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Molecular and Cellular Biology Volume 27, 2007 - Issue 1
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Article

Targeted Deletion of the Muscular Dystrophy Gene myotilin Does Not Perturb Muscle Structure or Function in Mice

Monica Moza1 Department of Pathology and Neuroscience Program, Biomedicum Helsinki, P.O. Box 63, Haartmaninkatu 8, 00014 University of Helsinki, Helsinki, FinlandCorrespondence[email protected]
,
Luca Mologni1 Department of Pathology and Neuroscience Program, Biomedicum Helsinki, P.O. Box 63, Haartmaninkatu 8, 00014 University of Helsinki, Helsinki, Finland
,
Ras Trokovic2 Institute of Biotechnology, Viikki Biocenter, Developmental Biology Program, P.O. Box 56, Viikinkaari 9, 00014 University of Helsinki, Helsinki, Finland
,
Georgine Faulkner3 International Center for Genetic Engineering and Biotechnology, Padriciano 99, Trieste, Italy
,
Juha Partanen2 Institute of Biotechnology, Viikki Biocenter, Developmental Biology Program, P.O. Box 56, Viikinkaari 9, 00014 University of Helsinki, Helsinki, Finland
&
Olli Carpén1 Department of Pathology and Neuroscience Program, Biomedicum Helsinki, P.O. Box 63, Haartmaninkatu 8, 00014 University of Helsinki, Helsinki, Finland;4 Department of Pathology, University of Turku, and Turku University Central Hospital, Kiinamyllynkatu 10, 20520Turku, Finland
Pages 244-252 | Received 30 Mar 2006, Accepted 17 Oct 2006, Published online: 27 Mar 2023

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Julien Ochala, Olli Carpén & Lars Larsson. (2009) Maintenance of muscle mass, fiber size, and contractile function in mice lacking the Z-disc protein myotilin. Upsala Journal of Medical Sciences 114:4, pages 235-241.
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Pernilla von Nandelstadh, Mohamed Ismail, Chiara Gardin, Heli Suila, Ivano Zara, Anna Belgrano, Giorgio Valle, Olli Carpen & Georgine Faulkner. (2009) A Class III PDZ Binding Motif in the Myotilin and FATZ Families Binds Enigma Family Proteins: a Common Link for Z-Disc Myopathies. Molecular and Cellular Biology 29:3, pages 822-834.
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Kirsty Wadmore, Amar J. Azad & Katja Gehmlich. (2021) The Role of Z-disc Proteins in Myopathy and Cardiomyopathy. International Journal of Molecular Sciences 22:6, pages 3058.
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Kendal Prill & John F. Dawson. (2020) Assembly and Maintenance of Sarcomere Thin Filaments and Associated Diseases. International Journal of Molecular Sciences 21:2, pages 542.
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Vid Puž, Miha Pavšič, Brigita Lenarčič & Kristina Djinović-Carugo. (2017) Conformational plasticity and evolutionary analysis of the myotilin tandem Ig domains. Scientific Reports 7:1.
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Dipak k. Dube, Jushuo Wang, Christopher Pellenz, Yingli Fan, Syamalima Dube, Mingda Han, Kersti Linask, Jean M. Sanger & Joseph W. Sanger. (2014) Expression of Myotilin During Chicken Development. The Anatomical Record 297:9, pages 1596-1603.
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OMAR A. MAHMOOD & XIN MEI JIANG. (2014) Limb-girdle muscular dystrophies: Where next after six decades from the first proposal (Review). Molecular Medicine Reports 9:5, pages 1515-1532.
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Marie-Louise Bang, Yusu Gu, Nancy D. Dalton, Kirk L. Peterson, Kenneth R. Chien & Ju Chen. (2014) The Muscle Ankyrin Repeat Proteins CARP, Ankrd2, and DARP Are Not Essential for Normal Cardiac Development and Function at Basal Conditions and in Response to Pressure Overload. PLoS ONE 9:4, pages e93638.
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Vasco Sequeira, Louise L.A.M Nijenkamp, Jessica A. Regan & Jolanda van der Velden. (2014) The physiological role of cardiac cytoskeleton and its alterations in heart failure. Biochimica et Biophysica Acta (BBA) - Biomembranes 1838:2, pages 700-722.
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Jian Liu, Lindsay M Wallace, Sara E Garwick-Coppens, Darcée D Sloboda, Carol S Davis, Chady H Hakim, Michael A Hauser, Susan V Brooks, Jerry R Mendell & Scott Q Harper. (2014) RNAi-mediated Gene Silencing of Mutant Myotilin Improves Myopathy in LGMD1A Mice. Molecular Therapy - Nucleic Acids 3, pages e160.
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Vanessa L.S. LaPointe, Jan de Boer & Adam J. Engler. 2014. Tissue Engineering. Tissue Engineering 111 148 .
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Jushuo Wang, Dipak K. Dube, Balraj Mittal, Jean M. Sanger & Joseph W. Sanger. (2011) Myotilin dynamics in cardiac and skeletal muscle cells. Cytoskeleton 68:12, pages 661-670.
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Pernilla von Nandelstadh, Rabah Soliymani, Marc Baumann & Olli Carpen. (2011) Analysis of myotilin turnover provides mechanistic insight into the role of myotilinopathy-causing mutations. Biochemical Journal 436:1, pages 113-121.
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Duygu Selcen & Andrew G. Engel. 2011. Muscular Dystrophies. Muscular Dystrophies 143 154 .
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Monkol Lek & Kathryn N. North. (2010) Are biological sensors modulated by their structural scaffolds? The role of the structural muscle proteins α-actinin-2 and α-actinin-3 as modulators of biological sensors. FEBS Letters 584:14, pages 2974-2980.
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Hai-ping Zhao, Dan Lü, Wei Zhang, Li Zhang, Shu-mei Wang, Chun-mei Ma, Chuan Qin & Lian-feng Zhang. (2010) Protective action of tetramethylpyrazine phosphate against dilated cardiomyopathy in cTnTR141W transgenic mice. Acta Pharmacologica Sinica 31:3, pages 281-288.
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Kumaran Chandrasekharan & Paul T. Martin. 2010. Functional Glycomics. Functional Glycomics 291 322 .
Robert W. Burgess, Gregory A. Cox & Kevin L. Seburn. 2010. Mouse Models for Drug Discovery. Mouse Models for Drug Discovery 347 393 .
Lindsay M. Wallace, Sara E. Garwick & Scott Q. Harper. 2010. Muscle Gene Therapy. Muscle Gene Therapy 99 115 .
Carol A. Otey, Richard Dixon, Christianna Stack & Silvia M. Goicoechea. (2009) Cytoplasmic Ig-domain proteins: Cytoskeletal regulators with a role in human disease. Cell Motility and the Cytoskeleton 66:8, pages 618-634.
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Outi Heikkinen, Perttu Permi, Harri Koskela, Olli Carpén, Jari Ylänne & Ilkka Kilpeläinen. (2009) Solution structure of the first immunoglobulin domain of human myotilin. Journal of Biomolecular NMR 44:2, pages 107-112.
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M. Zheng, H. Cheng, X. Li, J. Zhang, L. Cui, K. Ouyang, L. Han, T. Zhao, Y. Gu, N. D. Dalton, M.-L. Bang, K. L. Peterson & J. Chen. (2008) Cardiac-specific ablation of Cypher leads to a severe form of dilated cardiomyopathy with premature death. Human Molecular Genetics 18:4, pages 701-713.
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Luk Cox, Lieve Umans, Frederique Cornelis, Danny Huylebroeck & An Zwijsen. (2008) A broken heart: A stretch too far. International Journal of Cardiology 131:1, pages 33-44.
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Duygu Selcen. (2008) Myofibrillar myopathies. Current Opinion in Neurology 21:5, pages 585-589.
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Isidre Ferrer & Montse Olivé. (2008) Molecular pathology of myofibrillar myopathies. Expert Reviews in Molecular Medicine 10.
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Hans H. Goebel, Michel Fardeau, Montse Olivé & Rolf Schröder. (2008) 156th ENMC International Workshop: Desmin and protein aggregate myopathies, 9–11 November 2007, Naarden, The Netherlands. Neuromuscular Disorders 18:7, pages 583-592.
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Sean M. Garvey, Yutao Liu, Sara E. Miller & Michael A. Hauser. (2008) Myotilin overexpression enhances myopathology in the LGMD1A mouse model. Muscle & Nerve 37:5, pages 663-667.
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Duygu Selcen & Olli Carpén. 2008. The Sarcomere and Skeletal Muscle Disease. The Sarcomere and Skeletal Muscle Disease 116 130 .
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Sawako Yamashiro, Mario Gimona & Shoichiro Ono. (2007) UNC-87, a calponin-related protein in C. elegans , antagonizes ADF/cofilin-mediated actin filament dynamics . Journal of Cell Science 120:17, pages 3022-3033.
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