Advanced search
Publication Cover
Molecular and Cellular Biology Volume 33, 2013 - Issue 15
Submit an article Journal homepage
67
Views
34
CrossRef citations to date
0
Altmetric
Article

Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing

Alister P. W. Funnella School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
,
Ka Sin Maka School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
,
Natalie A. Twinea School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
,
Gregory J. Pelkab Children's Medical Research Institute, Westmead, New South Wales, Australia
,
Laura J. Nortona School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
,
Tania Radziewicb Children's Medical Research Institute, Westmead, New South Wales, Australia
,
Melinda Powerb Children's Medical Research Institute, Westmead, New South Wales, Australia
,
Marc R. Wilkinsa School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
,
Kim S. Bell-Andersonc School of Molecular Bioscience, University of Sydney, Sydney, New South Wales, Australia
,
Stuart T. Fraserd Disciplines of Physiology, Anatomy and Histology, School of Medical Science, University of Sydney, Sydney, New South Wales, Australia
,
Andrew C. Perkinse Mater Medical Research Institute, Translational Research Institute, Woolloongabba, Queensland, Australia;f Division of Molecular Genetics and Development, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia
,
Patrick P. Tamb Children's Medical Research Institute, Westmead, New South Wales, Australia
,
Richard C. M. Pearsona School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
&
Merlin Crossleya School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, AustraliaCorrespondence[email protected]
 show all
Pages 2976-2987 | Received 17 Jan 2013, Accepted 19 May 2013, Published online: 20 Mar 2023

Citations (34)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Mikiko Suzuki, Masayuki Yamamoto & James Douglas Engel. (2014) Fetal Globin Gene Repressors as Drug Targets for Molecular Therapies To Treat the β-Globinopathies. Molecular and Cellular Biology 34:19, pages 3560-3569.
Read now

Articles from other publishers (33)

Poonam Tripathi, Sarita Agarwal, Kausik Mandal, Anshul Gupta & Aditya Narayan Sarangi. (2023) Impact of Genetic Polymorphisms in Modifier Genes in Determining Fetal Hemoglobin Levels in Beta-Thalassemia. Thalassemia Reports 13:1, pages 85-112.
Crossref
Kaustav Mukherjee & James J. Bieker. (2022) EKLF/Klf1 regulates erythroid transcription by its pioneering activity and selective control of RNA Pol II pause-release. Cell Reports 41:12, pages 111830.
Crossref
Sayed Haidar Abbas Raza, Sameer D Pant, Atif Khurshid Wani, Hadeer H. Mohamed, Norhan E. Khalifa, Hailah M. Almohaimeed, Aliah R. Alshanwani, Rasha Assiri, Waheeb S. Aggad, Ahmed E. Noreldin, Sameh A. Abdelnour, Zhe Wang & Linsen Zan. (2022) Krüppel-like factors family regulation of adipogenic markers genes in bovine cattle adipogenesis. Molecular and Cellular Probes 65, pages 101850.
Crossref
Andrew J. King, Duantida Songdej, Damien J. Downes, Robert A. Beagrie, Siyu Liu, Megan Buckley, Peng Hua, Maria C. Suciu, A. Marieke Oudelaar, Lars L. P. Hanssen, Danuta Jeziorska, Nigel Roberts, Stephanie J. Carpenter, Helena Francis, Jelena Telenius, Aude-Anais Olijnik, Jacqueline A. Sharpe, Jacqueline Sloane-Stanley, Jennifer Eglinton, Mira T. Kassouf, Stuart H. Orkin, Len A. Pennacchio, James O. J. Davies, Jim R. Hughes, Douglas R. Higgs & Christian Babbs. (2021) Reactivation of a developmentally silenced embryonic globin gene. Nature Communications 12:1.
Crossref
Wylly Ramsés García-Niño & Cecilia Zazueta. (2021) New insights of Krüppel-like transcription factors in adipogenesis and the role of their regulatory neighbors. Life Sciences 265, pages 118763.
Crossref
Sanjay Kumar, Abhijeet Behera, Priyanka Saha & Amit Kumar Srivastava. (2021) The role of Krüppel-like factor 8 in cancer biology: Current research and its clinical relevance. Biochemical Pharmacology 183, pages 114351.
Crossref
Xiang Guo, Jennifer Plank-Bazinet, Ivan Krivega, Ryan K Dale & Ann Dean. (2020) Embryonic erythropoiesis and hemoglobin switching require transcriptional repressor ETO2 to modulate chromatin organization. Nucleic Acids Research 48:18, pages 10226-10240.
Crossref
Alexander J. Knights, Emily J. Vohralik, Peter J. Houweling, Elizabeth S. Stout, Laura J. Norton, Stephanie J. Alexopoulos, Jinfen. J. Yik, Hanapi Mat Jusoh, Ellen M. Olzomer, Kim S. Bell-Anderson, Kathryn N. North, Kyle L. Hoehn, Merlin Crossley & Kate G. R. Quinlan. (2020) Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3). Nature Communications 11:1.
Crossref
Alexander J. Knights, Lu Yang, Manan Shah, Laura J. Norton, Gamran S. Green, Elizabeth S. Stout, Emily J. Vohralik, Merlin Crossley & Kate G.R. Quinlan. (2020) Krüppel-like factor 3 (KLF3) suppresses NF-κB–driven inflammation in mice. Journal of Biological Chemistry 295:18, pages 6080-6091.
Crossref
I. Van Hese, K. Goossens, L. Vandaele & G. Opsomer. (2020) Invited review: MicroRNAs in bovine colostrum—Focus on their origin and potential health benefits for the calf. Journal of Dairy Science 103:1, pages 1-15.
Crossref
Viola C. Lam, Lasse Folkersen, Oscar A. Aguilar & Lewis L. Lanier. (2019) KLF12 Regulates Mouse NK Cell Proliferation. The Journal of Immunology 203:4, pages 981-989.
Crossref
Apostolos Stratopoulos, Alexandra Kolliopoulou, Kariofyllis Karamperis, Anne John, Kyriaki Kydonopoulou, George Esftathiou, Argyro Sgourou, Alexandra Kourakli, Efthimia Vlachaki, Panagiota Chalkia, Stamatia Theodoridou, Manoussos N Papadakis, Spyridon Gerou, Argiris Symeonidis, Theodora Katsila, Bassam R Ali, Adamantia Papachatzopoulou & George P Patrinos. (2019) Genomic variants in members of the Krüppel-like factor gene family are associated with disease severity and hydroxyurea treatment efficacy in β-hemoglobinopathies patients. Pharmacogenomics 20:11, pages 791-801.
Crossref
Morgan Salmon, Michael Spinosa, Zendra E. Zehner, Gilbert R. Upchurch & Gorav Ailawadi. (2019) Klf4 , Klf2 , and Zfp148 activate autophagy‐related genes in smooth muscle cells during aortic aneurysm formation . Physiological Reports 7:8, pages e14058.
Crossref
Rong Wang, Jiali Xu, Jing Xu, Wei Zhu, Tianzhu Qiu, Jun Li, Meiling Zhang, Qianqian Wang, Tongpeng Xu, Renhua Guo, Kaihua Lu, Yongmei Yin, Yanhong Gu, Lingjun Zhu, Puwen Huang, Ping Liu, Lianke Liu, Wei De & Yongqian Shu. (2018) MiR‐326/Sp1/KLF3: A novel regulatory axis in lung cancer progression. Cell Proliferation 52:2.
Crossref
Andrew J. King & Douglas R. Higgs. (2018) Potential new approaches to the management of the Hb Bart’s hydrops fetalis syndrome: the most severe form of α-thalassemia. Hematology 2018:1, pages 353-360.
Crossref
Nina M. Pollak, Matthew Hoffman, Ira J. Goldberg & Konstantinos Drosatos. (2018) Krüppel-Like Factors. JACC: Basic to Translational Science 3:1, pages 132-156.
Crossref
Che-Yi Lin, Ming-Yuan Tsai, Yu-Hsiu Liu, Yu-Fen Lu, Yi-Chung Chen, Yun-Ren Lai, Hsin-Chi Liao, Huang-Wei Lien, Chung-Hsiang Yang, Chang-Jen Huang & Sheng-Ping L. Hwang. (2017) Klf8 regulates left-right asymmetric patterning through modulation of Kupffer’s vesicle morphogenesis and spaw expression. Journal of Biomedical Science 24:1.
Crossref
Melissa D. Ilsley, Kevin R. Gillinder, Graham W. Magor, Stephen Huang, Timothy L. Bailey, Merlin Crossley & Andrew C. Perkins. (2017) Krüppel-like factors compete for promoters and enhancers to fine-tune transcription. Nucleic Acids Research 45:11, pages 6572-6588.
Crossref
Laura J. Norton, Samantha Hallal, Elizabeth S. Stout, Alister P. W. Funnell, Richard C. M. Pearson, Merlin Crossley & Kate G. R. Quinlan. (2017) Direct competition between DNA binding factors highlights the role of Krüppel-like Factor 1 in the erythroid/megakaryocyte switch. Scientific Reports 7:1.
Crossref
Agnieszka B. Bialkowska, Vincent W. Yang & Sandeep K. Mallipattu. (2017) Krüppel-like factors in mammalian stem cells and development. Development 144:5, pages 737-754.
Crossref
Ka Sin Mak, Jon Burdach, Laura J. Norton, Richard CM Pearson, Merlin Crossley & Alister PW Funnell. (2016) Erratum to: Repression of chimeric transcripts emanating from endogenous retrotransposons by a sequence-specific transcription factor. Genome Biology 17:1.
Crossref
Debarati Mukherjee, Heng Lu, Lin Yu, Chunjiang He, Satadru K. Lahiri, Tianshu Li & Jihe Zhao. (2016) Krüppel-like factor 8 activates the transcription of C-X-C cytokine receptor type 4 to promote breast cancer cell invasion, transendothelial migration and metastasis. Oncotarget 7:17, pages 23552-23568.
Crossref
Andrew Perkins, Xiangmin Xu, Douglas R. Higgs, George P. Patrinos, Lionel ArnaudJames J. Bieker & Sjaak Philipsen. (2016) Krüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants. Blood 127:15, pages 1856-1862.
Crossref
Ming-Yuan Tsai, Yu-Fen Lu, Yu-Hsiu Liu, Huang-Wei Lien, Chang-Jen Huang, Jen-Leih Wu & Sheng-Ping L. Hwang. (2015) Modulation of p53 and met expression by Krüppel-like factor 8 regulates zebrafish cerebellar development . Developmental Neurobiology 75:9, pages 908-926.
Crossref
Graham W. MagorMichael R. TallackKevin R. GillinderCharles C. BellNaomi McCallumBronwyn Williams & Andrew C. Perkins. (2015) KLF1-null neonates display hydrops fetalis and a deranged erythroid transcriptome. Blood 125:15, pages 2405-2417.
Crossref
Rosalia C M Simmen, Melissa E Heard, Angela M Simmen, Maria Theresa M Montales, Meera Marji, Samantha Scanlon & John Mark P Pabona. (2015) The Krüppel-like factors in female reproductive system pathologies. Journal of Molecular Endocrinology 54:2, pages R89-R101.
Crossref
Vitri Dewi, Alister Kwok, Stella Lee, Ming Min Lee, Yee Mun Tan, Hannah R. Nicholas, Kyo-ichi Isono, Beeke Wienert, Ka Sin Mak, Alexander J. Knights, Kate G.R. Quinlan, Stuart J. Cordwell, Alister P.W. Funnell, Richard C.M. Pearson & Merlin Crossley. (2015) Phosphorylation of Krüppel-like Factor 3 (KLF3/BKLF) and C-terminal Binding Protein 2 (CtBP2) by Homeodomain-interacting Protein Kinase 2 (HIPK2) Modulates KLF3 DNA Binding and Activity. Journal of Biological Chemistry 290:13, pages 8591-8605.
Crossref
Yueling Zhang, Jin Hao, Yingcheng Zheng, Dian Jing, Yu Shen, Jun Wang & Zhihe Zhao. (2015) Role of Krüppel-like factors in cancer stem cells. Journal of Physiology and Biochemistry 71:1, pages 155-164.
Crossref
Alister PW Funnell, Douglas Vernimmen, Wooi F Lim, Ka Sin Mak, Beeke Wienert, Gabriella E Martyn, Crisbel M Artuz, Jon Burdach, Kate GR Quinlan, Douglas R Higgs, Emma Whitelaw, Richard CM Pearson & Merlin Crossley. (2014) Differential regulation of the α-globin locus by Krüppel-like factor 3 in erythroid and non-erythroid cells. BMC Molecular Biology 15:1.
Crossref
Ka Sin Mak, Jon Burdach, Laura J Norton, Richard CM Pearson, Merlin Crossley & Alister PW Funnell. (2014) Repression of chimeric transcripts emanating from endogenous retrotransposons by a sequence-specific transcription factor. Genome Biology 15:4.
Crossref
Mark Roosjen, Bradley McColl, Betty Kao, Linden J. Gearing, Marnie E. Blewitt & Jim Vadolas. (2013) Transcriptional regulators Myb and BCL11A interplay with DNA methyltransferase 1 in developmental silencing of embryonic and fetal β‐like globin genes. The FASEB Journal 28:4, pages 1610-1620.
Crossref
Vip ViprakasitSupachai EkwattanakitSuchada RiolueangNipon ChalaowChris FisherKaren LowerHitoshi KannoKalaya TachavanichSasithorn BejrachandraJariya SaipinMonthana Juntharaniyom, Kleebsabai SanpakitVoravarn S. TanphaichitrDuantida SongdejChristian BabbsRichard J. GibbonsSjaak Philipsen & Douglas R. Higgs. (2014) Mutations in Krüppel-like factor 1 cause transfusion-dependent hemolytic anemia and persistence of embryonic globin gene expression. Blood 123:10, pages 1586-1595.
Crossref
J. Burdach, A. P. W. Funnell, K. S. Mak, C. M. Artuz, B. Wienert, W. F. Lim, L. Y. Tan, R. C. M. Pearson & M. Crossley. (2013) Regions outside the DNA-binding domain are critical for proper in vivo specificity of an archetypal zinc finger transcription factor. Nucleic Acids Research 42:1, pages 276-289.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.