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Molecular and Cellular Biology Volume 34, 2014 - Issue 12
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Article

STAT1β Is Not Dominant Negative and Is Capable of Contributing to Gamma Interferon-Dependent Innate Immunity

Christian Sempera Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria
,
Nicole R. Leitnera Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria
,
Caroline Lassniga Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria;b University Center Biomodels Austria, University of Veterinary Medicine Vienna, Vienna, Austria
,
Matthias Parrinia Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria
,
Tanel Mahlakõivc Institute of Virology, University Medical Center Freiburg, Freiburg, Germany;d Spemann Graduate School of Biology and Medicine (SGBM), Albert Ludwigs University Freiburg, Freiburg, Germany
,
Michael Rammerstorfera Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria
,
Karin Lorenza Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria
,
Doris Riglera Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria
,
Simone Müllera Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria
,
Thomas Kolbeb University Center Biomodels Austria, University of Veterinary Medicine Vienna, Vienna, Austria;e Institute of Biotechnology in Animal Production, Department of Agrobiotechnology IFA-Tulln, University of Natural Resources and Life Sciences, Vienna, Austria
,
Claus Vogla Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria
,
Thomas Rülickef Institute of Laboratory Animal Science, University of Veterinary Medicine Vienna, Vienna, Austria
,
Peter Staehelic Institute of Virology, University Medical Center Freiburg, Freiburg, Germany
,
Thomas Deckerg Max F. Perutz Laboratories, University of Vienna, Vienna, Austria
,
Mathias Müllera Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria;b University Center Biomodels Austria, University of Veterinary Medicine Vienna, Vienna, Austria
&
Birgit Strobla Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, AustriaCorrespondence[email protected]
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Pages 2235-2248 | Received 03 Mar 2014, Accepted 31 Mar 2014, Published online: 20 Mar 2023

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Ivana Wiesauer, Clemens Gaumannmüller, Iris Steinparzer, Birgit Strobl & Pavel Kovarik. (2015) Promoter Occupancy of STAT1 in Interferon Responses Is Regulated by Processive Transcription. Molecular and Cellular Biology 35:4, pages 716-727.
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Articles from other publishers (27)

Sunkyung Choi, Namjoon Cho & Kee K. Kim. (2023) The implications of alternative pre-mRNA splicing in cell signal transduction. Experimental & Molecular Medicine 55:4, pages 755-766.
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Aarthi Subramani, Maria E. L. Hite, Sarah Garcia, Jack Maxwell, Hursha Kondee, Grace E. Millican, Erin E. McClelland, Rebecca L. Seipelt-Thiemann & David E. Nelson. (2023) Regulation of macrophage IFNγ-stimulated gene expression by the transcriptional coregulator CITED1. Journal of Cell Science 136:1.
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Mona Fendereski, Biswas Neupane, Farzana Nazneen, Fengwei Bai & Yan-Lin Guo. (2022) Mouse Trophoblast Cells Can Provide IFN-Based Antiviral Protection to Embryonic Stem Cells via Paracrine Signaling. The Journal of Immunology 208:12, pages 2761-2770.
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Manlio Tolomeo, Andrea Cavalli & Antonio Cascio. (2022) STAT1 and Its Crucial Role in the Control of Viral Infections. International Journal of Molecular Sciences 23:8, pages 4095.
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Atif Zafar, Hang Pong Ng, Rachel Diamond‐Zaluski, Gun‐Dong Kim, Ernest Ricky Chan, Sally L. Dunwoodie, Jonathan D. Smith & Ganapati H. Mahabeleshwar. (2021) CITED2 inhibits STAT1‐IRF1 signaling and atherogenesis. The FASEB Journal 35:9.
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Kuo-Chieh Liao & Mariano A. Garcia-Blanco. (2021) Role of Alternative Splicing in Regulating Host Response to Viral Infection. Cells 10:7, pages 1720.
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Rebecca Gupte, Tulip Nandu & W. Lee Kraus. (2021) Nuclear ADP-ribosylation drives IFNγ-dependent STAT1α enhancer formation in macrophages. Nature Communications 12:1.
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Klara Klein, Dagmar Stoiber, Veronika Sexl & Agnieszka Witalisz-Siepracka. (2021) Untwining Anti-Tumor and Immunosuppressive Effects of JAK Inhibitors—A Strategy for Hematological Malignancies?. Cancers 13:11, pages 2611.
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Kensei Kishimoto, Catera L. Wilder, Justin Buchanan, Minh Nguyen, Chidera Okeke, Alexander Hoffmann & Quen J. Cheng. (2021) High Dose IFN-β Activates GAF to Enhance Expression of ISGF3 Target Genes in MLE12 Epithelial Cells. Frontiers in Immunology 12.
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Xin Li, Fanchen Wang, Xiaolin Xu, Jinguo Zhang & Guoxiong Xu. (2021) The Dual Role of STAT1 in Ovarian Cancer: Insight Into Molecular Mechanisms and Application Potentials. Frontiers in Cell and Developmental Biology 9.
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Sandeep Sreevalsan, Marietta Döring, Maciej Paszkowski‐Rogacz, Melanie Brux, Carolina Blanck, Marten Meyer, Frank Momburg, Frank Buchholz & Mirko Theis. (2020) MLLT 6 maintains PD ‐L1 expression and mediates tumor immune resistance . EMBO reports 21:12.
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Katrin Meissl, Natalija Simonović, Lena Amenitsch, Agnieszka Witalisz-Siepracka, Klara Klein, Caroline Lassnig, Ana Puga, Claus Vogl, Andrea Poelzl, Markus Bosmann, Alexander Dohnal, Veronika Sexl, Mathias Müller & Birgit Strobl. (2020) STAT1 Isoforms Differentially Regulate NK Cell Maturation and Anti-tumor Activity. Frontiers in Immunology 11.
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Yannick Verhoeven, Sam Tilborghs, Julie Jacobs, Jorrit De Waele, Delphine Quatannens, Christophe Deben, Hans Prenen, Patrick Pauwels, Xuan Bich Trinh, An Wouters, Evelien L.J. Smits, Filip Lardon & Peter A. van Dam. (2020) The potential and controversy of targeting STAT family members in cancer. Seminars in Cancer Biology 60, pages 41-56.
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Hui Wu, Yinyin Zhang, Xingyu Lu, Jun Xiao, Pinghui Feng & Hao Feng. (2019) STAT1a and STAT1b of black carp play important roles in the innate immune defense against GCRV. Fish & Shellfish Immunology 87, pages 386-394.
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Juliane Friedrich, Lisanne Heim, Denis I. Trufa, Horia Sirbu, Ralf J. Rieker, Mircea T. Chiriac & Susetta Finotto. (2018) STAT1 deficiency supports PD-1/PD-L1 signaling resulting in dysfunctional TNFα mediated immune responses in a model of NSCLC. Oncotarget 9:98, pages 37157-37172.
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Matthias Parrini, Katrin Meissl, Mojoyinola Joanna Ola, Therese Lederer, Ana Puga, Sebastian Wienerroither, Pavel Kovarik, Thomas Decker, Mathias Müller & Birgit Strobl. (2018) The C-Terminal Transactivation Domain of STAT1 Has a Gene-Specific Role in Transactivation and Cofactor Recruitment. Frontiers in Immunology 9.
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Subburaj Ilangumaran, Bryan R.G. Williams & Dhan V. Kalvakolanu. (2018) Meeting summary: 2nd Aegean Conference on Cytokine Signaling in Cancer. Cytokine 108, pages 225-231.
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Ioana I. Nitulescu, Sara C. Meyer, Qiang Jeremy Wen, John D. Crispino, Madeleine E. Lemieux, Ross L. Levine, Henry E. Pelish & Matthew D. Shair. (2017) Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation. EBioMedicine 26, pages 112-125.
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Ying Zhang, Yelong Chen, Hailong Yun, Zhaoyong Liu, Min Su & Raymond Lai. (2017) STAT1β enhances STAT1 function by protecting STAT1α from degradation in esophageal squamous cell carcinoma. Cell Death & Disease 8:10, pages e3077-e3077.
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Katelijne De Wilde, Arne Martens, Stijn Lambrecht, Peggy Jacques, Michael B Drennan, Karlijn Debusschere, Srinath Govindarajan, Julie Coudenys, Eveline Verheugen, Fien Windels, Leen Catrysse, Rik Lories, Dennis McGonagle, Rudi Beyaert, Geert van Loo & Dirk Elewaut. (2017) A20 inhibition of STAT1 expression in myeloid cells: a novel endogenous regulatory mechanism preventing development of enthesitis. Annals of the Rheumatic Diseases 76:3, pages 585-592.
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Katrin Meissl, Sabine Macho-Maschler, Mathias Müller & Birgit Strobl. (2017) The good and the bad faces of STAT1 in solid tumours. Cytokine 89, pages 12-20.
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Johnathan Ho, Christin Pelzel, Andreas Begitt, Maureen Mee, Hany M. Elsheikha, David J. Scott & Uwe Vinkemeier. (2016) STAT2 Is a Pervasive Cytokine Regulator due to Its Inhibition of STAT1 in Multiple Signaling Pathways. PLOS Biology 14:10, pages e2000117.
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Emma L. Norris, Madeleine J. Headlam, Keyur A. Dave, David D. Smith, Alexander Bukreyev, Toshna Singh, Buddhika A. Jayakody, Keith J. Chappell, Peter L. Collins & Jeffrey J. Gorman. (2016) Proteoform-Specific Insights into Cellular Proteome Regulation. Molecular & Cellular Proteomics 15:10, pages 3297-3320.
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Rosalba Camicia, Hans C. Winkler & Paul O. Hassa. (2015) Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review. Molecular Cancer 14:1.
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Na-Jin Kang, Dong-Hwan Koo, Gyeoung-Jin KangSang-Chul HanBang-Won LeeYoung-Sang KohJin-Won HyunNam-Ho Lee, Mi-Hee Ko, Hee-Kyoung KangEun-Sook Yoo. (2015) Dieckol, a Component of Ecklonia cava, Suppresses the Production of MDC/CCL22 via Down-Regulating STAT1 Pathway in Interferon-γ Stimulated HaCaT Human Keratinocytes. Biomolecules & Therapeutics 23:3, pages 238-244.
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Tom Grunert, Avril Monahan, Caroline Lassnig, Claus Vogl, Mathias Müller & Monika Ehling-Schulz. (2014) Deciphering Host Genotype-Specific Impacts on the Metabolic Fingerprint of Listeria monocytogenes by FTIR Spectroscopy. PLoS ONE 9:12, pages e115959.
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