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Article

Filamin A Links Sphingosine Kinase 1 and Sphingosine-1-Phosphate Receptor 1 at Lamellipodia To Orchestrate Cell Migration

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Pages 5687-5697 | Received 20 Mar 2008, Accepted 09 Jul 2008, Published online: 27 Mar 2023

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Gabriela Schneider. 2020. Tumor Microenvironment. Tumor Microenvironment 129 153 .
Chiara Sassoli, Federica Pierucci, Sandra Zecchi-Orlandini & Elisabetta Meacci. (2019) Sphingosine 1-Phosphate (S1P)/ S1P Receptor Signaling and Mechanotransduction: Implications for Intrinsic Tissue Repair/Regeneration. International Journal of Molecular Sciences 20:22, pages 5545.
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Michael J. Pulkoski-Gross & Lina M. Obeid. (2018) Molecular mechanisms of regulation of sphingosine kinase 1. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1863:11, pages 1413-1422.
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Sarah E. Nicholas, Tyler G. Rowsey, Shrestha Priyadarsini, Nawajes A. Mandal & Dimitrios Karamichos. (2017) Unravelling the interplay of sphingolipids and TGF-β signaling in the human corneal stroma. PLOS ONE 12:8, pages e0182390.
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Melina G. Castro, Ludmila E. Campos, Yamila I. Rodriguez & Sergio E. Alvarez. 2018. Sphingosine-1-Phosphate. Sphingosine-1-Phosphate 117 131 .
Yamila I. Rodriguez, Ludmila E. Campos, Melina G. Castro, Ahmed Aladhami, Carole A. Oskeritzian & Sergio E. Alvarez. (2016) Sphingosine-1 Phosphate: A New Modulator of Immune Plasticity in the Tumor Microenvironment. Frontiers in Oncology 6.
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Sathya Narayanan Patmanathan, Steven P. Johnson, Sook Ling Lai, Suthashini Panja Bernam, Victor Lopes, Wenbin Wei, Maha Hafez Ibrahim, Federico Torta, Pradeep Narayanaswamy, Markus R. Wenk, Deron R. Herr, Paul G. Murray, Lee Fah Yap & Ian C. Paterson. (2016) Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2. Scientific Reports 6:1.
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Christopher White, Heba Alshaker, Colin Cooper, Matthias Winkler & Dmitri Pchejetski. (2016) The emerging role of FTY720 (Fingolimod) in cancer treatment. Oncotarget 7:17, pages 23106-23127.
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David P. Dimasi, Stuart M. Pitson & Claudine S. Bonder. (2016) Examining the Role of Sphingosine Kinase-2 in the Regulation of Endothelial Cell Barrier Integrity. Microcirculation 23:3, pages 248-265.
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Qian-Qian Shao, Tai-Ping Zhang, Wen-Jing Zhao, Zi-Wen Liu, Lei You, Li Zhou, Jun-Chao Guo & Yu-Pei Zhao. (2015) Filamin A: Insights into its Exact Role in Cancers. Pathology & Oncology Research 22:2, pages 245-252.
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Panfeng Fu, Peter V. Usatyuk, Jeffrey Jacobson, Anne E. Cress, Joe G. N. Garcia, Ravi Salgia & Viswanathan Natarajan. (2015) Role Played by Paxillin and Paxillin Tyrosine Phosphorylation in Hepatocyte Growth Factor/Sphingosine‐1‐Phosphate‐Mediated Reactive Oxygen Species Generation, Lamellipodia Formation, and Endothelial Barrier Function. Pulmonary Circulation 5:4, pages 619-630.
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Kristi Krebs, Anu Ruusmann, Grethel Simonlatser & Teet Velling. (2015) Expression of FLNa in human melanoma cells regulates the function of integrin α1β1 and phosphorylation and localisation of PKB/AKT/ERK1/2 kinases. European Journal of Cell Biology 94:12, pages 564-575.
Crossref
Joice de Faria Poloni & Diego Bonatto. (2015) Systems Chemo-Biology and Transcriptomic Meta-Analysis Reveal the Molecular Roles of Bioactive Lipids in Cardiomyocyte Differentiation. Journal of Cellular Biochemistry 116:9, pages 2018-2031.
Crossref
Lei Xiu, Na Chang, Le Yang, Xin Liu, Lin Yang, Jingjing Ge & Liying Li. (2015) Intracellular Sphingosine 1-Phosphate Contributes to Collagen Expression of Hepatic Myofibroblasts in Human Liver Fibrosis Independent of Its Receptors. The American Journal of Pathology 185:2, pages 387-398.
Crossref
Bruce A. Stanley, Tye Deering & Todd E. Fox. 2015. Bioactive Sphingolipids in Cancer Biology and Therapy. Bioactive Sphingolipids in Cancer Biology and Therapy 359 384 .
Alan Hammer & Maria Diakonova. 2015. Recent Advances in Prolactin Research. Recent Advances in Prolactin Research 97 137 .
Heba Alshaker, Jonathan Krell, Adam E Frampton, Jonathan Waxman, Oleg Blyuss, Alexey Zaikin, Mathias Winkler, Justin Stebbing, Ernesto Yagüe & Dmitri Pchejetski. (2014) Leptin induces upregulation of sphingosine kinase 1 in oestrogen receptor-negative breast cancer via Src family kinase-mediated, janus kinase 2-independent pathway. Breast Cancer Research 16:5.
Crossref
Eugene Y. Kim, Jamie L. Sturgill, Nitai C. Hait, Dorit Avni, Evelyn C. Valencia, Michael Maceyka, Santiago Lima, Jeremy Allegood, Wei‐Ching Huang, Shijun Zhang, Sheldon Milstien, Daniel Conrad & Sarah Spiegel. (2014) Role of sphingosine kinase 1 and sphingosine‐1‐phosphate in CD40 signaling and IgE class switching. The FASEB Journal 28:10, pages 4347-4358.
Crossref
Domenico M. Taglieri, Masuko Ushio-Fukai & Michelle M. Monasky. (2014) P21-activated kinase in inflammatory and cardiovascular disease. Cellular Signalling 26:9, pages 2060-2069.
Crossref
Shunya Kondo, Alessia Bottos, Jeremy C. Allegood, Regis Masson, Francisca G. Maurer, Christel Genoud, Patrick Kaeser, Andrea Huwiler, Masato Murakami, Sarah Spiegel & Nancy E. Hynes. (2014) Memo Has a Novel Role in S1P Signaling and Crucial for Vascular Development. PLoS ONE 9:4, pages e94114.
Crossref
Olivier Cuvillier. 2014. Molecular Mechanisms of Angiogenesis. Molecular Mechanisms of Angiogenesis 199 217 .
Rosalinda M Savoy & Paramita M Ghosh. (2013) The dual role of filamin A in cancer: can't live with (too much of) it, can't live without it. Endocrine-Related Cancer 20:6, pages R341-R356.
Crossref
Benjamin Weichand, Nicole Weis, Andreas Weigert, Nina Grossmann, Bodo Levkau & Bernhard Brüne. (2013) Apoptotic cells enhance sphingosine-1-phosphate receptor 1 dependent macrophage migration. European Journal of Immunology 43:12, pages 3306-3313.
Crossref
Heidi A. Neubauer & Stuart M. Pitson. (2013) Roles, regulation and inhibitors of sphingosine kinase 2. FEBS Journal 280:21, pages 5317-5336.
Crossref
Craig T. Wallington‐Beddoe, Kenneth F. Bradstock & Linda J. Bendall. (2013) Oncogenic properties of sphingosine kinases in haematological malignancies. British Journal of Haematology 161:5, pages 623-638.
Crossref
Lian-Wen Yuan, Dong-Cai Liu & Zhu-Lin Yang. (2013) Correlation of S1P1 and ERp29 expression to progression, metastasis, and poor prognosis of gallbladder adenocarcinoma. Hepatobiliary & Pancreatic Diseases International 12:2, pages 189-195.
Crossref
Melissa R. Pitman, Kate E. Jarman, Tamara M. Leclercq, Duyen H. Pham & Stuart M. Pitson. 2013. Lysophospholipid Receptors. Lysophospholipid Receptors 153 183 .
Alan HammerLeah RiderPeter OladimejiLeslie CookQuanwen Li, Raymond R. Mattingly & Maria Diakonova. (2013) Tyrosyl Phosphorylated PAK1 Regulates Breast Cancer Cell Motility in Response to Prolactin through Filamin A. Molecular Endocrinology 27:3, pages 455-465.
Crossref
K. Alexa Orr GandyDaniel CanalsMohamad AdadaMasayuki WadaPatrick RoddyAshley J. SniderYusuf A. HannunLina M. Obeid. (2013) Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins. Biochemical Journal 449:3, pages 661-672.
Crossref
Jan Ohotski, Joanne Edwards, Beatrix Elsberger, Carol Watson, Clare Orange, Elizabeth Mallon, Susan Pyne & Nigel J. Pyne. (2013) Identification of novel functional and spatial associations between sphingosine kinase 1, sphingosine 1-phosphate receptors and other signaling proteins that affect prognostic outcome in estrogen receptor-positive breast cancer. International Journal of Cancer 132:3, pages 605-616.
Crossref
Huasheng Chan & Stuart M. Pitson. (2013) Post-translational regulation of sphingosine kinases. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1831:1, pages 147-156.
Crossref
Nigel J. Pyne, Gerald Dubois & Susan Pyne. (2013) Role of sphingosine 1-phosphate and lysophosphatidic acid in fibrosis. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1831:1, pages 228-238.
Crossref
Heba Alshaker, Lysann Sauer, Danielle Monteil, Silvia Ottaviani, Shyam Srivats, Torsten Böhler & Dmitri Pchejetski. 2013. The Role of Sphingolipids in Cancer Development and Therapy. The Role of Sphingolipids in Cancer Development and Therapy 143 200 .
K. Alexa Orr Gandy & Lina M. Obeid. 2013. Sphingolipids in Disease. Sphingolipids in Disease 275 303 .
Jian Pan, Yan-Fang Tao, Zhuan Zhou, Bang-rong Cao, Shui-Yan Wu, Yan-Lan Zhang, Shao-Yan Hu, Wen-Li Zhao, Jian Wang, Guo-Liang Lou, Zhen Li, Xing Feng & Jian Ni. (2011) An novel role of sphingosine kinase-1 (SPHK1) in the invasion and metastasis of esophageal carcinoma. Journal of Translational Medicine 9:1.
Crossref
Jessie W. Yester, Etsegenet Tizazu, Kuzhuvelil B. Harikumar & Tomasz Kordula. (2011) Extracellular and intracellular sphingosine-1-phosphate in cancer. Cancer and Metastasis Reviews 30:3-4, pages 577-597.
Crossref
Susan Pyne, Robert Bittman & Nigel J. Pyne. (2011) Sphingosine Kinase Inhibitors and Cancer: Seeking the Golden Sword of Hercules. Cancer Research 71:21, pages 6576-6582.
Crossref
Dmitri Pchejetski, Torsten Böhler, Justin Stebbing & Jonathan Waxman. (2011) Therapeutic potential of targeting sphingosine kinase 1 in prostate cancer. Nature Reviews Urology 8:10, pages 569-578.
Crossref
Susan Pyne & Nigel J. Pyne. (2011) Translational aspects of sphingosine 1-phosphate biology. Trends in Molecular Medicine 17:8, pages 463-472.
Crossref
Eve-Ellen Govek, Mary E. Hatten & Linda Van Aelst. (2011) The role of Rho GTPase proteins in CNS neuronal migration. Developmental Neurobiology 71:6, pages 528-553.
Crossref
Stuart M. Pitson. (2011) Regulation of sphingosine kinase and sphingolipid signaling. Trends in Biochemical Sciences 36:2, pages 97-107.
Crossref
Nigel J. Pyne & Susan Pyne. (2010) Sphingosine 1-phosphate and cancer. Nature Reviews Cancer 10:7, pages 489-503.
Crossref
Sergio E. Alvarez, Kuzhuvelil B. Harikumar, Nitai C. Hait, Jeremy Allegood, Graham M. Strub, Eugene Y. Kim, Michael Maceyka, Hualiang Jiang, Cheng Luo, Tomasz Kordula, Sheldon Milstien & Sarah Spiegel. (2010) Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. Nature 465:7301, pages 1084-1088.
Crossref
Ashley J. Snider, K. Alexa Orr Gandy & Lina M. Obeid. (2010) Sphingosine kinase: Role in regulation of bioactive sphingolipid mediators in inflammation. Biochimie 92:6, pages 707-715.
Crossref
Alex-Xianghua Zhou, John H. Hartwig & Levent M. Akyürek. (2010) Filamins in cell signaling, transcription and organ development. Trends in Cell Biology 20:2, pages 113-123.
Crossref
Jeremy A. Hengst, Jacquelyn M. Guilford, Todd E. Fox, Xujun Wang, Elizabeth J. Conroy & Jong K. Yun. (2009) Sphingosine kinase 1 localized to the plasma membrane lipid raft microdomain overcomes serum deprivation induced growth inhibition. Archives of Biochemistry and Biophysics 492:1-2, pages 62-73.
Crossref
Jennifer R. Gamble, Wai Y. Sun, Xiaochun Li, Christopher N. Hahn, Stuart M. Pitson, Mathew A. Vadas & Claudine S. Bonder. (2009) Sphingosine Kinase-1 Associates with Integrin αVβ3 to Mediate Endothelial Cell Survival. The American Journal of Pathology 175:5, pages 2217-2225.
Crossref
Dmitri Kapitonov, Jeremy C. Allegood, Clint Mitchell, Nitai C. Hait, Jorge A. Almenara, Jeffrey K. Adams, Robert E. Zipkin, Paul Dent, Tomasz Kordula, Sheldon Milstien & Sarah Spiegel. (2009) Targeting Sphingosine Kinase 1 Inhibits Akt Signaling, Induces Apoptosis, and Suppresses Growth of Human Glioblastoma Cells and Xenografts. Cancer Research 69:17, pages 6915-6923.
Crossref
Roger H. Kim, Kazuaki Takabe, Sheldon Milstien & Sarah Spiegel. (2009) Export and functions of sphingosine-1-phosphate. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1791:7, pages 692-696.
Crossref
Huan Yu, Taro Okada, Masako Kobayashi, Dina M. Abo-Elmatty, Saleem Jahangeer & Shun-ichi Nakamura. (2009) Roles of extracellular and intracellular sphingosine 1-phosphate in cell migration. Genes to Cells 14:5, pages 597-605.
Crossref
Michael Maceyka, Sheldon Milstien & Sarah Spiegel. (2009) Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling. Journal of Lipid Research 50, pages S272-S276.
Crossref

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