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Molecular and Cellular Biology Volume 33, 2013 - Issue 23
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Article

Akt Switches TopBP1 Function from Checkpoint Activation to Transcriptional Regulation through Phosphoserine Binding-Mediated Oligomerization

Kang Liua Section of Hematology/Oncology, Departments of Medicine and Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
,
Joshua D. Gravesa Section of Hematology/Oncology, Departments of Medicine and Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
,
Jessica D. Scotta Section of Hematology/Oncology, Departments of Medicine and Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
,
Rongbao Lib Department of Medicinal Chemistry, Southern Research Institute, Birmingham, Alabama, USA
&
Weei-Chin Lina Section of Hematology/Oncology, Departments of Medicine and Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USACorrespondence[email protected]
Pages 4685-4700 | Received 27 Mar 2013, Accepted 12 Sep 2013, Published online: 20 Mar 2023

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Kang Liu, Joshua D. Graves, Yu-Ju Lee, Fang-Tsyr Lin & Weei-Chin Lin. (2020) Cell Cycle-Dependent Switch of TopBP1 Functions by Cdk2 and Akt. Molecular and Cellular Biology 40:8.
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Articles from other publishers (22)

Zejun Fang, Chaoju Gong, Zhuoni Ye, Wei Wang, Minjing Zhu, Yanyan Hu, Zhiguo Liu, Weihua Zhou & Hongzhang Li. (2022) TOPBP1 regulates resistance of gastric cancer to oxaliplatin by promoting transcription of PARP1. DNA Repair 111, pages 103278.
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Artem K. Velichko, Natalia Ovsyannikova, Nadezhda V. Petrova, Artem V. Luzhin, Maria Vorobjeva, Alexey S. Gavrikov, Alexander S. Mishin, Igor I. Kireev, Sergey V. Razin & Omar L. Kantidze. (2021) Treacle and TOPBP1 control replication stress response in the nucleolus. Journal of Cell Biology 220:8.
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Vaughn Thada & David Cortez. (2021) ATR activation is regulated by dimerization of ATR activating proteins. Journal of Biological Chemistry 296, pages 100455.
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Kang Liu, Joshua D. Graves, Fang-Tsyr Lin & Weei-Chin Lin. (2021) Overexpression of TopBP1, a canonical ATR/Chk1 activator, paradoxically hinders ATR/Chk1 activation in cancer. Journal of Biological Chemistry 296, pages 100382.
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Ahhyun Kim, Katrina Montales, Kenna Ruis, Holly Senebandith, Hovik Gasparyan, Quinn Cowan & W. Matthew Michael. (2020) Biochemical analysis of TOPBP1 oligomerization. DNA Repair 96, pages 102973.
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Ying Luo & Shiyuan Hong. (2020) The Role of Ataxia Telangiectasia Mutant and Rad3-Related DNA Damage Response in Pathogenesis of Human Papillomavirus. Pathogens 9:6, pages 506.
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Jacques Baudier, Jean Christophe Deloulme & Gary S. Shaw. (2020) The Zn 2+ and Ca 2+ ‐binding S100B and S100A1 proteins: beyond the myths . Biological Reviews 95:3, pages 738-758.
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Shiyuan Hong, Junfen Xu, Yan Li, Jorge Andrade, Paul Hoover, Paul J. Kaminski & Laimonis A. Laimins. (2019) Topoisomerase IIβ-binding protein 1 activates expression of E2F1 and p73 in HPV-positive cells for genome amplification upon epithelial differentiation. Oncogene 38:17, pages 3274-3287.
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Na Song, Xiaofang Che, Lu Xu, Jinglei Qu, Huachuan Zheng, Kezuo Hou, Xiujuan Qu & Yunpeng Liu. (2017) A novel function of hepatocyte growth factor in the activation of checkpoint kinase 1 phosphorylation in colon cancer cells. Molecular and Cellular Biochemistry 436:1-2, pages 29-38.
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Dipon Das, Nathan W. Smith, Xu Wang, Stacie L. Richardson, Matthew C.T. Hartman & Iain M. Morgan. (2017) Calcein represses human papillomavirus 16 E1-E2 mediated DNA replication via blocking their binding to the viral origin of replication. Virology 508, pages 180-187.
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Kang LiuFang-Tsyr LinJoshua D. GravesYu-Ju LeeWeei-Chin Lin. (2017) Mutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin. Proceedings of the National Academy of Sciences 114:19.
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Deepti Mathur, Elias Stratikopoulos, Sait Ozturk, Nicole Steinbach, Sarah Pegno, Sarah Schoenfeld, Raymund Yong, Vundavalli V. Murty, John M. Asara, Lewis C. Cantley & Ramon Parsons. (2017) PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition. Cancer Discovery 7:4, pages 380-390.
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Eva Vesela, Katarina Chroma, Zsofia Turi & Martin Mistrik. (2017) Common Chemical Inductors of Replication Stress: Focus on Cell‐Based Studies. Biomolecules 7:4, pages 19.
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Pavel Moudry, Kenji Watanabe, Kamila M. Wolanin, Jirina Bartkova, Isabel E. Wassing, Sugiko Watanabe, Robert Strauss, Rune Troelsgaard Pedersen, Vibe H. Oestergaard, Michael Lisby, Miguel Andújar-Sánchez, Apolinar Maya-Mendoza, Fumiko Esashi, Jiri Lukas & Jiri Bartek. (2016) TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity. Journal of Cell Biology 212:3, pages 281-288.
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Se Hee Han, Soo-Hyun Hahm, An Hue Vy Tran, Ji Hyung Chung, Myoung-Ki Hong, Hyun-Dong Paik, Key-Sun Kim & Ye Sun Han. (2015) A physical association between the human mutY homolog (hMYH) and DNA topoisomerase II-binding protein 1 (hTopBP1) regulates Chk1-induced cell cycle arrest in HEK293 cells. Cell & Bioscience 5:1.
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Shiuh-Rong Ho, Yu-Ju Lee & Weei-Chin Lin. (2015) Regulation of RNF144A E3 Ubiquitin Ligase Activity by Self-association through Its Transmembrane Domain. Journal of Biological Chemistry 290:38, pages 23026-23038.
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Rune Troelsgaard Pedersen, Thomas Kruse, Jakob Nilsson, Vibe H. Oestergaard & Michael Lisby. (2015) TopBP1 is required at mitosis to reduce transmission of DNA damage to G1 daughter cells. Journal of Cell Biology 210:4, pages 565-582.
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Miiko Sokka, Kirsi Rilla, Ilkka Miinalainen, Helmut Pospiech & Juhani E. Syväoja. (2015) High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation. Nucleic Acids Research 43:10, pages 4975-4989.
Crossref
Pinki Chowdhury, Gregory E. Lin, Kang Liu, Yongcheng Song, Fang-Tsyr Lin & Weei-Chin Lin. (2014) Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy. Nature Communications 5:1.
Crossref
Christopher P. Wardlaw, Antony M. Carr & Antony W. Oliver. (2014) TopBP1: A BRCT-scaffold protein functioning in multiple cellular pathways. DNA Repair 22, pages 165-174.
Crossref
P Meng & R Ghosh. (2014) Transcription addiction: can we garner the Yin and Yang functions of E2F1 for cancer therapy?. Cell Death & Disease 5:8, pages e1360-e1360.
Crossref
Yuan-Hao Lee, Youping Sun & Randolph Glickman. (2014) Ursolic Acid-Regulated Energy Metabolism—Reliever or Propeller of Ultraviolet-Induced Oxidative Stress and DNA Damage?. Proteomes 2:3, pages 399-425.
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