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Lysine Demethylase KDM6A in Differentiation, Development, and Cancer

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Article: e00341-20 | Published online: 03 Mar 2023

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Bi Shi, Wei Li & Hao Jiang. (2021) Epigenetic condensates regulate chromatin activity and tumorigenesis. Molecular & Cellular Oncology 8:5.
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Jia Yi, Lei Wang, Jiao Du, Mingyue Wang, Haifeng Shen, Zhiying Liu, Yao Qin, Jing Liu, Guosheng Hu, Rongquan Xiao, Jiancheng Ding, Xiaoyan Chen, Hongjiao Wang, Haihua Huang, Gaoliang Ouyang & Wen Liu. (2023) ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer. Developmental Cell 58:9, pages 760-778.e6.
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Li-Juan Chen, Xin-Yang Xu, Xiao-Dan Zhong, Yan-Jun Liu, Ming-Hui Zhu, Fan Tao, Chang-Yun Li, Qiu-Sheng She, Guan-Jun Yang & Jiong Chen. (2023) The role of lysine-specific demethylase 6A (KDM6A) in tumorigenesis and its therapeutic potentials in cancer therapy. Bioorganic Chemistry 133, pages 106409.
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Jing Chen, Jing-Xia Zhang, Hai-Xia Lei, Xing-Yu Li, Yong-Xin Yan, Yan-Ling Wang, Yu-Hong Lv, Yun-Li Yan & Yu-Hua Lei. (2023) 13-Cis Retinoic Acid Induces Neuronal Differentiation in Daoy (Medulloblastoma) Cells Through Epigenetic Regulation of Topoisomerase IIβ. Applied Biochemistry and Biotechnology.
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Gülden Özden-Yılmaz, Busra Savas, Ahmet Bursalı, Aleyna Eray, Alirıza Arıbaş, Serif Senturk, Ezgi Karaca, Gökhan Karakülah & Serap Erkek-Ozhan. (2023) Differential Occupancy and Regulatory Interactions of KDM6A in Bladder Cell Lines. Cells 12:6, pages 836.
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Anna Zuo, Jiarun Xie, Junqiao Shao, Shuyu Li, Haoyu Lin, Shaoting Wang, Wei Sun, Jinjin Xia, Weiqiang Jiang, Jia Sun & Ming Wang. (2023) Shenkang recipe alleviates renal aging in diabetic kidney disease by interfering with the lysine-specific demethylase KDM6B to modulate the PPAR-γ signaling pathway. Pharmacological Research - Modern Chinese Medicine 6, pages 100216.
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Xueying Ma, Xin Chen, Zhonghua Duan, Yuqiong Wu, Jiaen Shu, Pei Wu, Yiguo Zhao, Xu Wang & Yuhua Wang. (2023) Circadian rhythm disruption exacerbates the progression of macrophage dysfunction and alveolar bone loss in periodontitis. International Immunopharmacology 116, pages 109796.
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Wenxiu Ma, He Fang, Nicolas Pease, Galina N. Filippova, Christine M. Disteche & Joel B. Berletch. (2022) Sex-biased and parental allele-specific gene regulation by KDM6A. Biology of Sex Differences 13:1.
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Jeries Abu-Hanna, Jigisha A. Patel, Evangelos Anastasakis, Richard Cohen, Lucie H. Clapp, Marilena Loizidou & Mohammad M. R. Eddama. (2022) Therapeutic potential of inhibiting histone 3 lysine 27 demethylases: a review of the literature. Clinical Epigenetics 14:1.
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Yi Zhang, Bihui Zheng, Kexin Lou, Xinyu Xu & Youtao Xu. (2022) Methylation patterns of Lys9 and Lys27 on histone H3 correlate with patient outcome and tumor progression in lung cancer. Annals of Diagnostic Pathology 61, pages 152045.
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Hongyi Liao, Qingqiang Tu, Yunze Kang, Guping Mao, Zhiwen Li, Shu Hu, Puyi Sheng, Xudong Wang, Yiyang Xu, Dianbo Long, Yuanyuan Xu, Yan Kang & Ziji Zhang. (2022) CircNFIX regulates chondrogenesis and cartilage homeostasis by targeting the miR758 ‐3p/ KDM6A axis . Cell Proliferation 55:11.
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Yanjun Wen, Xin Chen, Huazhang Feng, Xu Wang, Xiaoli Kang, Peiquan Zhao, Chen Zhao & Yan Wei. (2022) Kdm6a deficiency in microglia/macrophages epigenetically silences Lcn2 expression and reduces photoreceptor dysfunction in diabetic retinopathy. Metabolism 136, pages 155293.
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Lucas E. Cabrera Zapata, Luis Miguel Garcia-Segura, María Julia Cambiasso & Maria Angeles Arevalo. (2022) Genetics and Epigenetics of the X and Y Chromosomes in the Sexual Differentiation of the Brain. International Journal of Molecular Sciences 23:20, pages 12288.
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Shaokang Zhao, Wenqiang Sun, Shi-Yi Chen, Yuchao Li, Jie Wang, Songjia Lai & Xianbo Jia. (2022) The exploration of miRNAs and mRNA profiles revealed the molecular mechanisms of cattle-yak male infertility. Frontiers in Veterinary Science 9.
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Lucas E. Cabrera Zapata, María Julia Cambiasso & Maria Angeles Arevalo. (2022) Epigenetic modifier Kdm6a/Utx controls the specification of hypothalamic neuronal subtypes in a sex-dependent manner. Frontiers in Cell and Developmental Biology 10.
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Wei-Shiung Lian, Re-Wen Wu, Jih-Yang Ko, Yu-Shan Chen, Shao-Yu Wang, Chun-Ping Yu, Holger Jahr & Feng-Sheng Wang. (2022) Histone H3K27 demethylase UTX compromises articular chondrocyte anabolism and aggravates osteoarthritic degeneration. Cell Death & Disease 13:6.
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Yixue Huang, Yunhao Xie, Dong Yang, Mingrui Xiong, Xingrui Chen, Di Wu, Qing Wang, Hong Chen, Ling Zheng & Kun Huang. (2022) Histone demethylase UTX aggravates acetaminophen overdose induced hepatotoxicity through dual mechanisms. Pharmacological Research 175, pages 106021.
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Tommaso Biagini, Francesco Petrizzelli, Salvatore Daniele Bianco, Niccolò Liorni, Alessandro Napoli, Stefano Castellana, Angelo Luigi Vescovi, Massimo Carella, Viviana Caputo & Tommaso Mazza. (2022) KDM6A missense variants hamper H3 histone demethylation in lung squamous cell carcinoma. Computational and Structural Biotechnology Journal 20, pages 3151-3160.
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Lei Liu, Jianfeng Cui, Yajing Zhao, Xiaochen Liu, Lipeng Chen, Yangyang Xia, Yong Wang, Shouzhen Chen, Shuna Sun, Benkang Shi & Yongxin Zou. (2021) KDM6A-ARHGDIB axis blocks metastasis of bladder cancer by inhibiting Rac1. Molecular Cancer 20:1.
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Hong-Xian Guo, Bao-Wei Li, Mei Hu, Shao-Yan Si & Kai Feng. (2021) Novel KDM6A mutation in a Chinese infant with Kabuki syndrome: A case report . World Journal of Clinical Cases 9:33, pages 10257-10264.
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Yajing Meng, Tianzhe Zhang, Ran Zheng, Song Ding, Jie Yang, Ran Liu, Yingan Jiang & Wei Jiang. (2021) Depletion of Demethylase KDM6 Enhances Early Neuroectoderm Commitment of Human PSCs. Frontiers in Cell and Developmental Biology 9.
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