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Article

Thrombin Activates AMP-Activated Protein Kinase in Endothelial Cells via a Pathway Involving Ca2+/Calmodulin-Dependent Protein Kinase Kinase β

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Pages 5933-5945 | Received 03 Mar 2006, Accepted 26 May 2006, Published online: 27 Mar 2023

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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Keir J. Menzies & David A. Hood. (2012) The role of SirT1 in muscle mitochondrial turnover. Mitochondrion 12:1, pages 5-13.
Crossref
Yuan Chi, Kai Li, Qiaojing Yan, Schuichi Koizumi, Liye Shi, Shuhei Takahashi, Ying Zhu, Hiroyuki Matsue, Masayuki Takeda, Masanori Kitamura & Jian Yao. (2011) Nonsteroidal Anti-Inflammatory Drug Flufenamic Acid Is a Potent Activator of AMP-Activated Protein Kinase. Journal of Pharmacology and Experimental Therapeutics 339:1, pages 257-266.
Crossref
D. Grahame Hardie. (2011) AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function. Genes & Development 25:18, pages 1895-1908.
Crossref
David Carling, Faith V Mayer, Matthew J Sanders & Steven J Gamblin. (2011) AMP-activated protein kinase: nature's energy sensor. Nature Chemical Biology 7:8, pages 512-518.
Crossref
Linghai Li, Huina Zhang, Tianzuo Li & Bingxi Zhang. (2011) Involvement of Adenosine Monophosphate-Activated Protein Kinase in Morphine-induced Cardioprotection. Journal of Surgical Research 169:2, pages 179-187.
Crossref
Elke Bess, Beate Fisslthaler, Timo Frömel & Ingrid Fleming. (2011) Nitric Oxide-Induced Activation of the AMP-Activated Protein Kinase α2 Subunit Attenuates IκB Kinase Activity and Inflammatory Responses in Endothelial Cells. PLoS ONE 6:6, pages e20848.
Crossref
Amélie Gormand, Emma Henriksson, Kristoffer Ström, Thomas Elbenhardt Jensen, Kei Sakamoto & Olga Göransson. (2011) Regulation of AMP-activated protein kinase by LKB1 and CaMKK in adipocytes. Journal of Cellular Biochemistry 112:5, pages 1364-1375.
Crossref
Claire ThorntonNicola J. BrightMagdalena SastrePhillip J. MuckettDavid Carling. (2011) AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure. Biochemical Journal 434:3, pages 503-512.
Crossref
Swenja SchuhmacherMarc ForetzMaike KnorrThomas JansenMarcus HortmannPhilip WenzelMatthias OelzeAndrei L. KleschyovAndreas DaiberJohn F. KeaneyJrJrGerhard WegenerKarl LacknerThomas MünzelBenoit ViolletEberhard Schulz. (2011) α1AMP-Activated Protein Kinase Preserves Endothelial Function During Chronic Angiotensin II Treatment by Limiting Nox2 Upregulation. Arteriosclerosis, Thrombosis, and Vascular Biology 31:3, pages 560-566.
Crossref
Kwang Min Lee, Sooyeon Jo, Hyunyoung Kim, Jongwon Lee & Chul-Seung Park. (2011) Functional modulation of AMP-activated protein kinase by cereblon. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1813:3, pages 448-455.
Crossref
D. Grahame Hardie. (2011) AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer. Biochemical Society Transactions 39:1, pages 1-13.
Crossref
Brynhildur Thors, Haraldur Halldórsson & Gudmundur Thorgeirsson. (2011) eNOS activation mediated by AMPK after stimulation of endothelial cells with histamine or thrombin is dependent on LKB1. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1813:2, pages 322-331.
Crossref
I. Leclerc, G. Sun, C. Morris, E. Fernandez-Millan, M. Nyirenda & G. A. Rutter. (2010) AMP-activated protein kinase regulates glucagon secretion from mouse pancreatic alpha cells. Diabetologia 54:1, pages 125-134.
Crossref
John W. Scott. 2011. Post-Translational Modifications in Health and Disease. Post-Translational Modifications in Health and Disease 199 232 .
Ping Wang, Yong Jiang, Yinsheng Wang, John Y Shyy & Kathryn A DeFea. (2010) Beta-arrestin inhibits CAMKKbeta-dependent AMPK activation downstream of protease-activated-receptor-2. BMC Biochemistry 11:1.
Crossref
D Grahame Hardie. (2010) Hot stuff: thyroid hormones and AMPK. Cell Research 20:12, pages 1282-1284.
Crossref
Xunde Wang, Xinchao Pan & Jianguo Song. (2010) AMP-activated protein kinase is required for induction of apoptosis and epithelial-to-mesenchymal transition. Cellular Signalling 22:11, pages 1790-1797.
Crossref
Young-Sun Lee, Yang-Soon Kim, Sun-Young Lee, Geun-Hyang Kim, Beom-Jun Kim, Seung-Hun Lee, Ki-Up Lee, Ghi-Su Kim, Seung-Whan Kim & Jung-Min Koh. (2010) AMP kinase acts as a negative regulator of RANKL in the differentiation of osteoclasts. Bone 47:5, pages 926-937.
Crossref
Goro Takami, Miyuki Ota, Akira Nakashima, Yoko S. Kaneko, Keiji Mori, Toshiharu Nagatsu & Akira Ota. (2010) Effects of atypical antipsychotics and haloperidol on PC12 cells: only aripiprazole phosphorylates AMP-activated protein kinase. Journal of Neural Transmission 117:10, pages 1139-1153.
Crossref
Voahanginirina RandriamboavonjyJohann IsaakTimo FrömelBenoit Viollet, Beate FisslthalerKlaus T. Preissner & Ingrid Fleming. (2010) AMPK α2 subunit is involved in platelet signaling, clot retraction, and thrombus stability. Blood 116:12, pages 2134-2140.
Crossref
Najeeb A Shirwany & Ming-Hui Zou. (2010) AMPK in cardiovascular health and disease. Acta Pharmacologica Sinica 31:9, pages 1075-1084.
Crossref
Michelle L. Bland, Robert J. Lee, Julie M. Magallanes, J. Kevin Foskett & Morris J. Birnbaum. (2010) AMPK supports growth in Drosophila by regulating muscle activity and nutrient uptake in the gut. Developmental Biology 344:1, pages 293-303.
Crossref
Koji Ohashi, Noriyuki Ouchi, Akiko Higuchi, Reuben J. Shaw & Kenneth Walsh. (2010) LKB1 Deficiency in Tie2-Cre-expressing Cells Impairs Ischemia-induced Angiogenesis. Journal of Biological Chemistry 285:29, pages 22291-22298.
Crossref
Eloise A. BradleyEtto C. EringaCoen D.A. StehouwerIolente KorstjensGeerten P. van Nieuw AmerongenRene MustersPieter SipkemaMichael G. ClarkStephen Rattigan. (2010) Activation of AMP-Activated Protein Kinase by 5-Aminoimidazole-4-Carboxamide-1-β- d -Ribofuranoside in the Muscle Microcirculation Increases Nitric Oxide Synthesis and Microvascular Perfusion . Arteriosclerosis, Thrombosis, and Vascular Biology 30:6, pages 1137-1142.
Crossref
Kenneth R. Hallows, Peter F. Mount, Núria M. Pastor-Soler & David A. Power. (2010) Role of the energy sensor AMP-activated protein kinase in renal physiology and disease. American Journal of Physiology-Renal Physiology 298:5, pages F1067-F1077.
Crossref
Nadine Stahmann, Angela Woods, Katrin Spengler, Amanda Heslegrave, Reinhard Bauer, Siegfried Krause, Benoit Viollet, David Carling & Regine Heller. (2010) Activation of AMP-activated Protein Kinase by Vascular Endothelial Growth Factor Mediates Endothelial Angiogenesis Independently of Nitric-oxide Synthase. Journal of Biological Chemistry 285:14, pages 10638-10652.
Crossref
Sarah FogartySimon A. HawleyKevin A. GreenNazan SanerKirsty J. MustardD. Grahame Hardie. (2010) Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP. Biochemical Journal 426:1, pages 109-118.
Crossref
Takao Kimura, Hideaki Tomura, Koichi Sato, Masaaki Ito, Isao Matsuoka, Doon-Soon Im, Atsushi Kuwabara, Chihiro Mogi, Hiroshi Itoh, Hitoshi Kurose, Masami Murakami & Fumikazu Okajima. (2010) Mechanism and Role of High Density Lipoprotein-induced Activation of AMP-activated Protein Kinase in Endothelial Cells. Journal of Biological Chemistry 285:7, pages 4387-4397.
Crossref
D. Grahame Hardie. 2010. Handbook of Cell Signaling. Handbook of Cell Signaling 551 557 .
Connie Ng Hess, Ruqin Kou, Rosalyn P. Johnson, Gordon K. Li & Thomas Michel. (2009) ADP Signaling in Vascular Endothelial Cells. Journal of Biological Chemistry 284:47, pages 32209-32224.
Crossref
Benjamin Y. Jin, Juliano L. Sartoretto, Vadim N. Gladyshev & Thomas Michel. (2009) Endothelial nitric oxide synthase negatively regulates hydrogen peroxide-stimulated AMP-activated protein kinase in endothelial cells. Proceedings of the National Academy of Sciences 106:41, pages 17343-17348.
Crossref
Girish Kewalramani, Prasanth Puthanveetil, Fang Wang, Min Suk Kim, Sylvia Deppe, Ashraf Abrahani, Dan S. Luciani, James D. Johnson & Brian Rodrigues. (2009) AMP-activated protein kinase confers protection against TNF-α-induced cardiac cell death. Cardiovascular Research 84:1, pages 42-53.
Crossref
John R. Ussher, Jagdip S. Jaswal, Cory S. Wagg, Heather E. Armstrong, David G. Lopaschuk, Wendy Keung & Gary D. Lopaschuk. (2009) Role of the atypical protein kinase Cζ in regulation of 5′-AMP-activated protein kinase in cardiac and skeletal muscle. American Journal of Physiology-Endocrinology and Metabolism 297:2, pages E349-E357.
Crossref
David B. Shackelford & Reuben J. Shaw. (2009) The LKB1–AMPK pathway: metabolism and growth control in tumour suppression. Nature Reviews Cancer 9:8, pages 563-575.
Crossref
Beate FisslthalerIngrid Fleming. (2009) Activation and Signaling by the AMP-Activated Protein Kinase in Endothelial Cells. Circulation Research 105:2, pages 114-127.
Crossref
Sergio L. ColomboSalvador Moncada. (2009) AMPKα1 regulates the antioxidant status of vascular endothelial cells. Biochemical Journal 421:2, pages 163-169.
Crossref
Gregory R. Steinberg & Bruce E. Kemp. (2009) AMPK in Health and Disease. Physiological Reviews 89:3, pages 1025-1078.
Crossref
B. D. Hegarty, N. Turner, G. J. Cooney & E. W. Kraegen. (2009) Insulin resistance and fuel homeostasis: the role of AMP-activated protein kinase. Acta Physiologica 196:1, pages 129-145.
Crossref
Regan M. Memmott & Phillip A. Dennis. (2009) Akt-dependent and -independent mechanisms of mTOR regulation in cancer. Cellular Signalling 21:5, pages 656-664.
Crossref
Cleide Gonçalves da SilvaAnke SpechtBarbara WegielChristiane FerranElzbieta Kaczmarek. (2009) Mechanism of Purinergic Activation of Endothelial Nitric Oxide Synthase in Endothelial Cells. Circulation 119:6, pages 871-879.
Crossref
Hiroyuki SuzukiEvangeline D. MotleyKunie EguchiAkinari HinokiHeigoro ShiraiVabren WattsLaura N. StemmleTimothy A. FieldsSatoru Eguchi. (2009) Distinct Roles of Protease-Activated Receptors in Signal Transduction Regulation of Endothelial Nitric Oxide Synthase. Hypertension 53:2, pages 182-188.
Crossref
Roberta Martinelli, Matthew Gegg, Rebecca Longbottom, Peter Adamson, Patric Turowski & John Greenwood. (2009) ICAM-1–mediated Endothelial Nitric Oxide Synthase Activation via Calcium and AMP-activated Protein Kinase Is Required for Transendothelial Lymphocyte Migration. Molecular Biology of the Cell 20:3, pages 995-1005.
Crossref
Tomoyuki YUASA, Keiji UCHIYAMA, Yuko OGURA, Masafumi KIMURA, Kiyoshi TESHIGAWARA, Toshio HOSAKA, Yoshinori TANAKA, Toshiyuki OBATA, Hiroyuki SANO, Kazuhiro KISHI & Yousuke EBINA. (2009) The Rab GTPase-Activating Protein AS160 as a Common Regulator of Insulin- and G.ALPHA.q-Mediated Intracellular GLUT4 Vesicle Distribution. Endocrine Journal 56:3, pages 345-359.
Crossref
Angela M. Bair, Prabhakar B. Thippegowda, Marc Freichel, Ni Cheng, Richard D. Ye, Stephen M. Vogel, Yanni Yu, Veit Flockerzi, Asrar B. Malik & Chinnaswamy Tiruppathi. (2009) Ca2+ Entry via TRPC Channels Is Necessary for Thrombin-induced NF-κB Activation in Endothelial Cells through AMP-activated Protein Kinase and Protein Kinase Cδ. Journal of Biological Chemistry 284:1, pages 563-574.
Crossref
Ji Yeong Lee, Beong Tak Jeon, Hyun Joo Shin, Dong Hoon Lee, Jae Yoon Han, Hyun Joon Kim, Sang Soo Kang, Gyeong Jae Cho, Wan Sung Choi & Gu Seob Roh. (2008) Temporal expression of AMP-activated protein kinase activation during the kainic acid-induced hippocampal cell death. Journal of Neural Transmission 116:1, pages 33-40.
Crossref
Regine Heller, Qing Chang, Gunter Ehrlich, Sherry N. Hsieh, Simone M. Schoenwaelder, Peter J. Kuhlencordt, Klaus T. Preissner, Emilio Hirsch & Reinhard Wetzker. (2008) Overlapping and distinct roles for PI3Kβ and γ isoforms in S1P-induced migration of human and mouse endothelial cells. Cardiovascular Research 80:1, pages 96-105.
Crossref
Junhua Zhang, Zhonglin Xie, Yunzhou Dong, Shuangxi Wang, Chao Liu & Ming-Hui Zou. (2008) Identification of Nitric Oxide as an Endogenous Activator of the AMP-activated Protein Kinase in Vascular Endothelial Cells. Journal of Biological Chemistry 283:41, pages 27452-27461.
Crossref
Brynhildur Thors, Haraldur Halldórsson, Gudbjorg Jónsdóttir & Gudmundur Thorgeirsson. (2008) Mechanism of thrombin mediated eNOS phosphorylation in endothelial cells is dependent on ATP levels after stimulation. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1783:10, pages 1893-1902.
Crossref
D Carling, M J Sanders & A Woods. (2008) The regulation of AMP-activated protein kinase by upstream kinases. International Journal of Obesity 32:S4, pages S55-S59.
Crossref
D G Hardie. (2008) AMPK: a key regulator of energy balance in the single cell and the whole organism. International Journal of Obesity 32:S4, pages S7-S12.
Crossref
Dana S. Hutchinson, Roger J. Summers & Tore Bengtsson. (2008) Regulation of AMP-activated protein kinase activity by G-protein coupled receptors: Potential utility in treatment of diabetes and heart disease. Pharmacology & Therapeutics 119:3, pages 291-310.
Crossref
Peter F. Mount, Natalie Lane, Sudharsan Venkatesan, Gregory R. Steinberg, Scott A. Fraser, Bruce E. Kemp & David A. Power. (2008) Bradykinin stimulates endothelial cell fatty acid oxidation by CaMKK-dependent activation of AMPK. Atherosclerosis 200:1, pages 28-36.
Crossref
Claire Thornton, Alessandro Sardini & David Carling. (2008) Muscarinic Receptor Activation of AMP-activated Protein Kinase Inhibits Orexigenic Neuropeptide mRNA Expression. Journal of Biological Chemistry 283:25, pages 17116-17122.
Crossref
Ming-Hui Zou & Yong Wu. (2008) AMP-ACTIVATED PROTEIN KINASE ACTIVATION AS A STRATEGY FOR PROTECTING VASCULAR ENDOTHELIAL FUNCTION. Clinical and Experimental Pharmacology and Physiology 35:5-6, pages 535-545.
Crossref
Nicola J. Bright, David Carling & Claire Thornton. (2008) Investigating the Regulation of Brain-specific Kinases 1 and 2 by Phosphorylation. Journal of Biological Chemistry 283:22, pages 14946-14954.
Crossref
Masako Yamauchi, Fukushi Kambe, Xia Cao, Xiuli Lu, Yasuko Kozaki, Yutaka Oiso & Hisao Seo. (2008) Thyroid Hormone Activates Adenosine 5′-Monophosphate-Activated Protein Kinase via Intracellular Calcium Mobilization and Activation of Calcium/Calmodulin-Dependent Protein Kinase Kinase-β. Molecular Endocrinology 22:4, pages 893-903.
Crossref
James G. Boyle, Pamela J. Logan, Marie-Ann Ewart, James A. Reihill, Stuart A. Ritchie, John M.C. Connell, Stephen J. Cleland & Ian P. Salt. (2008) Rosiglitazone Stimulates Nitric Oxide Synthesis in Human Aortic Endothelial Cells via AMP-activated Protein Kinase*. Journal of Biological Chemistry 283:17, pages 11210-11217.
Crossref
D. Grahame Hardie. (2008) Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease. FEBS Letters 582:1, pages 81-89.
Crossref
Brototi Roy & Umesh Rai. (2008) Role of adrenoceptor-coupled second messenger system in sympatho-adrenomedullary modulation of splenic macrophage functions in live fish Channa punctatus. General and Comparative Endocrinology 155:2, pages 298-306.
Crossref
Matthew J. Sanders, Zahabia S. Ali, Bronwyn D. Hegarty, Richard Heath, Michael A. Snowden & David Carling. (2007) Defining the Mechanism of Activation of AMP-activated Protein Kinase by the Small Molecule A-769662, a Member of the Thienopyridone Family. Journal of Biological Chemistry 282:45, pages 32539-32548.
Crossref
Qingwu W. Shen, Mei J. Zhu, Junfeng Tong, Jun Ren & Min Du. (2007) Ca 2+ /calmodulin-dependent protein kinase kinase is involved in AMP-activated protein kinase activation by α-lipoic acid in C2C12 myotubes . American Journal of Physiology-Cell Physiology 293:4, pages C1395-C1403.
Crossref
D. Grahame Hardie. (2007) AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nature Reviews Molecular Cell Biology 8:10, pages 774-785.
Crossref
Louis Hue & Mark H. Rider. (2007) The AMP-activated protein kinase: more than an energy sensor. Essays in Biochemistry 43, pages 121-138.
Crossref
Thomas E. Jensen, Adam J. Rose, Sebastian B. Jørgensen, Nina Brandt, Peter Schjerling, Jørgen F. P. Wojtaszewski & Erik A. Richter. (2007) Possible CaMKK-dependent regulation of AMPK phosphorylation and glucose uptake at the onset of mild tetanic skeletal muscle contraction. American Journal of Physiology-Endocrinology and Metabolism 292:5, pages E1308-E1317.
Crossref
Biplab Dasgupta & Jeffrey Milbrandt. (2007) Resveratrol stimulates AMP kinase activity in neurons. Proceedings of the National Academy of Sciences 104:17, pages 7217-7222.
Crossref
Matthew J. SandersPascal O. Grondin, Bronwyn D. Hegarty, Michael A. SnowdenDavid Carling. (2007) Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade. Biochemical Journal 403:1, pages 139-148.
Crossref
Evangeline D. MotleyKunie EguchiMyla M. PattersonPhillip D. PalmerHiroyuki SuzukiSatoru Eguchi. (2007) Mechanism of Endothelial Nitric Oxide Synthase Phosphorylation and Activation by Thrombin. Hypertension 49:3, pages 577-583.
Crossref
James A. Reihill, Marie-Ann Ewart, D. Grahame Hardie & Ian P. Salt. (2007) AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production. Biochemical and Biophysical Research Communications 354:4, pages 1084-1088.
Crossref
Mhairi C. TowlerD. Grahame Hardie. (2007) AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling. Circulation Research 100:3, pages 328-341.
Crossref
Reuben J Shaw. (2006) Glucose metabolism and cancer. Current Opinion in Cell Biology 18:6, pages 598-608.
Crossref
Kenta Imai, Kouichi Inukai, Yuichi Ikegami, Takuya Awata & Shigehiro Katayama. (2006) LKB1, an upstream AMPK kinase, regulates glucose and lipid metabolism in cultured liver and muscle cells. Biochemical and Biophysical Research Communications 351:3, pages 595-601.
Crossref

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