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Molecular and Cellular Biology Volume 30, 2010 - Issue 21
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Article

Inhibition of Human Peptide Deformylase Disrupts Mitochondrial Function

Sindy Escobar-Alvarez1 Molecular Pharmacology and Chemistry, Sloan-Kettering Institute, 410 E, 69th St., New York, New York10065;2 Department of Pharmacology, Cornell Weill Graduate School of Medical Sciences, 1300 York Ave., New York, New York10065
,
Jeffrey Gardner1 Molecular Pharmacology and Chemistry, Sloan-Kettering Institute, 410 E, 69th St., New York, New York10065
,
Aneesh Sheth1 Molecular Pharmacology and Chemistry, Sloan-Kettering Institute, 410 E, 69th St., New York, New York10065;2 Department of Pharmacology, Cornell Weill Graduate School of Medical Sciences, 1300 York Ave., New York, New York10065
,
Giovanni Manfredi3 Department of Neuroscience, Cornell Weill Graduate School of Medical Sciences, 1300 York Ave., New York, New York10065
,
Guangli Yang1 Molecular Pharmacology and Chemistry, Sloan-Kettering Institute, 410 E, 69th St., New York, New York10065
,
Ouathek Ouerfelli1 Molecular Pharmacology and Chemistry, Sloan-Kettering Institute, 410 E, 69th St., New York, New York10065
,
Mark L. Heaney4 Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York, New York10065
&
David A. Scheinberg1 Molecular Pharmacology and Chemistry, Sloan-Kettering Institute, 410 E, 69th St., New York, New York10065Correspondence[email protected]
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Pages 5099-5109 | Received 19 Apr 2010, Accepted 22 Aug 2010, Published online: 20 Mar 2023

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Abdelmadjid Guendouzi, Lotfi Belkhiri, Abdelkrim Guendouzi, Tahar Mohamed Taha Derouiche & Abdelhamid Djekoun. (2023) A combined in silico approaches of 2D-QSAR, molecular docking, molecular dynamics and ADMET prediction of anti-cancer inhibitor activity for actinonin derivatives. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-15.
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Yanzhi Guo, Yuqiao Han, Ziyan Li, Jiali Ji, Tong Zhu, Yijie Du & Suzhen Dong. (2023) A new inhibitor of human peptide deformylase suppresses cell proliferation and induces cell apoptosis and autophagy in cancers. Anti-Cancer Drugs 34:4, pages 483-494.
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Robert N. Lightowlers & Zofia M.A. Chrzanowska-Lightowlers. 2023. Encyclopedia of Cell Biology. Encyclopedia of Cell Biology 703 715 .
Kai Tang, Shu Wang, Wenshuo Gao, Yihui Song & Bin Yu. (2022) Harnessing the cyclization strategy for new drug discovery. Acta Pharmaceutica Sinica B 12:12, pages 4309-4326.
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Beiwu Lan, Hongyang Zhao, Yichun He, Zenghui Zhao, Nang Wang & Yufei Gao. (2022) Inhibition of human peptide deformylase by actinonin sensitizes glioblastoma cells to temozolomide chemotherapy. Experimental Cell Research 420:2, pages 113358.
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Chien-I Yang, Zikun Zhu, Jeffrey J. Jones, Brett Lomenick, Tsui-Fen Chou & Shu-ou Shan. (2022) System-wide analyses reveal essential roles of N-terminal protein modification in bacterial membrane integrity. iScience 25:8, pages 104756.
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Daniela Criscuolo, Rosario Avolio, Danilo Swann Matassa & Franca Esposito. (2021) Targeting Mitochondrial Protein Expression as a Future Approach for Cancer Therapy. Frontiers in Oncology 11.
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Eva Kummer & Nenad Ban. (2021) Mechanisms and regulation of protein synthesis in mitochondria. Nature Reviews Molecular Cell Biology 22:5, pages 307-325.
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Xiaofen Jin, Zengming Zhang, Zhipeng Nie, Chenghui Wang, Feilong Meng, Qiuzi Yi, Mengquan Chen, Jiji Sun, Jian Zou, Pingping Jiang & Min-Xin Guan. (2021) An animal model for mitochondrial tyrosyl-tRNA synthetase deficiency reveals links between oxidative phosphorylation and retinal function. Journal of Biological Chemistry 296, pages 100437.
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Hideto Kaba, Hiroko Fujita, Takeshi AgatsumaHiroaki Matsunami. (2020) Maternally inherited peptides as strain-specific chemosignals. Proceedings of the National Academy of Sciences 117:48, pages 30738-30743.
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Tanaji T. Talele. (2020) Opportunities for Tapping into Three-Dimensional Chemical Space through a Quaternary Carbon. Journal of Medicinal Chemistry 63:22, pages 13291-13315.
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Liu Hu, Xing Cai, Suzhen Dong, Yongjia Zhen, Jidi Hu, Shenjun Wang, Jingwen Jiang, Jiawu Huang, Yuqiao Han, Yu Qian, Yanqiu Yuan & Wenhao Hu. (2020) Synthesis and Anticancer Activity of Novel Actinonin Derivatives as HsPDF Inhibitors. Journal of Medicinal Chemistry 63:13, pages 6959-6978.
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Seiji Arai, Andreas Varkaris, Mannan Nouri, Sen Chen, Lisha Xie & Steven P Balk. (2020) MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation. eLife 9.
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Patricia Martinez-Quinones, Amel Komic, Cameron G. McCarthy, R. Clinton Webb & Camilla Ferreira Wenceslau. (2019) Targeting Endothelial Barrier Dysfunction Caused by Circulating Bacterial and Mitochondrial N-Formyl Peptides With Deformylase. Frontiers in Immunology 10.
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Hyun-Jung Kim, Priyanka Maiti & Antoni Barrientos. (2017) Mitochondrial ribosomes in cancer. Seminars in Cancer Biology 47, pages 67-81.
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Sonia Fieulaine, Rodolphe Alves de Sousa, Laure Maigre, Karim Hamiche, Mickael Alimi, Jean-Michel Bolla, Abbass Taleb, Alexis Denis, Jean-Marie Pagès, Isabelle Artaud, Thierry Meinnel & Carmela Giglione. (2016) A unique peptide deformylase platform to rationally design and challenge novel active compounds. Scientific Reports 6:1.
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Malgorzata Pierzchalska & Maja Grabacka. (2016) The potential role of some phytochemicals in recognition of mitochondrial damage-associated molecular patterns. Mitochondrion 30, pages 24-34.
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Jian Gao, Tao Wang, Shengzhi Qiu, Yasheng Zhu, Li Liang & Youguang Zheng. (2016) Structure-Based Drug Design of Small Molecule Peptide Deformylase Inhibitors to Treat Cancer. Molecules 21:4, pages 396.
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Uwe Richter, Taina Lahtinen, Paula Marttinen, Fumi Suomi & Brendan J. Battersby. (2015) Quality control of mitochondrial protein synthesis is required for membrane integrity and cell fitness. Journal of Cell Biology 211:2, pages 373-389.
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Ricarda Richter-Dennerlein, Sven Dennerlein & Peter Rehling. (2015) Integrating mitochondrial translation into the cellular context. Nature Reviews Molecular Cell Biology 16:10, pages 586-592.
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David A. Dorward, Christopher D. Lucas, Gavin B. Chapman, Christopher Haslett, Kevin Dhaliwal & Adriano G. Rossi. (2015) The Role of Formylated Peptides and Formyl Peptide Receptor 1 in Governing Neutrophil Function during Acute Inflammation. The American Journal of Pathology 185:5, pages 1172-1184.
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Simon R. Law, Reena Narsai & James Whelan. (2014) Mitochondrial biogenesis in plants during seed germination. Mitochondrion 19, pages 214-221.
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A Sheth, S Escobar-Alvarez, J Gardner, L Ran, M L Heaney & D A Scheinberg. (2014) Inhibition of human mitochondrial peptide deformylase causes apoptosis in c-myc-overexpressing hematopoietic cancers. Cell Death & Disease 5:3, pages e1152-e1152.
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Sonia Fieulaine, Michel Desmadril, Thierry Meinnel & Carmela Giglione. (2014) Understanding the highly efficient catalysis of prokaryotic peptide deformylases by shedding light on the determinants specifying the low activity of the human counterpart. Acta Crystallographica Section D Biological Crystallography 70:2, pages 242-252.
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Stephen P. East. 2014. Antimicrobials. Antimicrobials 287 305 .
Sang Jae Lee, Ok Sung Jung, Bong-Jin Lee, Kwang-Hwi Cho & Byung Il Lee. (2013) Identification of Potent Inhibitors against Human Peptide Deformylase as Anticancer Agents. Bulletin of the Korean Chemical Society 34:12, pages 3885-3887.
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Harsharan Randhawa, Shireen Chikara, Drew Gehring, Tuba Yildirim, Jyotsana Menon & Katie M Reindl. (2013) Overexpression of peptide deformylase in breast, colon, and lung cancers. BMC Cancer 13:1.
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Brendan J. Battersby & Uwe Richter. (2013) Why translation counts for mitochondria – retrograde signalling links mitochondrial protein synthesis to mitochondrial biogenesis and cell proliferation. Journal of Cell Science 126:19, pages 4331-4338.
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Claudia Di Toma, Theo Sonke, Peter J. Quaedflieg & Dick B. Janssen. (2013) Purification and use of E. coli peptide deformylase for peptide deprotection in chemoenzymatic peptide synthesis. Protein Expression and Purification 89:1, pages 73-79.
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Uwe Richter, Taina Lahtinen, Paula Marttinen, Maarit Myöhänen, Dario Greco, Giuseppe Cannino, Howard T. Jacobs, Niina Lietzén, Tuula A. Nyman & Brendan J. Battersby. (2013) A Mitochondrial Ribosomal and RNA Decay Pathway Blocks Cell Proliferation. Current Biology 23:6, pages 535-541.
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Martijn A. Huynen, Isabel Duarte & Radek Szklarczyk. (2013) Loss, replacement and gain of proteins at the origin of the mitochondria. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1827:2, pages 224-231.
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Isabel Pereira-Castro, Luís Teixeira da Costa, António Amorim & Luisa Azevedo. (2012) Transcriptional regulation of the human mitochondrial peptide deformylase (PDF). Biochemical and Biophysical Research Communications 421:4, pages 825-831.
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Zach Adam, Frédéric Frottin, Christelle Espagne, Thierry Meinnel & Carmela Giglione. (2011) Interplay Between N-Terminal Methionine Excision and FtsH Protease Is Essential for Normal Chloroplast Development and Function in Arabidopsis     . The Plant Cell 23:10, pages 3745-3760.
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Elena J. Tucker, Steven G. Hershman, Caroline Köhrer, Casey A. Belcher-Timme, Jinal Patel, Olga A. Goldberger, John Christodoulou, Jonathon M. Silberstein, Matthew McKenzie, Michael T. Ryan, Alison G. Compton, Jacob D. Jaffe, Steven A. Carr, Sarah E. Calvo, Uttam L. RajBhandary, David R. Thorburn & Vamsi K. Mootha. (2011) Mutations in MTFMT Underlie a Human Disorder of Formylation Causing Impaired Mitochondrial Translation. Cell Metabolism 14:3, pages 428-434.
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