40
Views
82
CrossRef citations to date
0
Altmetric
Article

Coupled RNA Processing and Transcription of Intergenic Primary MicroRNAs

, , , , , , & show all
Pages 5632-5638 | Received 22 May 2009, Accepted 03 Aug 2009, Published online: 21 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Dooyoung Lee & Chanseok Shin. (2018) Emerging roles of DROSHA beyond primary microRNA processing. RNA Biology 15:2, pages 186-193.
Read now
Emily F. Finnegan & Amy E. Pasquinelli. (2013) MicroRNA biogenesis: regulating the regulators. Critical Reviews in Biochemistry and Molecular Biology 48:1, pages 51-68.
Read now

Articles from other publishers (80)

Michela Saviana, Patricia Le, Lavender Micalo, Daniel Del Valle-Morales, Giulia Romano, Mario Acunzo, Howard Li & Patrick Nana-Sinkam. (2023) Crosstalk between miRNAs and DNA Methylation in Cancer. Genes 14:5, pages 1075.
Crossref
Jing Feng, Shaofan Hu, Keli Liu, Guiyin Sun & Yiguo Zhang. (2022) The Role of MicroRNA in the Regulation of Tumor Epithelial–Mesenchymal Transition. Cells 11:13, pages 1981.
Crossref
Takayuki Nojima & Nick J. Proudfoot. (2022) Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics. Nature Reviews Molecular Cell Biology 23:6, pages 389-406.
Crossref
Lucia Gonzalo, Ileana Tossolini, Tomasz Gulanicz, Damian A. Cambiagno, Anna Kasprowicz-Maluski, Dariusz Jan Smolinski, María Florencia Mammarella, Federico D. Ariel, Sebastian Marquardt, Zofia Szweykowska-Kulinska, Artur Jarmolowski & Pablo A. Manavella. (2022) R-loops at microRNA encoding loci promote co-transcriptional processing of pri-miRNAs in plants. Nature Plants 8:4, pages 402-418.
Crossref
Amanda F. Assis, Ernna H. Oliveira, Paula B. Donate, Silvana Giuliatti, Catherine Nguyen & Geraldo A. Passos. 2022. Transcriptomics in Health and Disease. Transcriptomics in Health and Disease 3 50 .
Giulia Buonaiuto, Fabio Desideri, Valeria Taliani & Monica Ballarino. (2021) Muscle Regeneration and RNA: New Perspectives for Ancient Molecules. Cells 10:10, pages 2512.
Crossref
Lola Llobat & Olivia Gourbault. (2021) Role of MicroRNAs in Human Osteosarcoma: Future Perspectives. Biomedicines 9:5, pages 463.
Crossref
Pedro Pais, Jorge Oliveira, Vanda Almeida, Melike Yilmaz, Pedro T. Monteiro & Miguel C. Teixeira. (2021) Transcriptome-wide differences between Saccharomyces cerevisiae and Saccharomyces cerevisiae var. boulardii: Clues on host survival and probiotic activity based on promoter sequence variability. Genomics 113:2, pages 530-539.
Crossref
Liu Hong, Hongli Sun & Brad A. Amendt. (2021) MicroRNA function in craniofacial bone formation, regeneration and repair. Bone 144, pages 115789.
Crossref
Nina M. Pollak, Justin J. Cooper-White & Joanne Macdonald. (2021) Translational control of enzyme scavenger expression with toxin-induced micro RNA switches. Scientific Reports 11:1.
Crossref
Forouzan Omidi, Sayed Abdolhakim Hosseini, Abbas Ahmadi, Kambiz Hassanzadeh, Shima Rajaei, Henry Manuel Cesaire & Vahedeh Hosseini. (2020) Discovering the signature of a lupus-related microRNA profile in the Gene Expression Omnibus repository. Lupus 29:11, pages 1321-1335.
Crossref
Olivia Gourbault & Lola Llobat. (2020) MicroRNAs as Biomarkers in Canine Osteosarcoma: A New Future?. Veterinary Sciences 7:4, pages 146.
Crossref
P. S. Vorozheykin & I. I. Titov. (2020) Erratum to: How Animal miRNAs Structure Influences Their Biogenesis. Russian Journal of Genetics 56:8, pages 1012-1024.
Crossref
Philipp J. Dexheimer & Luisa Cochella. (2020) MicroRNAs: From Mechanism to Organism. Frontiers in Cell and Developmental Biology 8.
Crossref
Renfu Shang, S. Chan Baek, Kijun Kim, Boseon Kim, V. Narry Kim & Eric C. Lai. (2020) Genomic Clustering Facilitates Nuclear Processing of Suboptimal Pri-miRNA Loci. Molecular Cell 78:2, pages 303-316.e4.
Crossref
Jong-Sun Lee & Joshua T. Mendell. (2020) Antisense-Mediated Transcript Knockdown Triggers Premature Transcription Termination. Molecular Cell 77:5, pages 1044-1054.e3.
Crossref
I. A. Zaporozhchenko, E. Yu. Rykova & P. P. Laktionov. (2020) The Fundamentals of miRNA Biology: Structure, Biogenesis, and Regulatory Functions. Russian Journal of Bioorganic Chemistry 46:1, pages 1-13.
Crossref
P. S. Vorozheykin & I. I. Titov. (2020) How miRNA Structure of Animals Influences Their Biogenesis. Russian Journal of Genetics 56:1, pages 17-29.
Crossref
Indoumady Baskara-Yhuellou & Jörg Tost. 2020. Inflammatory Disorders - Part B. Inflammatory Disorders - Part B 237 312 .
Thomas Treiber, Nora Treiber & Gunter Meister. (2018) Regulation of microRNA biogenesis and its crosstalk with other cellular pathways. Nature Reviews Molecular Cell Biology 20:1, pages 5-20.
Crossref
Paula Morales-Sánchez, Raúl Fernández Pérez, Pablo Santamarina, Sandra Rodriguez-Rodero, Agustin Fernandez-Fernandez & Mario F. Fraga. 2019. Bone Health. Bone Health 105 128 .
Giulia Pianigiani, Danilo Licastro, Paola Fortugno, Daniele Castiglia, Ivana Petrovic & Franco Pagani. (2018) Microprocessor-dependent processing of splice site overlapping microRNA exons does not result in changes in alternative splicing. RNA 24:9, pages 1158-1171.
Crossref
Cedric Belair, Soyeong Sim & Sandra L. Wolin. (2017) Noncoding RNA Surveillance: The Ends Justify the Means. Chemical Reviews 118:8, pages 4422-4447.
Crossref
David P. Bartel. (2018) Metazoan MicroRNAs. Cell 173:1, pages 20-51.
Crossref
Huiwu Ouyang, Kai Zhang, Kristi Fox-Walsh, Yang Yang, Chen Zhang, Jie Huang, Hairi Li, Yu Zhou & Xiang-Dong Fu. (2017) The RNA binding protein EWS is broadly involved in the regulation of pri-miRNA processing in mammalian cells. Nucleic Acids Research 45:21, pages 12481-12495.
Crossref
R.J. Ries, W. Yu, N. Holton, H. Cao & B.A. Amendt. (2017) Inhibition of the miR-17-92 Cluster Separates Stages of Palatogenesis . Journal of Dental Research 96:11, pages 1257-1264.
Crossref
Li Jiang, Changwei Shao, Qi-Jia Wu, Geng Chen, Jie Zhou, Bo Yang, Hairi Li, Lan-Tao Gou, Yi Zhang, Yangming Wang, Gene W Yeo, Yu Zhou & Xiang-Dong Fu. (2017) NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing. Nature Structural & Molecular Biology 24:10, pages 816-824.
Crossref
Belinda J. Goldie, Chantel Fitzsimmons, Judith Weidenhofer, Joshua R. Atkins, Dan O. Wang & Murray J. Cairns. (2017) miRNA Enriched in Human Neuroblast Nuclei Bind the MAZ Transcription Factor and Their Precursors Contain the MAZ Consensus Motif. Frontiers in Molecular Neuroscience 10.
Crossref
Dooyoung Lee, Jin-Wu Nam & Chanseok Shin. (2017) DROSHA targets its own transcript to modulate alternative splicing. RNA 23:7, pages 1035-1047.
Crossref
Thomas Treiber, Nora Treiber, Uwe Plessmann, Simone Harlander, Julia-Lisa Daiß, Norbert Eichner, Gerhard Lehmann, Kevin Schall, Henning Urlaub & Gunter Meister. (2017) A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis. Molecular Cell 66:2, pages 270-284.e13.
Crossref
Clara McClure, Melissa B McPeak, Dima Youssef, Zhi Q Yao, Charles E McCall & Mohamed El Gazzar. (2016) Stat3 and C/EBPβ synergize to induce miR‐21 and miR‐181b expression during sepsis. Immunology & Cell Biology 95:1, pages 42-55.
Crossref
William P. Schreiner & Amy E. Pasquinelli. 2017. Essentials of Noncoding RNA in Neuroscience. Essentials of Noncoding RNA in Neuroscience 1 17 .
Haoming Liu, Chunyang Liang, Rahul K. Kollipara, Masayuki Matsui, Xiong Ke, Byung-Cheon Jeong, Zhiqiang Wang, Kyoung Shin Yoo, Gaya P. Yadav, Lisa N. Kinch, Nicholas V. Grishin, Yunsun Nam, David R. Corey, Ralf Kittler & Qinghua Liu. (2016) HP1BP3, a Chromatin Retention Factor for Co-transcriptional MicroRNA Processing. Molecular Cell 63:3, pages 420-432.
Crossref
Nick J. Proudfoot. (2016) Transcriptional termination in mammals: Stopping the RNA polymerase II juggernaut. Science 352:6291.
Crossref
Chirag Nepal, Marion Coolen, Yavor Hadzhiev, Delphine Cussigh, Piotr Mydel, Vidar M. Steen, Piero Carninci, Jesper B. Andersen, Laure Bally-Cuif, Ferenc Müller & Boris Lenhard. (2016) Transcriptional, post-transcriptional and chromatin-associated regulation of pri-miRNAs, pre-miRNAs and moRNAs. Nucleic Acids Research 44:7, pages 3070-3081.
Crossref
Ryan J Bloom, Sally M Winkler & Christina D Smolke. (2015) Synthetic feedback control using an RNAi-based gene-regulatory device. Journal of Biological Engineering 9:1.
Crossref
Nova Fong, Kristopher Brannan, Benjamin Erickson, Hyunmin Kim, Michael A. Cortazar, Ryan M. Sheridan, Tram Nguyen, Shai Karp & David L. Bentley. (2015) Effects of Transcription Elongation Rate and Xrn2 Exonuclease Activity on RNA Polymerase II Termination Suggest Widespread Kinetic Competition. Molecular Cell 60:2, pages 256-267.
Crossref
Wenwen Fang & David P. Bartel. (2015) The Menu of Features that Define Primary MicroRNAs and Enable De Novo Design of MicroRNA Genes. Molecular Cell 60:1, pages 131-145.
Crossref
Alessia Loffreda, Aurora Rigamonti, Silvia Barabino & Silvia Lenzken. (2015) RNA-Binding Proteins in the Regulation of miRNA Activity: A Focus on Neuronal Functions. Biomolecules 5:4, pages 2363-2387.
Crossref
Shanye Yin, Yong Yu & Robin Reed. (2015) Primary microRNA processing is functionally coupled to RNAP II transcription in vitro. Scientific Reports 5:1.
Crossref
Scott M. Hammond. (2015) An overview of microRNAs. Advanced Drug Delivery Reviews 87, pages 3-14.
Crossref
Sven Diederichs. (2015) Micro-terminator: 'Hasta la vista, lncRNA!'. Nature Structural & Molecular Biology 22:4, pages 279-281.
Crossref
Ashish Dhir, Somdutta Dhir, Nick J Proudfoot & Catherine L Jopling. (2015) Microprocessor mediates transcriptional termination of long noncoding RNA transcripts hosting microRNAs. Nature Structural & Molecular Biology 22:4, pages 319-327.
Crossref
Omar S. Akbari, Chun-Hong Chen, John M. MarshallHaixia Huang, Igor Antoshechkin & Bruce A. Hay. (2012) Novel Synthetic Medea Selfish Genetic Elements Drive Population Replacement in Drosophila ; a Theoretical Exploration of Medea -Dependent Population Suppression . ACS Synthetic Biology 3:12, pages 915-928.
Crossref
Stefano Dini Modigliani, Mariangela Morlando, Lorenzo Errichelli, Mario Sabatelli & Irene Bozzoni. (2014) An ALS-associated mutation in the FUS 3′-UTR disrupts a microRNA–FUS regulatory circuitry. Nature Communications 5:1.
Crossref
Maud Contrant, Aurélie Fender, Béatrice Chane-Woon-Ming, Ramy Randrianjafy, Valérie Vivet-Boudou, Delphine Richer & Sébastien Pfeffer. (2014) Importance of the RNA secondary structure for the relative accumulation of clustered viral microRNAs. Nucleic Acids Research 42:12, pages 7981-7996.
Crossref
Ivano Legnini, Mariangela Morlando, Arianna Mangiavacchi, Alessandro Fatica & Irene Bozzoni. (2014) A Feedforward Regulatory Loop between HuR and the Long Noncoding RNA linc-MD1 Controls Early Phases of Myogenesis. Molecular Cell 53:3, pages 506-514.
Crossref
Karolina Duskova, Pruthvi Nagilla, Hai-Son Le, Priyadarshini Iyer, Anbupalam Thalamuthu, Jeremy Martinson, Ziv Bar-Joseph, William Buchanan, Charles Rinaldo & Velpandi Ayyavoo. (2013) MicroRNA regulation and its effects on cellular transcriptome in Human Immunodeficiency Virus-1 (HIV-1) infected individuals with distinct viral load and CD4 cell counts. BMC Infectious Diseases 13:1.
Crossref
Natalia Gromak, Martin Dienstbier, Sara Macias, Mireya Plass, Eduardo Eyras, Javier F. Cáceres & Nicholas J. Proudfoot. (2013) Drosha Regulates Gene Expression Independently of RNA Cleavage Function. Cell Reports 5:6, pages 1499-1510.
Crossref
Francesca Pagano, Elisabetta De Marinis, Francesco Grignani & Clara Nervi. (2013) Epigenetic role of miRNAs in normal and leukemic hematopoiesis. Epigenomics 5:5, pages 539-552.
Crossref
Valentina Libri, Pascal Miesen, Ronald P. van Rij & Amy H. Buck. (2013) Regulation of microRNA biogenesis and turnover by animals and their viruses. Cellular and Molecular Life Sciences 70:19, pages 3525-3544.
Crossref
Izabella Slezak-Prochazka, Joost Kluiver, Debora de Jong, Gertrud Kortman, Nancy Halsema, Sibrand Poppema, Bart-Jan Kroesen & Anke van den Berg. (2013) Cellular Localization and Processing of Primary Transcripts of Exonic MicroRNAs. PLoS ONE 8:9, pages e76647.
Crossref
Takashi S. Miki & Helge Großhans. (2013) The multifunctional RNase XRN2. Biochemical Society Transactions 41:4, pages 825-830.
Crossref
Shyam Twayana, Ivano Legnini, Marcella Cesana, Davide Cacchiarelli, Mariangela Morlando & Irene Bozzoni. (2013) Biogenesis and function of non-coding RNAs in muscle differentiation and in Duchenne muscular dystrophy. Biochemical Society Transactions 41:4, pages 844-849.
Crossref
Stefan L. Ameres & Phillip D. Zamore. (2013) Diversifying microRNA sequence and function. Nature Reviews Molecular Cell Biology 14:8, pages 475-488.
Crossref
Marcella Cesana & George Q. Daley. (2013) Deciphering the rules of ceRNA networks. Proceedings of the National Academy of Sciences 110:18, pages 7112-7113.
Crossref
Pietro Laneve, Claude Delaporte, Guillaume Trebuchet, Orban Komonyi, Hakima Flici, Anna Popkova, Giuseppe D'Agostino, Francesca Taglini, Irene Kerekes & Angela Giangrande. (2013) The Gcm/Glide molecular and cellular pathway: New actors and new lineages. Developmental Biology 375:1, pages 65-78.
Crossref
Manfred Schmid & Torben Heick Jensen. (2013) Transcription-associated quality control of mRNP. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1829:1, pages 158-168.
Crossref
Mariangela Morlando, Stefano Dini Modigliani, Giulia Torrelli, Alessandro Rosa, Valerio Di Carlo, Elisa Caffarelli & Irene Bozzoni. (2012) FUS stimulates microRNA biogenesis by facilitating co-transcriptional Drosha recruitment. The EMBO Journal 31:24, pages 4502-4510.
Crossref
Alexandre Wagschal, Emilie Rousset, Poornima Basavarajaiah, Xavier Contreras, Alex Harwig, Sabine Laurent-Chabalier, Mirai Nakamura, Xin Chen, Ke Zhang, Oussama Meziane, Frédéric Boyer, Hugues Parrinello, Ben Berkhout, Christophe Terzian, Monsef Benkirane & Rosemary Kiernan. (2012) Microprocessor, Setx, Xrn2, and Rrp6 Co-operate to Induce Premature Termination of Transcription by RNAPII. Cell 150:6, pages 1147-1157.
Crossref
Judit Ribas, Xiaohua Ni, Mark Castanares, Minzhi M. Liu, David Esopi, Srinivasan Yegnasubramanian, Ronald Rodriguez, Joshua T. Mendell & Shawn E. Lupold. (2012) A novel source for miR-21 expression through the alternative polyadenylation of VMP1 gene transcripts. Nucleic Acids Research 40:14, pages 6821-6833.
Crossref
Lee Davidson, Alastair Kerr & Steven West. (2012) Co-transcriptional degradation of aberrant pre-mRNA by Xrn2. The EMBO Journal 31:11, pages 2566-2578.
Crossref
Bellemer Clément, Bortolin-Cavaillé Marie-Line, Schmidt Ute, Jensen Stig Mølgaard Rask, Kjems Jørgen, Bertrand Edouard & Jérôme Cavaillé. (2012) Microprocessor dynamics and interactions at endogenous imprinted C19MC microRNA genes. Journal of Cell Science.
Crossref
Hiroshi I. Suzuki & Kohei Miyazono. 2012. Eukaryotic RNases and their Partners in RNA Degradation and Biogenesis, Part B. Eukaryotic RNases and their Partners in RNA Degradation and Biogenesis, Part B 163 183 .
Michal Krzyszton, Monika Zakrzewska-Placzek, Michal Koper & Joanna Kufel. 2012. Eukaryotic RNases and their Partners in RNA Degradation and Biogenesis, Part A. Eukaryotic RNases and their Partners in RNA Degradation and Biogenesis, Part A 131 163 .
Marcella Cesana, Davide Cacchiarelli, Ivano Legnini, Tiziana Santini, Olga Sthandier, Mauro Chinappi, Anna Tramontano & Irene Bozzoni. (2011) A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA. Cell 147:2, pages 358-369.
Crossref
Li Xing & Elliott Kieff. (2011) cis -Acting Effects on RNA Processing and Drosha Cleavage Prevent Epstein-Barr Virus Latency III BHRF1 Expression . Journal of Virology 85:17, pages 8929-8939.
Crossref
Zhen-Ya Li, Yang Xi, Wen-Nan Zhu, Chao Zeng, Zhu-Qin Zhang, Zhi-Chen Guo, De-Long Hao, Guang Liu, Lei Feng, Hou-Zao Chen, Feng Chen, Xiang Lv, De-Pei Liu & Chih-Chuan Liang. (2011) Positive regulation of hepatic miR-122 expression by HNF4α. Journal of Hepatology 55:3, pages 602-611.
Crossref
Jason N. Kuehner, Erika L. Pearson & Claire Moore. (2011) Unravelling the means to an end: RNA polymerase II transcription termination. Nature Reviews Molecular Cell Biology 12:5, pages 283-294.
Crossref
Juan Shan, Li Feng, Lei Luo, Wenqiao Wu, Chengwen Li, Shengfu Li & Youping Li. (2011) MicroRNAs: Potential biomarker in organ transplantation. Transplant Immunology 24:4, pages 210-215.
Crossref
Chase L. Beisel, Yvonne Y. Chen, Stephanie J. Culler, Kevin G. Hoff & Christina D. Smolke. (2011) Design of small molecule-responsive microRNAs based on structural requirements for Drosha processing. Nucleic Acids Research 39:7, pages 2981-2994.
Crossref
Priscilla M Van Wynsberghe, Zoya S Kai, Katlin B Massirer, Victoria H Burton, Gene W Yeo & Amy E Pasquinelli. (2011) LIN-28 co-transcriptionally binds primary let-7 to regulate miRNA maturation in Caenorhabditis elegans. Nature Structural & Molecular Biology 18:3, pages 302-308.
Crossref
Michael J Axtell, Jakub O Westholm & Eric C Lai. (2011) Vive la différence: biogenesis and evolution of microRNAs in plants and animals. Genome Biology 12:4, pages 221.
Crossref
H. I. Suzuki & K. Miyazono. (2010) Emerging complexity of microRNA generation cascades. Journal of Biochemistry 149:1, pages 15-25.
Crossref
Hiroshi I. Suzuki & Kohei Miyazono. (2010) Dynamics of microRNA biogenesis: crosstalk between p53 network and microRNA processing pathway. Journal of Molecular Medicine 88:11, pages 1085-1094.
Crossref
Ryan M. O'Connell, Dinesh S. Rao, Aadel A. Chaudhuri & David Baltimore. (2010) Physiological and pathological roles for microRNAs in the immune system. Nature Reviews Immunology 10:2, pages 111-122.
Crossref
Zoya S Kai & Amy E Pasquinelli. (2010) MicroRNA assassins: factors that regulate the disappearance of miRNAs. Nature Structural & Molecular Biology 17:1, pages 5-10.
Crossref
Jan M. Pawlicki & Joan A. Steitz. (2010) Nuclear networking fashions pre-messenger RNA and primary microRNA transcripts for function. Trends in Cell Biology 20:1, pages 52-61.
Crossref
Michele Trabucchi, Paola Briata, Witold Filipowicz, Andres Ramos, Roberto Gherzi & Michael G. Rosenfeld. 2010. Regulation of microRNAs. Regulation of microRNAs 36 42 .
Helge Großhans & Saibal Chatterjee. 2010. Regulation of microRNAs. Regulation of microRNAs 140 155 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.