonu Vooder, Robert PreissnerHannes HahneNeeme Tõnisson, Karl KramerKatharina GötzeFlorian Bassermann, Judith Schlegl, Hans-Christian Ehrlich, Stephan Aiche, Axel WalchPhilipp A. GreifSabine Schneider, Eduard Rudolf Felder, Juergen Ruland, Guillaume Médard, Irmela JeremiasKarsten Spiekermann & Bernhard Kuster. (2017) The target landscape of clinical kinase drugs. Science 358:6367.
Crossref
Caterina Di Pietro, Ping-xia Zhang, Timothy K. O’Rourke, Thomas S. Murray, Lin Wang, Clemente J. Britto, Jonathan L. Koff, Diane S. Krause, Marie E. Egan & Emanuela M. Bruscia. (2017) Ezrin links CFTR to TLR4 signaling to orchestrate anti-bacterial immune response in macrophages. Scientific Reports 7:1.
Crossref
Venkata N.S. Garikipati, Suresh K. Verma, Darukeshwara Jolardarashi, Zhongjian Cheng, Jessica Ibetti, Maria Cimini, Yan Tang, Mohsin Khan, Yujia Yue, Cindy Benedict, Emily Nickoloff, May M. Truongcao, Erhe Gao, Prasanna Krishnamurthy, David A. Goukassian, Walter J. Koch & Raj Kishore. (2017) Therapeutic inhibition of miR-375 attenuates post-myocardial infarction inflammatory response and left ventricular dysfunction via PDK-1-AKT signalling axis. Cardiovascular Research 113:8, pages 938-949.
Crossref
Jingyi Yan, Jianing Bai, Chen Gao, Yanling Liang, Baohua Zhao & Yanqing Bian. (2017) Chronic unpredictable stress abrogates the endotoxin tolerance induced by repeated peripheral LPS challenge via the TLR4 signaling pathway. Neuroscience Letters 645, pages 7-13.
Crossref
Eleni Vergadi, Eleftheria Ieronymaki, Konstantina Lyroni, Katerina Vaporidi & Christos Tsatsanis. (2017) Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization. The Journal of Immunology 198:3, pages 1006-1014.
Crossref
Megan M. Kaneda, Karen S. Messer, Natacha Ralainirina, Hongying Li, Christopher J. Leem, Sara Gorjestani, Gyunghwi Woo, Abraham V. Nguyen, Camila C. Figueiredo, Philippe Foubert, Michael C. Schmid, Melissa Pink, David G. Winkler, Matthew Rausch, Vito J. Palombella, Jeffery Kutok, Karen McGovern, Kelly A. Frazer, Xuefeng Wu, Michael Karin, Roman Sasik, Ezra E. W. Cohen & Judith A. Varner. (2016) PI3Kγ is a molecular switch that controls immune suppression. Nature 539:7629, pages 437-442.
Crossref
Jona Freysdottir, Oddny T. Logadottir, Sesselja S. Omarsdottir, Arnor Vikingsson & Ingibjorg Hardardottir. (2016) A polysaccharide fraction from Achillea millefolium increases cytokine secretion and reduces activation of Akt, ERK and NF-κB in THP-1 monocytes. Carbohydrate Polymers 143, pages 131-138.
Crossref
Shi Shi, Dongli Liang, Min Bao, Yilin Xie, Wangjie Xu, Lianyun Wang, Zhaoxia Wang & Zhongdong Qiao. (2016) Gx-50 Inhibits Neuroinflammation via α7 nAChR Activation of the JAK2/STAT3 and PI3K/AKT Pathways. Journal of Alzheimer's Disease 50:3, pages 859-871.
Crossref
Jessica A. Hamerman, Jessica Pottle, Minjian Ni, Yantao He, Zhong-Yin Zhang & Jane H. Buckner. (2016) Negative regulation of TLR signaling in myeloid cells-implications for autoimmune diseases. Immunological Reviews 269:1, pages 212-227.
Crossref
Gyuyoung Moon, Juhong Kim, Yoon Min, Sae Mi Wi, Jae-Hyuck Shim, Eunyoung Chun & Ki-Young Lee. (2015) Phosphoinositide-dependent kinase-1 inhibits TRAF6 ubiquitination by interrupting the formation of TAK1–TAB2 complex in TLR4 signaling. Cellular Signalling 27:12, pages 2524-2533.
Crossref
Rossana Zaru, Stephen P. Matthews, Alexander J. Edgar, Alan R. Prescott, Diego Gomez-Nicola, André Hanauer & Colin Watts. (2015) The PDK1–Rsk Signaling Pathway Controls Langerhans Cell Proliferation and Patterning. The Journal of Immunology 195:9, pages 4264-4272.
Crossref
Eva M. Sturm, Gerald P. Parzmair, Balázs Radnai, Robert B. Frei, Gunter J. Sturm, Astrid Hammer, Rufina Schuligoi, Irmgard Th. Lippe & Akos Heinemann. (2015) Phosphoinositide-dependent protein kinase 1 (PDK1) mediates potent inhibitory effects on eosinophils. European Journal of Immunology 45:5, pages 1548-1559.
Crossref
Matthew C. Morris, Elizabeth A. Gilliam & Liwu Li. (2015) Innate Immune Programing by Endotoxin and Its Pathological Consequences. Frontiers in Immunology 5.
Crossref
Fatemeh Hemmati, Rasoul Ghasemi, Norlinah Mohamed Ibrahim, Leila Dargahi, Zahurin Mohamed, Azman Ali Raymond & Abolhassan Ahmadiani. (2014) Crosstalk Between Insulin and Toll-like Receptor Signaling Pathways in the Central Nervous system. Molecular Neurobiology 50:3, pages 797-810.
Crossref
Emine Sahin, Stefan Haubenwallner, Mario Kuttke, Isabella Kollmann, Angela Halfmann, Alexander B. Dohnal, Li Chen, Paul Cheng, Bastian Hoesel, Elisa Einwallner, Julia Brunner, Julia B. Kral, Waltraud C. Schrottmaier, Kathrin Thell, Victoria Saferding, Stephan Blüml & Gernot Schabbauer. (2014) Macrophage PTEN Regulates Expression and Secretion of Arginase I Modulating Innate and Adaptive Immune Responses. The Journal of Immunology 193:4, pages 1717-1727.
Crossref
Paqui G. Través, María Pimentel-Santillana, Daniel Rico, Nuria Rodriguez, Thomas Miethke, Antonio Castrillo, Emmanuel A. Theodorakis, Paloma Martín-Sanz, Michael A. Palladino & Lisardo Boscá. (2014) Anti-inflammatory Actions of Acanthoic Acid-Related Diterpenes Involve Activation of the PI3K p110γ/δ Subunits and Inhibition of NF-κB. Chemistry & Biology 21:8, pages 955-966.
Crossref
B. L. Slomiany & A. Slomiany. (2013) Role of ghrelin-induced phosphatidylinositol 3-kinase activation in modulation of gastric mucosal inflammatory responses to Helicobacter pylori. Inflammopharmacology 22:3, pages 169-177.
Crossref
Tae-Hoon Kim, So-Jin Kim & Sun-Mee Lee. (2014) Stimulation of the α7 Nicotinic Acetylcholine Receptor Protects Against Sepsis by Inhibiting Toll-like Receptor via Phosphoinositide 3-Kinase Activation. The Journal of Infectious Diseases 209:10, pages 1668-1677.
Crossref
Jan Mauer, Bhagirath Chaurasia, Julia Goldau, Merly C Vogt, Johan Ruud, Khoa D Nguyen, Sebastian Theurich, A Christine Hausen, Joel Schmitz, Hella S Brönneke, Emma Estevez, Tamara L Allen, Andrea Mesaros, Linda Partridge, Mark A Febbraio, Ajay Chawla, F Thomas Wunderlich & Jens C Brüning. (2014) Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Nature Immunology 15:5, pages 423-430.
Crossref
William T. Festuccia, Philippe Pouliot, Inan Bakan, David M. Sabatini & Mathieu Laplante. (2014) Myeloid-Specific Rictor Deletion Induces M1 Macrophage Polarization and Potentiates In Vivo Pro-Inflammatory Response to Lipopolysaccharide. PLoS ONE 9:4, pages e95432.
Crossref
Yuka Hiroshima, Kenneth Hsu, Nicodemus Tedla, Yuen Ming Chung, Sharron Chow, Cristan Herbert & Carolyn L. Geczy. (2014) S100A8 Induces IL-10 and Protects against Acute Lung Injury. The Journal of Immunology 192:6, pages 2800-2811.
Crossref
Kristopher Clark. (2014) Protein kinase networks that limit TLR signalling. Biochemical Society Transactions 42:1, pages 11-24.
Crossref
M Hedl & C Abraham. (2013) Negative regulation of human mononuclear phagocyte function. Mucosal Immunology 6:2, pages 205-223.
Crossref
Hui Deng, Urmila Maitra, Matt Morris & Liwu Li. (2013) Molecular Mechanism Responsible for the Priming of Macrophage Activation. Journal of Biological Chemistry 288:6, pages 3897-3906.
Crossref
Marta López-PelaézStefano Fumagalli, Carlos SanzClara HerreroSusana Guerra, Margarita FernandezSusana Alemany. (2012) Cot/tpl2-MKK1/2-Erk1/2 controls mTORC1-mediated mRNA translation in Toll-like receptor–activated macrophages. Molecular Biology of the Cell 23:15, pages 2982-2992.
Crossref
Urmila Maitra, Hui Deng, Trevor Glaros, Bianca Baker, Daniel G. S. Capelluto, Zihai Li & Liwu Li. (2012) Molecular Mechanisms Responsible for the Selective and Low-Grade Induction of Proinflammatory Mediators in Murine Macrophages by Lipopolysaccharide. The Journal of Immunology 189:2, pages 1014-1023.
Crossref
Claudia M. Wunderlich, Denis Delić, Kristina Behnke, Andreas Meryk, Peter Ströhle, Bhagirath Chaurasia, Saleh Al-Quraishy, Frank Wunderlich, Jens C. Brüning & F. Thomas Wunderlich. (2012) Cutting Edge: Inhibition of IL-6 Trans -Signaling Protects from Malaria-Induced Lethality in Mice . The Journal of Immunology 188:9, pages 4141-4144.
Crossref
Catherine M. Cahill, Jack T. Rogers & W. Allan Walker. (2012) The Role of Phosphoinositide 3-Kinase Signaling in Intestinal Inflammation. Journal of Signal Transduction 2012, pages 1-13.
Crossref
S.-Y. Yao, C. Natarajan & S. Sriram. (2012) nNOS mediated mitochondrial injury in LPS stimulated oligodendrocytes. Mitochondrion 12:2, pages 336-344.
Crossref
Matthew Morris & Liwu Li. (2011) Molecular Mechanisms and Pathological Consequences of Endotoxin Tolerance and Priming. Archivum Immunologiae et Therapiae Experimentalis 60:1, pages 13-18.
Crossref
Matthias Wymann. 2012. Phosphoinositides I: Enzymes of Synthesis and Degradation. Phosphoinositides I: Enzymes of Synthesis and Degradation 111 181 .
Feng-Ling Yang, Yu-Liang Yang, Pei-Chun Liao, Ju-Ching Chou, Keng-Chang Tsai, An-Suei Yang, Fuu Sheu, Tzu-Lung Lin, Pei-Fang Hsieh, Jin-Town Wang, Kuo-Feng Hua & Shih-Hsiung Wu. (2011) Structure and Immunological Characterization of the Capsular Polysaccharide of a Pyrogenic Liver Abscess Caused by Klebsiella pneumoniae. Journal of Biological Chemistry 286:24, pages 21041-21051.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.