Citations (75)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (2)
Amy Jo Galliher-Beckley, Jason Grant Williams & John Anthony Cidlowski. (2011) Ligand-Independent Phosphorylation of the Glucocorticoid Receptor Integrates Cellular Stress Pathways with Nuclear Receptor Signaling
. Molecular and Cellular Biology 31:23, pages 4663-4675.
Read now
Read now
ShaguftaH. Khan, Faizan Ahmad, Nihal Ahmad, DanielC. Flynn & Raj Kumar. (2011) Protein-Protein Interactions: Principles, Techniques, and their Potential Role in New Drug Development. Journal of Biomolecular Structure and Dynamics 28:6, pages 929-938.
Read now
Read now
Articles from other publishers (73)
Freddy Jeanneteau, Onno C. Meijer & Marie‐Pierre Moisan. (2022) Structural basis of glucocorticoid receptor signaling bias. Journal of Neuroendocrinology 35:2.
Crossref
Crossref
Taewook Kang, Santosh Bhosale, Alistair Edwards & Martin R. Larsen. 2023. Encyclopedia of Cell Biology. Encyclopedia of Cell Biology
417
429
.
Anthony W. Ashton, Harpreet K. Dhanjal, Benjamin Rossner, Huma Mahmood, Vivek I. Patel, Mohammad Nadim, Manpreet Lota, Farhan Shahid, Zhiping Li, David Joyce, Matyas Pajkos, Zsuzsanna Dosztányi, Xuanmao Jiao & Richard G. Pestell. (2022) Acetylation of nuclear receptors in health and disease: an update. The FEBS Journal.
Crossref
Crossref
Laura Van Moortel, Jonathan Thommis, Brecht Maertens, An Staes, Dorien Clarisse, Delphine De Sutter, Claude Libert, Onno C. Meijer, Sven Eyckerman, Kris Gevaert & Karolien De Bosscher. (2022) Novel assays monitoring direct glucocorticoid receptor protein activity exhibit high predictive power for ligand activity on endogenous gene targets. Biomedicine & Pharmacotherapy 152, pages 113218.
Crossref
Crossref
Chi Zhang, Jinqiu Wu, Qinchang Chen, Haoyue Tan, Fuyan Huang, Jing Guo, Xiaowei Zhang, Hongxia Yu & Wei Shi. (2022) Allosteric binding on nuclear receptors: Insights on screening of non-competitive endocrine-disrupting chemicals. Environment International 159, pages 107009.
Crossref
Crossref
Girish Chandra Arya, Kamalpreet Kaur & Vikas Jaitak. (2021) Isoxazole derivatives as anticancer agent: A review on synthetic strategies, mechanism of action and SAR studies. European Journal of Medicinal Chemistry 221, pages 113511.
Crossref
Crossref
Raj Kumar. (2021) Role of conformational dynamics and flexibilities in the steroid receptor-coregulator protein complex formation. General and Comparative Endocrinology 309, pages 113780.
Crossref
Crossref
Jordan T. White, James Rives, Marla E. Tharp, James O. Wrabl, E. Brad Thompson & Vincent J. Hilser. (2021) Tumor Susceptibility Gene 101 Regulates the Glucocorticoid Receptor through Disorder-Mediated Allostery. Biochemistry 60:21, pages 1647-1657.
Crossref
Crossref
Jon K. Obst, Amy H. Tien & Marianne D. Sadar. 2021. Nuclear Receptors. Nuclear Receptors
613
642
.
Melanie Patt, Joël Gysi, Nourdine Faresse, John A. Cidlowski & Alex Odermatt. (2020) Protein phosphatase 1 alpha enhances glucocorticoid receptor activity by a mechanism involving phosphorylation of serine-211. Molecular and Cellular Endocrinology 518, pages 110873.
Crossref
Crossref
Raj KumarJenna F. DuMondShagufta H. KhanE. Brad Thompson, Yi He, Maurice B. BurgJoan D. Ferraris. (2020) NFAT5, which protects against hypertonicity, is activated by that stress via structuring of its intrinsically disordered domain. Proceedings of the National Academy of Sciences 117:33, pages 20292-20297.
Crossref
Crossref
Katarzyna Sołtys & Andrzej Ożyhar. (2020) Ordered structure-forming properties of the intrinsically disordered AB region of hRXRγ and its ability to promote liquid-liquid phase separation. The Journal of Steroid Biochemistry and Molecular Biology 198, pages 105571.
Crossref
Crossref
Simon Lea, Jian Li, Jonathan Plumb, Kate Gaffey, Sarah Mason, Rosie Gaskell, Chris Harbron & Dave Singh. (2020) P38 MAPK and glucocorticoid receptor crosstalk in bronchial epithelial cells. Journal of Molecular Medicine 98:3, pages 361-374.
Crossref
Crossref
Myriam Guillien, Albane le Maire, Assia Mouhand, Pau Bernadó, William Bourguet, Jean-Louis Banères & Nathalie Sibille. 2020. Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B. Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B
105
155
.
Raj Kumar & E. Thompson. (2019) Role of Phosphorylation in the Modulation of the Glucocorticoid Receptor’s Intrinsically Disordered Domain. Biomolecules 9:3, pages 95.
Crossref
Crossref
Nikolina Šoštarić, Francis J. O'Reilly, Piero Giansanti, Albert J.R. Heck, Anne-Claude Gavin & Vera van Noort. (2018) Effects of Acetylation and Phosphorylation on Subunit Interactions in Three Large Eukaryotic Complexes. Molecular & Cellular Proteomics 17:12, pages 2387-2401.
Crossref
Crossref
Evdokiya Salamanova, Joana Costeira-Paulo, Kyou-Hoon Han, Do-Hyoung Kim, Lennart Nilsson & Anthony P.H. Wright. (2018) A subset of functional adaptation mutations alter propensity for α-helical conformation in the intrinsically disordered glucocorticoid receptor tau1core activation domain. Biochimica et Biophysica Acta (BBA) - General Subjects 1862:6, pages 1452-1461.
Crossref
Crossref
Shagufta H. Khan, William A. McLaughlin & Raj Kumar. (2017) Site-specific phosphorylation regulates the structure and function of an intrinsically disordered domain of the glucocorticoid receptor. Scientific Reports 7:1.
Crossref
Crossref
Ruth Hendus-Altenburger, Matteo Lambrughi, Thilde Terkelsen, Stine F. Pedersen, Elena Papaleo, Kresten Lindorff-Larsen & Birthe B. Kragelund. (2017) A phosphorylation-motif for tuneable helix stabilisation in intrinsically disordered proteins – Lessons from the sodium proton exchanger 1 (NHE1). Cellular Signalling 37, pages 40-51.
Crossref
Crossref
Lasse Staby, Charlotte O'Shea, Martin Willemoës, Frederik Theisen, Birthe B. Kragelund & Karen Skriver. (2017) Eukaryotic transcription factors: paradigms of protein intrinsic disorder. Biochemical Journal 474:15, pages 2509-2532.
Crossref
Crossref
Daniel M. Cohen & David J. Steger. (2017) Nuclear Receptor Function through Genomics: Lessons from the Glucocorticoid Receptor. Trends in Endocrinology & Metabolism 28:7, pages 531-540.
Crossref
Crossref
Alexander F. Chin & Vincent J. Hilser. (2017) What’s in an Average? An Ensemble View of Phosphorylation Effects. Structure 25:4, pages 573-575.
Crossref
Crossref
Emily R. Weikum, Matthew T. Knuesel, Eric A. Ortlund & Keith R. Yamamoto. (2017) Glucocorticoid receptor control of transcription: precision and plasticity via allostery. Nature Reviews Molecular Cell Biology 18:3, pages 159-174.
Crossref
Crossref
Sarah L Shammas. (2017) Mechanistic roles of protein disorder within transcription. Current Opinion in Structural Biology 42, pages 155-161.
Crossref
Crossref
Eduardo Villarreal-Ramirez, David Eliezer, Ramon Garduño-Juarez, Arne Gericke, Jose Manuel Perez-Aguilar & Adele Boskey. (2017) Phosphorylation regulates the secondary structure and function of dentin phosphoprotein peptides. Bone 95, pages 65-75.
Crossref
Crossref
Juan Zeng, Fan Jiang & Yun-Dong Wu. (2016) Mechanism of Phosphorylation-Induced Folding of 4E-BP2 Revealed by Molecular Dynamics Simulations. Journal of Chemical Theory and Computation 13:1, pages 320-328.
Crossref
Crossref
Lisa T.C.M. van Weert & Onno C. Meijer. 2017. Hormones, Brain and Behavior. Hormones, Brain and Behavior
149
157
.
Eylem Kulkoyluoglu & Zeynep Madak-Erdogan. (2016) Nuclear and extranuclear-initiated estrogen receptor signaling crosstalk and endocrine resistance in breast cancer. Steroids 114, pages 41-47.
Crossref
Crossref
Janet P. Hapgood, Chanel Avenant & Johnson M. Moliki. (2016) Glucocorticoid-independent modulation of GR activity: Implications for immunotherapy. Pharmacology & Therapeutics 165, pages 93-113.
Crossref
Crossref
Sandra L. Grimm, Sean M. Hartig & Dean P. Edwards. (2016) Progesterone Receptor Signaling Mechanisms. Journal of Molecular Biology 428:19, pages 3831-3849.
Crossref
Crossref
Birthe B. Kragelund, Signe M. Schenstrøm, Caio A. Rebula, Vikram Govind Panse & Rasmus Hartmann-Petersen. (2016) DSS1/Sem1, a Multifunctional and Intrinsically Disordered Protein. Trends in Biochemical Sciences 41:5, pages 446-459.
Crossref
Crossref
Alaji Bah & Julie D. Forman-Kay. (2016) Modulation of Intrinsically Disordered Protein Function by Post-translational Modifications. Journal of Biological Chemistry 291:13, pages 6696-6705.
Crossref
Crossref
Xiaoyong Zhi, X. Edward Zhou, Karsten Melcher & H. Eric Xu. (2016) Structures and regulation of non-X orphan nuclear receptors: A retinoid hypothesis. The Journal of Steroid Biochemistry and Molecular Biology 157, pages 27-40.
Crossref
Crossref
Maria A. Sacta, Yurii ChinenovInez Rogatsky. (2016) Glucocorticoid Signaling: An Update from a Genomic Perspective. Annual Review of Physiology 78:1, pages 155-180.
Crossref
Crossref
Peter Tompa. (2016) The principle of conformational signaling. Chemical Society Reviews 45:15, pages 4252-4284.
Crossref
Crossref
M.R. Larsen & A.V.G. Edwards. 2016. Encyclopedia of Cell Biology. Encyclopedia of Cell Biology
177
186
.
T Joshi, M Johnson, R Newton & M A Giembycz. (2015)
The long-acting β
2
-adrenoceptor agonist, indacaterol, enhances glucocorticoid receptor-mediated transcription in human airway epithelial cells in a gene- and agonist-dependent manner
. British Journal of Pharmacology 172:10, pages 2634-2653.
Crossref
Crossref
A. Keith Dunker, Sarah E. Bondos, Fei Huang & Christopher J. Oldfield. (2015) Intrinsically disordered proteins and multicellular organisms. Seminars in Cell & Developmental Biology 37, pages 44-55.
Crossref
Crossref
Raj Kumar & Iain J. McEwan. 2015. Nuclear Receptors: From Structure to the Clinic. Nuclear Receptors: From Structure to the Clinic
41
57
.
Sandra L. Grimm, Robert D. Ward, Alison E. Obr, Heather L. Franco, Rodrigo Fernandez-Valdivia, Jung-Sun Kim, Justin M. Roberts, Jae-Wook Jeong, Francesco J. DeMayo, John P. Lydon, Dean P. Edwards & Nancy L. Weigel. (2014) A Role for Site-Specific Phosphorylation of Mouse Progesterone Receptor at Serine 191 in Vivo. Molecular Endocrinology 28:12, pages 2025-2037.
Crossref
Crossref
Sofie Vandevyver, Lien Dejager & Claude Libert. (2014) Comprehensive Overview of the Structure and Regulation of the Glucocorticoid Receptor. Endocrine Reviews 35:4, pages 671-693.
Crossref
Crossref
Ran Xue, Mikhail N. Zakharov, Yu Xia, Shalender Bhasin, James C. Costello & Ravi Jasuja. (2014) Research Resource: EPSLiM: Ensemble Predictor for Short Linear Motifs in Nuclear Hormone Receptors. Molecular Endocrinology 28:5, pages 768-777.
Crossref
Crossref
Thomas Scior, Moritz Verhoff, Itzel Gutierrez-Aztatzi, Hermann P.T. Ammon, Stefan Laufer & Oliver Werz. (2014) Interference of Boswellic Acids with the Ligand Binding Domain of the Glucocorticoid Receptor. Journal of Chemical Information and Modeling 54:3, pages 978-986.
Crossref
Crossref
S. Stoney SimonsJrJr, Dean P. Edwards & Raj Kumar. (2014) Minireview: Dynamic Structures of Nuclear Hormone Receptors: New Promises and Challenges. Molecular Endocrinology 28:2, pages 173-182.
Crossref
Crossref
Ana Clara Liberman, María Antunica-Noguerol & Eduardo Arzt. (2014) Modulation of the Glucocorticoid Receptor Activity by Post-Translational Modifications. Nuclear Receptor Research 1, pages 1-15.
Crossref
Crossref
Raj Kumar, Carmen M. Moure, Shagufta H. Khan, Celetta Callaway, Sandra L. Grimm, Devrishi Goswami, Patrick R. Griffin & Dean P. Edwards. (2013) Regulation of the Structurally Dynamic N-terminal Domain of Progesterone Receptor by Protein-induced Folding. Journal of Biological Chemistry 288:42, pages 30285-30299.
Crossref
Crossref
Lindsey S. Treviño & Nancy L. Weigel. (2013) Phosphorylation: a fundamental regulator of steroid receptor action. Trends in Endocrinology & Metabolism 24:10, pages 515-524.
Crossref
Crossref
Madhanagopal Anandapadamanaban, Cecilia Andresen, Sara Helander, Yoshifumi Ohyama, Marina I Siponen, Patrik Lundström, Tetsuro Kokubo, Mitsuhiko Ikura, Martin Moche & Maria Sunnerhagen. (2013) High-resolution structure of TBP with TAF1 reveals anchoring patterns in transcriptional regulation. Nature Structural & Molecular Biology 20:8, pages 1008-1014.
Crossref
Crossref
S. Stoney SimonsJr.Jr. & Raj Kumar. (2013) Variable steroid receptor responses: Intrinsically disordered AF1 is the key. Molecular and Cellular Endocrinology 376:1-2, pages 81-84.
Crossref
Crossref
Lisa C Watson, Kristopher M Kuchenbecker, Benjamin J Schiller, John D Gross, Miles A Pufall & Keith R Yamamoto. (2013) The glucocorticoid receptor dimer interface allosterically transmits sequence-specific DNA signals. Nature Structural & Molecular Biology 20:7, pages 876-883.
Crossref
Crossref
C. Dejean & D. Richard. (2013) Mécanismes d’action des glucocorticoïdes. La Revue de Médecine Interne 34:5, pages 264-268.
Crossref
Crossref
A.S. Woods & S.N. Jackson. (2013) How adenylate cyclase choreographs the pas de deux of the receptors heteromerization dance. Neuroscience 238, pages 335-344.
Crossref
Crossref
Marije aan den Toorn, Mieke M. E. Huijbers, Sacco C. de Vries & Carlo P. M. van Mierlo. (2012) The Arabidopsis thaliana SERK1 Kinase Domain Spontaneously Refolds to an Active State In Vitro. PLoS ONE 7:12, pages e50907.
Crossref
Crossref
Shagufta H. Khan, Smita Awasthi, Chunhua Guo, Devrishi Goswami, Jun Ling, Patrick R. Griffin, S. Stoney SimonsJr.Jr. & Raj Kumar. (2012) Binding of the N-terminal Region of Coactivator TIF2 to the Intrinsically Disordered AF1 Domain of the Glucocorticoid Receptor Is Accompanied by Conformational Reorganizations. Journal of Biological Chemistry 287:53, pages 44546-44560.
Crossref
Crossref
Raj Kumar & Iain J. McEwan. (2012) Allosteric Modulators of Steroid Hormone Receptors: Structural Dynamics and Gene Regulation. Endocrine Reviews 33:2, pages 271-299.
Crossref
Crossref
Heike I. Rösner & Birthe B. Kragelund. 2011. Comprehensive Physiology. Comprehensive Physiology
1491
1539
.
Shagufta H. Khan & Raj Kumar. (2012) Role of an intrinsically disordered conformation in AMPK-mediated phosphorylation of ULK1 and regulation of autophagy. Mol. BioSyst. 8:1, pages 91-96.
Crossref
Crossref
Iain J. McEwan. (2012) Intrinsic disorder in the androgen receptor: identification, characterisation and drugability. Mol. BioSyst. 8:1, pages 82-90.
Crossref
Crossref
Krista K. Hill, Sarah C. Roemer, Mair E.A. Churchill & Dean P. Edwards. (2012) Structural and functional analysis of domains of the progesterone receptor. Molecular and Cellular Endocrinology 348:2, pages 418-429.
Crossref
Crossref
R. Kumar & E.B. Thompson. (2012) Folding of the glucocorticoid receptor N-terminal transactivation function: Dynamics and regulation. Molecular and Cellular Endocrinology 348:2, pages 450-456.
Crossref
Crossref
Ucheor B. Choi, Shifeng Xiao, Lonnie P. Wollmuth & Mark E. Bowen. (2011) Effect of Src Kinase Phosphorylation on Disordered C-terminal Domain of N-Methyl-d-aspartic Acid (NMDA) Receptor Subunit GluN2B Protein. Journal of Biological Chemistry 286:34, pages 29904-29912.
Crossref
Crossref
Ilse M. Beck, Karolien De Bosscher & Guy Haegeman. (2011) Glucocorticoid receptor mutants: man-made tools for functional research. Trends in Endocrinology & Metabolism 22:8, pages 295-310.
Crossref
Crossref
Mads M. Aagaard, Rasmus Siersbæk & Susanne Mandrup. (2011) Molecular basis for gene-specific transactivation by nuclear receptors. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1812:8, pages 824-835.
Crossref
Crossref
Raj Kumar, Mikhail N. Zakharov, Shagufta H. Khan, Rika Miki, Hyeran Jang, Gianluca Toraldo, Rajan Singh, Shalender Bhasin & Ravi Jasuja. (2011) The Dynamic Structure of the Estrogen Receptor. Journal of Amino Acids 2011, pages 1-7.
Crossref
Crossref
Shagufta H. Khan, Jun Ling & Raj Kumar. (2011) TBP Binding-Induced Folding of the Glucocorticoid Receptor AF1 Domain Facilitates Its Interaction with Steroid Receptor Coactivator-1. PLoS ONE 6:7, pages e21939.
Crossref
Crossref
Shagufta H. Khan, John A. Arnott & Raj Kumar. (2011) Naturally Occurring Osmolyte, Trehalose Induces Functional Conformation in an Intrinsically Disordered Activation Domain of Glucocorticoid Receptor. PLoS ONE 6:5, pages e19689.
Crossref
Crossref
Ann-Beth Nørholm, Ruth Hendus-Altenburger, Gabriel Bjerre, Magnus Kjaergaard, Stine F. Pedersen & Birthe B. Kragelund. (2011)
The Intracellular Distal Tail of the Na
+
/H
+
Exchanger NHE1 Is Intrinsically Disordered: Implications for NHE1 Trafficking
. Biochemistry 50:17, pages 3469-3480.
Crossref
Crossref
Agnieszka Dziedzic-Letka, Grzegorz Rymarczyk, Tomasz M. Kapłon, Andrzej Górecki, Agnieszka Szamborska-Gbur, Magdalena Wojtas, Piotr Dobryszycki & Andrzej Ożyhar. (2011) Intrinsic disorder of Drosophila melanogaster hormone receptor 38 N-terminal domain. Proteins: Structure, Function, and Bioinformatics 79:2, pages 376-392.
Crossref
Crossref
Nihal Ahmad & Raj Kumar. (2011) Steroid hormone receptors in cancer development: A target for cancer therapeutics. Cancer Letters 300:1, pages 1-9.
Crossref
Crossref
Katharina Fischer, Sharon M. Kelly, Kate Watt, Nicholas C. Price & Iain J. McEwan. (2010) Conformation of the Mineralocorticoid Receptor N-terminal Domain: Evidence for Induced and Stable Structure. Molecular Endocrinology 24:10, pages 1935-1948.
Crossref
Crossref
Rhett G. Molloy, Wai Kit Ma, Andrew C. Allen, Kevin Greenwood, Lynn Bryan, Rebecca Sacora, LaBrittney Williams & Matthew J. Gage. (2010) Aquifex aeolicus FlgM protein exhibits a temperature-dependent disordered nature. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1804:7, pages 1457-1466.
Crossref
Crossref
Anne Bugge & Susanne Mandrup. (2010) Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation. PPAR Research 2010, pages 1-12.
Crossref
Crossref
Iain J. McEwan & Ann M. Nardulli. (2009) Nuclear Hormone Receptor Architecture - Form and Dynamics: The 2009 FASEB Summer Conference on Dynamic Structure of the Nuclear Hormone Receptors. Nuclear Receptor Signaling 7:1, pages nrs.07011.
Crossref
Crossref