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Molecular and Cellular Biology Volume 26, 2006 - Issue 14
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Article

Role of p38 in Replication of Trypanosoma brucei Kinetoplast DNA

Beiyu Liu1 Department of Biological Chemistry, Johns Hopkins Medical School, Baltimore, Maryland21205
,
Henrik Molina1 Department of Biological Chemistry, Johns Hopkins Medical School, Baltimore, Maryland21205
,
Dario Kalume1 Department of Biological Chemistry, Johns Hopkins Medical School, Baltimore, Maryland21205
,
Akhilesh Pandey1 Department of Biological Chemistry, Johns Hopkins Medical School, Baltimore, Maryland21205
,
Jack D. Griffith2 Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina27599
&
Paul T. Englund1 Department of Biological Chemistry, Johns Hopkins Medical School, Baltimore, Maryland21205Correspondence[email protected]
Pages 5382-5393 | Received 01 Mar 2006, Accepted 05 May 2006, Published online: 27 Mar 2023

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Jane C. Hines & Dan S. Ray. (2010) A Mitochondrial DNA Primase Is Essential for Cell Growth and Kinetoplast DNA Replication in Trypanosoma brucei. Molecular and Cellular Biology 30:6, pages 1319-1328.
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Articles from other publishers (43)

Simona Amodeo, Irina Bregy & Torsten Ochsenreiter. (2022) Mitochondrial genome maintenance—the kinetoplast story. FEMS Microbiology Reviews.
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Aline A. Zuma, Emile dos Santos Barrias & Wanderley de Souza. (2021) Basic Biology of Trypanosoma cruzi. Current Pharmaceutical Design 27:14, pages 1671-1732.
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Jonathan C. Miller, Stephanie B. Delzell, Jeniffer Concepción-Acevedo, Michael J. Boucher & Michele M. Klingbeil. (2020) A DNA polymerization-independent role for mitochondrial DNA polymerase I-like protein C in African trypanosomes. Journal of Cell Science 133:9.
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Davide Michieletto, Robert Fitzpatrick & Rae M. Robertson-Anderson. (2019) Maximally stiffening composites require maximally coupled rather than maximally entangled polymer species. Soft Matter 15:33, pages 6703-6717.
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Carlos A.H. Fernandes, Arina M. Perez, Andrea C. Barros, Thiago R. Dreyer, Marcelo S. da Silva, Edna Gicela O. Morea, Marcos R.M. Fontes & Maria Isabel N. Cano. (2019) Dual cellular localization of the Leishmania amazonensis Rbp38 (LaRbp38) explains its affinity for telomeric and mitochondrial DNA. Biochimie 162, pages 15-25.
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Clare Halliday, Karen Billington, Ziyin Wang, Ross Madden, Samuel Dean, Jack Daniel Sunter & Richard John Wheeler. (2019) Cellular landmarks of Trypanosoma brucei and Leishmania mexicana. Molecular and Biochemical Parasitology 230, pages 24-36.
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Kojo Mensa-Wilmot, Benjamin Hoffman, Justin Wiedeman, Catherine Sullenberger & Amrita Sharma. (2019) Kinetoplast Division Factors in a Trypanosome. Trends in Parasitology 35:2, pages 119-128.
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Arunkumar Krishnan, A. Maxwell Burroughs, Lakshminarayan M. Iyer & L. Aravind. (2018) Unexpected Evolution of Lesion-Recognition Modules in Eukaryotic NER and Kinetoplast DNA Dynamics Proteins from Bacterial Mobile Elements. iScience 9, pages 192-208.
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Olga Klebanov-Akopyan, Amartya Mishra, Galina Glousker, Yehuda Tzfati & Joseph Shlomai. (2018) Trypanosoma brucei UMSBP2 is a single-stranded telomeric DNA binding protein essential for chromosome end protection. Nucleic Acids Research 46:15, pages 7757-7771.
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Simona Amodeo, Martin Jakob & Torsten Ochsenreiter. (2018) Characterization of the novel mitochondrial genome replication factor MiRF172 in Trypanosoma brucei . Journal of Cell Science.
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Alena Zíková, Vladimír Hampl, Zdeněk Paris, Jiří Týč & Julius Lukeš. (2016) Aerobic mitochondria of parasitic protists: Diverse genomes and complex functions. Molecular and Biochemical Parasitology 209:1-2, pages 46-57.
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Jaspreet S. Grewal, Karen McLuskey, Debanu Das, Elmarie Myburgh, Jonathan Wilkes, Elaine Brown, Leandro Lemgruber, Matthew K. Gould, Richard J. Burchmore, Graham H. Coombs, Achim Schnaufer & Jeremy C. Mottram. (2016) PNT1 Is a C11 Cysteine Peptidase Essential for Replication of the Trypanosome Kinetoplast. Journal of Biological Chemistry 291:18, pages 9492-9500.
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Diane-Ethna Mbang-Benet, Yvon Sterkers, Lucien Crobu, Amélie Sarrazin, Patrick Bastien & Michel Pagès. (2015) RNA interference screen reveals a high proportion of mitochondrial proteins essential for correct cell cycle progress in Trypanosoma brucei. BMC Genomics 16:1.
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Richard G. Wong, Katelynn Kazane, Dmitri A. Maslov, Kestrel Rogers, Ruslan Aphasizhev & Larry Simpson. (2015) U-insertion/deletion RNA editing multiprotein complexes and mitochondrial ribosomes in Leishmania tarentolae are located in antipodal nodes adjacent to the kinetoplast DNA. Mitochondrion 25, pages 76-86.
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H.O. Dyary, A.K. Arifah, R.S.K. Sharma, A. Rasedee, M.S. Mohd Aspollah, Z.A. Zakaria, A. Zuraini & M.N. Somchit. (2015) In vivo antitrypanosomal activity of Garcinia hombroniana aqueous extract. Research in Veterinary Science 100, pages 226-231.
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Jiří Týč, Michele M. Klingbeil & Julius Lukeš. (2015) Mitochondrial Heat Shock Protein Machinery Hsp70/Hsp40 Is Indispensable for Proper Mitochondrial DNA Maintenance and Replication. mBio 6:1.
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Zdeněk Verner, Somsuvro Basu, Corinna Benz, Sameer Dixit, Eva Dobáková, Drahomíra Faktorová, Hassan Hashimi, Eva Horáková, Zhenqiu Huang, Zdeněk Paris, Priscila Peña-Diaz, Lucie Ridlon, Jiří Týč, David Wildridge, Alena Zíková & Julius Lukeš. 2015. 73 151 .
Jianyang Wang, Valeria Pappas-Brown, Paul T. Englund & Robert E. Jensen. (2014) TbKAP6, a Mitochondrial HMG Box-Containing Protein in Trypanosoma brucei, Is the First Trypanosomatid Kinetoplast-Associated Protein Essential for Kinetoplast DNA Replication and Maintenance. Eukaryotic Cell 13:7, pages 919-932.
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Julius Lukeš, Tomáš Skalický, Jiří Týč, Jan Votýpka & Vyacheslav Yurchenko. (2014) Evolution of parasitism in kinetoplastid flagellates. Molecular and Biochemical Parasitology 195:2, pages 115-122.
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Kirsten Beck, Nathalie Acestor, Anjelique Schulfer, Atashi Anupama, Jason Carnes, Aswini K. Panigrahi & Ken Stuart. (2013) Trypanosoma brucei Tb927.2.6100 Is an Essential Protein Associated with Kinetoplast DNA. Eukaryotic Cell 12:7, pages 970-978.
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Rachel Bezalel‐Buch, Nurit Yaffe & Joseph Shlomai. 2013. Trypanosomatid Diseases. Trypanosomatid Diseases 243 260 .
Robert E. Jensen & Paul T. Englund. (2012) Network News: The Replication of Kinetoplast DNA. Annual Review of Microbiology 66:1, pages 473-491.
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Jeniffer Concepción-Acevedo, Juemin Luo & Michele M. Klingbeil. (2012) Dynamic Localization of Trypanosoma brucei Mitochondrial DNA Polymerase ID. Eukaryotic Cell 11:7, pages 844-855.
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Jianyang Wang, Paul T. Englund & Robert E. Jensen. (2012) TbPIF8, a Trypanosoma brucei protein related to the yeast Pif1 helicase, is essential for cell viability and mitochondrial genome maintenance. Molecular Microbiology 83:3, pages 471-485.
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David F. Bruhn, Mark P. Sammartino & Michele M. Klingbeil. (2011) Three Mitochondrial DNA Polymerases Are Essential for Kinetoplast DNA Replication and Survival of Bloodstream Form Trypanosoma brucei. Eukaryotic Cell 10:6, pages 734-743.
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Jane C. Hines & Dan S. Ray. (2011) A Second Mitochondrial DNA Primase Is Essential for Cell Growth and Kinetoplast Minicircle DNA Replication in Trypanosoma brucei. Eukaryotic Cell 10:3, pages 445-454.
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Arnab Roy Chowdhury, Rahul Bakshi, Jianyang Wang, Gokben Yildirir, Beiyu Liu, Valeria Pappas-Brown, Gökhan Tolun, Jack D. Griffith, Theresa A. Shapiro, Robert E. Jensen & Paul T. Englund. (2010) The Killing of African Trypanosomes by Ethidium Bromide. PLoS Pathogens 6:12, pages e1001226.
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David F. Bruhn, Brian Mozeleski, Laurie Falkin & Michele M. Klingbeil. (2010) Mitochondrial DNA polymerase POLIB is essential for minicircle DNA replication in African trypanosomes. Molecular Microbiology 75:6, pages 1414-1425.
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Beiyu Liu, Gokben Yildirir, Jianyang Wang, Gökhan Tolun, Jack D. Griffith & Paul T. Englund. (2010) TbPIF1, a Trypanosoma brucei Mitochondrial DNA Helicase, Is Essential for Kinetoplast Minicircle Replication. Journal of Biological Chemistry 285:10, pages 7056-7066.
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Julius Lukeš, Hassan Hashimi, Zdeněk Verner & Zdeňka Čičová. 2010. Structures and Organelles in Pathogenic Protists. Structures and Organelles in Pathogenic Protists 227 252 .
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Beiyu Liu, Jianyang Wang, Gokben Yildirir & Paul T. Englund. (2009) TbPIF5 Is a Trypanosoma brucei Mitochondrial DNA Helicase Involved in Processing of Minicircle Okazaki Fragments. PLoS Pathogens 5:9, pages e1000589.
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Beiyu Liu, Jianyang Wang, Nurit Yaffe, Megan E. Lindsay, Zhixing Zhao, Aviad Zick, Joseph Shlomai & Paul T. Englund. (2009) Trypanosomes Have Six Mitochondrial DNA Helicases with One Controlling Kinetoplast Maxicircle Replication. Molecular Cell 35:4, pages 490-501.
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Julian Chandler, Anthula V. Vandoros, Brian Mozeleski & Michele M. Klingbeil. (2008) Stem-Loop Silencing Reveals that a Third Mitochondrial DNA Polymerase, POLID, Is Required for Kinetoplast DNA Replication in Trypanosomes. Eukaryotic Cell 7:12, pages 2141-2146.
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Megan E. Lindsay, Eva Gluenz, Keith Gull & Paul T. Englund. (2008) A new function of Trypanosoma brucei mitochondrial topoisomerase II is to maintain kinetoplast DNA network topology . Molecular Microbiology 70:6, pages 1465-1476.
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Hassan Hashimi, Alena Zíková, Aswini K. Panigrahi, Kenneth D. Stuart & Julius Lukeš. (2008) TbRGG1, an essential protein involved in kinetoplastid RNA metabolism that is associated with a novel multiprotein complex. RNA 14:5, pages 970-980.
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Ziyin Li, Megan E. Lindsay, Shawn A. Motyka, Paul T. Englund & Ching C. Wang. (2008) Identification of a Bacterial-Like HslVU Protease in the Mitochondria of Trypanosoma brucei and Its Role in Mitochondrial DNA Replication. PLoS Pathogens 4:4, pages e1000048.
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Jane R. Scocca & Theresa A. Shapiro. (2007) A mitochondrial topoisomerase IA essential for late theta structure resolution in African trypanosomes. Molecular Microbiology 67:4, pages 820-829.
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Neta MilmanShawn A. Motyka, Paul T. Englund, Derrick Robinson & Joseph Shlomai. (2007) Mitochondrial origin-binding protein UMSBP mediates DNA replication and segregation in trypanosomes. Proceedings of the National Academy of Sciences 104:49, pages 19250-19255.
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Yue Li, Yu Sun, Jane C. Hines & Dan S. Ray. (2007) Identification of New Kinetoplast DNA Replication Proteins in Trypanosomatids Based on Predicted S-Phase Expression and Mitochondrial Targeting. Eukaryotic Cell 6:12, pages 2303-2310.
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Cristina B.B. Lira, Miriam A. Giardini, Jair L. Siqueira Neto, Fábio F. Conte & Maria Isabel N. Cano. (2007) Telomere biology of trypanosomatids: beginning to answer some questions. Trends in Parasitology 23:8, pages 357-362.
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C.B.B. Lira, J.L. Siqueira Neto, M.A. Giardini, F.V. Winck, C.H.I. Ramos & M.I.N. Cano. (2007) LaRbp38: A Leishmania amazonensis protein that binds nuclear and kinetoplast DNAs. Biochemical and Biophysical Research Communications 358:3, pages 854-860.
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Yanan Liu & Paul T. Englund. (2007) The rotational dynamics of kinetoplast DNA replication. Molecular Microbiology 64:3, pages 676-690.
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