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Research Article

Cell Cycle-Dependent Switch of TopBP1 Functions by Cdk2 and Akt

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Article: e00599-19 | Received 21 Nov 2019, Accepted 07 Jan 2020, Published online: 03 Mar 2023

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Yan Zhao, Xinping Huang, Dan Zhu, Min Wei, Jiechen Luo, Shuyu Yu, Yonglu Tian & Xiaofeng Zheng. (2022) Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy. Cell Death & Differentiation 29:12, pages 2531-2544.
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Yuewen Zhang, Lei Wu, Zhao Wang, Jinpeng Wang, Shrabasti Roychoudhury, Bartlomiej Tomasik, Gang Wu, Geng Wang, Xinrui Rao & Rui Zhou. (2022) Replication Stress: A Review of Novel Targets to Enhance Radiosensitivity-From Bench to Clinic. Frontiers in Oncology 12.
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Rebecca L. Kelly, Amelia M. Huehls, Annapoorna Venkatachalam, Catherine J. Huntoon, Yuichi J. Machida & Larry M. Karnitz. (2022) Intra-S phase checkpoint kinase Chk1 dissociates replication proteins Treslin and TopBP1 through multiple mechanisms during replication stress. Journal of Biological Chemistry 298:4, pages 101777.
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Zejun Fang, Chaoju Gong, Zhuoni Ye, Wei Wang, Minjing Zhu, Yanyan Hu, Zhiguo Liu, Weihua Zhou & Hongzhang Li. (2022) TOPBP1 regulates resistance of gastric cancer to oxaliplatin by promoting transcription of PARP1. DNA Repair 111, pages 103278.
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Pablo Parra-Nunez, Claire Cooper & Eugenio Sanchez-Moran. (2021) The Role of DNA Topoisomerase Binding Protein 1 (TopBP1) in Genome Stability in Arabidopsis. Plants 10:12, pages 2568.
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Kang Liu, Joshua D. Graves, Fang-Tsyr Lin & Weei-Chin Lin. (2021) Overexpression of TopBP1, a canonical ATR/Chk1 activator, paradoxically hinders ATR/Chk1 activation in cancer. Journal of Biological Chemistry 296, pages 100382.
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