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Molecular and Cellular Biology Volume 34, 2014 - Issue 13
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Article

The Pim-1 Protein Kinase Is an Important Regulator of MET Receptor Tyrosine Kinase Levels and Signaling

Bo Cena Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA;c The Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, USACorrespondence[email protected] [email protected]
,
Ying Xiongd Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
,
Jin H. Songb Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA;c The Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, USA
,
Sandeep Mahajanc The Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, USA
,
Rachel DuPontf Oncology iMed, AstraZeneca, Waltham, Massachusetts, USA
,
Kristen McEachernf Oncology iMed, AstraZeneca, Waltham, Massachusetts, USA
,
Daniel J. DeAngelog Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
,
Jorge E. Cortesh Department of Leukemia, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA
,
Mark D. Mindeni Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada
,
Allen Ebensj Genentech, Inc., South San Francisco, California, USA
,
Alice Mimsa Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
,
Amanda C. LaRuec The Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, USA;d Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA;e Research Services, Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina, USA
&
Andrew S. Krafta Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA;c The Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, USACorrespondence[email protected] [email protected]
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Pages 2517-2532 | Received 28 Jan 2014, Accepted 15 Apr 2014, Published online: 20 Mar 2023

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Aziz ur Rehman Aziz, Sumbal Farid, Kairong Qin, Hanqin Wang & Bo Liu. (2020) Regulation of insulin resistance and glucose metabolism by interaction of PIM kinases and insulin receptor substrates. Archives of Physiology and Biochemistry 126:2, pages 129-138.
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Lisa S. Chen, Ji-Yeon Yang, Han Liang, Jorge E. Cortes & Varsha Gandhi. (2016) Protein profiling identifies mTOR pathway modulation and cytostatic effects of Pim kinase inhibitor, AZD1208, in acute myeloid leukemia. Leukemia & Lymphoma 57:12, pages 2863-2873.
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Aanchal Rathi, Dhiraj Kumar, Gulam Mustafa Hasan, Mohammad Mahfuzul Haque & Md Imtaiyaz Hassan. (2021) Therapeutic targeting of PIM KINASE signaling in cancer therapy: Structural and clinical prospects. Biochimica et Biophysica Acta (BBA) - General Subjects 1865:11, pages 129995.
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Andrea L. Casillas, Shailender S. Chauhan, Rachel K. Toth, Alva G. Sainz, Amber N. Clements, Corbin C. Jensen, Paul R. Langlais, Cindy K. Miranti, Anne E. Cress & Noel A. Warfel. (2021) Direct phosphorylation and stabilization of HIF-1α by PIM1 kinase drives angiogenesis in solid tumors. Oncogene 40:32, pages 5142-5152.
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Jeremiah J Bearss, Sathish KR Padi, Neha Singh, Marina Cardo‐Vila, Jin H Song, Ghassan Mouneimne, Nikita Fernandes, Yang Li, Matthew R Harter, Jaime MC Gard, Anne E Cress, Wolfgang Peti, Andrew DL Nelson, J Ross Buchan, Andrew S Kraft & Koichi Okumura. (2021) EDC3 phosphorylation regulates growth and invasion through controlling P‐body formation and dynamics. EMBO reports 22:4.
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Hwangseo Park, Jinwon Jeon, Kewon Kim, Soyeon Choi & Sungwoo Hong. (2021) Structure-Based Virtual Screening and De Novo Design of PIM1 Inhibitors with Anticancer Activity from Natural Products. Pharmaceuticals 14:3, pages 275.
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Iwona Bednarz-Misa, Mariusz A. Bromke & Małgorzata Krzystek-Korpacka. 2021. Tumor Microenvironment. Tumor Microenvironment 9 49 .
Niina M. Santio, Veera Vainio, Tuuli Hoikkala, Kwan Long Mung, Mirka Lång, Riitta Vahakoski, Justyna Zdrojewska, Eleanor T. Coffey, Elena Kremneva, Eeva-Marja Rainio & Päivi J. Koskinen. (2020) PIM1 accelerates prostate cancer cell motility by phosphorylating actin capping proteins. Cell Communication and Signaling 18:1.
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Chenjing Zhu, Huashan Shi, Min Wu & Xiawei Wei. (2020) A dual MET/AXL small‐molecule inhibitor exerts efficacy against gastric carcinoma through killing cancer cells as well as modulating tumor microenvironment. MedComm 1:1, pages 103-118.
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Sean P. Kennedy, Michael O’Neill, Darren Cunningham, Patrick G. Morris, Sinead Toomey, Carmen Blanco-Aparicio, Sonia Martinez, Joaquin Pastor, Alex J. Eustace & Bryan T. Hennessy. (2020) Preclinical evaluation of a novel triple-acting PIM/PI3K/mTOR inhibitor, IBL-302, in breast cancer. Oncogene 39:14, pages 3028-3040.
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Tom Malone, Lea Schäfer, Nathalie Simon, Susan Heavey, Sinead Cuffe, Stephen Finn, Gillian Moore & Kathy Gately. (2020) Current perspectives on targeting PIM kinases to overcome mechanisms of drug resistance and immune evasion in cancer. Pharmacology & Therapeutics 207, pages 107454.
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Watanabe, Nogami, Okada, Akiyama, Umezawa & Miura. (2019) FLT3-ITD Activates RSK1 to Enhance Proliferation and Survival of AML Cells by Activating mTORC1 and eIF4B Cooperatively with PIM or PI3K and by Inhibiting Bad and BIM. Cancers 11:12, pages 1827.
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Sathish K. R. PadiNeha SinghJeremiah J. BearssVirginie OliveJin H. SongMarina Cardó-VilaAndrew S. KraftKoichi Okumura. (2019) Phosphorylation of DEPDC5, a component of the GATOR1 complex, releases inhibition of mTORC1 and promotes tumor growth. Proceedings of the National Academy of Sciences 116:41, pages 20505-20510.
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Juan Yang, Rui Li, Dan Zhao & Sheng Zheng. (2019) Downregulation of microRNA‐214 improves therapeutic potential of allogeneic bone marrow–derived mesenchymal stem cell by targeting PIM‐1 in rats with acute liver failure. Journal of Cellular Biochemistry 120:8, pages 12887-12903.
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Fabiola Cervantes-Gomez, Christine M. Stellrecht, Mary L. Ayres, Michael J. Keating, William G. Wierda & Varsha Gandhi. (2019) PIM kinase inhibitor, AZD1208, inhibits protein translation and induces autophagy in primary chronic lymphocytic leukemia cells. Oncotarget 10:29, pages 2793-2809.
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Lianjing Cao, Fan Wang, Shouying Li, Xinyue Wang, Dingzhi Huang & Richeng Jiang. (2019) PIM1 kinase promotes cell proliferation, metastasis and tumor growth of lung adenocarcinoma by potentiating the c-MET signaling pathway. Cancer Letters 444, pages 116-126.
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Bandish Kapadia, Nahid M. Nanaji, Kavita Bhalla, Binny Bhandary, Rena Lapidus, Afshin Beheshti, Andrew M. Evens & Ronald B. Gartenhaus. (2018) Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL. Nature Communications 9:1.
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Aziz Aziz, Sumbal Farid, Kairong Qin, Hanqin Wang & Bo Liu. (2018) PIM Kinases and Their Relevance to the PI3K/AKT/mTOR Pathway in the Regulation of Ovarian Cancer. Biomolecules 8:1, pages 7.
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Niina M. Santio & Päivi J. Koskinen. (2017) PIM kinases: From survival factors to regulators of cell motility. The International Journal of Biochemistry & Cell Biology 93, pages 74-85.
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Ningfei An, Bo Cen, Houjian Cai, Jin H. Song, Andrew Kraft & Yubin Kang. (2016) Pim1 kinase regulates c-Kit gene translation. Experimental Hematology & Oncology 5:1.
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Ryan P. Wurz, Christine Sastri, Derin C. D’Amico, Brad Herberich, Claire L.M. Jackson, Liping H. Pettus, Andrew S. Tasker, Bin Wu, Nadia Guerrero, J. Russell Lipford, Jeffrey T. Winston, Yajing Yang, Paul Wang, Yen Nguyen, Kristin L. Andrews, Xin Huang, Matthew R. Lee, Christopher Mohr, J.D. Zhang, Darren L. Reid, Yang Xu, Yihong Zhou & Hui-Ling Wang. (2016) Discovery of imidazopyridazines as potent Pim-1/2 kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 26:22, pages 5580-5590.
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Goodwin G. Jinesh, Sharada Mokkapati, Keyi Zhu & Edwin E. Morales. (2016) Pim kinase isoforms: devils defending cancer cells from therapeutic and immune attacks. Apoptosis 21:11, pages 1203-1213.
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Yubao WangMichael BegleyQing LiHai-Tsang HuangAna LakoMichael J. EckNathanael S. GrayTimothy J. MitchisonLewis C. Cantley & Jean J. Zhao. (2016) Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival. Proceedings of the National Academy of Sciences 113:35, pages 9810-9815.
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Danni Deng, Lei Wang, Yao Chen, Bowen Li, Lian Xue, Naiyuan Shao, Qiang Wang, Xiwei Xia, Yilin Yang & Feng Zhi. (2016) MicroRNA‐124‐3p regulates cell proliferation, invasion, apoptosis, and bioenergetics by targeting PIM1 in astrocytoma. Cancer Science 107:7, pages 899-907.
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Yunfei Liao, Yong Feng, Jacson Shen, Yan Gao, Gregory Cote, Edwin Choy, David Harmon, Henry Mankin, Francis Hornicek & Zhenfeng Duan. (2016) Clinical and biological significance of PIM1 kinase in osteosarcoma. Journal of Orthopaedic Research 34:7, pages 1185-1194.
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Jin H. Song, Sathish K. R. Padi, Libia A. Luevano, Mark D. Minden, Daniel J. DeAngelo, Gary Hardiman, Lauren E. Ball, Noel A. Warfel & Andrew S. Kraft. (2016) Insulin receptor substrate 1 is a substrate of the Pim protein kinases. Oncotarget 7:15, pages 20152-20165.
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Jack Zhang & Andy Babic. (2016) Regulation of the MET oncogene: molecular mechanisms . Carcinogenesis 37:4, pages 345-355.
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YERNAR TURSYNBAY, JINFU ZHANG, ZHI LI, TURSONJAN TOKAY, ZHAXYBAY ZHUMADILOV, DENGLONG WU & YINGQIU XIE. (2016) Pim-1 kinase as cancer drug target: An update. Biomedical Reports 4:2, pages 140-146.
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YINGQIU XIE & SAMAT BAYAKHMETOV. (2016) PIM1 kinase as a promise of targeted therapy in prostate cancer stem cells. Molecular and Clinical Oncology 4:1, pages 13-17.
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Ming Chen, Bing Yi, Ni Zhu, Xin Wei, Guan-Xin Zhang, Shengdong Huang & Jianxin Sun. (2016) Pim1 kinase promotes angiogenesis through phosphorylation of endothelial nitric oxide synthase at Ser-633. Cardiovascular Research 109:1, pages 141-150.
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Ningfei An, Ying Xiong, Amanda C. LaRue, Andrew S. Kraft & Bo Cen. (2015) Activation of Pim Kinases Is Sufficient to Promote Resistance to MET Small-Molecule Inhibitors. Cancer Research 75:24, pages 5318-5328.
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Martín Roffé, Fernanda C. Lupinacci, Luana C. Soares, Glaucia N. Hajj & Vilma R. Martins. (2015) Two widely used RSK inhibitors, BI-D1870 and SL0101, alter mTORC1 signaling in a RSK-independent manner. Cellular Signalling 27:8, pages 1630-1642.
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Noel A. Warfel & Andrew S. Kraft. (2015) PIM kinase (and Akt) biology and signaling in tumors. Pharmacology & Therapeutics 151, pages 41-49.
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Marina Y. Zemskova, Jin H. Song, Bo Cen, Javier Cerda-Infante, Viviana P. Montecinos & Andrew S. Kraft. (2015) Regulation of prostate stromal fibroblasts by the PIM1 protein kinase. Cellular Signalling 27:1, pages 135-146.
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