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Molecular and Cellular Biology Volume 27, 2007 - Issue 19
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Article

Functional Defects of SKAP-55-Deficient T Cells Identify a Regulatory Role for the Adaptor in LFA-1 Adhesion

Hongyan Wang1 Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, CambridgeCB2 1QP;2 Molecular Immunology Section, Department of Immunology, Imperial College London, Hammersmith Hospital, LondonW12 0NN, United Kingdom
,
Hebin Liu1 Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, CambridgeCB2 1QP;2 Molecular Immunology Section, Department of Immunology, Imperial College London, Hammersmith Hospital, LondonW12 0NN, United Kingdom
,
Yuning Lu1 Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, CambridgeCB2 1QP;2 Molecular Immunology Section, Department of Immunology, Imperial College London, Hammersmith Hospital, LondonW12 0NN, United Kingdom
,
Matt Lovatt2 Molecular Immunology Section, Department of Immunology, Imperial College London, Hammersmith Hospital, LondonW12 0NN, United Kingdom
,
Bin Wei2 Molecular Immunology Section, Department of Immunology, Imperial College London, Hammersmith Hospital, LondonW12 0NN, United Kingdom
&
Christopher E. Rudd1 Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, CambridgeCB2 1QP;2 Molecular Immunology Section, Department of Immunology, Imperial College London, Hammersmith Hospital, LondonW12 0NN, United KingdomCorrespondence[email protected]
Pages 6863-6875 | Received 29 Mar 2007, Accepted 17 Jul 2007, Published online: 27 Mar 2023

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Amelie Witte, Bernhard Meineke, Jana Sticht, Lars Philipsen, Benno Kuropka, Andreas J. Müller, Christian Freund, Burkhart Schraven & Stefanie Kliche. (2017) D120 and K152 within the PH Domain of T Cell Adapter SKAP55 Regulate Plasma Membrane Targeting of SKAP55 and LFA-1 Affinity Modulation in Human T Lymphocytes. Molecular and Cellular Biology 37:7.
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Benno Kuropka, Burkhart Schraven, Stefanie Kliche, Eberhard Krause & Christian Freund. (2016) Tyrosine-phosphorylation of the scaffold protein ADAP and its role in T cell signaling. Expert Review of Proteomics 13:6, pages 545-554.
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Articles from other publishers (43)

Yiwei Xiong, Yanli Li, Xinxing Cui, Lifeng Zhang, Xiaodong Yang & Hebin Liu. (2022) ADAP restraint of STAT1 signaling regulates macrophage phagocytosis in immune thrombocytopenia. Cellular & Molecular Immunology 19:8, pages 898-912.
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Nirdosh Dadwal, Charlie Mix, Annegret Reinhold, Amelie Witte, Christian Freund, Burkhart Schraven & Stefanie Kliche. (2021) The Multiple Roles of the Cytosolic Adapter Proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Events. Frontiers in Immunology 12.
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Christopher E. Rudd. (2021) How the Discovery of the CD4/CD8-p56lck Complexes Changed Immunology and Immunotherapy. Frontiers in Cell and Developmental Biology 9.
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Naiqi Yang, Yiwei Xiong, Yan Wang, Yulan Yi, Jingfei Zhu, Feng Ma, Jing Li & Hebin Liu. (2021) ADAP Y571 Phosphorylation Is Required to Prime STAT3 for Activation in TLR4-Stimulated Macrophages. The Journal of Immunology 206:4, pages 814-826.
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Nagaja Capitani, Laura Patrussi, Mario Milco D’Elios & Cosima Tatiana Baldari. 2021. Cellular Primary Immunodeficiencies. Cellular Primary Immunodeficiencies 43 63 .
Youg Raj Thaker, Monika Raab, Klaus Strebhardt & Christopher E. Rudd. (2019) GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity. Nature Communications 10:1.
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Monika Raab, Klaus Strebhardt & Christopher E. Rudd. (2019) Immune adaptor SKAP1 acts a scaffold for Polo-like kinase 1 (PLK1) for the optimal cell cycling of T-cells. Scientific Reports 9:1.
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Monika Raab, Klaus Strebhardt & Christopher E. Rudd. (2018) Immune adaptor protein SKAP1 (SKAP-55) forms homodimers as mediated by the N-terminal region. BMC Research Notes 11:1.
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Jiali Cheng, Yukai Jing, Danqing Kang, Lu Yang, Jingwen Li, Ze Yu, Zican Peng, Xingbo Li, Yin Wei, Quan Gong, Richard J. Miron, Yufeng Zhang & Chaohong Liu. (2018) The Role of Mst1 in Lymphocyte Homeostasis and Function. Frontiers in Immunology 9.
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Yiwei Xiong, Chengjin Ye, Naiqi Yang, Madanqi Li & Hebin Liu. (2017) Ubc9 Binds to ADAP and Is Required for Rap1 Membrane Recruitment, Rac1 Activation, and Integrin-Mediated T Cell Adhesion. The Journal of Immunology 199:12, pages 4142-4154.
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Monika Raab, Yuning Lu, Karsten Kohler, Xin Smith, Klaus Strebhardt & Christopher E. Rudd. (2017) LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation. Nature Communications 8:1.
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Gerald P Parzmair, Marcus Gereke, Oxana Haberkorn, Michaela Annemann, Lisa Podlasly, Stefanie Kliche, Annegret Reinhold, Burkhart Schraven & Dunja Bruder. (2017) ADAP plays a pivotal role in CD4+ T cell activation but is only marginally involved in CD8+ T cell activation, differentiation, and immunity to pathogens. Journal of Leukocyte Biology 101:2, pages 407-419.
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Xiaoyan Xu, Lei Han, Guixian Zhao, Shengjie Xue, Yunzhen Gao, Jun Xiao, Shicheng Zhang, Peng Chen, Zhi-ying Wu, Jianping Ding, Ronggui Hu, Bin Wei & Hongyan Wang. (2017) LRCH1 interferes with DOCK8-Cdc42–induced T cell migration and ameliorates experimental autoimmune encephalomyelitis. Journal of Experimental Medicine 214:1, pages 209-226.
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Marlen Thiere, Stefanie Kliche, Bettina Müller, Jan Teuber, Isabell Nold & Oliver Stork. (2016) Integrin Activation Through the Hematopoietic Adapter Molecule ADAP Regulates Dendritic Development of Hippocampal Neurons. Frontiers in Molecular Neuroscience 9.
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Qianqian Zhang, Hehua Dai, Karim M. Yatim, Khodor Abou-Daya, Amanda L. Williams, Martin H. Oberbarnscheidt, Geoffrey Camirand, Christopher E. Rudd & Fadi G. Lakkis. (2016) CD8+ Effector T Cell Migration to Pancreatic Islet Grafts Is Dependent on Cognate Antigen Presentation by Donor Graft Cells. The Journal of Immunology 197:4, pages 1471-1476.
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Seung Hee Jung, Eun Hye Yoo, Mi Jin Yu, Hyeon Myeong Song, Hee Yoon Kang, Je-Yoel Cho & Jong Ran Lee. (2016) ARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and Integrin-Mediated Adhesion. The Journal of Immunology 197:3, pages 942-952.
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Xin Smith, Alison Taylor & Christopher E. Rudd. (2016) T-cell immune adaptor SKAP1 regulates the induction of collagen-induced arthritis in mice. Immunology Letters 176, pages 122-127.
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Fabien Garçon & Klaus Okkenhaug. (2016) PI3Kδ promotes CD4 + T‐cell interactions with antigen‐presenting cells by increasing LFA‐1 binding to ICAM‐1 . Immunology & Cell Biology 94:5, pages 486-495.
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Daina Lim, Yuning Lu & Christopher E. Rudd. (2016) Non-cleavable talin rescues defect in the T-cell conjugation of T-cells deficient in the immune adaptor SKAP1. Immunology Letters 172, pages 40-46.
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Ana Dios-Esponera, Soledad Isern de Val, Silvia Sevilla-Movilla, Rosa García-Verdugo, David García-Bernal, Nohemí Arellano-Sánchez, Carlos Cabañas & Joaquin Teixidó. (2015) Positive and negative regulation by SLP-76/ADAP and Pyk2 of chemokine-stimulated T-lymphocyte adhesion mediated by integrin α4β1. Molecular Biology of the Cell 26:18, pages 3215-3228.
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Chunyang Li, Weiyun Li, Jun Xiao, Shaozhuo Jiao, Fei Teng, Shengjie Xue, Chi Zhang, Chun Sheng, Qibin Leng, Christopher E Rudd, Bin Wei & Hongyan Wang. (2015) ADAP and SKAP 55 deficiency suppresses PD ‐1 expression in CD 8 + cytotoxic T lymphocytes for enhanced anti‐tumor immunotherapy . EMBO Molecular Medicine 7:6, pages 754-769.
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Michael J. Ophir, Beiyun C. Liu & Stephen C. Bunnell. (2013) The N terminus of SKAP55 enables T cell adhesion to TCR and integrin ligands via distinct mechanisms. Journal of Cell Biology 203:6, pages 1021-1041.
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Bin Wei, Lei Han, Truus E M Abbink, Elisabetta Groppelli, Daina Lim, Youg Raj Thaker, Wei Gao, Rongrong Zhai, Jianhua Wang, Andrew Lever, Clare Jolly, Hongyan Wang & Christopher E Rudd. (2013) Immune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptors. Retrovirology 10:1.
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Yanbo Zhang & Hongyan Wang. (2012) Integrin signalling and function in immune cells. Immunology 135:4, pages 268-275.
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Richard Marcotte, Kevin R. Brown, Fernando Suarez, Azin Sayad, Konstantina Karamboulas, Paul M. Krzyzanowski, Fabrice Sircoulomb, Mauricio Medrano, Yaroslav Fedyshyn, Judice L.Y. Koh, Dewald van Dyk, Bohdana Fedyshyn, Marianna Luhova, Glauber C. Brito, Franco J. Vizeacoumar, Frederick S. Vizeacoumar, Alessandro Datti, Dahlia Kasimer, Alla Buzina, Patricia Mero, Christine Misquitta, Josee Normand, Maliha Haider, Troy Ketela, Jeffrey L. Wrana, Robert Rottapel, Benjamin G. Neel & Jason Moffat. (2012) Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells. Cancer Discovery 2:2, pages 172-189.
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Stefanie KlicheTim WorbsXiaoqian WangJanine DegenIrene PatzakBernhard MeinekeMauro TogniMarkus Moser, Annegret ReinholdFriedemann KieferChristian FreundReinhold FörsterBurkhart Schraven. (2012) CCR7-mediated LFA-1 functions in T cells are regulated by 2 independent ADAP/SKAP55 modules. Blood 119:3, pages 777-785.
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Monika Raab, Xin Smith, Yves Matthess, Klaus Strebhardt & Christopher E. Rudd. (2011) SKAP1 Protein PH Domain Determines RapL Membrane Localization and Rap1 Protein Complex Formation for T Cell Receptor (TCR) Activation of LFA-1. Journal of Biological Chemistry 286:34, pages 29663-29670.
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Brandon J. Burbach, Rupa Srivastava, Melissa A. Ingram, Jason S. Mitchell & Yoji Shimizu. (2011) The Pleckstrin Homology Domain in the SKAP55 Adapter Protein Defines the Ability of the Adapter Protein ADAP To Regulate Integrin Function and NF-κB Activation. The Journal of Immunology 186:11, pages 6227-6237.
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Koko Katagiri & Tatsuo Kinashi. 2012. Integrin and Cell Adhesion Molecules. Integrin and Cell Adhesion Molecules 279 296 .
Tatsuo Kinashi. 2012. Integrin and Cell Adhesion Molecules. Integrin and Cell Adhesion Molecules 261 278 .
Monther Al-Alwan, Sen Hou, Ting-ting Zhang, Kennedy Makondo & Aaron J. Marshall. (2010) Bam32/DAPP1 Promotes B Cell Adhesion and Formation of Polarized Conjugates with T Cells. The Journal of Immunology 184:12, pages 6961-6969.
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Hongyan Wang, Daina Lim & Christopher E. Rudd. (2010) Immunopathologies linked to integrin signalling. Seminars in Immunopathology 32:2, pages 173-182.
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Monika Raab, Hongyan Wang, Yuning Lu, Xin Smith, Zhonglin Wu, Klaus Strebhardt, John E. Ladbury & Christopher E. Rudd. (2010) T Cell Receptor “Inside-Out” Pathway via Signaling Module SKAP1-RapL Regulates T Cell Motility and Interactions in Lymph Nodes. Immunity 32:4, pages 541-556.
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Hongyan Wang, Yuning Lu & Christopher E. Rudd. (2010) SKAP1 is dispensable for chemokine-induced migration of primary T-cells. Immunology Letters 128:2, pages 148-153.
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Jessica Horn, Xiaoqian Wang, Peter Reichardt, Theresia E. Stradal, Nicole Warnecke, Luca Simeoni, Matthias Gunzer, Deborah Yablonski, Burkhart Schraven & Stefanie Kliche. (2009) Src Homology 2-Domain Containing Leukocyte-Specific Phosphoprotein of 76 kDa Is Mandatory for TCR-Mediated Inside-Out Signaling, but Dispensable for CXCR4-Mediated LFA-1 Activation, Adhesion, and Migration of T Cells. The Journal of Immunology 183:9, pages 5756-5767.
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Ting-ting Zhang, Hongzhao Li, Samuel M. Cheung, Jennifer L. Costantini, Sen Hou, Monther Al-Alwan & Aaron J. Marshall. (2009) Phosphoinositide 3-kinase-regulated adapters in lymphocyte activation. Immunological Reviews 232:1, pages 255-272.
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Damiana Alvarez-Errico, Eva Lessmann & Juan Rivera. (2009) Adapters in the organization of mast cell signaling. Immunological Reviews 232:1, pages 195-217.
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Hongyan Wang, Bin Wei, Georges Bismuth & Christopher E. Rudd. (2009) SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility. Proceedings of the National Academy of Sciences 106:30, pages 12436-12441.
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Clare L. AbramClifford A. Lowell. (2009) The Ins and Outs of Leukocyte Integrin Signaling. Annual Review of Immunology 27:1, pages 339-362.
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Kenneth D. Swanson, Yong Tang, Derek F. Ceccarelli, Florence Poy, Jan P. Sliwa, Benjamin G. Neel & Michael J. Eck. (2008) The Skap-hom Dimerization and PH Domains Comprise a 3′-Phosphoinositide-Gated Molecular Switch. Molecular Cell 32:4, pages 564-575.
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Brandon J. Burbach, Rupa Srivastava, Ricardo B. Medeiros, William E. O'Gorman, Erik J. Peterson & Yoji Shimizu. (2008) Distinct Regulation of Integrin-Dependent T Cell Conjugate Formation and NF-κB Activation by the Adapter Protein ADAP. The Journal of Immunology 181:7, pages 4840-4851.
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Hongyan Wang & Christopher E. Rudd. (2008) SKAP-55, SKAP-55-related and ADAP adaptors modulate integrin-mediated immune-cell adhesion. Trends in Cell Biology 18:10, pages 486-493.
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Helga Schneider, Hongyan Wang, Monika Raab, Elke Valk, Xin Smith, Matt Lovatt, Zhonglin Wu, Braudel Maqueira-Iglesias, Klaus Strebhardt & Christopher E. Rudd. (2008) Adaptor SKAP-55 Binds p21ras Activating Exchange Factor RasGRP1 and Negatively Regulates the p21ras-ERK Pathway in T-Cells. PLoS ONE 3:3, pages e1718.
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