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Molecular and Cellular Biology Volume 28, 2008 - Issue 3
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Article

A Non-Tumor Suppressor Role for Basal p19ARF in Maintaining Nucleolar Structure and Function

Anthony J. Apicelli1 Departments of Internal Medicine, Division of Molecular Oncology;2 Cell Biology and Physiology
,
Leonard B. Maggi Jr.1 Departments of Internal Medicine, Division of Molecular Oncology;2 Cell Biology and Physiology
,
Angela C. Hirbe1 Departments of Internal Medicine, Division of Molecular Oncology
,
Alexander P. Miceli1 Departments of Internal Medicine, Division of Molecular Oncology;2 Cell Biology and Physiology
,
Mary E. Olanich1 Departments of Internal Medicine, Division of Molecular Oncology;2 Cell Biology and Physiology
,
Crystal L. Schulte-Winkeler1 Departments of Internal Medicine, Division of Molecular Oncology;2 Cell Biology and Physiology
,
Anthony J. Saporita1 Departments of Internal Medicine, Division of Molecular Oncology;2 Cell Biology and Physiology;3 Cancer Biology Pathway, Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri63110
,
Michael Kuchenreuther1 Departments of Internal Medicine, Division of Molecular Oncology;2 Cell Biology and Physiology;3 Cancer Biology Pathway, Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri63110
,
José Sanchez1 Departments of Internal Medicine, Division of Molecular Oncology;2 Cell Biology and Physiology
,
Katherine Weilbaecher1 Departments of Internal Medicine, Division of Molecular Oncology;3 Cancer Biology Pathway, Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri63110
&
Jason D. Weber1 Departments of Internal Medicine, Division of Molecular Oncology;2 Cell Biology and Physiology;3 Cancer Biology Pathway, Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri63110Correspondence[email protected]
 show all
Pages 1068-1080 | Received 20 Mar 2007, Accepted 14 Nov 2007, Published online: 27 Mar 2023

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Alexander P. Miceli, Anthony J. Saporita & Jason D. Weber. (2012) Hypergrowth mTORC1 Signals Translationally Activate the ARF Tumor Suppressor Checkpoint. Molecular and Cellular Biology 32:2, pages 348-364.
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Carlo Vascotto, Damiano Fantini, Milena Romanello, Laura Cesaratto, Marta Deganuto, Antonio Leonardi, J. Pablo Radicella, Mark R. Kelley, Chiara D'Ambrosio, Andrea Scaloni, Franco Quadrifoglio & Gianluca Tell. (2009) APE1/Ref-1 Interacts with NPM1 within Nucleoli and Plays a Role in the rRNA Quality Control Process. Molecular and Cellular Biology 29:7, pages 1834-1854.
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Articles from other publishers (32)

Dharaniya Sakthivel, Alexandra Brown-Suedel & Lisa Bouchier-Hayes. 2023. Control of Cell Cycle & Cell Proliferation. Control of Cell Cycle & Cell Proliferation 203 241 .
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Che-Pei Kung & Jason D. Weber. (2022) It’s Getting Complicated—A Fresh Look at p53-MDM2-ARF Triangle in Tumorigenesis and Cancer Therapy. Frontiers in Cell and Developmental Biology 10.
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Che-Pei Kung, Kyle A. Cottrell, Sua Ryu, Emily R. Bramel, Raleigh D. Kladney, Emily A. Bao, Eric C. Freeman, Thwisha Sabloak, Leonard Maggi & Jason D. Weber. (2020) Evaluating the therapeutic potential of ADAR1 inhibition for triple-negative breast cancer. Oncogene 40:1, pages 189-202.
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Kyle A. Cottrell, Ryan C. Chiou & Jason D. Weber. (2020) Upregulation of 5′-terminal oligopyrimidine mRNA translation upon loss of the ARF tumor suppressor. Scientific Reports 10:1.
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Eric Gibbs, Barbara Perrone, Alia Hassan, Rainer Kümmerle & Richard Kriwacki. (2020) NPM1 exhibits structural and dynamic heterogeneity upon phase separation with the p14ARF tumor suppressor. Journal of Magnetic Resonance 310, pages 106646.
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Vanessa Oliveira, Nitin Mahajan, Melissa L. Bates, Chakrapani Tripathi, Kyusik Q. Kim, Hani S. Zaher, Leonard B. Maggi Jr & Michael H. Tomasson. (2019) The snoRNA target of t(4;14) in multiple myeloma regulates ribosome biogenesis. FASEB BioAdvances 1:7, pages 404-414.
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Rosa Fontana, Michela Ranieri, Girolama La Mantia & Maria Vivo. (2019) Dual Role of the Alternative Reading Frame ARF Protein in Cancer. Biomolecules 9:3, pages 87.
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Diana M. Mitrea, Bappaditya Chandra, Mylene C. Ferrolino, Eric B. Gibbs, Michele Tolbert, Michael R. White & Richard W. Kriwacki. (2018) Methods for Physical Characterization of Phase-Separated Bodies and Membrane-less Organelles. Journal of Molecular Biology 430:23, pages 4773-4805.
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Mikael S. Lindström, Deana Jurada, Sladana Bursac, Ines Orsolic, Jiri Bartek & Sinisa Volarevic. (2018) Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis. Oncogene 37:18, pages 2351-2366.
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Diana M. Mitrea & Richard W. Kriwacki. (2018) On the relationship status for Arf and NPM1 – it's complicated. The FEBS Journal 285:5, pages 828-831.
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Sucheta Kulkarni, James M. Dolezal, Huabo Wang, Laura Jackson, Jie Lu, Brian P. Frodey, Atinuke Dosunmu-Ogunbi, Youjun Li, Marc Fromherz, Audry Kang, Lucas Santana-Santos, Panayiotis V. Benos & Edward V. Prochownik. (2017) Ribosomopathy-like properties of murine and human cancers. PLOS ONE 12:8, pages e0182705.
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Hui Liang, Xi Chen, Qi Yin, Danhui Ruan, Xuyang Zhao, Cong Zhang, Michael A. McNutt & Yuxin Yin. (2017) PTENβ is an alternatively translated isoform of PTEN that regulates rDNA transcription. Nature Communications 8:1.
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Jason A Pfister & Santosh R D’Mello. (2015) Insights into the regulation of neuronal viability by nucleophosmin/B23. Experimental Biology and Medicine 240:6, pages 774-786.
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Shan Wang, Siying Wang, Lihua Yang, Hua Guo, Xue Kong, Lin Yuan, Guichun Xing, Fuchu He & Lingqiang Zhang. (2015) ARF-mediated SUMOylation of Apak antagonizes ubiquitylation and promotes its nucleolar accumulation to inhibit 47S pre-rRNA synthesis. Journal of Molecular Cell Biology 7:2, pages 154-167.
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Karl Holmberg Olausson, Monica Nistér & Mikael S. Lindström. (2014) Loss of Nucleolar Histone Chaperone NPM1 Triggers Rearrangement of Heterochromatin and Synergizes with a Deficiency in DNA Methyltransferase DNMT3A to Drive Ribosomal DNA Transcription. Journal of Biological Chemistry 289:50, pages 34601-34619.
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Leonard B. MaggiJr.Jr., Crystal L. Winkeler, Alexander P. Miceli, Anthony J. Apicelli, Suzanne N. Brady, Michael J. Kuchenreuther & Jason D. Weber. (2014) ARF tumor suppression in the nucleolus. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1842:6, pages 831-839.
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Mattia Poletto, Lisa Lirussi, David M. Wilson3rd3rd & Gianluca Tell. (2014) Nucleophosmin modulates stability, activity, and nucleolar accumulation of base excision repair proteins. Molecular Biology of the Cell 25:10, pages 1641-1652.
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Isabelle Dichamp, Paule Séité, Gérard Agius, Alice Barbarin & Agnès Beby-Defaux. (2014) Human Papillomavirus 16 Oncoprotein E7 Stimulates UBF1-Mediated rDNA Gene Transcription, Inhibiting a p53-Independent Activity of p14ARF. PLoS ONE 9:5, pages e96136.
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Donatella Ponti, Gian Carlo Bellenchi, Rosa Puca, Daniela Bastianelli, Marella Maroder, Giuseppe Ragona, Pascal Roussel, Marc Thiry, Dan Mercola & Antonella Calogero. (2014) The Transcription Factor EGR1 Localizes to the Nucleolus and Is Linked to Suppression of Ribosomal Precursor Synthesis. PLoS ONE 9:5, pages e96037.
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Jason T. Forys, Catherine E. Kuzmicki, Anthony J. Saporita, Crystal L. Winkeler, Leonard B. MaggiJr.Jr. & Jason D. Weber. (2014) ARF and p53 Coordinate Tumor Suppression of an Oncogenic IFN-β-STAT1-ISG15 Signaling Axis. Cell Reports 7:2, pages 514-526.
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M J Kuchenreuther & J D Weber. (2013) The ARF tumor-suppressor controls Drosha translation to prevent Ras-driven transformation. Oncogene 33:3, pages 300-307.
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Nadine Hein, Katherine M. Hannan, Amee J. George, Elaine Sanij & Ross D. Hannan. (2013) The nucleolus: an emerging target for cancer therapy. Trends in Molecular Medicine 19:11, pages 643-654.
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Jeongyoon Lee, Douglas N. Foster, Walter G. Bottje, Hyeon-Min Jang, Yohanna G. Chandra, Lauren E. Gentles & Byung-Whi Kong. (2013) Establishment of an immortal chicken embryo liver-derived cell line. Poultry Science 92:6, pages 1604-1612.
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Mu-Shui Dai, Kishore B. Challagundla, Xiao-Xin Sun, Lakshmi Reddy Palam, Shelya X. Zeng, Ronald C. Wek & Hua Lu. (2012) Physical and Functional Interaction between Ribosomal Protein L11 and the Tumor Suppressor ARF. Journal of Biological Chemistry 287:21, pages 17120-17129.
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Anthony J. Saporita, Hsiang-Chun Chang, Crystal L. Winkeler, Anthony J. Apicelli, Raleigh D. Kladney, Jianbo Wang, R. Reid Townsend, Loren S. Michel & Jason D. Weber. (2011) RNA Helicase DDX5 Is a p53-Independent Target of ARF That Participates in Ribosome Biogenesis. Cancer Research 71:21, pages 6708-6717.
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Daniel A. Rauch, Michelle A. Hurchla, John C. Harding, Hongju Deng, Lauren K. Shea, Mark C. Eagleton, Stefan Niewiesk, Michael D. Lairmore, David Piwnica-Worms, Thomas J. Rosol, Jason D. Weber, Lee Ratner & Katherine N. Weilbaecher. (2010) The ARF Tumor Suppressor Regulates Bone Remodeling and Osteosarcoma Development in Mice. PLoS ONE 5:12, pages e15755.
Crossref
Danièle Hernandez-Verdun, Pascal Roussel, Marc Thiry, Valentina Sirri & Denis L. J. Lafontaine. (2010) The nucleolus: structure/function relationship in RNA metabolism. Wiley Interdisciplinary Reviews: RNA 1:3, pages 415-431.
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Denis DryginWilliam G. RiceIngrid Grummt. (2010) The RNA Polymerase I Transcription Machinery: An Emerging Target for the Treatment of Cancer. Annual Review of Pharmacology and Toxicology 50:1, pages 131-156.
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Brunangelo Falini. 2010. Acute Myelogenous Leukemia. Acute Myelogenous Leukemia 149 168 .
Rebekah Stackpole Zimmerman & Naomi Rosenberg. (2008) Changes in p19 Arf Localization Accompany Apoptotic Crisis during Pre-B-Cell Transformation by Abelson Murine Leukemia Virus . Journal of Virology 82:17, pages 8383-8391.
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Brunangelo Falini. (2008) Acute Myeloid Leukemia with Mutated Nucleophosmin. Clinical Leukemia 2:3, pages 163-173.
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