Advanced search
Publication Cover
Molecular and Cellular Biology Volume 28, 2008 - Issue 18
Submit an article Journal homepage
23
Views
74
CrossRef citations to date
0
Altmetric
Article

Rap1a Is a Key Regulator of Fibroblast Growth Factor 2-Induced Angiogenesis and Together with Rap1b Controls Human Endothelial Cell Functions

Jingliang Yan1 Department of Biochemistry and Molecular Biology;2 Walther Cancer Institute
,
Fang Li3 Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana
,
David A. Ingram1 Department of Biochemistry and Molecular Biology;3 Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana
&
Lawrence A. Quilliam1 Department of Biochemistry and Molecular Biology;2 Walther Cancer InstituteCorrespondence[email protected]
Pages 5803-5810 | Received 07 Mar 2008, Accepted 02 Jul 2008, Published online: 27 Mar 2023

Citations (74)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (6)

Saeideh Nakhaei-Rad, Fereshteh Haghighi, Parivash Nouri, Soheila Rezaei Adariani, Jana Lissy, Neda S. Kazemein Jasemi, Radovan Dvorsky & Mohammad Reza Ahmadian. (2018) Structural fingerprints, interactions, and signaling networks of RAS family proteins beyond RAS isoforms. Critical Reviews in Biochemistry and Molecular Biology 53:2, pages 130-156.
Read now
Xin Ning & Yaoliang Deng. (2017) Identification of key pathways and genes influencing prognosis in bladder urothelial carcinoma. OncoTargets and Therapy 10, pages 1673-1686.
Read now
Christopher W Wilson & Weilan Ye. (2014) Regulation of vascular endothelial junction stability and remodeling through Rap1-Rasip1 signaling. Cell Adhesion & Migration 8:2, pages 76-83.
Read now
Willem-Jan Pannekoek, Anneke Post & Johannes L Bos. (2014) Rap1 signaling in endothelial barrier control. Cell Adhesion & Migration 8:2, pages 100-107.
Read now
Haibo Wang, Erika S Wittchen & M Elizabeth Hartnett. (2011) Breaking barriers: insight into the pathogenesis of neovascular age-related macular degeneration. Eye and Brain 3, pages 19-28.
Read now
Erika S. Wittchen, Amir Aghajanian & Keith Burridge. (2011) Isoform-specific differences between Rap1A and Rap1B GTPases in the formation of endothelial cell junctions. Small GTPases 2:2, pages 65-76.
Read now

Articles from other publishers (68)

Guru Prasad Sharma, Ramoji Kosuru, Sribalaji Lakshmikanthan, Shikan Zheng, Yao Chen, Robert Burns, Gang Xin, Weiguo Cui & Magdalena Chrzanowska. (2022) Endothelial Rap1B mediates T-cell exclusion to promote tumor growth: a novel mechanism underlying vascular immunosuppression. Angiogenesis 26:2, pages 265-278.
Crossref
Fang-Fang Zhang, Liang Zhang, Lin Zhao, Yu Lu, Xin Dong, Yan-Qi Liu, Yu Li, Shuang Guo, Si-Yuan Zheng, Ying Xiao & Yu-Zhu Jiang. (2023) The circular RNA Rap1b promotes Hoxa5 transcription by recruiting Kat7 and leading to increased Fam3a expression, which inhibits neuronal apoptosis in acute ischemic stroke. Neural Regeneration Research 18:10, pages 2237.
Crossref
Ali Raza Jahejo, Sayyad Ali Raza Bukhari, Nasir Rajput, Nazeer Hussain Kalhoro, Imdad Hussain Leghari, Sayed Haidar Abbas Raza, Zhen Li, Wen-zhong Liu & Wen-xia Tian. (2022) Transcriptome-based biomarker gene screening and evaluation of the extracellular fatty acid-binding protein (Ex-FABP) on immune and angiogenesis-related genes in chicken erythrocytes of tibial dyschondroplasia. BMC Genomics 23:1.
Crossref
Xin Shen, Weiwen Zhu, Ping Zhang, Yu Fu, Jie Cheng, Laikui Liu, Rongyao Xu & Hongbing Jiang. (2022) Macrophage miR-149-5p induction is a key driver and therapeutic target for BRONJ. JCI Insight 7:16.
Crossref
Eng-Soon Khor, Suzita Mohd Noor & Pooi-Fong Wong. (2021) MiR-107 inhibits the sprouting of intersegmental vessels of zebrafish embryos. Protoplasma 259:3, pages 691-702.
Crossref
Stephanie D. Burr, Christopher C. Dorroh & James A. StewartJr.Jr.. (2022) Rap1a Activity Elevated the Impact of Endogenous AGEs in Diabetic Collagen to Stimulate Increased Myofibroblast Transition and Oxidative Stress. International Journal of Molecular Sciences 23:9, pages 4480.
Crossref
Kiyotake Yamamoto, Yuki Takagi, Koji Ando & Shigetomo Fukuhara. (2021) Rap1 Small GTPase Regulates Vascular Endothelial-Cadherin-Mediated Endothelial Cell–Cell Junctions and Vascular Permeability. Biological and Pharmaceutical Bulletin 44:10, pages 1371-1379.
Crossref
Takayuki Ikeda, Yoshino Yoshitake, Yasuo Yoshitomi, Hidehito Saito-Takatsuji, Yasuhito Ishigaki & Hideto Yonekura. (2021) EPAC2 acts as a negative regulator in Matrigel-driven tubulogenesis of human microvascular endothelial cells. Scientific Reports 11:1.
Crossref
Sonali Nashine. (2021) Potential Therapeutic Candidates for Age-Related Macular Degeneration (AMD). Cells 10:9, pages 2483.
Crossref
Ramoji Kosuru, Bandana Singh, Sribalaji Lakshmikanthan, Yoshinori Nishijima, Jeannette Vasquez-Vivar, David X. Zhang & Magdalena Chrzanowska. (2021) Distinct Signaling Functions of Rap1 Isoforms in NO Release From Endothelium. Frontiers in Cell and Developmental Biology 9.
Crossref
Stephanie D. Burr & James A. StewartJr.Jr.. (2021) Rap1a Regulates Cardiac Fibroblast Contraction of 3D Diabetic Collagen Matrices by Increased Activation of the AGE/RAGE Cascade. Cells 10:6, pages 1286.
Crossref
Ricardo Salomón, Felipe E. Reyes-López, Lluis Tort, Joana P. Firmino, Carmen Sarasquete, Juan B. Ortiz-Delgado, José C. Quintela, José M. Pinilla-Rosas, Eva Vallejos-Vidal & Enric Gisbert. (2021) Medicinal Plant Leaf Extract From Sage and Lemon Verbena Promotes Intestinal Immunity and Barrier Function in Gilthead Seabream (Sparus aurata). Frontiers in Immunology 12.
Crossref
Shweta Singh, Hien C. Nguyen, Mehroz Ehsan, David C. R. Michels, Priyanka Singh, Mohammad Qadura & Krishna K. Singh. (2020) Pravastatin‐induced changes in expression of long non‐coding and coding RNAs in endothelial cells. Physiological Reports 9:1.
Crossref
Ali Raza Jahejo, Ding Zhang, Sheng Niu, Raza Ali Mangi, Afrasyab Khan, Muhammad Farhan Qadir, Ajab Khan, Huan-chun Chen & Wen-xia Tian. (2020) Transcriptome-based screening of intracellular pathways and angiogenesis related genes at different stages of thiram induced tibial lesions in broiler chickens. BMC Genomics 21:1.
Crossref
Ali Raza Jahejo, Nasir Rajput, Jam Kashif, Dildar Hussain Kalhoro, Sheng Niu, Meng-li Qiao, Ding Zhang, Muhammad Farhan Qadir, Raza Ali Mangi, Afrasyab Khan, Anam Ahsan, Ajab Khan & Wen-xia Tian. (2020) Recombinant glutathione-S-transferase A3 protein regulates the angiogenesis-related genes of erythrocytes in thiram induced tibial lesions. Research in Veterinary Science 131, pages 244-253.
Crossref
Vanda Gaonac’h-Lovejoy, Cécile Boscher, Chantal Delisle & Jean-Philippe Gratton. (2020) Rap1 Is Involved in Angiopoietin-1-Induced Cell-Cell Junction Stabilization and Endothelial Cell Sprouting. Cells 9:1, pages 155.
Crossref
Marta Checchi, Jessika Bertacchini, Francesco Cavani, Maria Sara Magarò, Luca Reggiani Bonetti, Geltrude Rita Pugliese, Roberto Tamma, Domenico Ribatti, Delphine B. Maurel & Carla Palumbo. (2020) Scleral ossicles: angiogenic scaffolds, a novel biomaterial for regenerative medicine applications. Biomaterials Science 8:1, pages 413-425.
Crossref
Sarath Babu NukalaLuca RegazzoniGiancarlo AldiniErika ZoddaOlga Tura-CeideNicholas L. MillsMarta CascanteMarina CariniAlfonsina D’Amato. (2019) Differentially Expressed Proteins in Primary Endothelial Cells Derived From Patients With Acute Myocardial Infarction. Hypertension 74:4, pages 947-956.
Crossref
Xin Jin, Xin Di, Ruimin Wang, He Ma, Chang Tian, Min Zhao, Shan Cong, Jiaying Liu, Ranwei Li & Ke Wang. (2019) RBM10 inhibits cell proliferation of lung adenocarcinoma via RAP1/AKT/CREB signalling pathway. Journal of Cellular and Molecular Medicine 23:6, pages 3897-3904.
Crossref
Seung-Sik Rho, Isao Kobayashi, Eri Oguri-Nakamura, Koji Ando, Masakazu Fujiwara, Naomi Kamimura, Hiromi Hirata, Atsuo Iida, Yoshiko Iwai, Naoki Mochizuki & Shigetomo Fukuhara. (2019) Rap1b Promotes Notch-Signal-Mediated Hematopoietic Stem Cell Development by Enhancing Integrin-Mediated Cell Adhesion. Developmental Cell 49:5, pages 681-696.e6.
Crossref
Yunbo Ke, Pratap Karki, Chenou Zhang, Yue Li, Trang Nguyen, Konstantin G. Birukov & Anna A. Birukova. (2019) Mechanosensitive Rap1 activation promotes barrier function of lung vascular endothelium under cyclic stretch. Molecular Biology of the Cell 30:8, pages 959-974.
Crossref
Seema Shah, Ethan J. Brock, Kyungmin Ji & Raymond R. Mattingly. (2019) Ras and Rap1: A tale of two GTPases. Seminars in Cancer Biology 54, pages 29-39.
Crossref
Isao Kobayashi, Jingjing Kobayashi-Sun, Yuto Hirakawa, Madoka Ouchi, Koyuki Yasuda, Hiroyasu Kamei, Shigetomo Fukuhara & Masaaki Yamaguchi. (2019) Dual role of Jam3b in early hematopoietic and vascular development. Development.
Crossref
Akio Shimizu, Dimitar Zankov, Misuzu Kurokawa-Seo & Hisakazu Ogita. (2018) Vascular Endothelial Growth Factor-A Exerts Diverse Cellular Effects via Small G Proteins, Rho and Rap. International Journal of Molecular Sciences 19:4, pages 1203.
Crossref
William G. RobichauxIIIIII & Xiaodong Cheng. (2018) Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development. Physiological Reviews 98:2, pages 919-1053.
Crossref
Katarzyna Głombik, Aneta Stachowicz, Ewa Trojan, Joanna Ślusarczyk, Maciej Suski, Katarzyna Chamera, Katarzyna Kotarska, Rafał Olszanecki & Agnieszka Basta-Kaim. (2018) Mitochondrial proteomics investigation of frontal cortex in an animal model of depression: Focus on chronic antidepressant drugs treatment. Pharmacological Reports 70:2, pages 322-330.
Crossref
Patricia Molina-Ortiz, Tanguy Orban, Maud Martin, Audrey Habets, Franck Dequiedt & Stéphane Schurmans. (2018) Rasa3 controls turnover of endothelial cell adhesion and vascular lumen integrity by a Rap1-dependent mechanism. PLOS Genetics 14:1, pages e1007195.
Crossref
Tamica N Collins, Yingyu Mao, Hongge Li, Michael Bouaziz, Angela Hong, Gen-Sheng Feng, Fen Wang, Lawrence A Quilliam, Lin Chen, Taeju Park, Tom Curran & Xin Zhang. (2018) Crk proteins transduce FGF signaling to promote lens fiber cell elongation. eLife 7.
Crossref
Sophia Doll, Martina Dreßen, Philipp E. Geyer, Daniel N. Itzhak, Christian Braun, Stefanie A. Doppler, Florian Meier, Marcus-Andre Deutsch, Harald Lahm, Rüdiger Lange, Markus Krane & Matthias Mann. (2017) Region and cell-type resolved quantitative proteomic map of the human heart. Nature Communications 8:1.
Crossref
Magdalena Chrzanowska-Wodnicka. (2017) Rap1 in endothelial biology. Current Opinion in Hematology 24:3, pages 248-255.
Crossref
Tomokatsu Iwamura, Hideki Narumi, Tomohiko Suzuki, Hideyuki Yanai, Katsuyuki Mori, Koji Yamashita, Yoshiaki Tsushima, Tomomi Asano, Akiko Izawa, Shinobu Momen, Kazumi Nishimura, Hiromi Tsuchiyama, Masashi Uchida, Yuji Yamashita, Kiyoshi Okano & Tadatsugu Taniguchi. (2017) Novel pegylated interferon‐β as strong suppressor of the malignant ascites in a peritoneal metastasis model of human cancer. Cancer Science 108:4, pages 581-589.
Crossref
Jennifer B. StottVincenzo BarreseIain A. Greenwood. (2016) Kv7 Channel Activation Underpins EPAC-Dependent Relaxations of Rat Arteries. Arteriosclerosis, Thrombosis, and Vascular Biology 36:12, pages 2404-2411.
Crossref
Neibla Priego, María Arechederra, Celia Sequera, Paloma Bragado, Ana Vázquez-Carballo, Álvaro Gutiérrez-Uzquiza, Víctor Martín-Granado, Juan José Ventura, Marcelo G. Kazanietz, Carmen Guerrero & Almudena Porras. (2016) C3G knock-down enhances migration and invasion by increasing Rap1-mediated p38α activation, while it impairs tumor growth through p38α-independent mechanisms. Oncotarget 7:29, pages 45060-45078.
Crossref
Young Ou, Gordon Chan, Jeremy Zuo, Jerome B. Rattner & Frans A. van der Hoorn. (2016) Purinergic A2b Receptor Activation by Extracellular Cues Affects Positioning of the Centrosome and Nucleus and Causes Reduced Cell Migration. Journal of Biological Chemistry 291:29, pages 15388-15403.
Crossref
Michael Koval. 2016. Drug Delivery Across Physiological Barriers. Drug Delivery Across Physiological Barriers 3 39 .
J C S Ho, A Nadeem, A Rydström, M Puthia & C Svanborg. (2015) Targeting of nucleotide-binding proteins by HAMLET—a conserved tumor cell death mechanism. Oncogene 35:7, pages 897-907.
Crossref
Magdalena Chrzanowska-Wodnicka, Gilbert C. White, Lawrence A. Quilliam & Kevin J. Whitehead. (2015) Small GTPase Rap1 Is Essential for Mouse Development and Formation of Functional Vasculature. PLOS ONE 10:12, pages e0145689.
Crossref
Sribalaji Lakshmikanthan, Xiaodong Zheng, Yoshinori Nishijima, Magdalena Sobczak, Aniko Szabo, Jeannette Vasquez‐Vivar, David X Zhang & Magdalena Chrzanowska‐Wodnicka. (2015) Rap1 promotes endothelial mechanosensing complex formation, NO release and normal endothelial function . EMBO reports 16:5, pages 628-637.
Crossref
Anna A. Birukova, Fanyong Meng, Yufeng Tian, Angelo Meliton, Nicolene Sarich, Lawrence A. Quilliam & Konstantin G. Birukov. (2015) Prostacyclin post-treatment improves LPS-induced acute lung injury and endothelial barrier recovery via Rap1. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1852:5, pages 778-791.
Crossref
Leslie A. Mitchell, Christina Ward, Mike Kwon, Patrick O. Mitchell, David A. Quintero, Asma Nusrat, Charles A. Parkos & Michael Koval. (2015) Junctional Adhesion Molecule A Promotes Epithelial Tight Junction Assembly to Augment Lung Barrier Function. The American Journal of Pathology 185:2, pages 372-386.
Crossref
Sribalaji LakshmikanthanBartosz J. ZiebaZhi-Dong GeKo MomotaniXiaodong ZhengHayley LundMykhaylo V. ArtamonovJason E. MaasAniko SzaboDavid X. ZhangJohn A. AuchampachDavid L. MattsonAvril V. SomlyoMagdalena Chrzanowska-Wodnicka. (2014) Rap1b in Smooth Muscle and Endothelium Is Required for Maintenance of Vascular Tone and Normal Blood Pressure. Arteriosclerosis, Thrombosis, and Vascular Biology 34:7, pages 1486-1494.
Crossref
Jacqueline Sayyah, Alena Bartakova, Nekeisha Nogal, Lawrence A. Quilliam, Dwayne G. Stupack & Joan Heller Brown. (2014) The Ras-related Protein, Rap1A, Mediates Thrombin-stimulated, Integrin-dependent Glioblastoma Cell Proliferation and Tumor Growth. Journal of Biological Chemistry 289:25, pages 17689-17698.
Crossref
Kenkichi Sugimoto, Suzuka Yoshida, Yuka Mashio, Naoka Toyota, Yanjiang Xing, Henan Xu, Yuki Fujita, Zhijun Huang, Maki Touma & Qiong Wu. (2014) Role of FGF10 on tumorigenesis by MS-K. Genes to Cells 19:2, pages 112-125.
Crossref
Christopher W. WilsonLeon H. ParkerChristopher J. HallTanya SmyczekJudy MakAiley CrowGeorge Posthuma, Ann De Mazière, Meredith Sagolla, Cecile Chalouni, Philip VitorinoMerone Roose-GirmaSøren WarmingJudith Klumperman, Philip S. CrosierWeilan Ye. (2013) Rasip1 regulates vertebrate vascular endothelial junction stability through Epac1-Rap1 signaling. Blood 122:22, pages 3678-3690.
Crossref
Gervaise Loirand, Vincent Sauzeau & Pierre Pacaud. (2013) Small G Proteins in the Cardiovascular System: Physiological and Pathological Aspects. Physiological Reviews 93:4, pages 1659-1720.
Crossref
Erika S. Wittchen, Eiichi Nishimura, Manabu McCloskey, Haibo Wang, Lawrence A. Quilliam, Magdalena Chrzanowska-Wodnicka & M. Elizabeth Hartnett. (2013) Rap1 GTPase Activation and Barrier Enhancement in RPE Inhibits Choroidal Neovascularization In Vivo. PLoS ONE 8:9, pages e73070.
Crossref
Magdalena Chrzanowska-Wodnicka. (2013) Distinct functions for Rap1 signaling in vascular morphogenesis and dysfunction. Experimental Cell Research 319:15, pages 2350-2359.
Crossref
Michael C. Schmid, Irene Franco, Sang Won Kang, Emilio Hirsch, Lawrence A. Quilliam & Judith A. Varner. (2013) PI3-Kinase γ Promotes Rap1a-Mediated Activation of Myeloid Cell Integrin α4β1, Leading to Tumor Inflammation and Growth. PLoS ONE 8:4, pages e60226.
Crossref
Yunhu Pan, Yushu Dong, Wugang Hou, Zhiyu Ji, Kailin Zhi, Zhongmin Yin, Hua Wen & Yitan Chen. (2013) Effects of PEMF on microcirculation and angiogenesis in a model of acute hindlimb ischemia in diabetic rats. Bioelectromagnetics 34:3, pages 180-188.
Crossref
Chang-Han Chen, Hui-Ching Chuang, Chao-Cheng Huang, Fu-Min Fang, Hsuan-Ying Huang, Hsin-Ting Tsai, Li-Jen Su, Li-Yen Shiu, Steve Leu & Chih-Yen Chien. (2013) Overexpression of Rap-1A Indicates a Poor Prognosis for Oral Cavity Squamous Cell Carcinoma and Promotes Tumor Cell Invasion via Aurora-A Modulation. The American Journal of Pathology 182:2, pages 516-528.
Crossref
Jyotsana Menon, Robert C. Doebele, Suzana Gomes, Elena Bevilacqua, Katie M. Reindl & Marsha Rich Rosner. (2012) A Novel Interplay between Rap1 and PKA Regulates Induction of Angiogenesis in Prostate Cancer. PLoS ONE 7:11, pages e49893.
Crossref
Selvi C. JeyarajNicholas T. UngerAli H. EidSrabani MitraN. Paul El-DahdahLawrence A. QuilliamNicholas A. Flavahan & Maqsood A. Chotani. (2012) Cyclic AMP-Rap1A signaling activates RhoA to induce α 2c -adrenoceptor translocation to the cell surface of microvascular smooth muscle cells . American Journal of Physiology-Cell Physiology 303:5, pages C499-C511.
Crossref
Reiner Wimmer, Botond Cseh, Barbara Maier, Karina Scherrer & Manuela Baccarini. (2012) Angiogenic Sprouting Requires the Fine Tuning of Endothelial Cell Cohesion by the Raf-1/Rok-α Complex. Developmental Cell 22:1, pages 158-171.
Crossref
Brian Cox, Parveen Sharma, Andreas I. Evangelou, Kathie Whiteley, Vladimir Ignatchenko, Alex Ignatchenko, Dora Baczyk, Marie Czikk, John Kingdom, Janet Rossant, Anthony O. Gramolini, S. Lee Adamson & Thomas Kislinger. (2011) Translational Analysis of Mouse and Human Placental Protein and mRNA Reveals Distinct Molecular Pathologies in Human Preeclampsia. Molecular & Cellular Proteomics 10:12, pages M111.012526.
Crossref
Wenyi Li, Bi Jin, Lynn A. Cornelius, Bin Zhou, Xiaoyang Fu, Dan Shang & Hong Zheng. (2011) Inhibitory effects of Rap1GAP overexpression on proliferation and migration of endothelial cells via ERK and Akt pathways. Journal of Huazhong University of Science and Technology [Medical Sciences] 31:6, pages 721-727.
Crossref
Yushan Zhang & Yehia Daaka. (2011) PGE2 promotes angiogenesis through EP4 and PKA Cγ pathway. Blood 118:19, pages 5355-5364.
Crossref
Sribalaji Lakshmikanthan, Magdalena Sobczak, Changzoon Chun, Angela Henschel, Jillian Dargatz, Ramani Ramchandran & Magdalena Chrzanowska-Wodnicka. (2011) Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin αvβ3. Blood 118:7, pages 2015-2026.
Crossref
Elaine A McSherry, Kieran Brennan, Lance Hudson, Arnold DK Hill & Ann M Hopkins. (2011) Breast cancer cell migration is regulated through junctional adhesion molecule-A-mediated activation of Rap1 GTPase. Breast Cancer Research 13:2.
Crossref
N. Donos, S. Hamlet, N. P. Lang, G. E. Salvi, G. Huynh-Ba, D. D. Bosshardt & S. Ivanovski. (2011) Gene expression profile of osseointegration of a hydrophilic compared with a hydrophobic microrough implant surface. Clinical Oral Implants Research 22:4, pages 365-372.
Crossref
Selvi C. Jeyaraj, Nicholas T. Unger & Maqsood A. Chotani. (2011) Rap1 GTPases: An emerging role in the cardiovasculature. Life Sciences 88:15-16, pages 645-652.
Crossref
Magdalena Chrzanowska-Wodnicka. (2010) Regulation of angiogenesis by a small GTPase Rap1. Vascular Pharmacology 53:1-2, pages 1-10.
Crossref
Neil D. Young, Bronwyn E. Campbell, Ross S. Hall, Aaron R. Jex, Cinzia Cantacessi, Thewarach Laha, Woon-Mok Sohn, Banchob Sripa, Alex Loukas, Paul J. Brindley & Robin B. Gasser. (2010) Unlocking the Transcriptomes of Two Carcinogenic Parasites, Clonorchis sinensis and Opisthorchis viverrini. PLoS Neglected Tropical Diseases 4:6, pages e719.
Crossref
E.W. Frische & F.J.T. Zwartkruis. (2010) Rap1, a mercenary among the Ras-like GTPases. Developmental Biology 340:1, pages 1-9.
Crossref
Eva Faurobert & Corinne Albiges-Rizo. (2010) Recent insights into cerebral cavernous malformations: a complex jigsaw puzzle under construction. FEBS Journal 277:5, pages 1084-1096.
Crossref
Álvaro Gutiérrez-Uzquiza, María Arechederra, Isabel Molina, Rocío Baños, Vera Maia, Manuel Benito, Carmen Guerrero & Almudena Porras. (2010) C3G down-regulates p38 MAPK activity in response to stress by Rap-1 independent mechanisms: Involvement in cell death. Cellular Signalling 22:3, pages 533-542.
Crossref
Robert C. DoebeleFrank T. Schulze-HoepfnerJia HongAlexandre ChlenskiBenjamin D. Zeitlin, Kushboo GoelSuzana GomesYuru LiuMark K. AbeJacques E. Nor, Mark W. Lingen & Marsha Rich Rosner. (2009) A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis. Blood 114:20, pages 4592-4600.
Crossref
Hoshimi Kanemura, Takaya Satoh, Shymaa E. Bilasy, Shuji Ueda, Masanori Hirashima & Tohru Kataoka. (2009) Impaired vascular development in the yolk sac and allantois in mice lacking RA-GEF-1. Biochemical and Biophysical Research Communications 387:4, pages 754-759.
Crossref
Xiaochun LiMilena StankovicBoris P.-L. LeeMichel Aurrand-LionsChris N. HahnYing LuBeat A. ImhofMathew A. VadasJennifer R. Gamble. (2009) JAM-C Induces Endothelial Cell Permeability Through Its Association and Regulation of β 3 Integrins . Arteriosclerosis, Thrombosis, and Vascular Biology 29:8, pages 1200-1206.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.