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Molecular and Cellular Biology Volume 26, 2006 - Issue 14
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Article

Control of Translocations between Highly Diverged Genes by Sgs1, the Saccharomyces cerevisiae Homolog of the Bloom'sSyndrome Protein

Kristina H. Schmidt1 Ludwig Institute for Cancer Research, Departments of Medicine and Cellular and Molecular Medicine, and Cancer Center, University of California San Diego, School of Medicine, La Jolla, California92093;2 Department of Biology, University of South Florida, 4202 E. Fowler Avenue, SCA110, Tampa, Florida33620Correspondence[email protected]
,
Joann Wu1 Ludwig Institute for Cancer Research, Departments of Medicine and Cellular and Molecular Medicine, and Cancer Center, University of California San Diego, School of Medicine, La Jolla, California92093
&
Richard D. Kolodner1 Ludwig Institute for Cancer Research, Departments of Medicine and Cellular and Molecular Medicine, and Cancer Center, University of California San Diego, School of Medicine, La Jolla, California92093
Pages 5406-5420 | Received 27 Jan 2006, Accepted 28 Apr 2006, Published online: 27 Mar 2023

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Alejandro Luque, Sarra C Sebai, Vincent Sauveplane, Odile Ramaen & Rudy Pandjaitan. (2014) In vivo evolution of metabolic pathways: Assembling old parts to build novel and functional structures. Bioengineered 5:6, pages 347-356.
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José F. Ruiz, Belén Gómez-González & Andrés Aguilera. (2009) Chromosomal Translocations Caused by Either Pol32-Dependent or Pol32-Independent Triparental Break-Induced Replication. Molecular and Cellular Biology 29:20, pages 5441-5454.
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Catherine E. Smith, Alicia F. Lam & Lorraine S. Symington. (2009) Aberrant Double-Strand Break Repair Resulting in Half Crossovers in Mutants Defective for Rad51 or the DNA Polymerase δ Complex. Molecular and Cellular Biology 29:6, pages 1432-1441.
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Articles from other publishers (51)

Theresa Zacheja, Agnes Toth, Gabor M. Harami, Qianlu Yang, Eike Schwindt, Mihály Kovács, Katrin Paeschke & Peter Burkovics. (2020) Mgs1 protein supports genome stability via recognition of G‐quadruplex DNA structures. The FASEB Journal 34:9, pages 12646-12662.
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Bin-zhong Li, Christopher D Putnam & Richard David Kolodner. (2020) Mechanisms underlying genome instability mediated by formation of foldback inversions in Saccharomyces cerevisiae. eLife 9.
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Matteo Ferrari, Chetan C. Rawal, Samuele Lodovichi, Maria Y. Vietri & Achille Pellicioli. (2020) Rad9/53BP1 promotes DNA repair via crossover recombination by limiting the Sgs1 and Mph1 helicases. Nature Communications 11:1.
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Julius Muellner & Kristina H. Schmidt. (2020) Yeast Genome Maintenance by the Multifunctional PIF1 DNA Helicase Family. Genes 11:2, pages 224.
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Sonia Vidushi Gupta & Kristina Hildegard Schmidt. (2020) Maintenance of Yeast Genome Integrity by RecQ Family DNA Helicases. Genes 11:2, pages 205.
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Anjana SrivatsanBinzhong LiDafne N. SanchezSteven B. SomachVandeclecio L. da SilvaSandro J. de SouzaChristopher D. PutnamRichard D. Kolodner. (2019) Essential Saccharomyces cerevisiae genome instability suppressing genes identify potential human tumor suppressors . Proceedings of the National Academy of Sciences 116:35, pages 17377-17382.
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Manisha Jalan, Judith Oehler, Carl A Morrow, Fekret Osman & Matthew C Whitby. (2019) Factors affecting template switch recombination associated with restarted DNA replication. eLife 8.
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In-Joon Baek, Courtney Parke & Arthur J. Lustig. (2018) The mre11A470T mutation and homeologous interactions increase error-prone BIR. Gene 665, pages 49-56.
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Elis Eleutherio, Aline de Araujo Brasil, Mauro Braga França, Diego Seixas Gomes de Almeida, Germana Breves Rona & Rayne Stfhany Silva Magalhães. (2018) Oxidative stress and aging: Learning from yeast lessons. Fungal Biology 122:6, pages 514-525.
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Jiying Sun, Lin Shi, Aiko Kinomura, Atsuhiko Fukuto, Yasunori Horikoshi, Yukako Oma, Masahiko Harata, Masae Ikura, Tsuyoshi Ikura, Roland Kanaar & Satoshi Tashiro. (2018) Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations. eLife 7.
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Lillian Campos-Doerfler, Salahuddin Syed & Kristina H Schmidt. (2018) Sgs1 Binding to Rad51 Stimulates Homology-Directed DNA Repair in Saccharomyces cerevisiae . Genetics 208:1, pages 125-138.
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Christopher D Putnam & Richard D Kolodner. (2017) Pathways and Mechanisms that Prevent Genome Instability in Saccharomyces cerevisiae . Genetics 206:3, pages 1187-1225.
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Priyanka Verma & Roger A. Greenberg. (2016) Noncanonical views of homology-directed DNA repair. Genes & Development 30:10, pages 1138-1154.
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Suvi Jain, Neal Sugawara & James E. Haber. (2016) Role of Double-Strand Break End-Tethering during Gene Conversion in Saccharomyces cerevisiae. PLOS Genetics 12:4, pages e1005976.
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Christopher D. Putnam, Anjana Srivatsan, Rahul V. Nene, Sandra L. Martinez, Sarah P. Clotfelter, Sara N. Bell, Steven B. Somach, Jorge E.S. de Souza, André F. Fonseca, Sandro J. de Souza & Richard D. Kolodner. (2016) A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers. Nature Communications 7:1.
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Alison Rattray, Gustavo Santoyo, Brenda Shafer & Jeffrey N. Strathern. (2015) Elevated Mutation Rate during Meiosis in Saccharomyces cerevisiae. PLoS Genetics 11:1, pages e1004910.
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Ranjith P. Anand, Olga Tsaponina, Patricia W. Greenwell, Cheng-Sheng Lee, Wei Du, Thomas D. Petes & James E. Haber. (2014) Chromosome rearrangements via template switching between diverged repeated sequences. Genes & Development 28:21, pages 2394-2406.
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Olga Tsaponina & James E. Haber. (2014) Frequent Interchromosomal Template Switches during Gene Conversion in S. cerevisiae. Molecular Cell 55:4, pages 615-625.
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Josée Guirouilh-Barbat, Sarah Lambert, Pascale Bertrand & Bernard S. Lopez. (2014) Is homologous recombination really an error-free process?. Frontiers in Genetics 5.
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Alejandro Luque, Sarra C. Sebai, Beatrix Santiago-Schübel, Yann Le Coz, Delphine Jenot, Odile Ramaen, Vincent Sauveplane & Rudy Pandjaitan. (2014) In vivo evolution of metabolic pathways by homeologous recombination in mitotic cells. Metabolic Engineering 23, pages 123-135.
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Christopher D. Putnam, Katielee Pallis, Tikvah K. Hayes & Richard D. Kolodner. (2014) DNA Repair Pathway Selection Caused by Defects in TEL1, SAE2, and De Novo Telomere Addition Generates Specific Chromosomal Rearrangement Signatures. PLoS Genetics 10:4, pages e1004277.
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Jessica A. Kennedy, Gary W. Daughdrill & Kristina H. Schmidt. (2013) A transient α-helical molecular recognition element in the disordered N-terminus of the Sgs1 helicase is critical for chromosome stability and binding of Top3/Rmi1. Nucleic Acids Research 41:22, pages 10215-10227.
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Diana D. Villarreal, Kihoon Lee, Angela Deem, Eun Yong Shim, Anna Malkova & Sang Eun Lee. (2012) Microhomology Directs Diverse DNA Break Repair Pathways and Chromosomal Translocations. PLoS Genetics 8:11, pages e1003026.
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Cynthia Sakofsky, Sandeep Ayyar & Anna Malkova. (2012) Break-Induced Replication and Genome Stability. Biomolecules 2:4, pages 483-504.
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Antony M. Carr, Andrew L. Paek & Ted Weinert. (2011) DNA replication: Failures and inverted fusions. Seminars in Cell & Developmental Biology 22:8, pages 866-874.
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Jason E. Chan & Richard D. Kolodner. (2011) A Genetic and Structural Study of Genome Rearrangements Mediated by High Copy Repeat Ty1 Elements. PLoS Genetics 7:5, pages e1002089.
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Lillian Doerfler, Lorena Harris, Emilie Viebranz & Kristina H Schmidt. (2011) Differential genetic interactions between Sgs1, DNA-damage checkpoint components and DNA repair factors in the maintenance of chromosome stability. Genome Integrity 2:1, pages 8.
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Hamed Mirzaei, Salahuddin Syed, Jessica Kennedy & Kristina H. Schmidt. (2011) Sgs1 Truncations Induce Genome Rearrangements but Suppress Detrimental Effects of BLM Overexpression in Saccharomyces cerevisiae. Journal of Molecular Biology 405:4, pages 877-891.
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Hirohito Endo, Satoshi Kawashima, Lui Sato, Mong Sing Lai, Takemi Enomoto, Masayuki Seki & Masami Horikoshi. (2010) Chromatin dynamics mediated by histone modifiers and histone chaperones in postreplicative recombination. Genes to Cells 15:9, pages 945-958.
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Christopher D. Putnam & Richard D. Kolodner. (2010) Determination of Gross Chromosomal Rearrangement Rates. Cold Spring Harbor Protocols 2010:9, pages pdb.prot5492.
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Kristina H. Schmidt, Emilie Viebranz, Lillian Doerfler, Christina Lester & Aaron Rubenstein. (2010) Formation of Complex and Unstable Chromosomal Translocations in Yeast. PLoS ONE 5:8, pages e12007.
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Vanessa A. Marrero & Lorraine S. Symington. (2010) Extensive DNA End Processing by Exo1 and Sgs1 Inhibits Break-Induced Replication. PLoS Genetics 6:7, pages e1001007.
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Irina V. Tereshchenko, Yanping Chen, Lisa D. McDaniel, Roger A. Schultz, Jay A. Tischfield & Changshun Shao. (2010) Small scale genetic alterations contribute to increased mutability at the X-linked Hprt locus in vivo in Blm hypomorphic mice. DNA Repair 9:5, pages 551-557.
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Alessia Errico & Vincenzo Costanzo. (2010) Differences in the DNA replication of unicellular eukaryotes and metazoans: known unknowns. EMBO reports 11:4, pages 270-278.
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Kristina H. Schmidt, Emilie B. Viebranz, Lorena B. Harris, Hamed Mirzaei-Souderjani, Salahuddin Syed & Robin Medicus. (2010) Defects in DNA Lesion Bypass Lead to Spontaneous Chromosomal Rearrangements and Increased Cell Death. Eukaryotic Cell 9:2, pages 315-324.
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Andrew L. Paek, Salma Kaochar, Hope Jones, Aly Elezaby, Lisa Shanks & Ted Weinert. (2009) Fusion of nearby inverted repeats by a replication-based mechanism leads to formation of dicentric and acentric chromosomes that cause genome instability in budding yeast. Genes & Development 23:24, pages 2861-2875.
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T Weinert, S Kaochar, H Jones, A Paek & AJ Clark. (2009) The replication fork's five degrees of freedom, their failure and genome rearrangements. Current Opinion in Cell Biology 21:6, pages 778-784.
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Sang Eun Lee & Kyungjae Myung. (2009) Faithful after break-up: suppression of chromosomal translocations. Cellular and Molecular Life Sciences 66:19, pages 3149-3160.
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P. J. Hastings, James R. Lupski, Susan M. Rosenberg & Grzegorz Ira. (2009) Mechanisms of change in gene copy number. Nature Reviews Genetics 10:8, pages 551-564.
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Christopher D. Putnam, Tikvah K. Hayes & Richard D. Kolodner. (2009) Specific pathways prevent duplication-mediated genome rearrangements. Nature 460:7258, pages 984-989.
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Vincent Pennaneach & Richard D. Kolodner. (2009) Stabilization of Dicentric Translocations through Secondary Rearrangements Mediated by Multiple Mechanisms in S. cerevisiae. PLoS ONE 4:7, pages e6389.
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P. J. Hastings, Grzegorz Ira & James R. Lupski. (2009) A Microhomology-Mediated Break-Induced Replication Model for the Origin of Human Copy Number Variation. PLoS Genetics 5:1, pages e1000327.
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Michael Kappeler, Elisabeth Kranz, Katrina Woolcock, Oleg Georgiev & Walter Schaffner. (2008) Drosophila bloom helicase maintains genome integrity by inhibiting recombination between divergent DNA sequences. Nucleic Acids Research 36:21, pages 6907-6917.
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Julia Y. Lee, Jonathan L. Mogen, Alejandro Chavez & F. Brad Johnson. (2008) Sgs1 RecQ Helicase Inhibits Survival of Saccharomyces cerevisiae Cells Lacking Telomerase and Homologous Recombination. Journal of Biological Chemistry 283:44, pages 29847-29858.
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Ji-Young Hwang, Stephanie Smith, Audrey Ceschia, Jordi Torres-Rosell, Luis Aragon & Kyungjae Myung. (2008) Smc5–Smc6 complex suppresses gross chromosomal rearrangements mediated by break-induced replications. DNA Repair 7:9, pages 1426-1436.
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Soma Banerjee, Stephanie Smith, Ji-Hyun Oum, Hung-Jiun Liaw, Ji-Young Hwang, Nilabja Sikdar, Akira Motegi, Sang Eun Lee & Kyungjae Myung. (2008) Mph1p promotes gross chromosomal rearrangement through partial inhibition of homologous recombination. Journal of Cell Biology 181:7, pages 1083-1093.
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Tony Nolan, Germano Cecere, Carmine Mancone, Tonino Alonzi, Marco Tripodi, Caterina Catalanotto & Carlo Cogoni. (2008) The RNA-dependent RNA polymerase essential for post-transcriptional gene silencing in Neurospora crassa interacts with replication protein A. Nucleic Acids Research 36:2, pages 532-538.
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Vivek Tripathi, Tirunelvely Nagarjuna & Sagar Sengupta. (2007) BLM helicase–dependent and –independent roles of 53BP1 during replication stress–mediated homologous recombination. The Journal of Cell Biology 178:1, pages 9-14.
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Catherine E. Smith, Bertrand Llorente & Lorraine S. Symington. (2007) Template switching during break-induced replication. Nature 447:7140, pages 102-105.
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. (2007) Current awareness on yeast. Yeast 24:2, pages 137-144.
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Kristina H. Schmidt & Richard D. Kolodner. (2006) Suppression of spontaneous genome rearrangements in yeast DNA helicase mutants. Proceedings of the National Academy of Sciences 103:48, pages 18196-18201.
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