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Molecular and Cellular Biology Volume 36, 2016 - Issue 22
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Article

p66Shc Couples Mechanical Signals to RhoA through Focal Adhesion Kinase-Dependent Recruitment of p115-RhoGEF and GEF-H1

Ru-Feng Wua Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, Texas, USA
,
Chengxu Liaoa Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, Texas, USA
,
Guosheng Fua Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, Texas, USA
,
Heather N. Hayengab Department of Bioengineering, University of Texas at Dallas, Richardson, Texas, USA
,
Kejia Yangc Department of Chemistry, University of Texas at Dallas, Richardson, Texas, USA
,
Zhenyi Mad Department of Immunology, Biochemistry and Molecular Biology, Tianjin Key Laboratory of Medical Epigenetics, Tianjin Medical University, Tianjin, China
,
Zhe Liud Department of Immunology, Biochemistry and Molecular Biology, Tianjin Key Laboratory of Medical Epigenetics, Tianjin Medical University, Tianjin, China
&
Lance S. Teradaa Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, Texas, USACorrespondence[email protected]
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Pages 2824-2837 | Received 30 Mar 2016, Accepted 25 Aug 2016, Published online: 18 Mar 2023

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Noah Fine, Ioannis D. Dimitriou & Robert Rottapel. (2020) Go with the flow: GEF-H1 mediated shear stress mechanotransduction in neutrophils. Small GTPases 11:1, pages 23-31.
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Lance S. Terada. (2019) Shc and the mechanotransduction of cellular anchorage and metastasis. Small GTPases 10:1, pages 64-71.
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Articles from other publishers (15)

Landon Haslem, Jennifer M. Hays & Franklin A. Hays. (2022) p66Shc in Cardiovascular Pathology. Cells 11:11, pages 1855.
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Roshia Ali, Hilal Ahmad Mir, Rabia Hamid, Basharat Bhat, Riaz A. Shah, Firdous A. Khanday & Sahar Saleem Bhat. (2022) Actin Modulation Regulates the Alpha-1-Syntrophin/p66Shc Mediated Redox Signaling Contributing to the RhoA GTPase Protein Activation in Breast Cancer Cells. Frontiers in Oncology 12.
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Brandon S. Lane, Brigitte Heller, Morley D. Hollenberg & Clark D. Wells. (2021) The RGS-RhoGEFs control the amplitude of YAP1 activation by serum. Scientific Reports 11:1.
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Lance S. Terada. 2021. Anoikis. Anoikis 69 94 .
Kyle Lewis, Alex Kiepas, Jesse Hudson, Julien Senecal, Jacqueline R. Ha, Elena Voorand, Matthew G. Annis, Valerie Sabourin, Ryuhjin Ahn, Rachel La Selva, Sébastien Tabariès, Brian E. Hsu, Matthew J. Siegel, Matthew Dankner, Eduardo Cepeda Canedo, Mathieu Lajoie, Ian R. Watson, Claire M. Brown, Peter M. Siegel & Josie Ursini-Siegel. (2020) p66ShcA functions as a contextual promoter of breast cancer metastasis. Breast Cancer Research 22:1.
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Hilal Ahmad Mir, Roshia Ali, Umar Mushtaq & Firdous A. Khanday. (2020) Structure-functional implications of longevity protein p66Shc in health and disease. Ageing Research Reviews 63, pages 101139.
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Alex Kiepas, Elena Voorand, Julien Senecal, Ryuhjin Ahn, Matthew G. Annis, Kévin Jacquet, George Tali, Nicolas Bisson, Josie Ursini-Siegel, Peter M. Siegel & Claire M. Brown. (2020) The SHCA adapter protein cooperates with lipoma-preferred partner in the regulation of adhesion dynamics and invadopodia formation. Journal of Biological Chemistry 295:31, pages 10535-10559.
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Keith Burridge, Elizabeth Monaghan-Benson & David M. Graham. (2019) Mechanotransduction: from the cell surface to the nucleus via RhoA. Philosophical Transactions of the Royal Society B: Biological Sciences 374:1779, pages 20180229.
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Rebeca Rosas‐Hernández, Yadira Bastián, Andrea Juárez Tello, Ángeles Ramírez‐Saíto, Diana María Escobar García, Amaury Pozos‐Guillén & J. Alfredo Mendez. (2019) AMPA receptors modulate the reorganization of F‐actin in Bergmann glia cells through the activation of RhoA. Journal of Neurochemistry 149:2, pages 242-254.
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Joanna Stanicka, Leonie Rieger, Sandra O’Shea, Orla Cox, Michael Coleman, Ciara O’Flanagan, Barbara Addario, Nuala McCabe, Richard Kennedy & Rosemary O’Connor. (2018) FES-related tyrosine kinase activates the insulin-like growth factor-1 receptor at sites of cell adhesion. Oncogene 37:23, pages 3131-3150.
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Andrew J. McKenzie, Stephanie R. Hicks, Kathryn V. Svec, Hannah Naughton, Zöe L. Edmunds & Alan K. Howe. (2018) The mechanical microenvironment regulates ovarian cancer cell morphology, migration, and spheroid disaggregation. Scientific Reports 8:1.
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Jens Isak AndersenCristian Pablo PennisiTrine FinkVladimir Zachar. (2018) Focal Adhesion Kinase Activation Is Necessary for Stretch-Induced Alignment and Enhanced Differentiation of Myogenic Precursor Cells. Tissue Engineering Part A 24:7-8, pages 631-640.
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Antoine Abou-Jaoude, Lise Badiqué, Mohamed Mlih, Sara Awan, Sunning Guo, Alexandre Lemle, Clauda Abboud, Sophie Foppolo, Lionel Host, Jérôme Terrand, Hélène Justiniano, Joachim Herz, Rachel L. Matz & Philippe Boucher. (2018) Loss of the adaptor protein ShcA in endothelial cells protects against monocyte macrophage adhesion, LDL-oxydation, and atherosclerotic lesion formation. Scientific Reports 8:1.
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Sayan Chakraborty & Wanjin Hong. (2018) Linking Extracellular Matrix Agrin to the Hippo Pathway in Liver Cancer and Beyond. Cancers 10:2, pages 45.
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Kevin D. Wright, Alexander Staruschenko & Andrey Sorokin. (2018) Role of adaptor protein p66Shc in renal pathologies. American Journal of Physiology-Renal Physiology 314:2, pages F143-F153.
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