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Molecular and Cellular Biology Volume 27, 2007 - Issue 16
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Article

Regulation of Urokinase Receptor Expression by p53: Novel Role in Stabilization of uPAR mRNA

Sreerama Shetty1 Texas Lung Injury Institute, Department of Specialty Care Services, The University of Texas Health Center at Tyler, 11937 U.S. Highway 271, Tyler, Texas75708Correspondence[email protected]
,
Thirunavukkarasu Velusamy1 Texas Lung Injury Institute, Department of Specialty Care Services, The University of Texas Health Center at Tyler, 11937 U.S. Highway 271, Tyler, Texas75708
,
Steven Idell1 Texas Lung Injury Institute, Department of Specialty Care Services, The University of Texas Health Center at Tyler, 11937 U.S. Highway 271, Tyler, Texas75708
,
Praveenkumar Shetty1 Texas Lung Injury Institute, Department of Specialty Care Services, The University of Texas Health Center at Tyler, 11937 U.S. Highway 271, Tyler, Texas75708
,
Andrew P. Mazar2 Attenuon LLC, 11535 Sorrento Valley Rd., San Diego, California92121
,
Yashodhar P. Bhandary1 Texas Lung Injury Institute, Department of Specialty Care Services, The University of Texas Health Center at Tyler, 11937 U.S. Highway 271, Tyler, Texas75708
&
Rashmi S. Shetty1 Texas Lung Injury Institute, Department of Specialty Care Services, The University of Texas Health Center at Tyler, 11937 U.S. Highway 271, Tyler, Texas75708
 show all
Pages 5607-5618 | Received 15 Jan 2007, Accepted 10 Apr 2007, Published online: 01 Apr 2023

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Shilpa Johnson, Sadiya B. Shaikh, Fatheema Muneesa, Barki Rashmi & Yashodhar P. Bhandary. (2020) Radiation induced apoptosis and pulmonary fibrosis: curcumin an effective intervention?. International Journal of Radiation Biology 96:6, pages 709-717.
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Shih-Chi Su, Chiao-Wen Lin, Wei-En Yang, Wen-Lang Fan & Shun-Fa Yang. (2016) The urokinase-type plasminogen activator (uPA) system as a biomarker and therapeutic target in human malignancies. Expert Opinion on Therapeutic Targets 20:5, pages 551-566.
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Articles from other publishers (26)

Taryn B. Hogan, Nivedita Tiwari, M.R. Nagaraja, Shwetha K. Shetty, Liang Fan, Rashmi S. Shetty, Yashodhar P. Bhandary & Sreerama Shetty. (2022) Caveolin-1 peptide regulates p53-microRNA-34a feedback in fibrotic lung fibroblasts. iScience 25:4, pages 104022.
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M. Fathimath Muneesa, Sadiya B. Shaikh, T.M. Jeena & Yashodhar P. Bhandary. (2021) Inflammatory mediators in various molecular pathways involved in the development of pulmonary fibrosis. International Immunopharmacology 96, pages 107608.
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Julie A Barta, Kristen Pauley, Andrew V Kossenkov & Steven B McMahon. (2020) The lung-enriched p53 mutants V157F and R158L/P regulate a gain of function transcriptome in lung cancer. Carcinogenesis 41:1, pages 67-77.
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Markus Eckstein, Verena Sailer, Boye Schnack Nielsen, Thomas Wittenberg, Veit Wiesmann, Verena Lieb, Elke Nolte, Arndt Hartmann, Glen Kristiansen, Nicolas Wernert, Bernd Wullich, Helge Taubert & Sven Wach. (2019) Co-staining of microRNAs and their target proteins by miRNA in situ hybridization and immunohistofluorescence on prostate cancer tissue microarrays. Laboratory Investigation 99:10, pages 1527-1534.
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Shwetha K. Shetty, Nivedita Tiwari, Amarnath S. Marudamuthu, Bijesh Puthusseri, Yashodhar P. Bhandary, Jian Fu, Jeffrey Levin, Steven Idell & Sreerama Shetty. (2017) p53 and miR-34a Feedback Promotes Lung Epithelial Injury and Pulmonary Fibrosis. The American Journal of Pathology 187:5, pages 1016-1034.
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Yashodhar Prabhakar Bhandary. (2016) p53-Fibrinolytic system and acute lung injury. Biologia 71:10, pages 1098-1102.
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Silvia Di Agostino, Giovanni Sorrentino, Eleonora Ingallina, Fabio Valenti, Maria Ferraiuolo, Silvio Bicciato, Silvano Piazza, Sabrina Strano, Giannino Del Sal & Giovanni Blandino. (2015) YAP enhances the pro‐proliferative transcriptional activity of mutant p53 proteins . EMBO reports 17:2, pages 188-201.
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Zhiwei Hu, Samira A. Brooks, Valérian Dormoy, Chia-Wen Hsu, Hsue-Yin Hsu, Liang-Tzung Lin, Thierry Massfelder, W.Kimryn Rathmell, Menghang Xia, Fahd Al-Mulla, Rabeah Al-Temaimi, Amedeo Amedei, Dustin G. Brown, Kalan R. Prudhomme, Anna Maria Colacci, Roslida A. Hamid, Chiara Mondello, Jayadev Raju, Elizabeth P. Ryan, Jordan Woodrick, A.Ivana Scovassi, Neetu Singh, Monica Vaccari, Rabindra Roy, Stefano Forte, Lorenzo Memeo, Hosni K. Salem, Leroy Lowe, Lasse Jensen, William H. Bisson & Nicole Kleinstreuer. (2015) Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis. Carcinogenesis 36:Suppl 1, pages S184-S202.
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Natalie Falkenberg, Nataša Anastasov, Annalisa Schaub, Vanja Radulovic, Manfred Schmitt, Viktor Magdolen & Michaela Aubele. (2015) Secreted uPAR isoform 2 (uPAR7b) is a novel direct target of miR-221. Oncotarget 6:10, pages 8103-8114.
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Amarnath S. Marudamuthu, Shwetha K. Shetty, Yashodhar P. Bhandary, Sophia Karandashova, Michael Thompson, Venkatachalem Sathish, Galina Florova, Taryn B. Hogan, Christina M. Pabelick, Y.S. Prakash, Yoshikazu Tsukasaki, Jian Fu, Mitsuo Ikebe, Steven Idell & Sreerama Shetty. (2015) Plasminogen Activator Inhibitor-1 Suppresses Profibrotic Responses in Fibroblasts from Fibrotic Lungs. Journal of Biological Chemistry 290:15, pages 9428-9441.
Crossref
Yashodhar P. Bhandary, Shwetha K. Shetty, Amarnath S. Marudamuthu, Jian Fu, Barbara M. Pinson, Jeffrey Levin & Sreerama Shetty. (2015) Role of p53–fibrinolytic system cross-talk in the regulation of quartz-induced lung injury. Toxicology and Applied Pharmacology 283:2, pages 92-98.
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Amarnath Satheesh Marudamuthu, Yashodhar Prabhakar Bhandary, Shwetha Kumari Shetty, Jian Fu, Venkatachalem Sathish, YS Prakash & Sreerama Shetty. (2015) Role of the Urokinase-Fibrinolytic System in Epithelial–Mesenchymal Transition during Lung Injury. The American Journal of Pathology 185:1, pages 55-68.
Crossref
Zhuo Chen, Peng Xu, Jincan Chen, Hongwei Chen, Ping Hu, Xueyuan Chen, Lin Lin, Yunmei Huang, Ke Zheng, Shanyong Zhou, Rui Li, Song Chen, Jianyong Liu, Jinping Xue & Mingdong Huang. (2014) Zinc phthalocyanine conjugated with the amino-terminal fragment of urokinase for tumor-targeting photodynamic therapy. Acta Biomaterialia 10:10, pages 4257-4268.
Crossref
Xiufeng Liu, Fan Qiu, Zhipeng Liu, Yan Lan, Kai Wang, Ping-Kun Zhou, Yao Wang & Zi-Chun Hua. (2014) Urokinase-type plasminogen activator receptor regulates apoptotic sensitivity of colon cancer HCT116 cell line to TRAIL via JNK-p53 pathway. Apoptosis 19:10, pages 1532-1544.
Crossref
N Falkenberg, N Anastasov, K Rappl, H Braselmann, G Auer, A Walch, M Huber, I Höfig, M Schmitt, H Höfler, M J Atkinson & M Aubele. (2013) MiR-221/-222 differentiate prognostic groups in advanced breast cancers and influence cell invasion. British Journal of Cancer 109:10, pages 2714-2723.
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Yashodhar P. Bhandary, Shwetha K. Shetty, Amarnath S. Marudamuthu, Hong-Long Ji, Pierre F. Neuenschwander, Vijay Boggaram, Gilbert F. Morris, Jian Fu, Steven Idell & Sreerama Shetty. (2013) Regulation of Lung Injury and Fibrosis by p53-Mediated Changes in Urokinase and Plasminogen Activator Inhibitor-1. The American Journal of Pathology 183:1, pages 131-143.
Crossref
Joerg Hendrik Leupold & Heike Allgayer. 2012. Matrix Proteases in Health and Disease. Matrix Proteases in Health and Disease 227 249 .
Yashodhar P. Bhandary, Shwetha K. Shetty, Amarnath S. Marudamuthu, Margaret R. Gyetko, Steven Idell, Mehrnaz Gharaee-Kermani, Rashmi S. Shetty, Barry C. Starcher & Sreerama Shetty. (2012) Regulation of alveolar epithelial cell apoptosis and pulmonary fibrosis by coordinate expression of components of the fibrinolytic system. American Journal of Physiology-Lung Cellular and Molecular Physiology 302:5, pages L463-L473.
Crossref
Heike Allgayer. (2010) Translational research on u-PAR. European Journal of Cancer 46:7, pages 1241-1251.
Crossref
Harvey W. Smith & Chris J. Marshall. (2010) Regulation of cell signalling by uPAR. Nature Reviews Molecular Cell Biology 11:1, pages 23-36.
Crossref
Tae-Don KimJu Yeong ParkInpyo Choi. (2009) Post-transcriptional Regulation of NK Cell Activation. Immune Network 9:4, pages 115.
Crossref
Sreerama Shetty, Joseph Padijnayayveetil, Torry Tucker, Dorota Stankowska & Steven Idell. (2008) The fibrinolytic system and the regulation of lung epithelial cell proteolysis, signaling, and cellular viability. American Journal of Physiology-Lung Cellular and Molecular Physiology 295:6, pages L967-L975.
Crossref
Rohit G. Saldanha, Ning Xu, Mark P. Molloy, Duncan A. Veal & Mark S. Baker. (2008) Differential Proteome Expression Associated with Urokinase Plasminogen Activator Receptor (uPAR) Suppression in Malignant Epithelial Cancer. Journal of Proteome Research 7:11, pages 4792-4806.
Crossref
Praveenkumar Shetty, Thirunavukkarasu Velusamy, Yashodhar P. Bhandary, Rashmi S. Shetty, Ming-Cheh Liu & Sreerama Shetty. (2008) Urokinase Expression by Tumor Suppressor Protein p53. American Journal of Respiratory Cell and Molecular Biology 39:3, pages 364-372.
Crossref
Sreerama Shetty, Praveenkumar Shetty, Steven Idell, Thirunavukkarasu Velusamy, Yashodhar P. Bhandary & Rashmi S. Shetty. (2008) Regulation of Plasminogen Activator Inhibitor-1 Expression by Tumor Suppressor Protein p53. Journal of Biological Chemistry 283:28, pages 19570-19580.
Crossref
Soichi Kojima. 2008. Recent Advances in Thrombosis and Hemostasis 2008. Recent Advances in Thrombosis and Hemostasis 2008 301 313 .

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