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Article

T-Cell Receptor Microclusters Critical for T-Cell Activation Are Formed Independently of Lipid Raft Clustering

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Pages 3421-3429 | Received 09 Feb 2010, Accepted 07 May 2010, Published online: 20 Mar 2023

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Iztok Urbančič, Lisa Schiffelers, Edward Jenkins, Weijian Gong, Ana Mafalda Santos, Falk Schneider, Caitlin O’Brien‐Ball, Mai Tuyet Vuong, Nicole Ashman, Erdinc Sezgin & Christian Eggeling. (2021) Aggregation and mobility of membrane proteins interplay with local lipid order in the plasma membrane of T cells. FEBS Letters 595:16, pages 2127-2146.
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Yiyuan Gao, Yuedi Wang, Feifei Luo & Yiwei Chu. (2021) Optimization of T Cell Redirecting Strategies: Obtaining Inspirations From Natural Process of T Cell Activation. Frontiers in Immunology 12.
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Micaela G. Fosdick, Pratik Rajesh Chheda, Phuong M. Tran, Alex Wolff, Ronal Peralta, Michael Y. Zhang, Robert Kerns & Jon C. D. Houtman. (2021) Suppression of human T cell activation by derivatives of glycerol monolaurate. Scientific Reports 11:1.
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Zhaoqian Su, Kalyani Dhusia & Yinghao Wu. (2021) Understanding the impacts of cellular environments on ligand binding of membrane receptors by computational simulations. The Journal of Chemical Physics 154:5, pages 055101.
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Lakshmi Balagopalan, Kumarkrishna Raychaudhuri & Lawrence E. Samelson. (2021) Microclusters as T Cell Signaling Hubs: Structure, Kinetics, and Regulation. Frontiers in Cell and Developmental Biology 8.
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Loredana Saveanu, Andres E. Zucchetti, Irini Evnouchidou, Laurence Ardouin & Claire Hivroz. (2019) Is there a place and role for endocytic TCR signaling? . Immunological Reviews 291:1, pages 57-74.
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Jiawen Chen, Bo Wang & Yinghao Wu. (2018) Structural Characterization and Function Prediction of Immunoglobulin-like Fold in Cell Adhesion and Cell Signaling. Journal of Chemical Information and Modeling 58:2, pages 532-542.
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Fany M. Iseka, Benjamin T. Goetz, Insha Mushtaq, Wei An, Luke R. Cypher, Timothy A. Bielecki, Eric C. Tom, Priyanka Arya, Sohinee Bhattacharyya, Matthew D. Storck, Craig L. Semerad, James E. Talmadge, R. Lee Mosley, Vimla Band & Hamid Band. (2018) Role of the EHD Family of Endocytic Recycling Regulators for TCR Recycling and T Cell Function. The Journal of Immunology 200:2, pages 483-499.
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Xue Wang, Bing Sun, Christelle Mbondji, Santanu Biswas, Jiangqin Zhao & Indira Hewlett. (2017) Differences in Activation of HIV-1 Replication by Superinfection With HIV-1 and HIV-2 in U1 Cells. Journal of Cellular Physiology 232:7, pages 1746-1753.
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Valentin Jaumouillé & Sergio Grinstein. 2017. Myeloid Cells in Health and Disease. Myeloid Cells in Health and Disease 507 526 .
Rianne Bartelds, Jonathan Barnoud, Arnold J. Boersma, Siewert J. Marrink & Bert Poolman. (2017) Lipid phase separation in the presence of hydrocarbons in giant unilamellar vesicles. AIMS Biophysics 4:4, pages 528-542.
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Akiko Hashimoto-Tane, Tadashi Yokosuka & Takashi Saito. 2017. The Immune Synapse. The Immune Synapse 51 64 .
Jiawen ChenZhong-Ru XieYinghao Wu. (2016) Elucidating the Functional Roles of Spatial Organization in Cross-Membrane Signal Transduction by a Hybrid Simulation Method. Journal of Computational Biology 23:7, pages 566-584.
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Valentin Jaumouillé & Sergio Grinstein. (2016) Molecular Mechanisms of Phagosome Formation. Microbiology Spectrum 4:3.
Crossref
Jonathan Pacheco, Josué O. Ramírez-Jarquín & Luis Vaca. 2016. Calcium Entry Pathways in Non-excitable Cells. Calcium Entry Pathways in Non-excitable Cells 353 378 .
Jelena Dinic, Astrid Riehl, Jeremy Adler & Ingela Parmryd. (2015) The T cell receptor resides in ordered plasma membrane nanodomains that aggregate upon patching of the receptor. Scientific Reports 5:1.
Crossref
Florian Baumgart & Gerhard J. Schütz. (2015) Detecting protein association at the T cell plasma membrane. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1853:4, pages 791-801.
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Bhanu Kanth Manne, Rachit Badolia, Carol A. Dangelmaier & Satya P. Kunapuli. (2015) C-type lectin like receptor 2 (CLEC-2) signals independently of lipid raft microdomains in platelets. Biochemical Pharmacology 93:2, pages 163-170.
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Juliette Griffié, Garth Burn & Dylan M. Owen. 2015. Lipid Domains. Lipid Domains 125 165 .
Masakazu Nagafuku & Jin-ichi Inokuchi. 2015. Sugar Chains. Sugar Chains 35 54 .
Zhong-Ru Xie, Jiawen Chen & Yinghao Wu. (2014) Linking 3D and 2D binding kinetics of membrane proteins by multiscale simulations. Protein Science 23:12, pages 1789-1799.
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Nicholas J. Gay, Martyn F. Symmons, Monique Gangloff & Clare E. Bryant. (2014) Assembly and localization of Toll-like receptor signalling complexes. Nature Reviews Immunology 14:8, pages 546-558.
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Xue Wang, Jiying Tan, Jiangqin Zhao, Viswannath Ragupathy, Mohan Haleyurgirisetty & Indira Hewlett. (2014) Some findings of FADD knockdown in inhibition of HIV-1 replication in Jurkat cells and PBMCs. Molecular and Cellular Biochemistry 393:1-2, pages 181-190.
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Laurel Oldach & Jin Zhang. (2014) Genetically Encoded Fluorescent Biosensors for Live-Cell Visualization of Protein Phosphorylation. Chemistry & Biology 21:2, pages 186-197.
Crossref
Nicole M. Chapman, Sean F. Connolly, Erin L. Reinl & Jon C. D. Houtman. (2013) Focal Adhesion Kinase Negatively Regulates Lck Function Downstream of the T Cell Antigen Receptor. The Journal of Immunology 191:12, pages 6208-6221.
Crossref
J. Joris Witsenburg, Heike Glauner, Jörg P. Müller, Johannes M. M. Groenewoud, Günter Roth, Frank-Dietmar Böhmer, Merel J. W. Adjobo-Hermans & Roland Brock. (2013) A Quantitative Assessment of Costimulation and Phosphatase Activity on Microclusters in Early T Cell Signaling. PLoS ONE 8:10, pages e79277.
Crossref
John R. Silvius. (2013) Membrane Nanodomains. Colloquium Series on Building Blocks of the Cell: Cell Structure and Function 1:1, pages 1-103.
Crossref
Pedro Roda-Navarro. (2013) Microspectroscopy reveals mechanisms of lymphocyte activation. Integr. Biol. 5:2, pages 300-311.
Crossref
Jérémie Rossy, Dylan M Owen, David J Williamson, Zhengmin Yang & Katharina Gaus. (2012) Conformational states of the kinase Lck regulate clustering in early T cell signaling. Nature Immunology 14:1, pages 82-89.
Crossref
Harmony F. Turk, Jennifer M. Monk, Tim Y. Hou & Robert S. Chapkin. 2013. Obesity, Inflammation and Cancer. Obesity, Inflammation and Cancer 305 339 .
Rebekah R. Bartelt & Jon C. D. Houtman. (2012) The adaptor protein LAT serves as an integration node for signaling pathways that drive T cell activation. WIREs Systems Biology and Medicine 5:1, pages 101-110.
Crossref
Etienne Gagnon, David A. Schubert, Susana Gordo, H. Hamlet Chu & Kai W. Wucherpfennig. (2012) Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain. Journal of Experimental Medicine 209:13, pages 2423-2439.
Crossref
Omer Dushek, Jesse Goyette & P. Anton van der Merwe. (2012) Non-catalytic tyrosine-phosphorylated receptors. Immunological Reviews 250:1, pages 258-276.
Crossref
Sara B. Triffo, Hector H. Huang, Adam W. Smith, Eldon T. Chou & Jay T. Groves. (2012) Monitoring Lipid Anchor Organization in Cell Membranes by PIE-FCCS. Journal of the American Chemical Society 134:26, pages 10833-10842.
Crossref
Joseph J. Illingworth & P. Anton van der Merwe. (2012) Dissecting T-cell activation with high-resolution live-cell microscopy. Immunology 135:3, pages 198-206.
Crossref
Colleen Kennedy, Matthew D Nelson & Anil K Bamezai. (2011) Analysis of detergent-free lipid rafts isolated from CD4+ T cell line: interaction with antigen presenting cells promotes coalescing of lipid rafts. Cell Communication and Signaling 9:1.
Crossref
Chih-Jung Hsu & Tobias Baumgart. (2011) Spatial Association of Signaling Proteins and F-Actin Effects on Cluster Assembly Analyzed via Photoactivation Localization Microscopy in T Cells. PLoS ONE 6:8, pages e23586.
Crossref
Michael B. Fessler & John S. Parks. (2011) Intracellular Lipid Flux and Membrane Microdomains as Organizing Principles in Inflammatory Cell Signaling. The Journal of Immunology 187:4, pages 1529-1535.
Crossref
Anis Larbi, Graham Pawelec, Siew Cheng Wong, David Goldeck, June Jing-Yi Tai & Tamas Fulop. (2011) Impact of age on T cell signaling: A general defect or specific alterations?. Ageing Research Reviews 10:3, pages 370-378.
Crossref
Olga M. Antón, Laura Andrés-Delgado, Natalia Reglero-Real, Alicia Batista & Miguel A. Alonso. (2011) MAL Protein Controls Protein Sorting at the Supramolecular Activation Cluster of Human T Lymphocytes. The Journal of Immunology 186:11, pages 6345-6356.
Crossref
Pavel Otáhal, Supansa Pata, Pavla Angelisová, Václav Hořejší & Tomáš Brdička. (2011) The effects of membrane compartmentalization of csk on TCR signaling. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1813:2, pages 367-376.
Crossref
Lakshmi Balagopalan, Eilon Sherman, Valarie A. Barr & Lawrence E. Samelson. (2010) Imaging techniques for assaying lymphocyte activation in action. Nature Reviews Immunology 11:1, pages 21-33.
Crossref
P. Anton van der Merwe & Omer Dushek. (2010) Mechanisms for T cell receptor triggering. Nature Reviews Immunology 11:1, pages 47-55.
Crossref
Nadejda Ladygina, Brent R. Martin & Amnon Altman. 2011. 1 44 .
Takashi Saito, Tadashi Yokosuka & Akiko Hashimoto-Tane. (2010) Dynamic regulation of T cell activation and co-stimulation through TCR-microclusters. FEBS Letters 584:24, pages 4865-4871.
Crossref
Václav Hořejší, Pavel Otáhal & Tomáš Brdička. (2010) LAT - an important raft-associated transmembrane adaptor protein. Delivered on 6 July 2009 at the 34th FEBS Congress in Prague, Czech Republic. FEBS Journal 277:21, pages 4383-4397.
Crossref

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