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Molecular and Cellular Biology Volume 30, 2010 - Issue 10
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Article

Functional Effects of PTPN11 (SHP2) Mutations Causing LEOPARD Syndrome on Epidermal Growth Factor-Induced Phosphoinositide 3-Kinase/AKT/Glycogen Synthase Kinase 3β Signaling

Thomas Edouard1 INSERM U563, Centre de Physiopathologie de Toulouse-Purpan, F-31024Toulouse, France
,
Jean-Philippe Combier1 INSERM U563, Centre de Physiopathologie de Toulouse-Purpan, F-31024Toulouse, France
,
Audrey Nédélec1 INSERM U563, Centre de Physiopathologie de Toulouse-Purpan, F-31024Toulouse, France
,
Sophie Bel-Vialar3 Centre de Biologie du Développement, CNRS UMR5547, F-31062Toulouse, France
,
Mélanie Métrich4 INSERM UMRS 769, Signalisation et Physiopathologie Cardiaque, Université Paris Sud 11, F-92296Châtenay-Malabry, France
,
Francoise Conte-Auriol1 INSERM U563, Centre de Physiopathologie de Toulouse-Purpan, F-31024Toulouse, France;2 CHRU and Université Toulouse III, Hôpital Purpan, F-31059Toulouse, France
,
Stanislas Lyonnet5 Université Paris Descartes and INSERM U781, Hôpital Necker, F-75743Paris, France
,
Béatrice Parfait6 Université Paris Descartes and INSERM U745, UFR Pharmacie, F-75270Paris, France
,
Maithé Tauber1 INSERM U563, Centre de Physiopathologie de Toulouse-Purpan, F-31024Toulouse, France;2 CHRU and Université Toulouse III, Hôpital Purpan, F-31059Toulouse, France
,
Jean-Pierre Salles1 INSERM U563, Centre de Physiopathologie de Toulouse-Purpan, F-31024Toulouse, France;2 CHRU and Université Toulouse III, Hôpital Purpan, F-31059Toulouse, France
,
Frank Lezoualc'h4 INSERM UMRS 769, Signalisation et Physiopathologie Cardiaque, Université Paris Sud 11, F-92296Châtenay-Malabry, France
,
Armelle Yart1 INSERM U563, Centre de Physiopathologie de Toulouse-Purpan, F-31024Toulouse, FranceCorrespondence[email protected] [email protected]
&
Patrick Raynal1 INSERM U563, Centre de Physiopathologie de Toulouse-Purpan, F-31024Toulouse, France;2 CHRU and Université Toulouse III, Hôpital Purpan, F-31059Toulouse, FranceCorrespondence[email protected] [email protected]
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Pages 2498-2507 | Received 19 May 2009, Accepted 17 Feb 2010, Published online: 20 Mar 2023

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Giulio Calcagni, Marta Unolt, Maria Cristina Digilio, Anwar Baban, Paolo Versacci, Marco Tartaglia, Antonio Baldini & Bruno Marino. (2017) Congenital heart disease and genetic syndromes: new insights into molecular mechanisms. Expert Review of Molecular Diagnostics 17:9, pages 861-870.
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Panna Tandon, Frank L. Conlon & Joan M. Taylor. (2012) ROCKs cause SHP-wrecks and broken hearts. Small GTPases 3:4, pages 209-212.
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