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Molecular and Cellular Biology Volume 26, 2006 - Issue 17
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Article

Binding of SH2-B Family Members within a Potential Negative Regulatory Region Maintains JAK2 in an Active State

Jason H. Kurzer1 Graduate Program in Cellular and Molecular Biology
,
Pipsa Saharinen2 Molecular/Cancer Biology Laboratory, University of Helsinki, FIN-00014Helsinki, Finland
,
Olli Silvennoinen3 Institute of Medical Technology, University of Tampere, and Department of Clinical Microbiology, Tampere University Hospital, FIN-33014Tampere, Finland
&
Christin Carter-Su4 Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan48109-0662Correspondence[email protected]
Pages 6381-6394 | Received 31 Mar 2006, Accepted 26 Jun 2006, Published online: 27 Mar 2023

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Ray M. Joe, Anabel Flores, Michael E. Doche, Joel M. Cline, Erik S. Clutter, Paul B. Vander, Heimo Riedel, Lawrence S. Argetsinger & Christin Carter-Su. (2018) Phosphorylation of the Unique C-Terminal Tail of the Alpha Isoform of the Scaffold Protein SH2B1 Controls the Ability of SH2B1α To Enhance Nerve Growth Factor Function. Molecular and Cellular Biology 38:6.
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Karoline Gäbler, Iris Behrmann & Claude Haan. (2013) JAK2 mutants (e.g., JAK2V617F) and their importance as drug targets in myeloproliferative neoplasms. JAK-STAT 2:3.
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Megumi Funakoshi-Tago, Stéphane Pelletier, Hiroshi Moritake, Evan Parganas & James N. Ihle. (2008) Jak2 FERM Domain Interaction with the Erythropoietin Receptor Regulates Jak2 Kinase Activity. Molecular and Cellular Biology 28:5, pages 1792-1801.
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Articles from other publishers (28)

Li-Na Wang, Zi-Teng Zhang, Li Wang, Hai-Xiang Wei, Tao Zhang, Li-Ming Zhang, Hang Lin, Heng Zhang & Shao-Qiang Wang. (2022) TGF-β1/SH2B3 axis regulates anoikis resistance and EMT of lung cancer cells by modulating JAK2/STAT3 and SHP2/Grb2 signaling pathways. Cell Death & Disease 13:5.
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Anna E. Marneth & Ann Mullally. (2020) The Molecular Genetics of Myeloproliferative Neoplasms. Cold Spring Harbor Perspectives in Medicine 10:2, pages a034876.
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Anabel Flores, Lawrence S. Argetsinger, Lukas K.J. StadlerAlvaro E. Malaga, Paul B. Vander, Lauren C. DeSantis, Ray M. Joe, Joel M. Cline, Julia M. KeoghElana HenningInes BarrosoEdson Mendes de OliveiraGowri Chandrashekar, Erik S. Clutter, Yixin Hu, Jeanne Stuckey, I. Sadaf FarooqiMartin G. MyersJr.Jr. & Christin Carter-Su. (2019) Crucial Role of the SH2B1 PH Domain for the Control of Energy Balance. Diabetes 68:11, pages 2049-2062.
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Susann Schulze, Rayk Stengel, Nadja Jaekel, Song‐Yau Wang, Georg–Nikolaus Franke, Martin Roskos, Melanie Schneider, Dietger Niederwieser & Haifa Kathrin Al‐Ali. (2019) Concomitant and noncanonical JAK2 and MPL mutations in JAK2 V617F‐ and MPLW 515 L‐positive myelofibrosis . Genes, Chromosomes and Cancer 58:11, pages 747-755.
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Henrik M. Hammarén, Anniina T. Virtanen, Juuli Raivola & Olli Silvennoinen. (2019) The regulation of JAKs in cytokine signaling and its breakdown in disease. Cytokine 118, pages 48-63.
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Marissa A. McKercher, Xiaoyang Guan, Zhongping Tan & Deborah S. Wuttke. (2017) Diversity in peptide recognition by the SH2 domain of SH2B1. Proteins: Structure, Function, and Bioinformatics 86:2, pages 164-176.
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N Maslah, B Cassinat, E Verger, J-J Kiladjian & L Velazquez. (2017) The role of LNK/SH2B3 genetic alterations in myeloproliferative neoplasms and other hematological disorders. Leukemia 31:8, pages 1661-1670.
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Jeffrey J. Babon, Isabelle S. Lucet, James M. Murphy, Nicos A. Nicola & Leila N. Varghese. (2014) The molecular regulation of Janus kinase (JAK) activation. Biochemical Journal 462:1, pages 1-13.
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S Gery & H P Koeffler. (2012) Role of the adaptor protein LNK in normal and malignant hematopoiesis. Oncogene 32:26, pages 3111-3118.
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Erin E. O'LearyAnna M. Mazurkiewicz-MuñozLawrence S. ArgetsingerTravis J. MauresHung T. Huynh & Christin Carter-Su. (2013) Identification of Steroid-Sensitive Gene-1/Ccdc80 as a JAK2-Binding Protein. Molecular Endocrinology 27:4, pages 619-634.
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Laura Velazquez. (2012) The Lnk Adaptor Protein: A Key Regulator of Normal and Pathological Hematopoiesis. Archivum Immunologiae et Therapiae Experimentalis 60:6, pages 415-429.
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Mojib Javadi, Edda Hofstätter, Natalie Stickle, Bryan K. Beattie, Robert Jaster, Christin Carter-Su & Dwayne L. Barber. (2012) The SH2B1 Adaptor Protein Associates with a Proximal Region of the Erythropoietin Receptor. Journal of Biological Chemistry 287:31, pages 26223-26234.
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Julie Devallière & Béatrice Charreau. (2011) The adaptor Lnk (SH2B3): An emerging regulator in vascular cells and a link between immune and inflammatory signaling. Biochemical Pharmacology 82:10, pages 1391-1402.
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Nathan J. Lanning, Hsiao-Wen Su, Lawrence S. Argetsinger & Christin Carter-Su. (2011) Identification of SH2B1β as a focal adhesion protein that regulates focal adhesion size and number. Journal of Cell Science 124:18, pages 3095-3105.
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Fanny Baran-MarszakHajer MagdoudChristophe DesterkeAnabell AlvaradoClaudine RogerStéphanie HarelElizabeth MazoyerBruno CassinatSylvie ChevretCarole Tonetti, Stéphane Giraudier, Pierre FenauxFlorence CymbalistaNadine Varin-BlankMarie-Caroline Le Bousse-KerdilèsJean-Jacques Kiladjian & Laura Velazquez. (2010) Expression level and differential JAK2-V617F–binding of the adaptor protein Lnk regulates JAK2-mediated signals in myeloproliferative neoplasms. Blood 116:26, pages 5961-5971.
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Streamson ChuaJr.Jr.. (2010) SH2B1—The Adaptor Protein that Could. Endocrinology 151:9, pages 4100-4102.
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David L. Morris, Kae Won Cho & Liangyou Rui. (2010) Critical Role of the Src Homology 2 (SH2) Domain of Neuronal SH2B1 in the Regulation of Body Weight and Glucose Homeostasis in Mice. Endocrinology 151:8, pages 3643-3651.
Crossref
Anna Siemiątkowska, Maria Bieniaszewska, Andrzej Hellmann & Janusz Limon. (2010) JAK2 and MPL gene mutations in V617F-negative myeloproliferative neoplasms. Leukemia Research 34:3, pages 387-389.
Crossref
Mazen Kurdi & George W. Booz. (2009) JAK redux: a second look at the regulation and role of JAKs in the heart. American Journal of Physiology-Heart and Circulatory Physiology 297:5, pages H1545-H1556.
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Dipak Barua, James R. Faeder & Jason M. Haugh. (2009) A Bipolar Clamp Mechanism for Activation of Jak-Family Protein Tyrosine Kinases. PLoS Computational Biology 5:4, pages e1000364.
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Joji NakayamaMutsumi YamamotoKatsuhiko HayashiHitoshi SatohKenji BundoMasato KuboRyo GoitsukaMichael A. Farrar & Daisuke Kitamura. (2009) BLNK suppresses pre–B-cell leukemogenesis through inhibition of JAK3. Blood 113:7, pages 1483-1492.
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Issam McDoom, Xianyue Ma, Annet Kirabo, Kuang-Yung Lee, David A. Ostrov & Peter P. Sayeski. (2008) Identification of Tyrosine 972 as a Novel Site of Jak2 Tyrosine Kinase Phosphorylation and Its Role in Jak2 Activation. Biochemistry 47:32, pages 8326-8334.
Crossref
Manchao Zhang, Youping Deng & Heimo Riedel. (2008) PSM/SH2B1 splice variants: Critical role in src catalytic activation and the resulting STAT3s-mediated mitogenic response. Journal of Cellular Biochemistry 104:1, pages 105-118.
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Fumitaka Kawakami, Kanzo Suzuki & Kenzo Ohtsuki. (2008) A Novel Consensus Phosphorylation Motif in Sulfatide- and Cholesterol-3-sulfate-Binding Protein Substrates for CK1 in Vitro. Biological and Pharmaceutical Bulletin 31:2, pages 193-200.
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Manchao Zhang, Youping Deng, Ruchi Tandon, Cheng Bai & Heimo Riedel. (2008) Essential role of PSM/SH2-B variants in insulin receptor catalytic activation and the resulting cellular responses. Journal of Cellular Biochemistry 103:1, pages 162-181.
Crossref
Zhiqin Li, Yingjiang Zhou, Christin Carter-Su, Martin G. MyersJr.Jr. & Liangyou Rui. (2007) SH2B1 Enhances Leptin Signaling by Both Janus Kinase 2 Tyr813 Phosphorylation-Dependent and -Independent Mechanisms. Molecular Endocrinology 21:9, pages 2270-2281.
Crossref
Travis J. Maures, Jason H. Kurzer & Christin Carter-Su. (2007) SH2B1 (SH2-B) and JAK2: a multifunctional adaptor protein and kinase made for each other. Trends in Endocrinology & Metabolism 18:1, pages 38-45.
Crossref
Nathan J. Lanning & Christin Carter-Su. (2007) Recent advances in growth hormone signaling. Reviews in Endocrine and Metabolic Disorders 7:4, pages 225-235.
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