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Molecular and Cellular Biology Volume 29, 2009 - Issue 20
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Article

Generation of a Novel Allelic Series of Cryptochrome Mutants via Mutagenesis Reveals Residues Involved in Protein-Protein Interaction and CRY2-Specific Repression

Ellena V. McCarthy1 Department of Biology, University of Virginia, Charlottesville, Virginia
,
Julie E. Baggs2 Pharmacology Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania
,
Jeanne M. Geskes2 Pharmacology Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania
,
John B. Hogenesch2 Pharmacology Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania
&
Carla B. Green1 Department of Biology, University of Virginia, Charlottesville, VirginiaCorrespondence[email protected]
Pages 5465-5476 | Received 18 May 2009, Accepted 09 Aug 2009, Published online: 21 Mar 2023

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Onur Ozcan, Seref Gul & Ibrahim Halil Kavakli. (2023) Dynamic regulation of the serine loop by distant mutations reveals allostery in cryptochrome1. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-12.
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Articles from other publishers (21)

Alanna B. Chan, Gian Carlo G. Parico, Jennifer L. Fribourgh, Lara H. Ibrahim, Michael J. Bollong, Carrie L. Partch & Katja A. Lamia. (2021) CRY2 missense mutations suppress P53 and enhance cell growth . Proceedings of the National Academy of Sciences 118:27.
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Seref Gul, Cihan Aydin, Onur Ozcan, Berke Gurkan, Saliha Surme, Ibrahim Baris & Ibrahim Halil Kavakli. (2020) The Arg-293 of Cryptochrome1 is responsible for the allosteric regulation of CLOCK-CRY1 binding in circadian rhythm. Journal of Biological Chemistry 295:50, pages 17187-17199.
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Milena Damulewicz & Gabriella M. Mazzotta. (2020) One Actor, Multiple Roles: The Performances of Cryptochrome in Drosophila. Frontiers in Physiology 11.
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Huachun Liu, Tiantian Su, Wenjin He, Qin Wang & Chentao Lin. (2020) The Universally Conserved Residues Are Not Universally Required for Stable Protein Expression or Functions of Cryptochromes. Molecular Biology and Evolution 37:2, pages 327-340.
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Clark Rosensweig & Carla B. Green. (2018) Periodicity, repression, and the molecular architecture of the mammalian circadian clock. European Journal of Neuroscience 51:1, pages 139-165.
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Reena Saini, Mariusz Jaskolski & Seth J. Davis. (2019) Circadian oscillator proteins across the kingdoms of life: structural aspects. BMC Biology 17:1.
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Clark Rosensweig, Kimberly A. Reynolds, Peng Gao, Isara Laothamatas, Yongli Shan, Rama Ranganathan, Joseph S. Takahashi & Carla B. Green. (2018) An evolutionary hotspot defines functional differences between CRYPTOCHROMES. Nature Communications 9:1.
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Anna KriebsSabine D. JordanErin SotoEmma HenrikssonColby R. SandateMegan E. Vaughan, Alanna B. ChanDrew DuglanStephanie J. PappAnne-Laure HuberMegan E. AfetianRuth T. YuXuan ZhaoMichael DownesRonald M. Evans & Katja A. Lamia. (2017) Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity. Proceedings of the National Academy of Sciences 114:33, pages 8776-8781.
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Alicia K. Michael, Jennifer L. Fribourgh, Russell N. Van Gelder & Carrie L. Partch. (2017) Animal Cryptochromes: Divergent Roles in Light Perception, Circadian Timekeeping and Beyond. Photochemistry and Photobiology 93:1, pages 128-140.
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Torsten Merbitz-Zahradnik & Eva Wolf. (2015) How is the inner circadian clock controlled by interactive clock proteins?. FEBS Letters 589:14, pages 1516-1529.
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John H. Abel, Lukas A. Widmer, Peter C. St. John, Jorg Stelling & Francis J. Doyle. (2015) A Coupled Stochastic Model Explains Differences in Cry Knockout Behavior. IEEE Life Sciences Letters 1:1, pages 3-6.
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Shannon N Nangle, Clark Rosensweig, Nobuya Koike, Hajime Tei, Joseph S Takahashi, Carla B Green & Ning Zheng. (2014) Molecular assembly of the period-cryptochrome circadian transcriptional repressor complex. eLife 3.
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Carrie L. Partch, Carla B. Green & Joseph S. Takahashi. (2014) Molecular architecture of the mammalian circadian clock. Trends in Cell Biology 24:2, pages 90-99.
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Ruoting Yang, Maria Rodriguez-Fernandez, Peter C. St. John & Francis J DoyleIIIIII. 2014. Modelling Methodology for Physiology and Medicine. Modelling Methodology for Physiology and Medicine 159 187 .
Peng Gao, Seung-Hee Yoo, Kyung-Jong Lee, Clark Rosensweig, Joseph S. Takahashi, Benjamin P. Chen & Carla B. Green. (2013) Phosphorylation of the Cryptochrome 1 C-terminal Tail Regulates Circadian Period Length. Journal of Biological Chemistry 288:49, pages 35277-35286.
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Anna Czarna, Alex Berndt, Hari Raj Singh, Astrid Grudziecki, Andreas G. Ladurner, Gyula Timinszky, Achim Kramer & Eva Wolf. (2013) Structures of Drosophila Cryptochrome and Mouse Cryptochrome1 Provide Insight into Circadian Function. Cell 153:6, pages 1394-1405.
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Sneha N. Anand, Elizabeth S. Maywood, Johanna E. Chesham, Greg Joynson, Gareth T. Banks, Michael H. Hastings & Patrick M. Nolan. (2013) Distinct and Separable Roles for Endogenous CRY1 and CRY2 within the Circadian Molecular Clockwork of the Suprachiasmatic Nucleus, as Revealed by the Fbxl3 Afh Mutation . The Journal of Neuroscience 33:17, pages 7145-7153.
Crossref
Sanjoy K. Khan, Haiyan Xu, Maki Ukai-Tadenuma, Brittany Burton, Yongmei Wang, Hiroki R. Ueda & Andrew C. Liu. (2012) Identification of a Novel Cryptochrome Differentiating Domain Required for Feedback Repression in Circadian Clock Function. Journal of Biological Chemistry 287:31, pages 25917-25926.
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Anna Czarna, Helena Breitkreuz, Carsten C. Mahrenholz, Julia Arens, Holger M. Strauss & Eva Wolf. (2011) Quantitative Analyses of Cryptochrome-mBMAL1 Interactions. Journal of Biological Chemistry 286:25, pages 22414-22425.
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Maki Ukai-Tadenuma, Rikuhiro G. Yamada, Haiyan Xu, Jürgen A. Ripperger, Andrew C. Liu & Hiroki R. Ueda. (2011) Delay in Feedback Repression by Cryptochrome 1 Is Required for Circadian Clock Function. Cell 144:2, pages 268-281.
Crossref
Hideki Ukai & Hiroki R. Ueda. (2010) Systems Biology of Mammalian Circadian Clocks. Annual Review of Physiology 72:1, pages 579-603.
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