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Molecular and Cellular Biology Volume 28, 2008 - Issue 18
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Article

Prep1 Deficiency Induces Protection from Diabetes and Increased Insulin Sensitivity through a p160-Mediated Mechanism

Francesco Oriente1 Dipartimento di Biologia e Patologia Cellulare e Molecolare & Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Università degli Studi di Napoli Federico II, Naples, Italy
,
Luis Cesar Fernandez Diaz3 IFOM (FIRC Institute of Molecular Oncology), via Adamello 16, 20134Milan, Italy
,
Claudia Miele1 Dipartimento di Biologia e Patologia Cellulare e Molecolare & Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Università degli Studi di Napoli Federico II, Naples, Italy
,
Salvatore Iovino1 Dipartimento di Biologia e Patologia Cellulare e Molecolare & Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Università degli Studi di Napoli Federico II, Naples, Italy
,
Silvia Mori3 IFOM (FIRC Institute of Molecular Oncology), via Adamello 16, 20134Milan, Italy
,
Victor Manuel Diaz4 Università Vita Salute San Raffaele, via Olgettina 60, 20132Milan, Italy
,
Giancarlo Troncone2 Dipartimento di Scienze Biomorfologiche e Funzionali, Università degli Studi di Napoli Federico II, Naples, Italy
,
Angela Cassese1 Dipartimento di Biologia e Patologia Cellulare e Molecolare & Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Università degli Studi di Napoli Federico II, Naples, Italy
,
Pietro Formisano1 Dipartimento di Biologia e Patologia Cellulare e Molecolare & Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Università degli Studi di Napoli Federico II, Naples, Italy
,
Francesco Blasi3 IFOM (FIRC Institute of Molecular Oncology), via Adamello 16, 20134Milan, Italy;4 Università Vita Salute San Raffaele, via Olgettina 60, 20132Milan, Italy
&
Francesco Beguinot1 Dipartimento di Biologia e Patologia Cellulare e Molecolare & Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Università degli Studi di Napoli Federico II, Naples, ItalyCorrespondence[email protected]
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Pages 5634-5645 | Received 22 Jan 2008, Accepted 04 Jul 2008, Published online: 27 Mar 2023

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Timo Kanzleiter, Michaela Rath, Dmitry Penkov, Dmytro Puchkov, Nadja Schulz, Francesco Blasi & Annette Schürmann. (2014) Pknox1/Prep1 Regulates Mitochondrial Oxidative Phosphorylation Components in Skeletal Muscle. Molecular and Cellular Biology 34:2, pages 290-298.
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Andreina Bruno, Caterina Di Sano, Hans-Uwe Simon, Pascal Chanez, Angelo Maria Patti, Serena Di Vincenzo, Paola Dino, Vittoria D’Esposito, Pietro Formisano, Francesco Beguinot & Elisabetta Pace. (2021) Leptin and TGF-β1 Downregulate PREP1 Expression in Human Adipose-Derived Mesenchymal Stem Cells and Mature Adipocytes. Frontiers in Cell and Developmental Biology 9.
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Blanca Felipe-Abrio & Amancio Carnero. (2020) The Tumor Suppressor Roles of MYBBP1A, a Major Contributor to Metabolism Plasticity and Stemness. Cancers 12:1, pages 254.
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Ilaria Cimmino, Francesca Margheri, Francesco Prisco, Giuseppe Perruolo, Vittoria D'Esposito, Anna Laurenzana, Gabriella Fibbi, Orlando Paciello, Nunzianna Doti, Menotti Ruvo, Claudia Miele, Francesco Beguinot, Pietro Formisano & Francesco Oriente. (2019) Prep1 regulates angiogenesis through a PGC‐1α‐mediated mechanism. The FASEB Journal 33:12, pages 13893-13904.
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Giorgia Maroni, Daniele Panetta, Raffaele Luongo, Indira Krishnan, Federica La Rosa, Daniela Campani, Piero Salvadori, Patricia Iozzo, Francesco Blasi, Dmitry Penkov, Elena Levantini & Maria Magli. (2019) The Role of Prep1 in the Regulation of Mesenchymal Stromal Cells. International Journal of Molecular Sciences 20:15, pages 3639.
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Blanca Felipe‐Abrio, Eva M. Verdugo‐Sivianes & Amancio Carnero. (2019) c‐MYB‐ and PGC1a‐dependent metabolic switch induced by MYBBP1A loss in renal cancer. Molecular Oncology 13:7, pages 1519-1533.
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Cécile L. Bandet, Sophie Tan-Chen, Olivier Bourron, Hervé Le Stunff & Eric Hajduch. (2019) Sphingolipid Metabolism: New Insight into Ceramide-Induced Lipotoxicity in Muscle Cells. International Journal of Molecular Sciences 20:3, pages 479.
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Luigi Albano, Paolo Emidio Macchia & Paola Ungaro. 2019. Handbook of Nutrition, Diet, and Epigenetics. Handbook of Nutrition, Diet, and Epigenetics 761 776 .
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Dan Ye, Guohua Lou, Tianbao Zhang, Fengqin Dong & Yanning Liu. (2018) MiR-17 family-mediated regulation of Pknox1 influences hepatic steatosis and insulin signaling. Journal of Cellular and Molecular Medicine 22:12, pages 6167-6175.
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Serena Ricci, Davide Viggiano, Ilaria Cimmino, Giuseppe Perruolo, Serena Cabaro, Antonietta Liotti, Francesca Fiory, Rosa Spinelli, Angelina Di Carlo, Francesco Beguinot, Pietro Formisano & Francesco Oriente. (2018) Prep1 Deficiency Affects Olfactory Perception and Feeding Behavior by Impairing BDNF-TrkB Mediated Neurotrophic Signaling. Molecular Neurobiology 55:8, pages 6801-6815.
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Francesco Oriente, Giuseppe Perruolo, Ilaria Cimmino, Serena Cabaro, Antonietta Liotti, Michele Longo, Claudia Miele, Pietro Formisano & Francesco Beguinot. (2018) Prep1, A Homeodomain Transcription Factor Involved in Glucose and Lipid Metabolism. Frontiers in Endocrinology 9.
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Antonietta Liotti, Serena Cabaro, Ilaria Cimmino, Serena Ricci, Claudio Procaccini, Orlando Paciello, Gregory A. Raciti, Rosa Spinelli, Susanna Iossa, Giuseppe Matarese, Claudia Miele, Pietro Formisano, Francesco Beguinot & Francesco Oriente. (2018) Prep1 deficiency improves metabolic response in white adipose tissue. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1863:5, pages 515-525.
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Ilaria Cimmino, Virginia Lorenzo, Francesca Fiory, Nunzianna Doti, Serena Ricci, Serena Cabaro, Antonietta Liotti, Luigi Vitagliano, Michele Longo, Claudia Miele, Pietro Formisano, Francesco Beguinot, Menotti Ruvo & Francesco Oriente. (2017) A peptide antagonist of Prep1-p160 interaction improves ceramide-induced insulin resistance in skeletal muscle cells. Oncotarget 8:42, pages 71845-71858.
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Luigi Albano, Paolo Emidio Macchia & Paola Ungaro. 2017. Handbook of Nutrition, Diet, and Epigenetics. Handbook of Nutrition, Diet, and Epigenetics 1 16 .
Konstantin Kulebyakin, Dmitry Penkov, Francesco Blasi, Zhanna Akopyan & Vsevolod Tkachuk. (2016) The transcription factor Prep1 controls hepatic insulin sensitivity and gluconeogenesis by targeting nuclear localization of FOXO1. Biochemical and Biophysical Research Communications 481:1-2, pages 182-188.
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Virginia Lorenzo, Fabiola Mascanzoni, Luigi Vitagliano, Menotti Ruvo & Nunzianna Doti. (2016) The Interacting Domains of PREP1 and p160 are Endowed with a Remarkable Structural Stability. Molecular Biotechnology 58:5, pages 328-339.
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D. N. Penkov, Zh. A. Akopyan, T. N. Kochegura & A. D. Egorov. (2016) Transcriptional control of insulin-sensitive glucose carrier Glut4 expression in adipose tissue cells. Doklady Biochemistry and Biophysics 467:1, pages 145-149.
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Salvatore Iovino, Alison M. Burkart, Laura Warren, Mary Elizabeth Patti & C. Ronald Kahn. (2016) Myotubes derived from human-induced pluripotent stem cells mirror in vivo insulin resistance. Proceedings of the National Academy of Sciences 113:7, pages 1889-1894.
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Gregory Alexander Raciti, Michele Longo, Luca Parrillo, Marco Ciccarelli, Paola Mirra, Paola Ungaro, Pietro Formisano, Claudia Miele & Francesco Béguinot. (2015) Understanding type 2 diabetes: from genetics to epigenetics. Acta Diabetologica 52:5, pages 821-827.
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Audrey Laurent, Manuela Calabrese, Hans-Jörg Warnatz, Marie-Laure Yaspo, Vsevolod Tkachuk, Miguel Torres, Francesco Blasi & Dmitry Penkov. (2015) ChIP-Seq and RNA-Seq Analyses Identify Components of the Wnt and Fgf Signaling Pathways as Prep1 Target Genes in Mouse Embryonic Stem Cells. PLOS ONE 10:4, pages e0122518.
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Maurizio RisolinoNadia MandiaFrancescopaolo IavaroneLeila DardaeiElena LongobardiSerena FernandezFrancesco TalottaFabrizio BianchiFederica PisatiLorenzo SpaggiariPatrick N. Harter, Michel Mittelbronn, Dorothea Schulte, Mariarosaria Incoronato, Pier Paolo Di FioreFrancesco BlasiPasquale Verde. (2014) Transcription factor PREP1 induces EMT and metastasis by controlling the TGF-β–SMAD3 pathway in non-small cell lung adenocarcinoma. Proceedings of the National Academy of Sciences 111:36.
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Gregory Alexander Raciti, Cecilia Nigro, Michele Longo, Luca Parrillo, Claudia Miele, Pietro Formisano & Francesco Béguinot. (2014) Personalized medicine and Type 2 diabetes: lesson from epigenetics. Epigenomics 6:2, pages 229-238.
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E. Longobardi, D. Penkov, D. Mateos, G. Florian, M. Torres & Francesco Blasi. (2013) Biochemistry of the tale transcription factors PREP, MEIS, and PBX in vertebrates. Developmental Dynamics 243:1, pages 59-75.
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Francesco Oriente, Serena Cabaro, Antonietta Liotti, Michele Longo, Luca Parrillo, Teresa Bruna Pagano, Gregory Alexander Raciti, Dmitry Penkov, Orlando Paciello, Claudia Miele, Pietro Formisano, Francesco Blasi & Francesco Beguinot. (2013) PREP1 deficiency downregulates hepatic lipogenesis and attenuates steatohepatitis in mice. Diabetologia 56:12, pages 2713-2722.
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Noemí Rueda, Jesús Flórez & Carmen Martínez-Cué. (2012) Apoptosis in Down’s syndrome: lessons from studies of human and mouse models. Apoptosis 18:2, pages 121-134.
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D. N. Penkov, A. D. Egorov, M. N. Mozgovaya & V. A. Tkachuk. (2013) Insulin resistance and adipogenesis: Role of transcription and secreted factors. Biochemistry (Moscow) 78:1, pages 8-18.
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Bertrand Chin-Ming Tan, Chang-Ching Yang, Chia-Ling Hsieh, Yin-Hsiang Chou, Chang-Zheng Zhong, Benjamin Yat-Ming Yung & Hsuan Liu. (2012) Epigeneitc silencing of ribosomal RNA genes by Mybbp1a. Journal of Biomedical Science 19:1.
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Chang-Ching Yang, Hsuan Liu, Shen Liang Chen, Tzu-Hao Wang, Chia-Ling Hsieh, Yi Huang, Shu-Jen Chen, Hua-Chien Chen, Benjamin Yat-Ming Yung & Bertrand Chin-Ming Tan. (2012) Epigenetic silencing of myogenic gene program by Myb-binding protein 1a suppresses myogenesis. The EMBO Journal 31:7, pages 1739-1751.
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F. Fiory, A. Lombardi, C. Miele, J. Giudicelli, F. Beguinot & E. Van Obberghen. (2011) Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E. Diabetologia 54:11, pages 2941-2952.
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Francesco OrienteSalvatore IovinoSerena CabaroAngela CasseseElena LongobardiClaudia MielePaola UngaroPietro FormisanoFrancesco BlasiFrancesco Beguinot. (2011) Prep1 Controls Insulin Glucoregulatory Function in Liver by Transcriptional Targeting of SHP1 Tyrosine Phosphatase . Diabetes 60:1, pages 138-147.
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Elisa Bernardi, Gianluca Deflorian, Federica Pezzinenti, Victor M. Diaz, Marina Mione & Francesco Blasi. (2010) Characterization of the Regulatory Region of the Zebrafish Prep1.1 Gene: Analogies to the Promoter of the Human PREP1. PLoS ONE 5:12, pages e15047.
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Nicola Micali, Elena Longobardi, Giorgio Iotti, Carmelo Ferrai, Laura Castagnaro, Mario Ricciardi, Francesco Blasi & Massimo P. Crippa. (2010) Down syndrome fibroblasts and mouse Prep1-overexpressing cells display increased sensitivity to genotoxic stress. Nucleic Acids Research 38:11, pages 3595-3604.
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Francesco Blasi. (2009) Prep1. AfCS-Nature Molecule Pages.
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