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Molecular and Cellular Biology Volume 26, 2006 - Issue 20
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Article

AML1/RUNX1 Phosphorylation by Cyclin-Dependent Kinases Regulates the Degradation of AML1/RUNX1 by the Anaphase-Promoting Complex

Joseph R. Biggs1 Division of Oncovirology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California92037
,
Luke F. Peterson1 Division of Oncovirology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California92037
,
Youhong Zhang2 Hollings Cancer Center, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, South Carolina29425
,
Andrew S. Kraft2 Hollings Cancer Center, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, South Carolina29425
&
Dong-Er Zhang1 Division of Oncovirology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California92037Correspondence[email protected]
Pages 7420-7429 | Received 06 Apr 2006, Accepted 25 Jul 2006, Published online: 27 Mar 2023

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Wei Li, Jamie Katy Hu & Miaofen G Hu. (2023) CDK6: an attractive therapeutic target for T-ALL/LBL. Expert Opinion on Therapeutic Targets 27:11, pages 1087-1096.
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Kobi J Simpson-Lavy, Drora Zenvirth & Michael Brandeis. (2015) Phosphorylation and dephosphorylation regulate APC/CCdh1 substrate degradation. Cell Cycle 14:19, pages 3138-3145.
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Johanna K. Ahlskog, Johanna K. Björk, Alexandra N. Elsing, Camilla Aspelin, Marko Kallio, Pia Roos-Mattjus & Lea Sistonen. (2010) Anaphase-Promoting Complex/Cyclosome Participates in the Acute Response to Protein-Damaging Stress. Molecular and Cellular Biology 30:24, pages 5608-5620.
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Samantha Bruno, Andrea Ghelli Luserna di Rorà, Roberta Napolitano, Simona Soverini, Giovanni Martinelli & Giorgia Simonetti. (2022) CDC20 in and out of mitosis: a prognostic factor and therapeutic target in hematological malignancies. Journal of Experimental & Clinical Cancer Research 41:1.
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Marisa J L Aitken, Prerna Malaney, Xiaorui Zhang, Shelley M Herbrich, Lauren Chan, Oscar Benitez, Ashley G Rodriguez, Huaxian Ma, Rodrigo Jacamo, Ruizhi Duan, Todd M Link, Steven M Kornblau, Rashmi Kanagal-Shamanna, Carlos E Bueso-Ramos & Sean M Post. (2022) Heterogeneous nuclear ribonucleoprotein K is overexpressed in acute myeloid leukemia and causes myeloproliferation in mice via altered Runx1 splicing . NAR Cancer 4:4.
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Sophie G. Kellaway, Daniel J.L. Coleman, Peter N. Cockerill, Manoj Raghavan & Constanze Bonifer. (2022) Molecular Basis of Hematological Disease Caused by Inherited or Acquired RUNX1 Mutations. Experimental Hematology 111, pages 1-12.
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Chengfang Zhou, Mei Kuang, Zhilong Liu, Xiaoqin Jia, Zhe Chen, Yuanyuan Liu, Zhigang Li, Weiru Wu, Le Ma, Jieping Chen & Yu Hou. (2021) Insufficiency of FZR1 disturbs HSC quiescence by inhibiting ubiquitin-dependent degradation of RUNX1 in aplastic anemia. Leukemia 36:3, pages 834-846.
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Michelle C. KruteinMatthew R. HartDonovan J. Anderson, Jasmin Jeffery, Andriana G. KotiniJin DaiSylvia ChienMichaela DelPrioreSara Borst, Jean Ann Maguire, Deborah L. French, Paul Gadue, Eirini P. Papapetrou, Siobán B. KeelPamela S. Becker & Marshall S. Horwitz. (2021) Restoring RUNX1 deficiency in RUNX1 familial platelet disorder by inhibiting its degradation . Blood Advances 5:3, pages 687-699.
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Wencui Sun, Jiahui Zeng, Jing Chang, Yuan Xue, Yonggang Zhang, Xu Pan, Ya Zhou, Mowen Lai, Guohui Bian, Qiongxiu Zhou, Jiaxing Liu, Bo Chen & Feng Ma. (2020) RUNX1-205, a novel splice variant of the human RUNX1 gene, has blockage effect on mesoderm–hemogenesis transition and promotion effect during the late stage of hematopoiesis. Journal of Molecular Cell Biology 12:5, pages 386-396.
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Renaud Mevel, Julia E. Draper, Michael Lie-a-Ling, Valerie Kouskoff & Georges Lacaud. (2019) RUNX transcription factors: orchestrators of development. Development 146:17.
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Taishi Yonezawa, Hirotaka Takahashi, Shiori Shikata, Tatsuya Sawasaki, Toshio Kitamura & Susumu Goyama. (2018) The ubiquitin ligase RNF38 promotes RUNX1 ubiquitination and enhances RUNX1-mediated suppression of erythroid transcription program. Biochemical and Biophysical Research Communications 505:3, pages 905-909.
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Hainan Liu, Yan Cui, Guang-Fei Wang, Qincai Dong, Yebao Yao, Ping Li, Cheng Cao & Xuan Liu. (2018) The nonreceptor tyrosine kinase c-Abl phosphorylates Runx1 and regulates Runx1-mediated megakaryocyte maturation. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1865:8, pages 1060-1072.
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Xiaoli Hou, Yongzhao Zhang, Wei Li, Alexander J. Hu, Chi Luo, Wenhui Zhou, Jamie K. Hu, Stefano G. Daniele, Jinfeng Wang, Jinghao Sheng, Yongsheng Fan, Andrew S. Greenberg, Stephen R. Farmer & Miaofen G. Hu. (2018) CDK6 inhibits white to beige fat transition by suppressing RUNX1. Nature Communications 9:1.
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Alessandra I. Riggio & Karen Blyth. (2017) The enigmatic role of RUNX1 in female-related cancers - current knowledge & future perspectives. The FEBS Journal 284:15, pages 2345-2362.
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Taishi Yonezawa, Hirotaka Takahashi, Shiori Shikata, Xiaoxiao Liu, Moe Tamura, Shuhei Asada, Tsuyoshi Fukushima, Tomofusa Fukuyama, Yosuke Tanaka, Tatsuya Sawasaki, Toshio Kitamura & Susumu Goyama. (2017) The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1–RUNX1T1. Journal of Biological Chemistry 292:30, pages 12528-12541.
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Elitza DeltchevaRachael Nimmo. (2017) RUNX transcription factors at the interface of stem cells and cancer. Biochemical Journal 474:11, pages 1755-1768.
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