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Molecular and Cellular Biology Volume 30, 2010 - Issue 10
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Article

Separable Functions of the Fission Yeast Spt5 Carboxyl-Terminal Domain (CTD) in Capping Enzyme Binding and Transcription Elongation Overlap with Those of the RNA Polymerase II CTD

Susanne Schneider1 Graduate Program in Molecular Biology, Weill Cornell Medical College, New York, New York10065;3 Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York10065
,
Yi Pei2 Molecular Biology Program, Sloan-Kettering Institute, New York, New York10065
,
Stewart Shuman1 Graduate Program in Molecular Biology, Weill Cornell Medical College, New York, New York10065;2 Molecular Biology Program, Sloan-Kettering Institute, New York, New York10065Correspondence[email protected] [email protected]
&
Beate Schwer1 Graduate Program in Molecular Biology, Weill Cornell Medical College, New York, New York10065;3 Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York10065Correspondence[email protected] [email protected]
Pages 2353-2364 | Received 29 Jan 2010, Accepted 04 Mar 2010, Published online: 20 Mar 2023

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Jennifer J. Chen, Jean Mbogning, Mark A. Hancock, Dorsa Majdpour, Manan Madhok, Hassan Nassour, Juliana C. Dallagnol, Viviane Pagé, David Chatenet & Jason C. Tanny. (2020) Spt5 Phosphorylation and the Rtf1 Plus3 Domain Promote Rtf1 Function through Distinct Mechanisms. Molecular and Cellular Biology 40:15.
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Jason C. Tanny. (2014) Chromatin modification by the RNA Polymerase II elongation complex. Transcription 5:5.
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Elizabeth A Bowman & William G Kelly. (2014) RNA Polymerase II transcription elongation and Pol II CTD Ser2 phosphorylation. Nucleus 5:3, pages 224-236.
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Michael Lidschreiber, Kristin Leike & Patrick Cramer. (2013) Cap Completion and C-Terminal Repeat Domain Kinase Recruitment Underlie the Initiation-Elongation Transition of RNA Polymerase II. Molecular and Cellular Biology 33:19, pages 3805-3816.
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Courtney V. St. Amour, Miriam Sansó, Christian A. Bösken, Karen M. Lee, Stéphane Larochelle, Chao Zhang, Kevan M. Shokat, Matthias Geyer & Robert P. Fisher. (2012) Separate Domains of Fission Yeast Cdk9 (P-TEFb) Are Required for Capping Enzyme Recruitment and Primed (Ser7-Phosphorylated) Rpb1 Carboxyl-Terminal Domain Substrate Recognition. Molecular and Cellular Biology 32:13, pages 2372-2383.
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Andreas Mayer, Amelie Schreieck, Michael Lidschreiber, Kristin Leike, Dietmar E. Martin & Patrick Cramer. (2012) The Spt5 C-Terminal Region Recruits Yeast 3′ RNA Cleavage Factor I. Molecular and Cellular Biology 32:7, pages 1321-1331.
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Zaur M. Kachaev, Lyubov A. Lebedeva, Eugene N. Kozlov & Yulii V. Shidlovskii. (2020) Interplay of mRNA capping and transcription machineries. Bioscience Reports 40:1.
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Ana M. SanchezStewart Shuman & Beate Schwer. (2018) RNA polymerase II CTD interactome with 3′ processing and termination factors in fission yeast and its impact on phosphate homeostasis. Proceedings of the National Academy of Sciences 115:45.
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Pabitra K. Parua, Gregory T. Booth, Miriam Sansó, Bradley Benjamin, Jason C. Tanny, John T. Lis & Robert P. Fisher. (2018) A Cdk9–PP1 switch regulates the elongation–termination transition of RNA polymerase II. Nature 558:7710, pages 460-464.
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Michael Babokhov, Mohammad M Mosaheb, Richard W Baker & Stephen M Fuchs. (2018) Repeat-Specific Functions for the C-Terminal Domain of RNA Polymerase II in Budding Yeast. G3 Genes|Genomes|Genetics 8:5, pages 1593-1601.
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Gregory T. Booth, Pabitra K. Parua, Miriam Sansó, Robert P. Fisher & John T. Lis. (2018) Cdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeast. Nature Communications 9:1.
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Zhiyuan Zhao, Ka-Wei Tang, Isabella Muylaert, Tore Samuelsson & Per Elias. (2017) CDK9 and SPT5 proteins are specifically required for expression of herpes simplex virus 1 replication-dependent late genes. Journal of Biological Chemistry 292:37, pages 15489-15500.
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Ameet Shetty, Scott P. Kallgren, Carina Demel, Kerstin C. Maier, Dan Spatt, Burak H. Alver, Patrick Cramer, Peter J. Park & Fred Winston. (2017) Spt5 Plays Vital Roles in the Control of Sense and Antisense Transcription Elongation. Molecular Cell 66:1, pages 77-88.e5.
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Yijun Qiu & David S. Gilmour. (2017) Identification of Regions in the Spt5 Subunit of DRB Sensitivity-inducing Factor (DSIF) That Are Involved in Promoter-proximal Pausing. Journal of Biological Chemistry 292:13, pages 5555-5570.
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Bo ZhangGuohua YangYu ChenYihong ZhaoPeng GaoBo LiuHaiyang WangZhi-Liang Zheng. (2016) C-terminal domain (CTD) phosphatase links Rho GTPase signaling to Pol II CTD phosphorylation in Arabidopsis and yeast . Proceedings of the National Academy of Sciences 113:50.
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Amanda J. Blythe, Berra Yazar-Klosinski, Michael W. Webster, Eefei Chen, Marylène Vandevenne, Katerina Bendak, Joel P. Mackay, Grant A. Hartzog & Alice Vrielink. (2016) The yeast transcription elongation factor Spt4/5 is a sequence-specific RNA binding protein. Protein Science 25:9, pages 1710-1721.
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Beate Schwer, Ana M. Sanchez & Stewart Shuman. (2015) RNA polymerase II CTD phospho-sites Ser5 and Ser7 govern phosphate homeostasis in fission yeast. RNA 21:10, pages 1770-1780.
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Huan Zhou, Qi Liu, Tianfang Shi, Yao Yu & Hong Lu. (2015) Genome-wide screen of fission yeast mutants for sensitivity to 6-azauracil, an inhibitor of transcriptional elongation. Yeast 32:10, pages 643-655.
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R. Dronamraju & B. D. Strahl. (2013) A feed forward circuit comprising Spt6, Ctk1 and PAF regulates Pol II CTD phosphorylation and transcription elongation. Nucleic Acids Research 42:2, pages 870-881.
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Grant A. Hartzog & Jianhua Fu. (2013) The Spt4–Spt5 complex: A multi-faceted regulator of transcription elongation. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1829:1, pages 105-115.
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Craig D. Kaplan, Huiyan Jin, Ivan Liang Zhang & Andrey Belyanin. (2012) Dissection of Pol II Trigger Loop Function and Pol II Activity–Dependent Control of Start Site Selection In Vivo. PLoS Genetics 8:4, pages e1002627.
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