Advanced search
Publication Cover
Molecular and Cellular Biology Volume 31, 2011 - Issue 3
Submit an article Journal homepage
34
Views
29
CrossRef citations to date
0
Altmetric
Article

Cooperative Signaling between Slit2 and Ephrin-A1 Regulates a Balance between Angiogenesis and Angiostasis

Charlene M. DunawayDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee37232
,
Yoonha HwangDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee37232
,
Craig W. LindsleyDepartment of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee37232;Department of Chemistry, Vanderbilt University School of Medicine, Nashville, Tennessee37232
,
Rebecca S. CookDepartment of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee37232;Vanderbilt-Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee37232
,
Jane Y. WuDepartment of Neurology and Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois60611
,
Mark BoothbyDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee37232;Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee37232
,
Jin ChenVeterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, Tennessee37212;Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee37232;Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee37232;Vanderbilt-Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee37232;Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee37232
&
Dana M. Brantley-SiedersDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee37232Correspondence[email protected]
 show all
Pages 404-416 | Received 09 Jun 2010, Accepted 20 Nov 2010, Published online: 21 Mar 2023

Citations (29)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Amanda Beauchamp, Mark O. Lively, Akiva Mintz, Denise Gibo, Jill Wykosky & Waldemar Debinski. (2012) EphrinA1 Is Released in Three Forms from Cancer Cells by Matrix Metalloproteases. Molecular and Cellular Biology 32:16, pages 3253-3264.
Read now

Articles from other publishers (28)

Kirsten B. Dorschel & John E. Wanebo. (2023) Physiological and pathophysiological mechanisms of the molecular and cellular biology of angiogenesis and inflammation in moyamoya angiopathy and related vascular diseases. Frontiers in Neurology 14.
Crossref
Anna Di Matteo, Elisa Belloni, Davide Pradella, Ambra Cappelletto, Nina Volf, Serena Zacchigna & Claudia Ghigna. (2020) Alternative splicing in endothelial cells: novel therapeutic opportunities in cancer angiogenesis. Journal of Experimental & Clinical Cancer Research 39:1.
Crossref
Simone Buraschi, Thomas Neill, Shi-Qiong Xu, Chiara Palladino, Antonino Belfiore, Renato V. Iozzo & Andrea Morrione. (2020) Progranulin/EphA2 axis: A novel oncogenic mechanism in bladder cancer. Matrix Biology 93, pages 10-24.
Crossref
Saumya Srivastava, Ka Ming Pang, Mari Iida, Michael S. Nelson, Jiayi Liu, Arin Nam, Jiale Wang, Isa Mambetsariev, Raju Pillai, Atish Mohanty, Nellie McDaniel, Amita Behal, Prakash Kulkarni, Deric L. Wheeler & Ravi Salgia. (2020) Activation of EPHA2-ROBO1 Heterodimer by SLIT2 Attenuates Non-canonical Signaling and Proliferation in Squamous Cell Carcinomas. iScience 23:11, pages 101692.
Crossref
Yongfeng Ding, Yanyan Chen, Mengjie Wu, Linrong Li, Yingying Huang, Haiyong Wang, Haohao Wang, Xiongfei Yu, Nong Xu & Lisong Teng. (2020) Identification of genes associated with gastric cancer survival and construction of a nomogram to improve risk stratification for patients with gastric cancer. Oncology Letters.
Crossref
Xiang Li, Shuang Zheng, Weijiang Tan, Hongqi Chen, Xiaohui Li, Jian Wu, Ting Luo, Xuecong Ren, W. Glen Pyle, Lijing Wang, Peter H. Backx, Ren Huang & Feng Hua Yang. (2020) Slit2 Protects Hearts Against Ischemia-Reperfusion Injury by Inhibiting Inflammatory Responses and Maintaining Myofilament Contractile Properties. Frontiers in Physiology 11.
Crossref
Zohaib Rana, Sarah Diermeier, Muhammad Hanif & Rhonda J. Rosengren. (2020) Understanding Failure and Improving Treatment Using HDAC Inhibitors for Prostate Cancer. Biomedicines 8:2, pages 22.
Crossref
Eileen Shiuan, Ashwin Inala, Shan Wang, Wenqiang Song, Victoria Youngblood, Jin Chen & Dana M. Brantley-Sieders. (2020) Host deficiency in ephrin-A1 inhibits breast cancer metastasis. F1000Research 9, pages 217.
Crossref
Eileen Shiuan, Ashwin Inala, Shan Wang, Wenqiang Song, Victoria Youngblood, Jin Chen & Dana M. Brantley-Sieders. (2020) Host deficiency in ephrin-A1 inhibits breast cancer metastasis. F1000Research 9, pages 217.
Crossref
James Melrose. (2019) Keratan sulfate ( KS )‐proteoglycans and neuronal regulation in health and disease: the importance of KS ‐glycodynamics and interactive capability with neuroregulatory ligands . Journal of Neurochemistry 149:2, pages 170-194.
Crossref
Eloisa Romano, Mirko Manetti, Irene Rosa, Bianca Saveria Fioretto, Lidia Ibba-Manneschi, Marco Matucci-Cerinic & Serena Guiducci. (2018) Slit2/Robo4 axis may contribute to endothelial cell dysfunction and angiogenesis disturbance in systemic sclerosis. Annals of the Rheumatic Diseases 77:11, pages 1665-1674.
Crossref
Roberto Ronca, Mohammed Benkheil, Stefania Mitola, Sofie Struyf & Sandra Liekens. (2017) Tumor angiogenesis revisited: Regulators and clinical implications. Medicinal Research Reviews 37:6, pages 1231-1274.
Crossref
Whasun Lim, Hyocheol Bae, Fuller W. Bazer & Gwonhwa Song. (2017) Functional Roles of Eph A-Ephrin A1 System in Endometrial Luminal Epithelial Cells During Early Pregnancy. Journal of Cellular Physiology 232:6, pages 1527-1538.
Crossref
Feng Zhang, Claudia Prahst, Thomas Mathivet, Laurence Pibouin-Fragner, Jiasheng Zhang, Gael Genet, Raymond Tong, Alexandre Dubrac & Anne Eichmann. (2016) The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization. Nature Communications 7:1.
Crossref
Victoria Youngblood, Shan Wang, Wenqiang Song, Debra Walter, Yoonha Hwang, Jin Chen & Dana M. Brantley-Sieders. (2015) Elevated Slit2 Activity Impairs VEGF-Induced Angiogenesis and Tumor Neovascularization in EphA2-Deficient Endothelium. Molecular Cancer Research 13:3, pages 524-537.
Crossref
Qian-Qian Zhang, Da-lei Zhou, Yan Lei, Li Zheng, Sheng-Xia Chen, Hong-Ju Gou, Qu-Liang Gu, Xiao-Dong He, Tian Lan, Cui-Ling Qi, Jiang-Chao Li, Yan-Qing Ding, Liang Qiao & Li-Jing Wang. (2014) Slit2/Robo1 signaling promotes intestinal tumorigenesis through Src-mediated activation of the Wnt/β-catenin pathway. Oncotarget 6:5, pages 3123-3135.
Crossref
U. Ruth Michaelis. (2014) Mechanisms of endothelial cell migration. Cellular and Molecular Life Sciences 71:21, pages 4131-4148.
Crossref
Andreas Göhrig, Katharina M. Detjen, Georg Hilfenhaus, Jan L. Körner, Martina Welzel, Ruza Arsenic, Rosa Schmuck, Marcus Bahra, Jane Y. Wu, Bertram Wiedenmann & Christian Fischer. (2014) Axon Guidance Factor SLIT2 Inhibits Neural Invasion and Metastasis in Pancreatic Cancer. Cancer Research 74:5, pages 1529-1540.
Crossref
Andreas Pircher, Jasmin Wellbrock, Walter Fiedler, Isabel Heidegger, Eberhard Gunsilius & Wolfgang Hilbe. (2014) New Antiangiogenic Strategies beyond Inhibition of Vascular Endothelial Growth Factor with Special Focus on Axon Guidance Molecules. Oncology 86:1, pages 46-52.
Crossref
Darren A. Yuen & Lisa A. Robinson. (2013) Slit2–Robo signaling. Current Opinion in Nephrology & Hypertension 22:4, pages 445-451.
Crossref
Anna R. Malik, Malgorzata Urbanska, Matylda Macias, Agnieszka Skalecka & Jacek Jaworski. (2013) Beyond control of protein translation: What we have learned about the non-canonical regulation and function of mammalian target of rapamycin (mTOR). Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1834:7, pages 1434-1448.
Crossref
Wesley T. O’Neal, William F. Griffin, Jessica L. Dries-Devlin, Susan D. Kent, Jin Chen, Monte S. Willis & Jitka A.I. Virag. (2013) Ephrin–Eph signaling as a potential therapeutic target for the treatment of myocardial infarction. Medical Hypotheses 80:6, pages 738-744.
Crossref
Sun-Wei Guo, Yu Zheng, Yuan Lu, Xishi Liu & Jian-Guo Geng. (2013) Slit2 Overexpression Results in Increased Microvessel Density and Lesion Size in Mice With Induced Endometriosis. Reproductive Sciences 20:3, pages 285-298.
Crossref
Liya Pi, Anitha K. Shenoy, Jianwen Liu, Seungbum Kim, Nikole Nelson, Huiming Xia, William W. Hauswirth, Bryon E. Petersen, Gregory S. Schultz & Edward W. Scott. (2012) CCN2/CTGF regulates neovessel formation via targeting structurally conserved cystine knot motifs in multiple angiogenic regulators . The FASEB Journal 26:8, pages 3365-3379.
Crossref
Mustapha Kandouz. (2012) The Eph/Ephrin family in cancer metastasis: communication at the service of invasion. Cancer and Metastasis Reviews 31:1-2, pages 353-373.
Crossref
Amanda Beauchamp & Waldemar Debinski. (2012) Ephs and ephrins in cancer: Ephrin-A1 signalling. Seminars in Cell & Developmental Biology 23:1, pages 109-115.
Crossref
Mimmi S. Ballard & Lindsay Hinck. 2012. Guidance Molecules in Cancer and Tumor Angiogenesis. Guidance Molecules in Cancer and Tumor Angiogenesis 187 235 .
Nyall R London & Dean Y Li. (2011) Robo4-dependent Slit signaling stabilizes the vasculature during pathologic angiogenesis and cytokine storm. Current Opinion in Hematology 18:3, pages 186-190.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.