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Molecular and Cellular Biology Volume 41, 2021 - Issue 9
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Research Article

The Cyclin-Dependent Kinase 8 (CDK8) Inhibitor DCA Promotes a Tolerogenic Chemical Immunophenotype in CD4+ T Cells via a Novel CDK8-GATA3-FOXP3 Pathway

Azlann Arnetta Benaroya Research Institute, Seattle, Washington, USA
,
Keagan G. Mooa Benaroya Research Institute, Seattle, Washington, USA
,
Kaitlin J. Flynna Benaroya Research Institute, Seattle, Washington, USA
,
Thomas B. Sundbergb Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA
,
Liv Johannessenc Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA
,
Alykhan F. Shamjib Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA
,
Nathanael S. Grayc Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA
,
Thomas Deckerd Max Perutz Labs, University of Vienna, Vienna, Austria
,
Ye Zhenge NOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, California, USA
,
Vivian H. Gersuka Benaroya Research Institute, Seattle, Washington, USA
,
Ziaur S. Rahmanf Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
,
David E. Levyg Department of Pathology, New York University School of Medicine, New York, New York, USA
,
Isabelle J. Mariég Department of Pathology, New York University School of Medicine, New York, New York, USA
,
Peter S. Linsleya Benaroya Research Institute, Seattle, Washington, USA
,
Ramnik J. Xavierh Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA;i The Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA
&
Bernard Khora Benaroya Research Institute, Seattle, Washington, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-4689-5092
ORCID Icon show all
Article: e00085-21 | Received 02 Mar 2021, Accepted 02 Jun 2021, Published online: 03 Mar 2023

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Marzena Staniszewska, Kajetan Kiełbowski, Klaudia Rusińska, Estera Bakinowska, Ewa Gromowska & Andrzej Pawlik. (2023) Targeting cyclin-dependent kinases in rheumatoid arthritis and psoriasis – a review of current evidence. Expert Opinion on Therapeutic Targets 27:11, pages 1097-1113.
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Articles from other publishers (2)

Xing Chen, Yaoyao Yan, Xiu Cheng, Zhaoyan Zhang, Chuanbiao He, Dan Wu, Dahai Zhao & Xinhua Liu. (2023) A novel CDK8 inhibitor with poly-substituted pyridine core: Discovery and anti-inflammatory activity evaluation in vivo. Bioorganic Chemistry 133, pages 106402.
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Tongbing Qi, Ying Luo, Weitong Cui, Yue Zhou, Xuan Ma, Dongming Wang, Xuewen Tian & Qinglu Wang. (2022) Crosstalk between the CBM complex/NF-κB and MAPK/P27 signaling pathways of regulatory T cells contributes to the tumor microenvironment. Frontiers in Cell and Developmental Biology 10.
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