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Molecular and Cellular Biology Volume 34, 2014 - Issue 21
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Article

Genomic Uracil Homeostasis during Normal B Cell Maturation and Loss of This Balance during B Cell Cancer Development

Sophia Shalhouta Department of Chemistry, Wayne State University, Detroit, Michigan, USA
,
Dania Haddadb Department of Immunology, University of Toronto, Toronto, Ontario, Canada
,
Angela Sosinc Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA
,
Thomas C. Hollandd Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan, USA
,
Ayad Al-Katibc Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA
,
Alberto Martinb Department of Immunology, University of Toronto, Toronto, Ontario, Canada
&
Ashok S. Bhagwata Department of Chemistry, Wayne State University, Detroit, Michigan, USA;d Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan, USACorrespondence[email protected]
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Pages 4019-4032 | Received 29 Apr 2014, Accepted 18 Aug 2014, Published online: 20 Mar 2023

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Sachini U. Siriwardena, Madusha L. W. Perera, Vimukthi Senevirathne, Jessica Stewart & Ashok S. Bhagwat. (2019) A Tumor-Promoting Phorbol Ester Causes a Large Increase in APOBEC3A Expression and a Moderate Increase in APOBEC3B Expression in a Normal Human Keratinocyte Cell Line without Increasing Genomic Uracils. Molecular and Cellular Biology 39:1.
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Abby M. Green, Sébastien Landry, Konstantin Budagyan, Daphne C. Avgousti, Sophia Shalhout, Ashok S. Bhagwat & Matthew D. Weitzman. (2016) APOBEC3A damages the cellular genome during DNA replication. Cell Cycle 15:7, pages 998-1008.
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Articles from other publishers (15)

Abdullah Alfaifi, Mohammed Y. Refai, Mohammed Alsaadi, Salem Bahashwan, Hafiz Malhan, Waiel Al-Kahiry, Enas Dammag, Ageel Ageel, Amjed Mahzary, Raed Albiheyri, Hussein Almehdar & Ishtiaq Qadri. (2023) Metabolomics: A New Era in the Diagnosis or Prognosis of B-Cell Non-Hodgkin’s Lymphoma. Diagnostics 13:5, pages 861.
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Marina Alexeeva, Marivi Nabong Moen, Xiang Ming Xu, Anette Rasmussen, Ingar Leiros, Finn Kirpekar, Arne Klungland, Lene Alsøe, Hilde Nilsen & Svein Bjelland. (2021) Intrinsic Strand-Incision Activity of Human UNG: Implications for Nick Generation in Immunoglobulin Gene Diversification. Frontiers in Immunology 12.
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Swarnagowri Vaidyanathan, Kumuditha M. Weerakoon-Ratnayake, Franklin I. Uba, Bo Hu, David Kaufman, Junseo Choi, Sunggook Park & Steven A. Soper. (2021) Thermoplastic nanofluidic devices for identifying abasic sites in single DNA molecules. Lab on a Chip 21:8, pages 1579-1589.
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Jessica A Stewart, Grant Schauer & Ashok S Bhagwat. (2020) Visualization of uracils created by APOBEC3A using UdgX shows colocalization with RPA at stalled replication forks. Nucleic Acids Research 48:20, pages e118-e118.
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Antonio Sarno, Marie Lundbæk, Nina Beate Liabakk, Per Arne Aas, Robin Mjelle, Lars Hagen, Mirta M L Sousa, Hans E Krokan & Bodil Kavli. (2019) Uracil–DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil. Nucleic Acids Research 47:9, pages 4569-4585.
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Petra Molnár, Lívia Marton, Richard Izrael, Hajnalka L. Pálinkás & Beáta G. Vértessy. (2018) Uracil moieties in Plasmodium falciparum genomic DNA . FEBS Open Bio 8:11, pages 1763-1772.
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Norah Owiti, Shanqiao Wei, Ashok S. Bhagwat & Nayun Kim. (2018) Unscheduled DNA synthesis leads to elevated uracil residues at highly transcribed genomic loci in Saccharomyces cerevisiae. PLOS Genetics 14:7, pages e1007516.
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Shanqiao Wei, Madusha L. W. Perera, Ramin Sakhtemani & Ashok S. Bhagwat. (2017) A novel class of chemicals that react with abasic sites in DNA and specifically kill B cell cancers. PLOS ONE 12:9, pages e0185010.
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Sachini U. Siriwardena, Kang Chen & Ashok S. Bhagwat. (2016) Functions and Malfunctions of Mammalian DNA-Cytosine Deaminases. Chemical Reviews 116:20, pages 12688-12710.
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Alessandro Allegra, Vanessa Innao, Demetrio Gerace, Oriana Bianco & Caterina Musolino. (2016) The metabolomic signature of hematologic malignancies. Leukemia Research 49, pages 22-35.
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Gergely Róna, Ildikó Scheer, Kinga Nagy, Hajnalka L. Pálinkás, Gergely Tihanyi, Máté Borsos, Angéla Békési & Beáta G. Vértessy. (2016) Detection of uracil within DNA using a sensitive labeling method for in vitro and cellular applications . Nucleic Acids Research 44:3, pages e28-e28.
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Xiwen GuCarmen J. Booth, Zongzhi Liu & Matthew P. Strout. (2016) AID-associated DNA repair pathways regulate malignant transformation in a murine model of BCL6-driven diffuse large B-cell lymphoma. Blood 127:1, pages 102-112.
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Astrid Zahn & Javier M. Di Noia. 2016. Encyclopedia of Immunobiology. Encyclopedia of Immunobiology 115 125 .
Shanqiao Wei, Sophia Shalhout, Young-Hoon Ahn & Ashok S. Bhagwat. (2015) A versatile new tool to quantify abasic sites in DNA and inhibit base excision repair. DNA Repair 27, pages 9-18.
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Henrik Sahlin Pettersen, Anastasia Galashevskaya, Berit Doseth, Mirta M.L. Sousa, Antonio Sarno, Torkild Visnes, Per Arne Aas, Nina-Beate Liabakk, Geir Slupphaug, Pål Sætrom, Bodil Kavli & Hans E. Krokan. (2015) AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature. DNA Repair 25, pages 60-71.
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