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Molecular and Cellular Biology Volume 34, 2014 - Issue 18
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Article

IQGAP1 Regulates Endothelial Barrier Function via EB1-Cortactin Cross Talk

Yufeng Tiana Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Illinois, USA
,
Xinyong Tiana Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Illinois, USA
,
Grzegorz Gawlaka Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Illinois, USA
,
James J. O'Donnell IIIa Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Illinois, USA
,
David B. Sacksb Department of Laboratory Medicine, National Institutes of Health, Bethesda, Maryland, USA
&
Anna A. Birukovaa Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Illinois, USACorrespondence[email protected]
Pages 3546-3558 | Received 18 Feb 2014, Accepted 04 Jul 2014, Published online: 20 Mar 2023

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Pauline Jeannot & Arnaud Besson. (2020) Cortactin function in invadopodia. Small GTPases 11:4, pages 256-270.
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Louise Thines, Francis J. Roushar, Andrew C. Hedman & David B. Sacks. (2023) The IQGAP scaffolds: Critical nodes bridging receptor activation to cellular signaling. Journal of Cell Biology 222:6.
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Louise Thines, Zhigang Li & David B. Sacks. (2023) IQGAP1 Is a Phosphotyrosine-Regulated Scaffold for SH2-Containing Proteins. Cells 12:3, pages 483.
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Narasimham Parinandi, Evgenia Gerasimovskaya & Alexander Verin. (2022) Editorial: Molecular mechanisms of lung endothelial permeability. Frontiers in Physiology 13.
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Yuehan Ma, Na Chang, Yuran Liu, Fuquan Liu, Chengbin Dong, Lei Hou, Changbo Qi, Lin Yang & Liying Li. (2022) Silencing IQGAP1 alleviates hepatic fibrogenesis via blocking bone marrow mesenchymal stromal cell recruitment to fibrotic liver. Molecular Therapy - Nucleic Acids 27, pages 471-483.
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Pratap Karki & Anna A. Birukova. (2021) Microtubules as Major Regulators of Endothelial Function: Implication for Lung Injury. Frontiers in Physiology 12.
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Pratap Karki, Boyoung Cha, Chen‐Ou Zhang, Yue Li, Yunbo Ke, Kamoltip Promnares, Kozo Kaibuchi, Akihiko Yoshimura, Konstantin G. Birukov & Anna A. Birukova. (2021) Microtubule‐dependent mechanism of anti‐inflammatory effect of SOCS1 in endothelial dysfunction and lung injury. The FASEB Journal 35:4.
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Dongjie Zhou, Zheng-Wen Nie & Xiang-Shun Cui. (2021) EB1 Is Essential for Spindle Formation and Chromosome Alignment During Oocyte Meiotic Maturation in Mice. Microscopy and Microanalysis 27:2, pages 385-391.
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Xiafeng Peng, Tiejun Wang, Han Gao, Xin Yue, Weiqi Bian, Jie Mei & Yan Zhang. (2021) The interplay between IQGAP1 and small GTPases in cancer metastasis. Biomedicine & Pharmacotherapy 135, pages 111243.
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Pratap Karki, Yunbo Ke, Chen-Ou Zhang, Yue Li, Yufeng Tian, Sophia Son, Akihiko Yoshimura, Kozo Kaibuchi, Konstantin G. Birukov & Anna A. Birukova. (2021) SOCS3–microtubule interaction via CLIP-170 and CLASP2 is critical for modulation of endothelial inflammation and lung injury. Journal of Biological Chemistry 296, pages 100239.
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Andrew C. Hedman, Dean E. McNulty, Zhigang Li, Laëtitia Gorisse, Roland S. Annan & David B. Sacks. (2020) Tyrosine phosphorylation of the scaffold protein IQGAP1 in the MET pathway alters function. Journal of Biological Chemistry 295:52, pages 18105-18121.
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Yi‐Shuan Sheen, Ming‐Hsien Lin, Wen‐Chia Tzeng & Chia‐Yu Chu. (2020) Purpuric drug eruptions induced by EGFR tyrosine kinase inhibitors are associated with IQGAP1‐mediated increase in vascular permeability. The Journal of Pathology 250:4, pages 452-463.
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Yosef Sabo, Kenia de los Santos & Stephen P. Goff. (2020) IQGAP1 Negatively Regulates HIV-1 Gag Trafficking and Virion Production. Cell Reports 30:12, pages 4065-4081.e4.
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David P. Sullivan, Prarthana J. Dalal, Fanny Jaulin, David B. Sacks, Geri Kreitzer & William A. Muller. (2019) Endothelial IQGAP1 regulates leukocyte transmigration by directing the LBRC to the site of diapedesis. Journal of Experimental Medicine 216:11, pages 2582-2601.
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Nadine Klusmeier, Hans-Joachim Schnittler & Jochen Seebach. (2019) A Novel Microscopic Assay Reveals Heterogeneous Regulation of Local Endothelial Barrier Function. Biophysical Journal 116:8, pages 1547-1559.
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Pratap Karki, Yunbo Ke, Yufeng Tian, Tomomi Ohmura, Albert Sitikov, Nicolene Sarich, Christopher P. Montgomery & Anna A. Birukova. (2019) Staphylococcus aureus–induced endothelial permeability and inflammation are mediated by microtubule destabilization. Journal of Biological Chemistry 294:10, pages 3369-3384.
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Michael Schnoor, Theresia E. Stradal & Klemens Rottner. (2018) Cortactin: Cell Functions of A Multifaceted Actin-Binding Protein. Trends in Cell Biology 28:2, pages 79-98.
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Pratap Karki & Anna A Birukova. (2023) Microtubules-Associated Rac Regulation of Endothelial Barrier: A Role of Asef in Acute Lung Injury. Journal of Investigative Medicine 65:8, pages 1089-1092.
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Tomomi Ohmura, Yufeng Tian, Nicolene Sarich, Yunbo Ke, Angelo Meliton, Alok S. Shah, Katrin Andreasson, Konstantin G. Birukov & Anna A. Birukova. (2017) Regulation of lung endothelial permeability and inflammatory responses by prostaglandin A2: role of EP4 receptor. Molecular Biology of the Cell 28:12, pages 1622-1635.
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Deborah A. Goldspink, Chris Rookyard, Benjamin J. Tyrrell, Jonathan Gadsby, James Perkins, Elizabeth K. Lund, Niels Galjart, Paul Thomas, Tom Wileman & Mette M. Mogensen. (2017) Ninein is essential for apico-basal microtubule formation and CLIP-170 facilitates its redeployment to non-centrosomal microtubule organizing centres. Open Biology 7:2, pages 160274.
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Xinyong Tian, Tomomi Ohmura, Alok S. Shah, Sophia Son, Yufeng Tian & Anna A. Birukova. (2017) Role of End Binding Protein-1 in endothelial permeability response to barrier-disruptive and barrier-enhancing agonists. Cellular Signalling 29, pages 1-11.
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Shinya Mizuno. 2017. Biochemical Basis and Therapeutic Implications of Angiogenesis. Biochemical Basis and Therapeutic Implications of Angiogenesis 105 131 .
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Haibo Wang, Xiaokun Han, Colin A Bretz, Silke Becker, Deeksha Gambhir, George W Smith, R Jude Samulski, Erika S Wittchen, Lawrence A Quilliam, Magdalena Chrzanowska-Wodnicka & M Elizabeth Hartnett. (2016) Retinal pigment epithelial cell expression of active Rap 1a by scAAV2 inhibits choroidal neovascularization. Molecular Therapy - Methods & Clinical Development 3, pages 16056.
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Simona Gallo, Valentina Sala, Stefano Gatti & Tiziana Crepaldi. (2015) Cellular and molecular mechanisms of HGF/Met in the cardiovascular system. Clinical Science 129:12, pages 1173-1193.
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Bradley C. Jackson, Iordanka A. Ivanova & Lina Dagnino. (2015) An ELMO2-RhoG-ILK network modulates microtubule dynamics. Molecular Biology of the Cell 26:14, pages 2712-2725.
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Andrew C Hedman, Jessica M Smith & David B Sacks. (2015) The biology of IQGAP proteins: beyond the cytoskeleton . EMBO reports 16:4, pages 427-446.
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Jessica M. Smith, Andrew C. Hedman & David B. Sacks. (2015) IQGAPs choreograph cellular signaling from the membrane to the nucleus. Trends in Cell Biology 25:3, pages 171-184.
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Xinyong Tian, Yufeng Tian, Grzegorz Gawlak, Fanyong Meng, Yoshihiro Kawasaki, Tetsu Akiyama & Anna A. Birukova. (2015) Asef controls vascular endothelial permeability and barrier recovery in the lung. Molecular Biology of the Cell 26:4, pages 636-650.
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Elizabeth I. Tang, Ka-Wai Mok, Will M. Lee & C. Yan Cheng. (2015) EB1 Regulates Tubulin and Actin Cytoskeletal Networks at the Sertoli Cell Blood-Testis Barrier in Male Rats: An In Vitro Study. Endocrinology 156:2, pages 680-693.
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Yufeng Tian, Grzegorz Gawlak, Alok S. Shah, Katherine Higginbotham, Xinyong Tian, Yoshihiro Kawasaki, Tetsu Akiyama, David B. Sacks & Anna A. Birukova. (2015) Hepatocyte Growth Factor-induced Asef-IQGAP1 Complex Controls Cytoskeletal Remodeling and Endothelial Barrier. Journal of Biological Chemistry 290:7, pages 4097-4109.
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