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Molecular and Cellular Biology Volume 39, 2019 - Issue 23
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Research Article

Long Noncoding RNA HOTAIR Promotes Endometrial Carcinoma Cell Proliferation by Binding to PTEN via the Activating Phosphatidylinositol 3-Kinase/Akt Signaling Pathway

Xiao-Hui Zhanga Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, People’s Republic of China;c NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), Hefei, Anhui Province, People's Republic of China;d Key Laboratory of Population Health across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, Hefei, Anhui Province, People's Republic of China;e Anhui Province Key Laboratory of Reproductive Health and Genetics, Hefei, Anhui Province, People's Republic of China;f Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Medical University, Hefei, Anhui Province, People's Republic of China
,
Pin Hub Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, People’s Republic of China
,
Yang-Qin Xiea Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, People’s Republic of China;e Anhui Province Key Laboratory of Reproductive Health and Genetics, Hefei, Anhui Province, People's Republic of China;f Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Medical University, Hefei, Anhui Province, People's Republic of China
,
Yong-Jun Kanga Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, People’s Republic of China;e Anhui Province Key Laboratory of Reproductive Health and Genetics, Hefei, Anhui Province, People's Republic of China;f Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Medical University, Hefei, Anhui Province, People's Republic of China
&
Min Lia Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, People’s Republic of China;c NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), Hefei, Anhui Province, People's Republic of China;d Key Laboratory of Population Health across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, Hefei, Anhui Province, People's Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-2561-7934
ORCID Icon
Article: e00251-19 | Received 14 Jun 2019, Accepted 13 Sep 2019, Published online: 03 Mar 2023

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Chunyue Chen, Xuejuan Jiang, Caifei Ding, Xin Sun, Lingyi Wan & Chenye Wang. (2023) Downregulated lncRNA HOTAIR ameliorates polycystic ovaries syndrome via IGF-1 mediated PI3K/Akt pathway. Gynecological Endocrinology 39:1.
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John R. Caradus. (2023) Intended and unintended consequences of genetically modified crops – myth, fact and/or manageable outcomes?. New Zealand Journal of Agricultural Research 66:6, pages 519-619.
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M. Ashraf & R. Munns. (2022) Evolution of Approaches to Increase the Salt Tolerance of Crops. Critical Reviews in Plant Sciences 41:2, pages 128-160.
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Articles from other publishers (14)

Xiaolu Chen, Jian Liu, Yanqiu Sun, Jianting Wen, Qin Zhou, Xiang Ding & Xianheng Zhang. (2023) Correlation analysis of differentially expressed long non-coding RNA HOTAIR with PTEN/PI3K/AKT pathway and inflammation in patients with osteoarthritis and the effect of baicalin intervention. Journal of Orthopaedic Surgery and Research 18:1.
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Ishaq Tantray, Rani Ojha & Aditya P. Sharma. (2023) Non-coding RNA and autophagy: Finding novel ways to improve the diagnostic management of bladder cancer. Frontiers in Genetics 13.
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Sumio Hayakawa, Tomokazu Ohishi, Yumiko Oishi, Mamoru Isemura & Noriyuki Miyoshi. (2022) Contribution of Non-Coding RNAs to Anticancer Effects of Dietary Polyphenols: Chlorogenic Acid, Curcumin, Epigallocatechin-3-Gallate, Genistein, Quercetin and Resveratrol. Antioxidants 11:12, pages 2352.
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Zahra Abedi kichi, Mona Soltani, Mina Rezaei, Zeinab Shirvani-Farsani & Mahbubeh Rojhannezhad. (2022) The Emerging Role of EMT-related lncRNAs in Therapy Resistance and their Applications as Biomarkers. Current Medicinal Chemistry 29:26, pages 4574-4601.
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Feng-Chih Kuo, Matt J. Neville, Rugivan Sabaratnam, Agata Wesolowska-Andersen, Daniel Phillips, Laura B.L. Wittemans, Andrea D. van Dam, Nellie Y. Loh, Marijana Todorčević, Nathan Denton, Katherine A. Kentistou, Peter K. Joshi, Constantinos Christodoulides, Claudia Langenberg, Philippe Collas, Fredrik Karpe & Katherine E. Pinnick. (2022) HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distribution. Cell Reports 40:4, pages 111136.
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Faiza Naz, Imran Tariq, Sajid Ali, Ahmed Somaida, Eduard Preis & Udo Bakowsky. (2021) The Role of Long Non-Coding RNAs (lncRNAs) in Female Oriented Cancers. Cancers 13:23, pages 6102.
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Anna Franca Cavaliere, Federica Perelli, Simona Zaami, Roberto Piergentili, Alberto Mattei, Giuseppe Vizzielli, Giovanni Scambia, Gianluca Straface, Stefano Restaino & Fabrizio Signore. (2021) Towards Personalized Medicine: Non-Coding RNAs and Endometrial Cancer. Healthcare 9:8, pages 965.
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Tiezhong Yi, Yicun Song, Lingling Zuo, Siyun Wang & Jintian Miao. (2021) LINC00470 Stimulates Methylation of PTEN to Facilitate the Progression of Endometrial Cancer by Recruiting DNMT3a Through MYC. Frontiers in Oncology 11.
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Ting Han, Mingbo Gao, Xin Wang, Wei Li, Jialu Zhuo, Zhihua Qu & Yiqiu Chen. (2021) LINC00665 activates Wnt/β-catenin signaling pathway to facilitate tumor progression of colorectal cancer via upregulating CTNNB1. Experimental and Molecular Pathology 120, pages 104639.
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Roberto Piergentili, Simona Zaami, Anna Franca Cavaliere, Fabrizio Signore, Giovanni Scambia, Alberto Mattei, Enrico Marinelli, Caterina Gulia & Federica Perelli. (2021) Non-Coding RNAs as Prognostic Markers for Endometrial Cancer. International Journal of Molecular Sciences 22:6, pages 3151.
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Soudeh Ghafouri-Fard, Sepideh Dashti, Molood Farsi & Mohammad Taheri. (2021) HOX transcript antisense RNA: An oncogenic lncRNA in diverse malignancies. Experimental and Molecular Pathology 118, pages 104578.
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Lingling Gao, Xin Nie, Wenchao Zhang, Rui Gou, Yuexin Hu, Yue Qi, Xiao Li, Qing Liu, Juanjuan Liu & Bei Lin. (2020) Identification of long noncoding RNA RP11-89K21.1 and RP11-357H14.17 as prognostic signature of endometrial carcinoma via integrated bioinformatics analysis. Cancer Cell International 20:1.
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Yun Liu, Yue Chang & Yi-xuan Cai. (2020) Inhibition of Lnc-OC1 Induced Cell Apoptosis and Decreased Cell Viability by Releasing miR-34a and Inhibiting PD-L1 in Endometrial Carcinoma. Reproductive Sciences 27:10, pages 1848-1856.
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Guanxue Xu, Wei Zhang, Zhenglong Wang, Man Chen & Bei Shi. (2020) Matrine regulates H2O2-induced oxidative stress through long non-coding RNA HOTAIR/miR-106b-5p axis via AKT and STAT3 pathways. Bioscience Reports 40:5.
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