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Molecular and Cellular Biology Volume 36, 2016 - Issue 1

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The Insertion in Fingers Domain in Human Telomerase Can Mediate Enzyme Processivity and Telomerase Recruitment to Telomeres in a TPP1-Dependent Manner

Tsz Wai Chua Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Canada;b Division of Experimental Medicine, McGill University, Montréal, Canada

Yasmin D'Souzaa Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Canada;c Department of Anatomy and Cell Biology, McGill University, Montréal, Canada

Chantal Autexiera Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Canada;b Division of Experimental Medicine, McGill University, Montréal, Canada;c Department of Anatomy and Cell Biology, McGill University, Montréal, CanadaCorrespondence[email protected]

Pages 210-222 | Received 04 Sep 2015, Accepted 19 Oct 2015, Published online: 18 Mar 2023

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https://doi.org/10.1128/MCB.00746-15
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Shilpa Padmanaban, Valerie M Tesmer & Jayakrishnan Nandakumar. (2023) Interaction hub critical for telomerase recruitment and primer-template handling for catalysis. Life Science Alliance 6:6, pages e202201727.
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Patrick Lambert-Lanteigne, Adrian Young & Chantal Autexier. (2023) Complex interaction network revealed by mutation of human telomerase ‘insertion in fingers’ and essential N-terminal domains and the telomere protein TPP1. Journal of Biological Chemistry 299:3, pages 102916.
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Zala Sekne, George E. Ghanim, Anne-Marie M. van Roon & Thi Hoang Duong Nguyen. (2022) Structural basis of human telomerase recruitment by TPP1-POT1. Science 375:6585, pages 1173-1176.
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Sabrina Ghadaouia, Marc-Alexandre Olivier, Aurélie Martinez, Tibila Kientega, Jian Qin, Patrick Lambert-Lanteigne, Guillaume B Cardin, Chantal Autexier, Nicolas Malaquin & Francis Rodier. (2021) Homologous recombination-mediated irreversible genome damage underlies telomere-induced senescence. Nucleic Acids Research 49:20, pages 11690-11707.
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Christopher R. Reilly, Mikko Myllymäki, Robert Redd, Shilpa PadmanabanDruha Karunakaran, Valerie TesmerFrederick D. Tsai, Christopher J. Gibson, Huma Q. Rana, Liang ZhongWael SaberStephen R. SpellmanZhen-Huan HuEsther H. Orr, Maxine M. Chen, Immaculata De Vivo, Daniel J. DeAngelo, Corey Cutler, Joseph H. Antin, Donna NeubergJudy E. Garber, Jayakrishnan NandakumarSuneet Agarwal & R. Coleman Lindsley. (2021) The clinical and functional effects of TERT variants in myelodysplastic syndrome . Blood 138:10, pages 898-911.
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Yao He, Yaqiang Wang, Baocheng Liu, Christina Helmling, Lukas Sušac, Ryan Cheng, Z. Hong Zhou & Juli Feigon. (2021) Structures of telomerase at several steps of telomere repeat synthesis. Nature 593:7859, pages 454-459.
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Sherilyn Grill, Shilpa Padmanaban, Ann Friedman, Eric Perkey, Frederick Allen, Valerie M. Tesmer, Jennifer Chase, Rami Khoriaty, Catherine E. Keegan, Ivan Maillard & Jayakrishnan Nandakumar. (2021) TPP1 mutagenesis screens unravel shelterin interfaces and functions in hematopoiesis. JCI Insight 6:9.
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Sherilyn Grill & Jayakrishnan Nandakumar. (2021) Molecular mechanisms of telomere biology disorders. Journal of Biological Chemistry 296, pages 100064.
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Yaqiang Wang, Marcus Gallagher-Jones, Lukas Sušac, He Song & Juli Feigon. (2020) A structurally conserved human and Tetrahymena telomerase catalytic core . Proceedings of the National Academy of Sciences 117:49, pages 31078-31087.
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Eric M. Smith, Devon F. Pendlebury & Jayakrishnan Nandakumar. (2019) Structural biology of telomeres and telomerase. Cellular and Molecular Life Sciences 77:1, pages 61-79.
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Valerie M. Tesmer, Eric M. Smith, Oana Danciu, Shilpa Padmanaban & Jayakrishnan Nandakumar. (2019) Combining conservation and species-specific differences to determine how human telomerase binds telomeres. Proceedings of the National Academy of Sciences 116:52, pages 26505-26515.
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Deanna E MacNeil, Patrick Lambert-Lanteigne & Chantal Autexier. (2019) N-terminal residues of human dyskerin are required for interactions with telomerase RNA that prevent RNA degradation. Nucleic Acids Research 47:10, pages 5368-5380.
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Jiansen Jiang, Yaqiang Wang, Lukas Sušac, Henry Chan, Ritwika Basu, Z. Hong Zhou & Juli Feigon. (2018) Structure of Telomerase with Telomeric DNA. Cell 173:5, pages 1179-1190.e13.
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Sherilyn Grill, Valerie M. Tesmer & Jayakrishnan Nandakumar. (2018) The N Terminus of the OB Domain of Telomere Protein TPP1 Is Critical for Telomerase Action. Cell Reports 22:5, pages 1132-1140.
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Yaqiang Wang & Juli Feigon. (2017) Structural biology of telomerase and its interaction at telomeres. Current Opinion in Structural Biology 47, pages 77-87.
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R. Alex WuHeather E. UptonJacob M. VoganKathleen Collins. (2017) Telomerase Mechanism of Telomere Synthesis. Annual Review of Biochemistry 86:1, pages 439-460.
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Henry ChanYaqiang WangJuli Feigon. (2017) Progress in Human and Tetrahymena Telomerase Structure Determination . Annual Review of Biophysics 46:1, pages 199-225.
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D.K. Hapangama, A. Kamal & G. Saretzki. (2016) Implications of telomeres and telomerase in endometrial pathology. Human Reproduction Update.
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Deanna MacNeil, Hélène Bensoussan & Chantal Autexier. (2016) Telomerase Regulation from Beginning to the End. Genes 7:9, pages 64.
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Juli Feigon, Henry Chan & Jiansen Jiang. (2016) Integrative structural biology of Tetrahymena telomerase – insights into catalytic mechanism and interaction at telomeres . The FEBS Journal 283:11, pages 2044-2050.
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Tsz Wai Chu, Deanna Elise MacNeil & Chantal Autexier. (2016) Multiple Mechanisms Contribute to the Cell Growth Defects Imparted by Human Telomerase Insertion in Fingers Domain Mutations Associated with Premature Aging Diseases. Journal of Biological Chemistry 291:16, pages 8374-8386.
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Johanna Mancini, Philippe Rousseau, Katherine J. Castor, Hanadi F. Sleiman & Chantal Autexier. (2016) Platinum(II) phenanthroimidazole G-quadruplex ligand induces selective telomere shortening in A549 cancer cells. Biochimie 121, pages 287-297.
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The Insertion in Fingers Domain in Human Telomerase Can Mediate Enzyme Processivity and Telomerase Recruitment to Telomeres in a TPP1-Dependent Manner

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The Insertion in Fingers Domain in Human Telomerase Can Mediate Enzyme Processivity and Telomerase Recruitment to Telomeres in a TPP1-Dependent Manner

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