Advanced search
Publication Cover
Molecular and Cellular Biology Volume 39, 2019 - Issue 5
Submit an article Journal homepage
135
Views
28
CrossRef citations to date
0
Altmetric
Research Article

Common and Differential Transcriptional Actions of Nuclear Receptors Liver X Receptors α and β in Macrophages

Ana Ramón-Vázqueza Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid, Madrid, Spain;b Unidad de Biomedicina (Unidad Asociada al CSIC), Instituto Universitario de Investigaciones Biomédicas y Sanitarias, Grupo de Investigación Medio Ambiente y Salud, Universidad de Las Palmas de Gran Canaria, Las Palmas, Spain
,
Juan Vladimir de la Rosaa Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid, Madrid, Spain;b Unidad de Biomedicina (Unidad Asociada al CSIC), Instituto Universitario de Investigaciones Biomédicas y Sanitarias, Grupo de Investigación Medio Ambiente y Salud, Universidad de Las Palmas de Gran Canaria, Las Palmas, Spain
,
Carlos Tabraueb Unidad de Biomedicina (Unidad Asociada al CSIC), Instituto Universitario de Investigaciones Biomédicas y Sanitarias, Grupo de Investigación Medio Ambiente y Salud, Universidad de Las Palmas de Gran Canaria, Las Palmas, Spain
,
Felix Lopezb Unidad de Biomedicina (Unidad Asociada al CSIC), Instituto Universitario de Investigaciones Biomédicas y Sanitarias, Grupo de Investigación Medio Ambiente y Salud, Universidad de Las Palmas de Gran Canaria, Las Palmas, Spain
,
Bonifacio Nicolas Díaz-Chicob Unidad de Biomedicina (Unidad Asociada al CSIC), Instituto Universitario de Investigaciones Biomédicas y Sanitarias, Grupo de Investigación Medio Ambiente y Salud, Universidad de Las Palmas de Gran Canaria, Las Palmas, Spain
,
Lisardo Boscaa Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid, Madrid, Spain;b Unidad de Biomedicina (Unidad Asociada al CSIC), Instituto Universitario de Investigaciones Biomédicas y Sanitarias, Grupo de Investigación Medio Ambiente y Salud, Universidad de Las Palmas de Gran Canaria, Las Palmas, Spain
,
Peter Tontonozc Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA
,
Susana Alemanya Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid, Madrid, Spain;b Unidad de Biomedicina (Unidad Asociada al CSIC), Instituto Universitario de Investigaciones Biomédicas y Sanitarias, Grupo de Investigación Medio Ambiente y Salud, Universidad de Las Palmas de Gran Canaria, Las Palmas, Spain
&
Antonio Castrilloa Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid, Madrid, Spain;b Unidad de Biomedicina (Unidad Asociada al CSIC), Instituto Universitario de Investigaciones Biomédicas y Sanitarias, Grupo de Investigación Medio Ambiente y Salud, Universidad de Las Palmas de Gran Canaria, Las Palmas, SpainCorrespondence[email protected]
 show all
Article: e00376-18 | Received 27 Jul 2018, Accepted 07 Dec 2018, Published online: 03 Mar 2023

Citations (28)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Sophie R. Liebergall, Jerry Angdisen, Shun Hang Chan, YingJu Chang, Timothy F. Osborne, Alexander F. Koeppel, Stephen D. Turner & Ira G. Schulman. (2020) Inflammation Triggers Liver X Receptor-Dependent Lipogenesis. Molecular and Cellular Biology 40:2.
Read now

Articles from other publishers (27)

Guerman Molostvov, Mariam Gachechiladze, Abeer M. Shaaban, Steven Hayward, Isaac Dean, Irundika H.K. Dias, Nahla Badr, Irini Danial, Fiyaz Mohammed, Vera Novitskaya, Liliia Paniushkina, Valerie Speirs, Andrew Hanby, Irina Nazarenko, David R. Withers, Steven van Laere, Heather M. Long & Fedor Berditchevski. (2023) Tspan6 stimulates the chemoattractive potential of breast cancer cells for B cells in an EV- and LXR-dependent manner. Cell Reports 42:3, pages 112207.
Crossref
Suzanne A.E. van Wouw, Marlene van den Berg, Maroua El Ouraoui, Amber Meurs, Jenina Kingma, Roelof Ottenhoff, Melanie Loix, Marten A. Hoeksema, Koen Prange, Gerard Pasterkamp, Jerome J.A. Hendriks, Jeroen F.J. Bogie, Jan B. van Klinken, Frederic M. Vaz, Aldo Jongejan, Menno P.J. de Winther & Noam Zelcer. (2023) Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages. Journal of Lipid Research 64:2, pages 100325.
Crossref
Alberto Canfrán-Duque, Noemi RotllanXinbo ZhangIrene Andrés-Blasco, Bonne M. Thompson, Jonathan SunNathan L. PriceMarta Fernández-FuertesJoseph W. FowlerDiego Gómez-CoronadoWilliam C. Sessa, Chiara Giannarelli, Robert J. Schneider, George TellidesJeffrey G. McDonaldCarlos Fernández-Hernando & Yajaira Suárez. (2023) Macrophage-Derived 25-Hydroxycholesterol Promotes Vascular Inflammation, Atherogenesis, and Lesion Remodeling. Circulation 147:5, pages 388-408.
Crossref
Dustin Beyer, Jessica Hoff, Oliver Sommerfeld, Alexander Zipprich, Nikolaus Gaßler & Adrian T. Press. (2022) The liver in sepsis: molecular mechanism of liver failure and their potential for clinical translation. Molecular Medicine 28:1.
Crossref
Chunhui Li, Huanghui Wu, Ha Sen Ta Na, Lu Wang, Chuanqi Zhong, Bin Deng, Cong Liu, Han Bao, Hanfei Sang & Lichao Hou. (2022) Neuronal-microglial liver X receptor β activating decrease neuroinflammation and chronic stress-induced depression-related behavior in mice. Brain Research 1797, pages 148112.
Crossref
Wenying Zhang, Changhui Zhang, Jun Luo, Huifen Xu, Jianxin Liu, Juan J. Loor & Hengbo Shi. (2022) The LXRB-SREBP1 network regulates lipogenic homeostasis by controlling the synthesis of polyunsaturated fatty acids in goat mammary epithelial cells. Journal of Animal Science and Biotechnology 13:1.
Crossref
Irene López-Mateo, Diego Rodríguez-Muñoz, Juan Vladimir de La Rosa, Antonio Castrillo, Susana Alemany & Ana Aranda. (2022) Regulation of metabolic and transcriptional responses by the thyroid hormone in cellular models of murine macrophages. Frontiers in Immunology 13.
Crossref
Liqian Ma, Hashni Epa Vidana Gamage, Srishti Tiwari, Chaeyeon Han, Madeline A Henn, Natalia Krawczynska, Payam Dibaeinia, Graeme J Koelwyn, Anasuya Das Gupta, Rafael Ovidio Bautista Rivas, Chris L Wright, Fangxiu Xu, Kathryn J Moore, Saurabh Sinha & Erik R Nelson. (2022) The Liver X Receptor Is Selectively Modulated to Differentially Alter Female Mammary Metastasis-associated Myeloid Cells. Endocrinology 163:7.
Crossref
Xinyang Fan, Yongyun Zhang, Lihua Qiu, Wei Zhu, Xingtiao Tu & Yongwang Miao. (2022) Identification and characterization of alternative splicing variants of buffalo LXRα expressed in mammary gland. Scientific Reports 12:1.
Crossref
Cutler T. Lewandowski, Megan S. Laham & Gregory R.J. Thatcher. (2022) Remembering your A, B, C's: Alzheimer's disease and ABCA1. Acta Pharmaceutica Sinica B 12:3, pages 995-1018.
Crossref
Lara Bideyan, Wenxin Fan, Karolina Elżbieta Kaczor-Urbanowicz, Christina Priest, David Casero & Peter Tontonoz. (2022) Integrative analysis reveals multiple modes of LXR transcriptional regulation in liver. Proceedings of the National Academy of Sciences 119:7.
Crossref
Jeroen F.J. Bogie, Tim Vanmierlo, Jasmine Vanmol, Silke Timmermans, Jo Mailleux, Katherine Nelissen, Erwin Wijnands, Kristiaan Wouters, Piet Stinissen, Jan-Åke Gustafsson, Knut R. Steffensen, Monique Mulder, Noam Zelcer & Jerome J.A. Hendriks. (2021) Liver X receptor beta deficiency attenuates autoimmune-associated neuroinflammation in a T cell-dependent manner. Journal of Autoimmunity 124, pages 102723.
Crossref
Bo Li, Min Lian, Yikang Li, Qiwei Qian, Jun Zhang, Qiaoyan Liu, Ruqi Tang & Xiong Ma. (2021) Myeloid-Derived Suppressive Cells Deficient in Liver X Receptor α Protected From Autoimmune Hepatitis. Frontiers in Immunology 12.
Crossref
Lillian Russo-Savage & Ira G. Schulman. (2021) Liver X receptors and liver physiology. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1867:6, pages 166121.
Crossref
Marica Cariello, Roberto Salvia, Jennifer Härdfeldt, Marilidia Piglionica, David Rutigliano, Pasquale Caldarola, Alice Ossoli, Michele Vacca, Giusi Graziano, Stefano Battaglia, Roberta Zerlotin, Maria Arconzo, Lucilla Crudele, Carlo Sabbà, Laura Calabresi & Antonio Moschetta. (2021) Intracoronary monocyte expression pattern and HDL subfractions after non-ST elevation myocardial infarction. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1867:6, pages 166116.
Crossref
Cristina M. Ramírez, Marta Torrecilla-Parra, Virginia Pardo-Marqués, Mario Fernández de-Frutos, Ana Pérez-García, Carlos Tabraue, Juan Vladimir de la Rosa, Patricia Martín-Rodriguez, Mercedes Díaz-Sarmiento, Uxue Nuñez, Marta C. Orizaola, Paqui G. Través, Marta Camps, Lisardo Boscá & Antonio Castrillo. (2021) Crosstalk Between LXR and Caveolin-1 Signaling Supports Cholesterol Efflux and Anti-Inflammatory Pathways in Macrophages. Frontiers in Endocrinology 12.
Crossref
Kirsty E. Waddington, George A. Robinson, Beatriz Rubio-Cuesta, Eden Chrifi-AlaouiSara AndreoneKok-Siong Poon, Iveta Ivanova, Lucia Martin-GutierrezDylan M. Owen, Elizabeth C. Jury & Inés Pineda-Torra. (2021) LXR directly regulates glycosphingolipid synthesis and affects human CD4+ T cell function. Proceedings of the National Academy of Sciences 118:21.
Crossref
Ryan G. Snodgrass, Yvonne Benatzy, Tobias Schmid, Dmitry Namgaladze, Malwina Mainka, Nils Helge Schebb, Dieter Lütjohann & Bernhard Brüne. (2020) Efferocytosis potentiates the expression of arachidonate 15-lipoxygenase (ALOX15) in alternatively activated human macrophages through LXR activation. Cell Death & Differentiation 28:4, pages 1301-1316.
Crossref
Hunter Bennett, Ty D. Troutman, Mashito Sakai & Christopher K. Glass. (2021) Epigenetic Regulation of Kupffer Cell Function in Health and Disease. Frontiers in Immunology 11.
Crossref
Ran Wang, Sean Campbell, Mohammed Amir, Sarah A. Mosure, Molly A. Bassette, Amber Eliason, Mark S. Sundrud, Theodore M. Kamenecka & Laura A. Solt. (2021) Genetic and pharmacological inhibition of the nuclear receptor RORα regulates TH17 driven inflammatory disorders. Nature Communications 12:1.
Crossref
Zsolt Czimmerer, Laszlo Halasz & Laszlo Nagy. (2020) Unorthodox Transcriptional Mechanisms of Lipid-Sensing Nuclear Receptors in Macrophages: Are We Opening a New Chapter?. Frontiers in Endocrinology 11.
Crossref
Shirin Moradifard, Moslem Hoseinbeyki, Mohammad Mehdi Emam, Fatemehsadat Parchiniparchin & Mina Ebrahimi-Rad. (2020) Association of the Sp1 binding site and -1997 promoter variations in COL1A1 with osteoporosis risk: The application of meta-analysis and bioinformatics approaches offers a new perspective for future research. Mutation Research/Reviews in Mutation Research 786, pages 108339.
Crossref
Estibaliz Glaría, Nicole A Letelier & Annabel F Valledor. (2020) Integrating the roles of liver X receptors in inflammation and infection: mechanisms and outcomes. Current Opinion in Pharmacology 53, pages 55-65.
Crossref
Maud Voisin, Matthew C Gage, Natalia Becares, Elina Shrestha, Edward A Fisher, Ines Pineda-Torra & Michael J Garabedian. (2020) LXRα Phosphorylation in Cardiometabolic Disease: Insight From Mouse Models. Endocrinology 161:7.
Crossref
He-ming Huang, Xin Jiang, Meng-lei Hao, Meng-jie Shan, Yong Qiu, Gai-feng Hu, Quan Wang, Zi-qing Yu, Ling-bing Meng & Yun-yun Zou. (2019) Identification of biomarkers in macrophages of atherosclerosis by microarray analysis. Lipids in Health and Disease 18:1.
Crossref
Kaori Endo-Umeda & Makoto Makishima. (2019) Liver X Receptors Regulate Cholesterol Metabolism and Immunity in Hepatic Nonparenchymal Cells. International Journal of Molecular Sciences 20:20, pages 5045.
Crossref
Sandra Cabrera, Mariana Maciel, Daniel Hernández-Barrientos, Jazmín Calyeca, Miguel Gaxiola, Moisés Selman & Annie Pardo. (2019) Delayed resolution of bleomycin-induced pulmonary fibrosis in absence of MMP13 (collagenase 3). American Journal of Physiology-Lung Cellular and Molecular Physiology 316:5, pages L961-L976.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.