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Molecular and Cellular Biology Volume 30, 2010 - Issue 11
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Article

The Ras Effector RASSF2 Controls the PAR-4 Tumor Suppressor

Howard Donninger1 Department of Medicine, James Graham Brown Cancer Center, Molecular Targets Program, University of Louisville, 505 S. Hancock St., Louisville, Kentucky40202
,
Luke Hesson2 Section of Medicine and Molecular Genetics, University of Birmingham, Wolfson Drive, EdgbastonB15 2TT, United Kingdom
,
Michele Vos3 Cell and Cancer Biology Branch, NCI, Rockville, Maryland
,
Kristin Beebe3 Cell and Cancer Biology Branch, NCI, Rockville, Maryland
,
Laura Gordon1 Department of Medicine, James Graham Brown Cancer Center, Molecular Targets Program, University of Louisville, 505 S. Hancock St., Louisville, Kentucky40202
,
David Sidransky4 Head and Neck Cancer Research Division, Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland
,
Jun Wei Liu4 Head and Neck Cancer Research Division, Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland
,
Thomas Schlegel5 Department of Pathology, University of Erlangen Nurnberg, 91054Erlangen, Germany
,
Shannon Payne5 Department of Pathology, University of Erlangen Nurnberg, 91054Erlangen, Germany
,
Arndt Hartmann6 Epigenomics, Inc., 1000 Seneca St., Ste. 300, Seattle, Washington98101
,
Farida Latif2 Section of Medicine and Molecular Genetics, University of Birmingham, Wolfson Drive, EdgbastonB15 2TT, United Kingdom
&
Geoffrey J. Clark1 Department of Medicine, James Graham Brown Cancer Center, Molecular Targets Program, University of Louisville, 505 S. Hancock St., Louisville, Kentucky40202Correspondence[email protected]
 show all
Pages 2608-2620 | Received 16 Feb 2009, Accepted 25 Mar 2010, Published online: 20 Mar 2023

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Charlotte Rombouts, An Aerts, Roel Quintens, Bjorn Baselet, Hussein El-Saghire, Mats Harms-Ringdahl, Siamak Haghdoost, Ann Janssen, Arlette Michaux, Ramesh Yentrapalli, Mohammed Abderrafi Benotmane, Patrick Van Oostveldt & Sarah Baatout. (2014) Transcriptomic profiling suggests a role for IGFBP5 in premature senescence of endothelial cells after chronic low dose rate irradiation. International Journal of Radiation Biology 90:7, pages 560-574.
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Seley Gharanei, Anna T Brini, Sumathi Vaiyapuri, Abdullah Alholle, Ashraf Dallol, Elena Arrigoni, Takeshi Kishida, Toru Hiruma, Smadar Avigad, Robert Grimer, Eamonn R Maher & Farida Latif. (2013) methylation is a strong prognostic marker in younger age patients with Ewing sarcoma. Epigenetics 8:9, pages 893-898.
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Parvesh Chaudhry, Mohan Singh, Sophie Parent & Eric Asselin. (2012) Prostate Apoptosis Response 4 (Par-4), a Novel Substrate of Caspase-3 during Apoptosis Activation. Molecular and Cellular Biology 32:4, pages 826-839.
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Articles from other publishers (26)

Ge Wang, Yuhao Bai, Jiarui Cui, Zirui Zong, Yuan Gao & Zhen Zheng. (2022) Computer-Aided Drug Design Boosts RAS Inhibitor Discovery. Molecules 27:17, pages 5710.
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Howard Donninger & Geoffrey J. Clark. 2022. Tumor Suppressor Par-4. Tumor Suppressor Par-4 253 262 .
François Fabi, Pascal Adam & Eric Asselin. 2021. Tumor Suppressor Par-4. Tumor Suppressor Par-4 41 58 .
P. Gargallo, A. Juan, Y. Yáñez, S. Dolz, V. Segura, V. Castel & A. Cañete. (2020) Precision medicine in Ewing sarcoma: a translational point of view. Clinical and Translational Oncology 22:9, pages 1440-1454.
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Samuel A. Stoner, Katherine Tin Heng Liu, Elizabeth T. Andrews, Mengdan Liu, Kei-Ichiro Arimoto, Ming Yan, Amanda G. Davis, Stephanie Weng, Michelle Dow, Su Xian, Russell C. DeKelver, Hannah Carter & Dong-Er Zhang. (2020) The RUNX1-ETO target gene RASSF2 suppresses t(8;21) AML development and regulates Rac GTPase signaling. Blood Cancer Journal 10:2.
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Mohammad Reza Zinatizadeh, Seyed Ali Momeni, Peyman Kheirandish Zarandi, Ghanbar Mahmoodi Chalbatani, Hassan Dana, Hamid Reza Mirzaei, Mohammad Esmaeil Akbari & Seyed Rouhollah Miri. (2019) The Role and Function of Ras-association domain family in Cancer: A Review. Genes & Diseases 6:4, pages 378-384.
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Andrea Clark, Komala Ponniah, Meghan Warden, Emily Raitt, Andrea Yawn & Steven Pascal. (2018) pH-Induced Folding of the Caspase-Cleaved Par-4 Tumor Suppressor: Evidence of Structure Outside of the Coiled Coil Domain. Biomolecules 8:4, pages 162.
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Christianne Hoey, Jessica Ray, Jouhyun Jeon, Xiaoyong Huang, Samira Taeb, Jarkko Ylanko, David W. Andrews, Paul C. Boutros & Stanley K. Liu. (2018) mi RNA ‐106a and prostate cancer radioresistance: a novel role for LITAF in ATM regulation . Molecular Oncology 12:8, pages 1324-1341.
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Hiroaki Iwasa, Shakhawoat Hossain & Yutaka Hata. (2018) Tumor suppressor C-RASSF proteins. Cellular and Molecular Life Sciences 75:10, pages 1773-1787.
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Leanne Bradley, Delia Koennig, Maria Laura Tognoli, Jelte van der Vaart & Eric O’Neill. 2018. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 4501 4523 .
Zongze Shen, Xing Qin, Ming Yan, Rongrong Li, Gang Chen, Jianjun Zhang & Wantao Chen. (2016) Cancer-associated fibroblasts promote cancer cell growth through a miR-7-RASSF2-PAR-4 axis in the tumor microenvironment. Oncotarget 8:1, pages 1290-1303.
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J.N. Mezzanotte & G.J. Clark. 2017. Conquering RAS. Conquering RAS 3 23 .
Leanne Bradley, Delia Koennig, Maria Laura Tognoli, Jelte van der Vaart & Eric O’Neill. 2017. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 1 23 .
Howard Donninger, M. Lee Schmidt, Jessica Mezzanotte, Thibaut Barnoud & Geoffrey J. Clark. (2016) Ras signaling through RASSF proteins. Seminars in Cell & Developmental Biology 58, pages 86-95.
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Thibaut Barnoud, Daniel Wilkey, Michael Merchant, Jennifer Clark & Howard Donninger. (2016) Proteomics Analysis Reveals Novel RASSF2 Interaction Partners. Cancers 8:3, pages 37.
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Wei Guo, Zhiming Dong, Jianli Cui, Yanli Guo, Supeng Shen, Xin Guo & Gang Kuang. (2015) Aberrant hypermethylation of RASSF2 in tumors and peripheral blood DNA as a biomarker for malignant progression and poor prognosis of esophageal squamous cell carcinoma. Clinical & Experimental Metastasis 33:1, pages 73-85.
Crossref
Seon Min Woo & Taeg Kyu Kwon. (2015) Prostate Apoptosis Response-4 (Par-4) as a Cancer Therapeutic Target. Journal of Life Science 25:8, pages 947-952.
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Natalia Volodko, Marilyn Gordon, Mohamed Salla, Haya Abu Ghazaleh & Shairaz Baksh. (2014) RASSF tumor suppressor gene family: Biological functions and regulation. FEBS Letters 588:16, pages 2671-2684.
Crossref
Slobodan Beronja, Peter Janki, Evan Heller, Wen-Hui Lien, Brice E. Keyes, Naoki Oshimori & Elaine Fuchs. (2013) RNAi screens in mice identify physiological regulators of oncogenic growth. Nature 501:7466, pages 185-190.
Crossref
Jia Jia Chan & Matilda Katan. (2013) PLCɛ and the RASSF family in tumour suppression and other functions. Advances in Biological Regulation 53:3, pages 258-279.
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Eliana Noelia AlonsoManuela OrozcoAlvaro Eloy NietoGabriela Andrea Balogh. (2013) Genes Related to Suppression of Malignant Phenotype Induced by Maitake D-Fraction in Breast Cancer Cells. Journal of Medicinal Food 16:7, pages 602-617.
Crossref
T. M. Darlington, M. A. Ehringer, C. Larson, T. L. Phang & R. A. Radcliffe. (2013) Transcriptome analysis of Inbred Long Sleep and Inbred Short Sleep mice. Genes, Brain and Behavior 12:2, pages 263-274.
Crossref
Maria Sofia Fernandes, Fátima Carneiro, Carla Oliveira & Raquel Seruca. (2013) Colorectal cancer and RASSF family-A special emphasis on RASSF1A. International Journal of Cancer 132:2, pages 251-258.
Crossref
Temuujin Dansranjavin, Florian Wagenlehner, Stefan Gattenloehner, Klaus Steger, Wolfgang Weidner, Reinhard Dammann & Undraga Schagdarsurengin. (2012) Epigenetic down regulation of RASSF10 and its possible clinical implication in prostate carcinoma. The Prostate 72:14, pages 1550-1558.
Crossref
Jennifer Clark, Jessica Freeman & Howard Donninger. (2012) Loss of RASSF2 Enhances Tumorigencity of Lung Cancer Cells and Confers Resistance to Chemotherapy. Molecular Biology International 2012, pages 1-8.
Crossref
DENG LUO, TING YE, TIAN-QIAN LI, PENG TANG, SHA-DONG MIN, GONG-FANG ZHAO, HUA HUANG, JIANG CHANG, YAN WANG, LIN LV, MING-LIANG LU & MENG-YAO ZHENG. (2012) Ectopic expression of RASSF2 and its prognostic role for gastric adenocarcinoma patients. Experimental and Therapeutic Medicine 3:3, pages 391-396.
Crossref

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