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Molecular and Cellular Biology Volume 33, 2013 - Issue 1
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Article

p38α Mitogen-Activated Protein Kinase Depletion and Repression of Signal Transduction to Translation Machinery by miR-124 and -128 in Neurons

Sarah K. LawsonDivision of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
,
Elena Y. DobrikovaDivision of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
,
Mayya ShveygertDivision of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
&
Matthias GromeierDivision of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USACorrespondence[email protected]
Pages 127-135 | Received 24 May 2012, Accepted 19 Oct 2012, Published online: 20 Mar 2023

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John Alam & Wiep Scheper. (2016) Targeting neuronal MAPK14/p38α activity to modulate autophagy in the Alzheimer disease brain. Autophagy 12:12, pages 2516-2520.
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Ying Jiang, John J. Alam, Stephen N. Gomperts, Paul Maruff, Afina W. Lemstra, Ursula A. Germann, Philip H. Stavrides, Sandipkumar Darji, Sandeep Malampati, James Peddy, Cynthia Bleiwas, Monika Pawlik, Anna Pensalfini, Dun-Sheng Yang, Shivakumar Subbanna, Balapal S. Basavarajappa, John F. Smiley, Amanda Gardner, Kelly Blackburn, Hui-May Chu, Niels D. Prins, Charlotte E. Teunissen, John E. Harrison, Philip Scheltens & Ralph A. Nixon. (2022) Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration. Nature Communications 13:1.
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Alberto Arencibia & Luis A. Salazar. (2022) Microarray meta-analysis reveals IL6 and p38β/MAPK11 as potential targets of hsa-miR-124 in endothelial progenitor cells: Implications for stent re-endothelization in diabetic patients. Frontiers in Cardiovascular Medicine 9.
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Justina Pajarskienė, Vytautas Kašėta, Kristina Vaikšnoraitė, Virginijus Tunaitis & Augustas Pivoriūnas. (2021) MicroRNA-124 acts as a positive regulator of IFN-β signaling in the lipopolysaccharide-stimulated human microglial cells. International Immunopharmacology 101, pages 108262.
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Pin-Hong Li, Li-Qun Wang, Jia-Yang He, Xiang-Long Zhu, Wei Huang, Shao-Wen Wang, Qi-Wei Qin & Hong-Yan Sun. (2021) MicroRNA-124 Promotes Singapore Grouper Iridovirus Replication and Negatively Regulates Innate Immune Response. Frontiers in Immunology 12.
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Jianzhu Bo, Fan Shi, Xi Wang, Yi Zhu, Lijin Zhang, Bin He, Shuang Li & Yanshu Zhang. (2020) Statistical Analysis for Identifying Differentially MicroRNA in Serum Exosomes of Lead Workers. Journal of Healthcare Engineering 2020, pages 1-10.
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Prita R. Asih, Emmanuel Prikas, Kristie Stefanoska, Amanda R. P. Tan, Holly I. Ahel & Arne Ittner. (2020) Functions of p38 MAP Kinases in the Central Nervous System. Frontiers in Molecular Neuroscience 13.
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Xiaohuan Xia, Yi Wang, Yunlong Huang, Han Zhang, Hongfang Lu & Jialin C. Zheng. (2019) Exosomal miRNAs in central nervous system diseases: biomarkers, pathological mediators, protective factors and therapeutic agents. Progress in Neurobiology 183, pages 101694.
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Longping Yao, Zhiyuan Zhu, Jiayu Wu, Yizhou Zhang, Hongbo Zhang, Xiang Sun, Chen Qian, Baoyan Wang, Linghai Xie, Shizhong Zhang & And Guohui Lu. (2019) MicroRNA‐124 regulates the expression of p62/p38 and promotes autophagy in the inflammatory pathogenesis of Parkinson's disease. The FASEB Journal 33:7, pages 8648-8665.
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Rui-Fang Dong, Li-Wen Tai, Bing Zhang, Fang-Kun Shi, Hong-Mei Liu, Peng-Cang Duan & Ye Cheng. (2019) Neuroprotective effect of FMS-like tyrosine kinase-3 silence on cerebral ischemia/reperfusion injury in a SH-SY5Y cell line. Gene 697, pages 152-158.
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Wen Wu, Wei Zhang, Mihyun Choi, Jinjing Zhao, Ping Gao, Min Xue, Harold A. Singer, David Jourd'heuil & Xiaochun Long. (2019) Vascular smooth muscle-MAPK14 is required for neointimal hyperplasia by suppressing VSMC differentiation and inducing proliferation and inflammation. Redox Biology 22, pages 101137.
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Yanqiu Liu, Yuzhen Zhang, Ping Liu, Hongying Bai, Xiaodong Li, Jianhao Xiao, Qian Yuan, Shuang Geng, Honglei Yin, Hui Zhang, Zhen Wang, Jinfeng Li, Shanshan Wang & Yunliang Wang. (2019) MicroRNA-128 knockout inhibits the development of Alzheimer's disease by targeting PPARγ in mouse models. European Journal of Pharmacology 843, pages 134-144.
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Marta Fumagalli, Marta Lombardi, Pierre Gressens & Claudia Verderio. (2018) How to reprogram microglia toward beneficial functions. Glia 66:12, pages 2531-2549.
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Sukanya Shyamasundar, Cynthia Ong, Lin-Yue Lanry Yung, S Thameem Dheen & Boon Huat Bay. (2018) miR-128 Regulates Genes Associated with Inflammation and Fibrosis of Rat Kidney Cells In Vitro . The Anatomical Record 301:5, pages 913-921.
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Philip Scheltens, Niels Prins, Adriaan Lammertsma, Maqsood Yaqub, Alida Gouw, Alle Meije Wink, Hui-May Chu, Bart N. M. van Berckel & John Alam. (2018) An exploratory clinical study of p38 α kinase inhibition in Alzheimer's disease . Annals of Clinical and Translational Neurology 5:4, pages 464-473.
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Yoshitoshi Kasuya, Hiroki Umezawa & Masahiko Hatano. (2018) Stress-Activated Protein Kinases in Spinal Cord Injury: Focus on Roles of p38. International Journal of Molecular Sciences 19:3, pages 867.
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María Salvador‐Bernáldez, Sara B Mateus, Iván Del Barco Barrantes, Simon C Arthur, Carlos Martínez‐A, Angel R Nebreda & Jesús M Salvador. (2017) p38α regulates cytokine‐induced IFNγ secretion via the Mnk1/eIF4E pathway in Th1 cells. Immunology & Cell Biology 95:9, pages 814-823.
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Isabelle Corre, François Paris & Jacques Huot. (2017) The p38 pathway, a major pleiotropic cascade that transduces stress and metastatic signals in endothelial cells. Oncotarget 8:33, pages 55684-55714.
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Şükrü Aydın Düzgün, Azmi Yerlikaya, Sezgin Zeren, Zülfü Bayhan, Emrah Okur & İhsan Boyacı. (2017) Differential effects of p38 MAP kinase inhibitors SB203580 and SB202190 on growth and migration of human MDA-MB-231 cancer cell line. Cytotechnology 69:4, pages 711-724.
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Jana L. McCaskill, Sarah Ressel, Andreas Alber, Jane Redford, Ultan F. Power, Jürgen Schwarze, Bernadette M. Dutia & Amy H. Buck. (2017) Broad-Spectrum Inhibition of Respiratory Virus Infection by MicroRNA Mimics Targeting p38 MAPK Signaling. Molecular Therapy - Nucleic Acids 7, pages 256-266.
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Xue Liang, Wenfeng Shangguan, Miaomiao Zhang, Shiyue Mei, Liyang Wang & Rongcun Yang. (2017) miR-128 enhances dendritic cell-mediated anti-tumor immunity via targeting of p38. Molecular Medicine Reports 16:2, pages 1307-1313.
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Guochao Mao, Pengyu Ren, Gang Wang, Feng Yan & Yuelin Zhang. (2016) MicroRNA-128-3p Protects Mouse Against Cerebral Ischemia Through Reducing p38α Mitogen-Activated Protein Kinase Activity. Journal of Molecular Neuroscience 61:2, pages 152-158.
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Yatong Chen, Jiahui Zhao, Yong Luo, Yongxing Wang & Yongguang Jiang. (2016) Downregulated expression of miRNA-149 promotes apoptosis in side population cells sorted from the TSU prostate cancer cell line. Oncology Reports 36:5, pages 2587-2600.
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Nadejda L. Korneeva, Anren Song, Hermann Gram, Mary Ann Edens & Robert E. Rhoads. (2016) Inhibition of Mitogen-activated Protein Kinase (MAPK)-interacting Kinase (MNK) Preferentially Affects Translation of mRNAs Containing Both a 5′-Terminal Cap and Hairpin. Journal of Biological Chemistry 291:7, pages 3455-3467.
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Michael C. Brown, Elena Y. Dobrikova, Mikhail I. Dobrikov, Ross W. Walton, Sarah L. Gemberling, Smita K. Nair, Annick Desjardins, John H. Sampson, Henry S. Friedman, Allan H. Friedman, Douglas S. Tyler, Darell D. Bigner & Matthias Gromeier. (2014) Oncolytic polio virotherapy of cancer. Cancer 120:21, pages 3277-3286.
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Fathi Emhemmed, Sarah Ali Azouaou, Frédéric Thuaud, Valérie Schini-Kerth, Laurent Désaubry, Christian D. Muller & Guy Fuhrmann. (2014) Selective anticancer effects of a synthetic flavagline on human Oct4-expressing cancer stem-like cells via a p38 MAPK-dependent caspase-3-dependent pathway. Biochemical Pharmacology 89:2, pages 185-196.
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