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Article

TPC1 Has Two Variant Isoforms, and Their Removal Has Different Effects on Endo-Lysosomal Functions Compared to Loss of TPC2

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Pages 3981-3992 | Received 19 Feb 2014, Accepted 11 Aug 2014, Published online: 20 Mar 2023

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Benjamin Chun-Kit Tong, Aston Jiaxi Wu, Alexis Shiying Huang, Rui Dong, Sandeep Malampati, Ashok Iyaswamy, Senthilkumar Krishnamoorthi, Sravan Gopalkrishnashetty Sreenivasmurthy, Zhou Zhu, Chengfu Su, Jia Liu, Juxian Song, Jia-Hong Lu, Jieqiong Tan, Weidong Pan, Min Li & King-Ho Cheung. (2022) Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease. Autophagy 18:3, pages 624-642.
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Sandra Feijóo-Bandín, María García-Vence, Vanessa García-Rúa, Esther Roselló-Lletí, Manuel Portolés, Miguel Rivera, José Ramón González-Juanatey & Francisca Lago. (2017) Two-pore channels (TPCs): Novel voltage-gated ion channels with pleiotropic functions. Channels 11:1, pages 20-33.
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Margarida Ruas, Antony Galione & John Parrington. (2015) Reply to “TPC1 Knockout Knocks Out TPC1”. Molecular and Cellular Biology 35:10, pages 1884-1884.
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Robert Hooper, Dev Churamani, Sean M. Davidson, Yaping Lin-Moshier, Timothy F. Walseth, Sandip Patel & Jonathan S. Marchant. (2015) TPC1 Knockout Knocks Out TPC1. Molecular and Cellular Biology 35:10, pages 1882-1883.
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