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Molecular and Cellular Biology Volume 30, 2010 - Issue 17
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Article

Sortilin Facilitates Signaling of Ciliary Neurotrophic Factor and Related Helical Type 1 Cytokines Targeting the gp130/Leukemia Inhibitory Factor Receptor β Heterodimer

Jakob Vejby Larsen1 MIND Center, Department of Medical Biochemistry, University of Aarhus, Aarhus, Denmark
,
Maria Hansen2 MIND Center, Department of Molecular Biology, University of Aarhus, Aarhus, Denmark
,
Bjarne Møller3 Department of Clinical Immunology, Skejby Hospital, Aarhus, Denmark
,
Peder Madsen1 MIND Center, Department of Medical Biochemistry, University of Aarhus, Aarhus, Denmark
,
Jürgen Scheller4 Institute of Biochemistry, Christian Albrechts University of Kiel, Kiel, Germany
,
Morten Nielsen1 MIND Center, Department of Medical Biochemistry, University of Aarhus, Aarhus, Denmark
&
Claus Munck Petersen1 MIND Center, Department of Medical Biochemistry, University of Aarhus, Aarhus, DenmarkCorrespondence[email protected]
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Pages 4175-4187 | Received 12 Mar 2010, Accepted 12 Jun 2010, Published online: 20 Mar 2023

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Lone Tjener Pallesen, Camilla Gustafsen, Jacob Flyvholm Cramer, Steen Vang Petersen, Søren Skou Thirup, Peder Madsen & Claus Munck Petersen. (2020) PAK Kinases Target Sortilin and Modulate Its Sorting. Molecular and Cellular Biology 40:3.
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Jakob Vejby Larsen & Claus Munck Petersen. (2017) SorLA in Interleukin-6 Signaling and Turnover. Molecular and Cellular Biology 37:11.
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Jakob Vejby Larsen, Anders Mejer Kristensen, Lone Tjener Pallesen, Johannes Bauer, Christian Bjerggaard Vægter, Morten Schallburg Nielsen, Peder Madsen & Claus Munck Petersen. (2016) Cytokine-Like Factor 1, an Essential Facilitator of Cardiotrophin-Like Cytokine:Ciliary Neurotrophic Factor Receptor α Signaling and sorLA-Mediated Turnover. Molecular and Cellular Biology 36:8, pages 1272-1286.
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Articles from other publishers (28)

Huifang Guo, Peng Chen, Runfan Luo, Yuting Zhang, Xi Xu & Xingchun Gou. (2022) The Roles of Ciliary Neurotrophic Factor - from Neuronutrition to Energy Metabolism. Protein & Peptide Letters 29:10, pages 815-828.
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Kelly A. Mitok, Mark P. Keller & Alan D. Attie. (2022) Sorting through the extensive and confusing roles of sortilin in metabolic disease. Journal of Lipid Research 63:8, pages 100243.
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Laura Crisponi, Insa Buers & Frank Rutsch. (2022) CRLF1 and CLCF1 in Development, Health and Disease. International Journal of Molecular Sciences 23:2, pages 992.
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Natalie A. Sims. (2021) Influences of the IL-6 cytokine family on bone structure and function. Cytokine 146, pages 155655.
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Anna R. Malik & Thomas E. Willnow. (2020) VPS10P Domain Receptors: Sorting Out Brain Health and Disease. Trends in Neurosciences 43:11, pages 870-885.
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Natalie A. Sims & Joseph A. Lorenzo. 2020. Principles of Bone Biology. Principles of Bone Biology 1205 1246 .
Sarah Nahlé, Sarah Pasquin, Véronique Laplante, François Rousseau, Mukut Sharma & Jean-François Gauchat. (2019) Cardiotrophin-like cytokine (CLCF1) modulates mesenchymal stem cell osteoblastic differentiation. Journal of Biological Chemistry 294:32, pages 11952-11959.
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Hugo Talbot, Sofiane Saada, Thomas Naves, Paul-François Gallet, Anne-Laure Fauchais & Marie-Odile Jauberteau. (2019) Regulatory Roles of Sortilin and SorLA in Immune-Related Processes. Frontiers in Pharmacology 9.
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Sarah Pasquin, Véronique Laplante, Shiriane Kouadri, Andreea Milasan, Gaétan Mayer, Aurélie Jeanne Tormo, Virginia Savin, Mukut Sharma, Catherine Martel & Jean-François Gauchat. (2018) Cardiotrophin-like Cytokine Increases Macrophage–Foam Cell Transition. The Journal of Immunology 201:8, pages 2462-2471.
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Simone Eggert, Carolin Thomas, Stefan Kins & Guido Hermey. (2017) Trafficking in Alzheimer’s Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin. Molecular Neurobiology 55:7, pages 5809-5829.
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Simon Boggild, Simon Molgaard, Simon Glerup & Jens Randel Nyengaard. (2018) Highly segregated localization of the functionally related vps10p receptors sortilin and SorCS2 during neurodevelopment. Journal of Comparative Neurology 526:8, pages 1267-1286.
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Sarah Pasquin, Salma Chehboun, Agnieszka Dejda, Yasmine Meliani, Virginia Savin, Gregory J. Warner, Roger Bosse, Aurélie Tormo, Gaétan Mayer, Mukut Sharma, Przemyslaw Sapieha, Catherine Martel & Jean-François Gauchat. (2018) Effect of human very low-density lipoproteins on cardiotrophin-like cytokine factor 1 (CLCF1) activity. Scientific Reports 8:1.
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Dovile Januliene, Jacob Lauwring Andersen, Jeppe Achton Nielsen, Esben Meldgaard Quistgaard, Maria Hansen, Dorthe Strandbygaard, Arne Moeller, Claus Munck Petersen, Peder Madsen & Søren Skou Thirup. (2017) Acidic Environment Induces Dimerization and Ligand Binding Site Collapse in the Vps10p Domain of Sortilin. Structure 25:12, pages 1809-1819.e3.
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Dovile Januliene, Arulmani Manavalan, Peter Lund Ovesen, Karen-Marie Pedersen, Søren Thirup, Anders Nykjær & Arne Moeller. (2017) Hidden Twins: SorCS Neuroreceptors Form Stable Dimers. Journal of Molecular Biology 429:19, pages 2907-2917.
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Simon Glerup, Rainer Schulz, Ulrich Laufs & Klaus-Dieter Schlüter. (2017) Physiological and therapeutic regulation of PCSK9 activity in cardiovascular disease. Basic Research in Cardiology 112:3.
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Emma C. Walker, Rachelle W. Johnson, Yifang Hu, Holly J. Brennan, Ingrid J. Poulton, Jian-Guo Zhang, Brendan J. Jenkins, Gordon K. Smyth, Nicos A. Nicola & Natalie A. Sims. (2016) Murine Oncostatin M Acts via Leukemia Inhibitory Factor Receptor to Phosphorylate Signal Transducer and Activator of Transcription 3 (STAT3) but Not STAT1, an Effect That Protects Bone Mass. Journal of Biological Chemistry 291:41, pages 21703-21716.
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Xing-Li Meng, Taniqua S. Day, Nathan McNeill, Paula Ashcraft, Thomas Frischmuth, Seng H. Cheng, Zhi-Ping Liu, Jin-Song Shen & Raphael Schiffmann. (2016) Molecular basis for globotriaosylceramide regulation and enzyme uptake in immortalized aortic endothelial cells from Fabry mice. Journal of Inherited Metabolic Disease 39:3, pages 447-455.
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Natalie A. Sims. (2015) Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders. Cytokine & Growth Factor Reviews 26:5, pages 517-522.
Crossref
Sarah Pasquin, Mukut Sharma & Jean-François Gauchat. (2015) Ciliary neurotrophic factor (CNTF): New facets of an old molecule for treating neurodegenerative and metabolic syndrome pathologies. Cytokine & Growth Factor Reviews 26:5, pages 507-515.
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Mads Kjolby, Morten Schallburg Nielsen & Claus Munck Petersen. (2015) Sortilin, Encoded by the Cardiovascular Risk Gene SORT1, and Its Suggested Functions in Cardiovascular Disease. Current Atherosclerosis Reports 17:4.
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Martin B. Mortensen, Mads Kjolby, Stine Gunnersen, Jakob V. Larsen, Johan Palmfeldt, Erling Falk, Anders Nykjaer & Jacob F. Bentzon. (2014) Targeting sortilin in immune cells reduces proinflammatory cytokines and atherosclerosis. Journal of Clinical Investigation 124:12, pages 5317-5322.
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Sandra Oetjen, Claudia Mahlke, Irm Hermans-Borgmeyer & Guido Hermey. (2014) Spatiotemporal expression analysis of the growth factor receptor SorCS3. Journal of Comparative Neurology 522:15, pages 3386-3402.
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Jakob Vejby Larsen, Guido Hermey, Esben Skipper Sørensen, Thaneas Prabakaran, Erik Ilsø Christensen, Jørgen Gliemann, Peder Madsen & Claus Munck Petersen. (2013) Human sorCS1 binds sortilin and hampers its cellular functions. Biochemical Journal 457:2, pages 277-288.
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Jennifer Baltes, Jakob Vejby Larsen, Karthikeyan Radhakrishnan, Constanze Geumann, Manuel Kratzke, Claus Munck Petersen & Peter Schu. (2014) σ1B-adaptin sorts sortilin in adipose tissue regulating adipogenesis. Journal of Cell Science.
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S. Glerup, A. Nykjaer & C. B. Vaegter. 2014. Neurotrophic Factors. Neurotrophic Factors 165 189 .
Ana M. Santos, Noelia López-Sánchez, David Martín-Oliva, Pedro de la Villa, Miguel A. Cuadros & José M. Frade. (2012) Sortilin Participates in Light-dependent Photoreceptor Degeneration in Vivo. PLoS ONE 7:4, pages e36243.
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Anders Nykjaer & Thomas E. Willnow. (2012) Sortilin: a receptor to regulate neuronal viability and function. Trends in Neurosciences 35:4, pages 261-270.
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Marie-Emmanuelle Mathieu, Claire Saucourt, Virginie Mournetas, Xavier Gauthereau, Nadine Thézé, Vincent Praloran, Pierre Thiébaud & Hélène Bœuf. (2011) LIF-Dependent Signaling: New Pieces in the Lego. Stem Cell Reviews and Reports 8:1, pages 1-15.
Crossref

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