42
Views
51
CrossRef citations to date
0
Altmetric
Article

Regulation of Cell Migration by Sphingomyelin Synthases: Sphingomyelin in Lipid Rafts Decreases Responsiveness to Signaling by the CXCL12/CXCR4 Pathway

, , , , , , , , , , & show all
Pages 3242-3252 | Received 25 Jan 2012, Accepted 30 May 2012, Published online: 20 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Song Mao & Songming Huang. (2014) The signaling pathway of stromal cell-derived factor-1 and its role in kidney diseases. Journal of Receptors and Signal Transduction 34:2, pages 85-91.
Read now

Articles from other publishers (50)

Beatrice Foglia, Marc Beltrà, Salvatore Sutti & Stefania Cannito. (2023) Metabolic Reprogramming of HCC: A New Microenvironment for Immune Responses. International Journal of Molecular Sciences 24:8, pages 7463.
Crossref
Juliette Vanderroost, Noémie Avalosse, Danahe Mohammed, Delia Hoffmann, Patrick Henriet, Christophe E. Pierreux, David Alsteens & Donatienne Tyteca. (2023) Cholesterol and Sphingomyelin Polarize at the Leading Edge of Migrating Myoblasts and Involve Their Clustering in Submicrometric Domains. Biomolecules 13:2, pages 319.
Crossref
Kotaro Sakamoto, Satoshi Asano, Yukio Ago & Takatsugu Hirokawa. (2022) AlphaFold version 2.0 elucidates the binding mechanism between VIPR2 and KS-133, and reveals an S–S bond (Cys25−Cys192) formation of functional significance for VIPR2. Biochemical and Biophysical Research Communications 636, pages 10-16.
Crossref
Xin Tracy Liu, Long Hoa Chung, Da Liu, Jinbiao Chen, Yu Huang, Jonathan D. Teo, Xingxing Daisy Han, Yinan Zhao, Fiona H. X. Guan, Collin Tran, Jun Yup Lee, Timothy A. Couttas, Ken Liu, Geoffery W. McCaughan, Mark D. Gorrell, Anthony S. Don, Shubiao Zhang & Yanfei Qi. (2022) Ablation of sphingosine kinase 2 suppresses fatty liver-associated hepatocellular carcinoma via downregulation of ceramide transfer protein. Oncogenesis 11:1.
Crossref
Satoshi Asano, Yuka Maetani, Yukio Ago & Takashi Kanematsu. (2022) Phospholipase C-related catalytically inactive protein enhances cisplatin-induced apoptotic cell death. European Journal of Pharmacology 933, pages 175273.
Crossref
Satoshi Asano, Misa Yamasaka, Kairi Ozasa, Kotaro Sakamoto, Atsuko Hayata-Takano, Takanobu Nakazawa, Hitoshi Hashimoto, James A. Waschek & Yukio Ago. (2022) Vasoactive intestinal peptide–VIPR2 signaling regulates tumor cell migration. Frontiers in Oncology 12.
Crossref
Sofía R. Gardeta, Eva M. García-Cuesta, Gianluca D’Agostino, Blanca Soler Palacios, Adriana Quijada-Freire, Pilar Lucas, Jorge Bernardino de la Serna, Carolina Gonzalez-Riano, Coral Barbas, José Miguel Rodríguez-Frade & Mario Mellado. (2022) Sphingomyelin Depletion Inhibits CXCR4 Dynamics and CXCL12-Mediated Directed Cell Migration in Human T Cells. Frontiers in Immunology 13.
Crossref
Jun Fujita, Makoto Taniguchi, Chieko Hashizume, Yoshibumi Ueda, Shota Sakai, Tadakazu Kondo, Mayumi Hashimoto-Nishimura, Kentaro Hanada, Takeo Kosaka & Toshiro Okazaki. (2022) Nuclear Ceramide Is Associated with Ataxia Telangiectasia Mutated Activation in the Neocarzinostatin-Induced Apoptosis of Lymphoblastoid Cells. Molecular Pharmacology 101:5, pages 322-333.
Crossref
Mariko Komuro, Masaki Nagane, Tomoki Fukuyama, Xiaolin Luo, Shinobu Hiraki, Masakatsu Miyanabe, Miyuki Ishikawa, Chiaki Niwa, Hironobu Murakami, Mariko Okamoto & Tadashi Yamashita. (2022) Sphingomyelin maintains the cutaneous barrier via regulation of the STAT3 pathway. The FASEB Journal 36:4.
Crossref
Tore Skotland & Kirsten Sandvig. (2022) Need for more focus on lipid species in studies of biological and model membranes. Progress in Lipid Research 86, pages 101160.
Crossref
Long Hoa Chung, Da Liu, Xin Tracy Liu & Yanfei Qi. (2021) Ceramide Transfer Protein (CERT): An Overlooked Molecular Player in Cancer. International Journal of Molecular Sciences 22:24, pages 13184.
Crossref
Arantza Perez-Valle, Beatriz Abad-García, Olatz Fresnedo, Gabriel Barreda-Gómez, Patricia Aspichueta, Aintzane Asumendi, Egoitz Astigarraga, José A. Fernández, María Dolores Boyano & Begoña Ochoa. (2021) A UHPLC-Mass Spectrometry View of Human Melanocytic Cells Uncovers Potential Lipid Biomarkers of Melanoma. International Journal of Molecular Sciences 22:21, pages 12061.
Crossref
Makoto Taniguchi & Toshiro Okazaki. (2021) Role of ceramide/sphingomyelin (SM) balance regulated through “SM cycle” in cancer. Cellular Signalling 87, pages 110119.
Crossref
Yoritaka FujiiMakoto Taniguchi, Shingo NagayaYoshibumi UedaChieko Hashizume, Ken WatanabeHiroyuki Takeya, Takeo KosakaToshiro Okazaki. (2021) A novel mechanism of thrombocytopenia by PS exposure through TMEM16F in sphingomyelin synthase 1 deficiency. Blood Advances 5:20, pages 4265-4277.
Crossref
Michele Dei Cas, Rita Paroni, Paola Signorelli, Alessandra Mirarchi, Laura Cerquiglini, Stefania Troiani, Samuela Cataldi, Michela Codini, Tommaso Beccari, Riccardo Ghidoni & Elisabetta Albi. (2020) Human breast milk as source of sphingolipids for newborns: comparison with infant formulas and commercial cow’s milk. Journal of Translational Medicine 18:1.
Crossref
Koichi Eguchi, Daisuke Mikami, Hui Sun, Takuya Tsumita, Kaori Takahashi, Katsuyuki Mukai, Kohei Yuyama & Yasuyuki Igarashi. (2020) Blood-brain barrier permeability analysis of plant ceramides. PLOS ONE 15:11, pages e0241640.
Crossref
Makoto Taniguchi, Yoshibumi Ueda, Michiko Matsushita, Shingo Nagaya, Chieko Hashizume, Kenta Arai, Kazuya Kabayama, Koichi Fukase, Ken Watanabe, Lusi Oka Wardhani, Kazuhiko Hayashi & Toshiro Okazaki. (2020) Deficiency of sphingomyelin synthase 2 prolongs survival by the inhibition of lymphoma infiltration through ICAM‐1 reduction. The FASEB Journal 34:3, pages 3838-3854.
Crossref
Bin-Bin Li, Zheng-Yang Chen, Nan Jiang, Song Guo, Jia-Qi Yang, Shao-Bin Chai, Hong-Feng Yan, Pei-Ming Sun, Gang Hu, Tao Zhang, Bing-Xin Xu, Hong-Wei Sun, Jin-Lian Zhou, He-Ming Yang & Yan Cui. (2020) Simulated microgravity significantly altered metabolism in epidermal stem cells. In Vitro Cellular & Developmental Biology - Animal 56:3, pages 200-212.
Crossref
Makoto Taniguchi & Toshiro Okazaki. (2020) Ceramide/Sphingomyelin Rheostat Regulated by Sphingomyelin Synthases and Chronic Diseases in Murine Models. Journal of Lipid and Atherosclerosis 9:3, pages 380.
Crossref
Satoshi Asano, Yasuka Ikura, Mitsuki Nishimoto, Yosuke Yamawaki, Kozue Hamao, Keiju Kamijo, Masato Hirata & Takashi Kanematsu. (2019) Phospholipase C-related catalytically inactive protein regulates cytokinesis by protecting phosphatidylinositol 4,5-bisphosphate from metabolism in the cleavage furrow. Scientific Reports 9:1.
Crossref
Elita Avota, Maria Nathalia de Lira & Sibylle Schneider-Schaulies. (2019) Sphingomyelin Breakdown in T Cells: Role of Membrane Compartmentalization in T Cell Signaling and Interference by a Pathogen. Frontiers in Cell and Developmental Biology 7.
Crossref
Justin M. Snider, Chiara Luberto & Yusuf A. Hannun. (2019) Approaches for probing and evaluating mammalian sphingolipid metabolism. Analytical Biochemistry 575, pages 70-86.
Crossref
Yun, Song, Hwang, Lee, Lee, Kang & Lee. (2019) Potential Nutritional and Metabolomic Advantages of High Fat Oral Supplementation in Pancreatectomized Pancreaticobiliary Cancer Patients. Nutrients 11:4, pages 893.
Crossref
Yeon-Jeong Kim, Peter Greimel & Yoshio Hirabayashi. (2018) GPRC5B-Mediated Sphingomyelin Synthase 2 Phosphorylation Plays a Critical Role in Insulin Resistance. iScience 8, pages 250-266.
Crossref
Govind KunduriDaniel Turner-EvansYutaka KonyaYoshihiro Izumi, Kunio NagashimaStephen LockettJoost HolthuisTakeshi BambaUsha Acharya & Jairaj K. Acharya. (2018) Defective cortex glia plasma membrane structure underlies light-induced epilepsy in cpes mutants . Proceedings of the National Academy of Sciences 115:38.
Crossref
Elin Rebecka Carlsson, Josefine Liv Gilling Grundtvig, Sten Madsbad & Mogens Fenger. (2018) Changes in Serum Sphingomyelin After Roux-en-Y Gastric Bypass Surgery Are Related to Diabetes Status. Frontiers in Endocrinology 9.
Crossref
Giovanni D'Angelo, Sitapriya Moorthi & Chiara Luberto. 2018. Sphingolipids in Cancer. Sphingolipids in Cancer 61 96 .
Orestes López-Ortega & Leopoldo Santos-Argumedo. (2017) Myosin 1g Contributes to CD44 Adhesion Protein and Lipid Rafts Recycling and Controls CD44 Capping and Cell Migration in B Lymphocytes. Frontiers in Immunology 8.
Crossref
Toshio Ohnishi, Chieko Hashizume, Makoto Taniguchi, Hidehiro Furumoto, Jia Han, Rongfen Gao, Shinichi Kinami, Takeo Kosaka & Toshiro Okazaki. (2017) Sphingomyelin synthase 2 deficiency inhibits the induction of murine colitis‐associated colon cancer. The FASEB Journal 31:9, pages 3816-3830.
Crossref
Hye-Youn Kim, Hwanhui Lee, So-Hyun Kim, Hanyong Jin, Jeehyeon Bae & Hyung-Kyoon Choi. (2017) Discovery of potential biomarkers in human melanoma cells with different metastatic potential by metabolic and lipidomic profiling. Scientific Reports 7:1.
Crossref
Yasuhiro Hayashi, Yoko Nemoto-Sasaki, Naoki Matsumoto, Takashi Tanikawa, Saori Oka, Yusuke Tanaka, Seisuke Arai, Ikuo Wada, Takayuki Sugiura & Atsushi Yamashita. (2017) Carboxyl-terminal Tail-mediated Homodimerizations of Sphingomyelin Synthases Are Responsible for Efficient Export from the Endoplasmic Reticulum. Journal of Biological Chemistry 292:3, pages 1122-1141.
Crossref
Olga Alekhina & Adriano Marchese. (2016) β-Arrestin1 and Signal-transducing Adaptor Molecule 1 (STAM1) Cooperate to Promote Focal Adhesion Kinase Autophosphorylation and Chemotaxis via the Chemokine Receptor CXCR4. Journal of Biological Chemistry 291:50, pages 26083-26097.
Crossref
Makoto Taniguchi, Takafumi Tasaki, Hideaki Ninomiya, Yoshibumi Ueda, Koh-ichi Kuremoto, Susumu Mitsutake, Yasuyuki Igarashi, Toshiro Okazaki & Tsutomu Takegami. (2016) Sphingomyelin generated by sphingomyelin synthase 1 is involved in attachment and infection with Japanese encephalitis virus. Scientific Reports 6:1.
Crossref
Masayuki Sugimoto, Yoichi Shimizu, Takeshi Yoshioka, Masato Wakabayashi, Yukari Tanaka, Kenichi Higashino, Yoshito Numata, Shota Sakai, Akio Kihara, Yasuyuki Igarashi & Yuji Kuge. (2015) Histological analyses by matrix-assisted laser desorption/ionization-imaging mass spectrometry reveal differential localization of sphingomyelin molecular species regulated by particular ceramide synthase in mouse brains. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1851:12, pages 1554-1565.
Crossref
Hideo Ogiso, Makoto Taniguchi & Toshiro Okazaki. (2015) Analysis of lipid-composition changes in plasma membrane microdomains. Journal of Lipid Research 56:8, pages 1594-1605.
Crossref
Kazuyuki Kitatani, Makoto Taniguchi & Toshiro Okazaki. (2015) Role of Sphingolipids and Metabolizing Enzymes in Hematological Malignancies. Molecules and Cells 38:6, pages 482-495.
Crossref
Umadevi V. Wesley, James F. Hatcher & Robert J. Dempsey. (2014) Sphingomyelin Synthase 1 Regulates Neuro-2a Cell Proliferation and Cell Cycle Progression Through Modulation of p27 Expression and Akt Signaling. Molecular Neurobiology 51:3, pages 1530-1541.
Crossref
V Edmond, F Dufour, G Poiroux, K Shoji, M Malleter, A Fouqué, S Tauzin, R Rimokh, O Sergent, A Penna, A Dupuy, T Levade, N Theret, O Micheau, B Ségui & P Legembre. (2014) Downregulation of ceramide synthase-6 during epithelial-to-mesenchymal transition reduces plasma membrane fluidity and cancer cell motility. Oncogene 34:8, pages 996-1005.
Crossref
Hua Ren, Chengwei Zhang, Liwei Su, Xin Bi, Chao Wang, Liang Wang & Bo Wu. (2015) Type II anti-CD20 mAb-induced lysosome mediated cell death is mediated through a ceramide-dependent pathway. Biochemical and Biophysical Research Communications 457:4, pages 572-577.
Crossref
Chih-Yun Hsia, Mark J. Richards & Susan Daniel. (2015) A review of traditional and emerging methods to characterize lipid–protein interactions in biological membranes. Analytical Methods 7:17, pages 7076-7094.
Crossref
Hirofumi Sawai, Makoto Taniguchi & Toshiro Okazaki. 2015. Bioactive Sphingolipids in Cancer Biology and Therapy. Bioactive Sphingolipids in Cancer Biology and Therapy 23 51 .
Alberto Ouro, Lide Arana, Io-Guané Rivera, Marta Ordoñez, Ana Gomez-Larrauri, Natalia Presa, Jorge Simón, Miguel Trueba, Patricia Gangoiti, Robert Bittman & Antonio Gomez-Muñoz. (2014) Phosphatidic acid inhibits ceramide 1-phosphate-stimulated macrophage migration. Biochemical Pharmacology 92:4, pages 642-650.
Crossref
Yasuhiro Hayashi, Yoko Nemoto-Sasaki, Takashi Tanikawa, Saori Oka, Kiyoto Tsuchiya, Kouta Zama, Susumu Mitsutake, Takayuki Sugiura & Atsushi Yamashita. (2014) Sphingomyelin Synthase 2, but Not Sphingomyelin Synthase 1, Is Involved in HIV-1 Envelope-mediated Membrane Fusion. Journal of Biological Chemistry 289:44, pages 30842-30856.
Crossref
Françoise Hullin-Matsuda, Tomohiko Taguchi, Peter Greimel & Toshihide Kobayashi. (2014) Lipid compartmentalization in the endosome system. Seminars in Cell & Developmental Biology 31, pages 48-56.
Crossref
Aaron Muth, Veethika Pandey, Navneet Kaur, Melissa Wason, Cheryl Baker, Xianlin Han, Teresa R. Johnson, Deborah A. Altomare & Otto PhanstielIVIV. (2014) Synthesis and Biological Evaluation of Antimetastatic Agents Predicated upon Dihydromotuporamine C and Its Carbocyclic Derivatives. Journal of Medicinal Chemistry 57:10, pages 4023-4034.
Crossref
Makoto Taniguchi & Toshiro Okazaki. (2014) The role of sphingomyelin and sphingomyelin synthases in cell death, proliferation and migration—from cell and animal models to human disorders. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1841:5, pages 692-703.
Crossref
Mitsuhiro Abe & Toshihide Kobayashi. (2014) Imaging local sphingomyelin-rich domains in the plasma membrane using specific probes and advanced microscopy. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1841:5, pages 720-726.
Crossref
Federica Migliardo, Hatem Tallima & Rashika El Ridi. (2014) Rigidity and resistance of larval- and adult schistosomes-medium interface. Biochemical and Biophysical Research Communications 446:1, pages 255-260.
Crossref
Hideo Ogiso, Makoto Taniguchi, Shinichi Araya, Shinya Aoki, Lusi Wardhani, Yuka Yamashita, Yoshibumi Ueda & Toshiro Okazaki. (2014) Comparative Analysis of Biological Sphingolipids with Glycerophospholipids and Diacylglycerol by LC-MS/MS. Metabolites 4:1, pages 98-114.
Crossref
Bryan Stephens & Tracy M. Handel. 2013. Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors. Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors 375 420 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.