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Molecular and Cellular Biology Volume 28, 2008 - Issue 17
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Article

Phosphorylated Ssk1 Prevents Unphosphorylated Ssk1 from Activating the Ssk2 Mitogen-Activated Protein Kinase Kinase Kinase in the Yeast High-Osmolarity Glycerol Osmoregulatory Pathway

Tetsuro HorieDivision of Molecular Cell Signaling, Institute of Medical Sciences, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo108-8639, Japan
,
Kazuo TatebayashiDivision of Molecular Cell Signaling, Institute of Medical Sciences, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo108-8639, Japan
,
Rika YamadaDivision of Molecular Cell Signaling, Institute of Medical Sciences, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo108-8639, Japan
&
Haruo SaitoDivision of Molecular Cell Signaling, Institute of Medical Sciences, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo108-8639, JapanCorrespondence[email protected]
Pages 5172-5183 | Received 11 Apr 2008, Accepted 16 Jun 2008, Published online: 27 Mar 2023

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Akiko Nishimura, Katsuyoshi Yamamoto, Masaaki Oyama, Hiroko Kozuka-Hata, Haruo Saito & Kazuo Tatebayashi. (2016) Scaffold Protein Ahk1, Which Associates with Hkr1, Sho1, Ste11, and Pbs2, Inhibits Cross Talk Signaling from the Hkr1 Osmosensor to the Kss1 Mitogen-Activated Protein Kinase. Molecular and Cellular Biology 36:7, pages 1109-1123.
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Katsuyoshi Yamamoto, Kazuo Tatebayashi & Haruo Saito. (2016) Binding of the Extracellular Eight-Cysteine Motif of Opy2 to the Putative Osmosensor Msb2 Is Essential for Activation of the Yeast High-Osmolarity Glycerol Pathway. Molecular and Cellular Biology 36:3, pages 475-487.
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Lauren S. Ryder & Nicholas J. Talbot. 2023. Plant Relationships. Plant Relationships 307 327 .
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Ke-Xin Jiang, Qian-Qian Liu, Na Bai, Mei-Chen Zhu, Ke-Qin Zhang & Jin-Kui Yang. (2022) AoSsk1, a Response Regulator Required for Mycelial Growth and Development, Stress Responses, Trap Formation, and the Secondary Metabolism in Arthrobotrys oligospora. Journal of Fungi 8:3, pages 260.
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Atsuya Urita, Yohei Ishibashi, Ryotaro Kawaguchi, Yukimi Yanase & Motohiro Tani. (2021) Crosstalk between protein kinase A and the HOG pathway under impaired biosynthesis of complex sphingolipids in budding yeast. The FEBS Journal 289:3, pages 766-786.
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Robert B. Bourret, Clay A. Foster & William E. Goldman. (2021) Predicted Functional and Structural Diversity of Receiver Domains in Fungal Two-Component Regulatory Systems. mSphere 6:5.
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Enping Cai, Shuquan Sun, Yizhen Deng, Peishen Huang, Xian Sun, Yuting Wang, Changqing Chang & Zide Jiang. (2021) Histidine Kinase Sln1 and cAMP/PKA Signaling Pathways Antagonistically Regulate Sporisorium scitamineum Mating and Virulence via Transcription Factor Prf1. Journal of Fungi 7:8, pages 610.
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Deepak Mishra, Tristan Bepler, Brian Teague, Bonnie Berger, Jim Broach & Ron Weiss. (2021) An engineered protein-phosphorylation toggle network with implications for endogenous network discovery. Science 373:6550.
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Araceli Vázquez-Ibarra, Griselda Rodríguez-Martínez, Gehenna Guerrero-Serrano, Laura Kawasaki, Laura Ongay-Larios & Roberto Coria. (2020) Negative feedback-loop mechanisms regulating HOG- and pheromone-MAPK signaling in yeast. Current Genetics 66:5, pages 867-880.
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Katie M. Branscum, Smita K. Menon, Clay A. Foster & Ann H. West. (2019) Insights revealed by the co‐crystal structure of the Saccharomyces cerevisiae histidine phosphotransfer protein Ypd1 and the receiver domain of its downstream response regulator Ssk1 . Protein Science 28:12, pages 2099-2111.
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T. Tristan Brandhorst, Iain R. L. Kean, Stephanie M. Lawry, Darin L. Wiesner & Bruce S. Klein. (2019) Phenylpyrrole fungicides act on triosephosphate isomerase to induce methylglyoxal stress and alter hybrid histidine kinase activity. Scientific Reports 9:1.
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Tomomi Takayama, Katsuyoshi Yamamoto, Haruo Saito & Kazuo Tatebayashi. (2019) Interaction between the transmembrane domains of Sho1 and Opy2 enhances the signaling efficiency of the Hog1 MAP kinase cascade in Saccharomyces cerevisiae. PLOS ONE 14:1, pages e0211380.
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Zhixing Wang, Ning An, Wenqiang Xu, Weixin Zhang, Xiangfeng Meng, Guanjun Chen & Weifeng Liu. (2018) Functional characterization of the upstream components of the Hog1-like kinase cascade in hyperosmotic and carbon sensing in Trichoderma reesei. Biotechnology for Biofuels 11:1.
Crossref
B. Eleazar Cohen. (2018) Membrane Thickness as a Key Factor Contributing to the Activation of Osmosensors and Essential Ras Signaling Pathways. Frontiers in Cell and Developmental Biology 6.
Crossref
Yutaro Yamaguchi, Yuka Katsuki, Seiya Tanaka, Ryotaro Kawaguchi, Hiroto Denda, Takuma Ikeda, Kouichi Funato & Motohiro Tani. (2018) Protective role of the HOG pathway against the growth defect caused by impaired biosynthesis of complex sphingolipids in yeast Saccharomyces cerevisiae . Molecular Microbiology 107:3, pages 363-386.
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Miriam Rodríguez-González, Laura Kawasaki, Nancy Velázquez-Zavala, Eunice Domínguez-Martín, Abraham Trejo-Medecigo, Natalia Martagón, Emilio Espinoza-Simón, Araceli Vázquez-Ibarra, Laura Ongay-Larios, Dimitris Georgellis, Eulàlia de Nadal, Francesc Posas & Roberto Coria. (2017) Role of the Sln1-phosphorelay pathway in the response to hyperosmotic stress in the yeast Kluyveromyces lactis . Molecular Microbiology 104:5, pages 822-836.
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Griselda Salas-Delgado, Laura Ongay-Larios, Laura Kawasaki-Watanabe, Imelda López-Villaseñor & Roberto Coria. (2017) The yeasts phosphorelay systems: a comparative view. World Journal of Microbiology and Biotechnology 33:6.
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Klement Stojanovski, Tony Ferrar, Hannah Benisty, Friedemann Uschner, Javier Delgado, Javier Jimenez, Carme Solé, Eulalia de Nadal, Edda Klipp, Francesc Posas, Luis Serrano & Christina Kiel. (2017) Interaction Dynamics Determine Signaling and Output Pathway Responses. Cell Reports 19:1, pages 136-149.
Crossref
Stephanie M. Lawry, Brad Tebbets, Iain Kean, Douglas Stewart, Joel Hetelle & Bruce S. Klein. (2017) Fludioxonil Induces Drk1, a Fungal Group III Hybrid Histidine Kinase, To Dephosphorylate Its Downstream Target, Ypd1. Antimicrobial Agents and Chemotherapy 61:2.
Crossref
Alison M. Day, Deborah A. Smith, Mélanie A. C. Ikeh, Mohammed Haider, Carmen M. Herrero-de-Dios, Alistair J. P. Brown, Brian A. Morgan, Lars P. Erwig, Donna M. MacCallum & Janet Quinn. (2017) Blocking two-component signalling enhances Candida albicans virulence and reveals adaptive mechanisms that counteract sustained SAPK activation. PLOS Pathogens 13:1, pages e1006131.
Crossref
Clay A. Foster & Ann H. West. (2016) Use of restrained molecular dynamics to predict the conformations of phosphorylated receiver domains in two‐component signaling systems. Proteins: Structure, Function, and Bioinformatics 85:1, pages 155-176.
Crossref
Tilen Konte, Ulrich Terpitz & Ana Plemenitaš. (2016) Reconstruction of the High-Osmolarity Glycerol (HOG) Signaling Pathway from the Halophilic Fungus Wallemia ichthyophaga in Saccharomyces cerevisiae. Frontiers in Microbiology 7.
Crossref
Joseph P Dexter, Ping Xu, Jeremy Gunawardena & Megan N McClean. (2015) Robust network structure of the Sln1-Ypd1-Ssk1 three-component phospho-relay prevents unintended activation of the HOG MAPK pathway in Saccharomyces cerevisiae. BMC Systems Biology 9:1.
Crossref
Tomoaki Mizuno, Yuto Masuda & Kenji Irie. (2015) The Saccharomyces cerevisiae AMPK, Snf1, Negatively Regulates the Hog1 MAPK Pathway in ER Stress Response. PLOS Genetics 11:9, pages e1005491.
Crossref
Anne Viefhues, Ina Schlathoelter, Adeline Simon, Muriel Viaud & Paul Tudzynski. (2015) Unraveling the Function of the Response Regulator BcSkn7 in the Stress Signaling Network of Botrytis cinerea. Eukaryotic Cell 14:7, pages 636-651.
Crossref
Kazuo Tatebayashi, Katsuyoshi Yamamoto, Miho Nagoya, Tomomi Takayama, Akiko Nishimura, Megumi Sakurai, Takashi Momma & Haruo Saito. (2015) Osmosensing and scaffolding functions of the oligomeric four-transmembrane domain osmosensor Sho1. Nature Communications 6:1.
Crossref
Thorsten Hamann. (2015) The plant cell wall integrity maintenance mechanism – A case study of a cell wall plasma membrane signaling network. Phytochemistry 112, pages 100-109.
Crossref
Alessandra Dantas, Alison Day, Mélanie Ikeh, Iaroslava Kos, Beatrice Achan & Janet Quinn. (2015) Oxidative Stress Responses in the Human Fungal Pathogen, Candida albicans. Biomolecules 5:1, pages 142-165.
Crossref
Hoda Sharifian, Fabienne Lampert, Klement Stojanovski, Sergi Regot, Stefania Vaga, Raymond Buser, Sung Sik Lee, Heinz Koeppl, Francesc Posas, Serge Pelet & Matthias Peter. (2015) Parallel feedback loops control the basal activity of the HOG MAPK signaling cascade. Integrative Biology 7:4, pages 412-422.
Crossref
Munia Amin, Varun B. Kothamachu, Elisenda Feliu, Birgit E. Scharf, Steven L. Porter & Orkun S. Soyer. (2014) Phosphate Sink Containing Two-Component Signaling Systems as Tunable Threshold Devices. PLoS Computational Biology 10:10, pages e1003890.
Crossref
Carlos A. Barba-Ostria. (2014) Los sistemas de dos componentes: circuitos moleculares versátiles. TIP 17:1, pages 62-76.
Crossref
Keiichiro TanakaKazuo TatebayashiAkiko NishimuraKatsuyoshi YamamotoHui-Yu YangHaruo Saito. (2014) Yeast Osmosensors Hkr1 and Msb2 Activate the Hog1 MAPK Cascade by Different Mechanisms. Science Signaling 7:314.
Crossref
Mohammed El-Mowafy, Mahmoud M Bahgat & Ursula Bilitewski. (2013) Deletion of the HAMP domains from the histidine kinase CaNik1p of Candida albicans or treatment with fungicides activates the MAP kinase Hog1p in S. cerevisiae transformants. BMC Microbiology 13:1.
Crossref
Jan S. Fassler & Ann H. West. (2013) Histidine Phosphotransfer Proteins in Fungal Two-Component Signal Transduction Pathways. Eukaryotic Cell 12:8, pages 1052-1060.
Crossref
Susumu Morigasaki, Aminah Ikner, Hisashi Tatebe & Kazuhiro Shiozaki. (2013) Response regulator–mediated MAPKKK heteromer promotes stress signaling to the Spc1 MAPK in fission yeast. Molecular Biology of the Cell 24:7, pages 1083-1092.
Crossref
Hui Zhi, Leihan Tang, Yiji Xia & Jianhua Zhang. (2013) Ssk1p-Independent Activation of Ssk2p Plays an Important Role in the Osmotic Stress Response in Saccharomyces cerevisiae: Alternative Activation of Ssk2p in Osmotic Stress. PLoS ONE 8:2, pages e54867.
Crossref
Haruo Saito & Francesc Posas. (2012) Response to Hyperosmotic Stress. Genetics 192:2, pages 289-318.
Crossref
Carl‐Fredrik Tiger, Falko Krause, Gunnar Cedersund, Robert Palmér, Edda Klipp, Stefan Hohmann, Hiroaki Kitano & Marcus Krantz. (2012) A framework for mapping, visualisation and automatic model creation of signal‐transduction networks. Molecular Systems Biology 8:1.
Crossref
Clemens Kühn & Edda Klipp. 2012. Advances in Systems Biology. Advances in Systems Biology 293 310 .
Eulàlia de Nadal, Gustav Ammerer & Francesc Posas. (2011) Controlling gene expression in response to stress. Nature Reviews Genetics 12:12, pages 833-845.
Crossref
JINHUA JIANG, YINGZI YUN, JING FU, WON-BO SHIM & ZHONGHUA MA. (2011) Involvement of a putative response regulator FgRrg-1 in osmotic stress response, fungicide resistance and virulence in Fusarium graminearum. Molecular Plant Pathology 12:5, pages 425-436.
Crossref
Deborah A. Smith, Brian A. Morgan & Janet Quinn. (2010) Stress signalling to fungal stress-activated protein kinase pathways. FEMS Microbiology Letters 306:1, pages 1-8.
Crossref
Alla O. Kaserer, Babak Andi, Paul F. Cook & Ann H. West. 2010. Methods in Enzymology: Two-Component Signaling Systems, Part C. Methods in Enzymology: Two-Component Signaling Systems, Part C 59 75 .
Verena Seidl, Lifu Song, Erika Lindquist, Sabine Gruber, Alexeji Koptchinskiy, Susanne Zeilinger, Monika Schmoll, Pedro Martínez, Jibin Sun, Igor Grigoriev, Alfredo Herrera-Estrella, Scott E Baker & Christian P Kubicek. (2009) Transcriptomic response of the mycoparasitic fungus Trichoderma atroviride to the presence of a fungal prey. BMC Genomics 10:1.
Crossref
Alla O. Kaserer, Babak Andi, Paul F. Cook & Ann H. West. (2009) Effects of Osmolytes on the SLN1-YPD1-SSK1 Phosphorelay System from Saccharomyces cerevisiae . Biochemistry 48:33, pages 8044-8050.
Crossref
Elvira Román, Fabien Cottier, Joachim F. Ernst & Jesús Pla. (2009) Msb2 Signaling Mucin Controls Activation of Cek1 Mitogen-Activated Protein Kinase in Candida albicans . Eukaryotic Cell 8:8, pages 1235-1249.
Crossref
Hui-Yu Yang, Kazuo Tatebayashi, Katsuyoshi Yamamoto & Haruo Saito. (2009) Glycosylation defects activate filamentous growth Kss1 MAPK and inhibit osmoregulatory Hog1 MAPK. The EMBO Journal 28:10, pages 1380-1391.
Crossref
. (2009) Current awareness on yeast. Yeast 26:3, pages 193-204.
Crossref

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