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Article

Cross Talk between Phosphatidylinositol 3-Kinase and Cyclic AMP (cAMP)-Protein Kinase A Signaling Pathways at the Level of a Protein Kinase B/β-Arrestin/cAMP Phosphodiesterase 4 Complex

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Pages 1660-1672 | Received 28 May 2009, Accepted 30 Dec 2009, Published online: 20 Mar 2023

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Crossref
Dianhua Jiang, Ting Xie, Jiurong Liang & Paul W. Noble. 2013. The Molecular Biology of Arrestins. The Molecular Biology of Arrestins 359 393 .
Satheeshmanikandan RS Thappali, Kanthikiran VS Varanasi, Sridhar Veeraraghavan, Swaroop Kumar VS Vakkalanka & Mukkanti K. (2012) Simultaneous quantitation of IC87114, roflumilast and its active metabolite roflumilast N-oxide in plasma by LC-MS/MS: application for a pharmacokinetic study. Journal of Mass Spectrometry 47:12, pages 1612-1619.
Crossref
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Crossref
Kristoffer Watten Brudvik & Kjetil Taskén. (2012) Modulation of T cell immune functions by the prostaglandin E2 - cAMP pathway in chronic inflammatory states. British Journal of Pharmacology 166:2, pages 411-419.
Crossref
Arun K. Shukla, Kunhong Xiao & Robert J. Lefkowitz. (2011) Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling. Trends in Biochemical Sciences 36:9, pages 457-469.
Crossref
Hannu Kankaanranta, Jouni Parkkonen, Pinja Ilmarinen-Salo, Mark A. Giembycz & Eeva Moilanen. (2011) Salbutamol delays human eosinophil apoptosis via a cAMP-dependent mechanism. Pulmonary Pharmacology & Therapeutics 24:4, pages 394-400.
Crossref
Randi Mosenden & Kjetil Taskén. (2011) Cyclic AMP-mediated immune regulation — Overview of mechanisms of action in T cells. Cellular Signalling 23:6, pages 1009-1016.
Crossref
Lindsay S. Wilson, George S. Baillie, Lisa M. Pritchard, Bibiana Umana, Anna Terrin, Manuela Zaccolo, Miles D. Houslay & Donald H. Maurice. (2011) A Phosphodiesterase 3B-based Signaling Complex Integrates Exchange Protein Activated by cAMP 1 and Phosphatidylinositol 3-Kinase Signals in Human Arterial Endothelial Cells. Journal of Biological Chemistry 286:18, pages 16285-16296.
Crossref
Sharron H. Francis, Mitsi A. Blount & Jackie D. Corbin. (2011) Mammalian Cyclic Nucleotide Phosphodiesterases: Molecular Mechanisms and Physiological Functions. Physiological Reviews 91:2, pages 651-690.
Crossref
Francesca Finetti, Silvia Rossi Paccani, Joel Rosenbaum & Cosima T. Baldari. (2011) Intraflagellar transport: a new player at the immune synapse. Trends in Immunology 32:4, pages 139-145.
Crossref
Kathryn A. DeFea. (2011) Beta-arrestins as regulators of signal termination and transduction: How do they determine what to scaffold?. Cellular Signalling 23:4, pages 621-629.
Crossref
Lingyun Zu, Zhenyun Shen, Jacob Wesley & Zheqing P. Cai. (2011) PTEN inhibitors cause a negative inotropic and chronotropic effect in mice. European Journal of Pharmacology 650:1, pages 298-302.
Crossref
Elisa Bjørgo, Kristine Moltu & Kjetil Taskén. 2011. Phosphodiesterases as Drug Targets. Phosphodiesterases as Drug Targets 345 363 .
Miles Houslay & Marco Conti. (2010) Phosphodiesterase 4D, cAMP specific. AfCS-Nature Molecule Pages.
Crossref
Isabelle Cornez & Kjetil Taskén. (2010) Spatiotemporal control of cyclic AMP immunomodulation through the PKA-Csk inhibitory pathway is achieved by anchoring to an Ezrin-EBP50-PAG scaffold in effector T cells. FEBS Letters 584:12, pages 2681-2688.
Crossref
Elisa Bjørgo & Kjetil Taskén. (2010) Novel mechanism of signaling by CD28. Immunology Letters 129:1, pages 1-6.
Crossref

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